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| 1 | Spatio-temporal trend and statistical distribution of extreme precipitation events in Huaihe River Basin during 1960-2009显示文摘Based on the daily precipitation data of 27 meteorological stations from 1960 to 2009 in the Huaihe River Basin, spatio-temporal trend and statistical distribution of extreme precipitation events in this area are analyzed. Annual maximum series (AM) and peak over threshold series (POT) are selected to simulate the probability distribution of extreme precipitation. The results show that positive trend of annual maximum precipitation is detected at most of used stations, only a small number of stations are found to depict a negative trend during the past five decades, and none of the positive or negative trend is significant. The maximum precipitation event almost occurred in the flooding period during the 1960s and 1970s. By the L-moments method, the parameters of three extreme distributions, i.e., Generalized extreme value distribution (GEV), Generalized Pareto distribution (GP) and Gamma distribution are estimated. From the results of goodness of fit test and Kolmogorov-Smirnov (K-S) test, AM series can be better fitted by GEV model and POT series can be better fitted by GP model. By the comparison of the precipitation amounts under different return levels, it can be found that the values obtained from POT series are a little larger than the values from AM series, and they can better simulate the observed values in the Huaihe River Basin. | XIA Jun SHE Dunxian ZHANG Yongyong DU Hong | 2012 | Journal of Geographical Sciences2012，22，2： | 24 |
| 2 | Biosynthesis of Triacylglycerol Molecules with a Tailored PUFA Profile in Industrial Microalgae显示文摘The composition of polyun saturated fatty acids (PUFAs) in triacylglycerols (TAGs) is key to health ben efits and for oil applications, yet the underlying genetic mechanism remains poorly understood. In this study, by in si Iico, ex vivo, and in vivo profili ng of type-2 diacylglycerol acyltransferases (DGAT2s) in Nannochloropsis oceanica we revealed two novel PUFA-preferring enzymes that discriminate individual PUFA species in TAG assembly, with NoDGAT2J for linoleic acid (LA) and NoDGAT2K for eicosapentaenoic acid (EPA). The LA and EPA composition of TAG molecules is mediated in vivo via the functional partitioning between NoDGAT2J and 2K, both of which are localized in the chloroplast envelope. By modulating transcript abundance of the DGAT2s, an N. oceanica strain bank was created, where proportions of LA and EPA in TAG vary by 18.7-fold (between 0.21% and 3.92% dry weight) and 34.7-fold (between 0.09% and 3.12% dry weight), respective!y. These findings lay the foundation for producing designer TAG molecules with tailored health benefits or for biofuel applications in industrial microalgae and higher-plant crops. | Yi Xin Chen Shen Yiting She Hong Chen Cong Wang Li Wei Kangsup Yoon Danxiang Han Qiang Hu Jian Xu | 2019 | Molecular Plant2019，12，4： | 10 |
| 3 | Histone methyltransferase G9a contributes to H3K27 methylation in vivo显示文摘 | Hui Wu Xiuzhen Chen Jun Xiong Yingfeng Li Hong Li Xiaojun Ding Sheng Liu She Chen Shaorong Gao Bing Zhu | 2011 | Cell Research2011，21，2： | 8 |
| 4 | Anti-mitotic chemotherapeutics promote apoptosis through TL1A-activated death receptor 3 in cancer cells显示文摘 | Chen Qi Xin Wang Zhirong Shen She Chen Hong Yu Noelle Williams Gelin Wang | 2018 | Cell Research2018，28，5： | 7 |
| 5 | Association of macular pigment optical density with early stage of non-proliferative diabetic retinopathy in Chinese patients with type 2 diabetes mellitus显示文摘AIM:To detect the association between macular pigment optical density(MPOD),which reflects the antioxidant ability of retina,and diabetic retinopathy(DR)and to investigate the correlated factors of MPOD.METHODS: Totally 435 subjects of urban Chinese were recruited to the study and divided into 3 groups: non-diabetes mellitus controls(NDM),diabetic patients without retinopathy(DWR),and patients with early stage of non-proliferative diabetic retinopathy(DR).Demographic and lifestyle characteristics were ascertained by questionnaire.A food-frequency questionnaire,general physical and ophthalmic examinations were completed for all participants.MPOD was measured by heterochromatic flicker photometry.Foveal thickness was measured by optical coherence tomography.The difference of MPOD among 3 groups was analyzed by analysis of covariance.The correlation analyses of MPOD with the candidate influence factors were assessed using the generalized estimating equations(GEE) model.RESULTS: Of the 435 participants,34 could not perform the MPOD measurements.Final analysis included 401 subjects,including 48 were in DR group,134 in DWR group,and 219 in NDM group.MPOD was not significantly different among DR(0.49 ±0.21),DWR(0.45 ±0.21),and NDM(0.49±0.17) groups(P=0.24) after adjustment for fasting plasma glycemia,central foveal thickness,green vegetables,Chinese wolfberry,carotene and vitamin E.For all the 401 participants included,MPOD was positively associated with central foveal thickness(E=0.0007,P=0.001),Chinese wolfberry(E=0.0345,P=0.01),and green vegetables(E=0.0596,P<0.001) intake.CONCLUSION: The data suggest that MPOD level is not statistically significantly influenced by the onset of diabetes or early stage of DR in the studied population.MPOD level is positively associated with thicker central foveal thickness and higher intake of foods containing carotenoids. | Chong-Yang She Hong Gu Jun Xu Xiu-Fen Yang Xue-Tao Ren Ning-Pu Liu | 2016 | International Journal of Ophthalmology(English edition)2016，9，10： | 5 |
| 6 | Mucosal-associated invariant T cells in hepatitis B virus-related liver failure显示文摘BACKGROUND Liver failure has high mortality and poor prognosis,and establishing new reliable markers for predicting its prognosis is necessary.Mucosal-associated invariant T(MAIT)cells are a novel population of innate-like lymphocytes involved in inflammatory liver disease,and their potential role in liver failure remains unclear.AIM To investigate alteration of circulating MAIT cells and assess its prognostic value in patients with hepatitis B virus(HBV)-related liver failure.METHODS We recruited 55 patients with HBV-related liver failure,48 patients with chronic hepatitis B and 40 healthy controls(HCs)from Nantong Third People’s Hospital Affiliated to Nantong University.Peripheral blood mononuclear cells were isolated,and the percentage and number of circulating MAIT cells were detected by flow cytometry.Plasma levels of interleukin(IL)-7,IL-12p70,IL-18 and interferon-αwere measured by Luminex assay.RESULTS Circulating MAIT cells were significantly decreased in HBV-related liver failure patients(percentage:2.00±1.22 vs 5.19±1.27%,P<0.0001;number:5.47±4.93 vs 84.43±19.59,P<0.0001)compared with HCs.More importantly,there was a significant reduction of MAIT cells in patients with middle/late-stage compared with early-stage liver failure.Circulating MAIT cells partially recovered after disease improvement,both in percentage(4.01±1.21 vs 2.04±0.95%,P<0.0001)and in cell count(17.24±8.56 vs 7.41±4.99,P<0.0001).The proportion(2.29±1.01 vs 1.58±1.38%,P<0.05)and number(7.30±5.70 vs 2.94±1.47,P<0.001)of circulating MAIT cells were significantly higher in the survival group than in the dead/liver transplantation group,and the Kaplan–Meier curve showed that lower expression of circulating MAIT cells(both percentage and cell count)predicted poor overall survival(P<0.01).Also,the levels of IL-12(20.26±5.42 pg/mL vs 17.76±2.79 pg/mL,P=0.01)and IL-18(1470.05±1525.38 pg/mL vs 362.99±109.64 pg/mL,P<0.0001)were dramatically increased in HBV-related liver failure patients compared with HCs.CONCLUSION Circulating MAIT cells may play an important role in the process of HBV-related liver failure and can be an important prognostic marker. | Hong Xue Han Li Lin-Ling Ju Xu-Dong Han Tiao-Chun Cheng Xi Luo Lin Chen Jian-Guo Shao Yong-Jun She Zhao-Lian Bian | 2020 | World Journal of Gastroenterology2020，26，31： | 4 |
| 7 | Diagnostic Performance of Urea Breath Test, Rapid Urea Test, and Histology for Helicobacter pylori Infection in Patients With Partial Gastrectomy: A Meta-analysis显示文摘 | Xue-Ying Tian Hong Zhu Jing Zhao Qiang She Guo-Xin Zhang | 2012 | Journal of Clinical Gastroenterology2012，，4： | 4 |
| 8 | H-infinity control for networked control systems (NCS) with time-varying delays显示文摘This paper discusses H-infin it y state feedback control for a networked control system with time-varying delays.Based on the free-weighing matri x method,a delay-dependent stability criterion satisfying a prescribed H-infini ty norm bound is presented for an NCS with unknown,time-varying and bounded del ays.And then,the criterion is transformed into suffici ent conditions based on linear matrix inequalities f or H-infinity control.The conditions thus obtained a re also used to design an H-infinity state feed back controller.This design method is further extend ed to solve the design problem of robust H-infin ity state feedback control.A numerical example demo nstrates the validity of the method. | Hong ZHAO Min WU Guoping LIU Jinhua SHE | 2005 | 控制理论与应用(英文版)2005，3，2： | 4 |
| 9 | Ionic Liquid-salt Aqueous Two-phase System, a Novel System for theExtraction of Abused Drugs显示文摘A 1-butyl-3-methylimidazolium chloride-salt aqueous two-phase system was studied on extraction of abused drugs. The effects of sorts of salts, temperature, concentration of salt and drugs on system were investigated systematically. A satisfactory extraction efficiency of 93% was obtained for papaverine while that of morphine was 65%. The extraction mechanism was primarily discussed. | She Hong LI Chi Yang HE Hu Wei LIU Ke An LI Feng LIU | 2005 | Chinese Chemical Letters2005，16，8： | 4 |
| 10 | Risk factors for delayed graft function in cardiac death donor renal transplants显示文摘 | SHAO Ming-jie YE Qi-fa MING Ying-zi SHE Xing-guo LIU Hong YE Shao-jun NIU Ying | 2012 | Chinese Medical Journal2012，，21： | 4 |
| 11 | Outcome of kidney transplantation between controlled cardiac death and brain death donors: a meta-analysis显示文摘 | Ming Yingzi Shao Mingjie Tian Tingting She Xingguo Liu Hong Ye Shaojun Ye Qifa | 2014 | Chinese Medical Journal2014，，15： | 3 |
| 12 | Protective effect of Sijunzi decoction on neuromuscular junction ultrastructure in autoimmune myasthenia gravis rats显示文摘OBJECTⅣE: To investigate the protective role of Sijunzi decoction in neuromuscular junction(NMJ)and muscle cell mitochondria ultrastructure; as well as its effects on the amount of adenosine triphosphate(ATP) and the activities of mitochondrial respiratory chain complexes I, Ⅱ, Ⅲ, and Ⅳ in autoimmune myasthenia gravis rats.METHODS: An experimental autoimmune myasthenia gravis(EAMG) rat model was established by inoculating rats with acetylcholine receptors extracted from Torpedo. Rats were divided into three groups: model, prednisone, and Sijunzi decoction, and were fed physiological saline, prednisone, or Sijunzi decoction, respectively. NMJ and muscle cell mitochondria ultrastructure were observed by transmission electron microscope. The amount of ATP was assessed by high performance liquid chromatography. The activities ofmitochondrial respiratory chain complexes I, Ⅱ, Ⅲ,and Ⅳ was determined using the Clark oxygen electrode method.RESULTS: In the model group, there were sparse muscle fibers, with decreased mitochondria, and sparse, diffluent, or absent NMJ folds. After intervention with Sijunzi decoction, the above pathology changes were improved: muscle fiber structure was clear and complete; the mitochondria count was higher; and the NMJ structure was close to normal. Gastrocnemius muscle mitochondria in the model group produced significantly less ATP than those in the prednisone group(P<0.01). Conversely, the ATP of Sijunzi decoction group was significantly higher than prednisone group(P<0.01). The activities of gastrocnemius muscle mitochondrial respiratory chain complexes I, Ⅱ, Ⅲ, and Ⅳ in both the prednisone and Sijunzi decoction groups was dramatically higher compared with the model group(P<0.05). The activities of complexes I and Ⅲ in the Sijunzi decoction group were significantly higher than those in the prednisone group(P<0.05), but there was no obvious difference in complex Ⅱ or Ⅳ activities between the two groups(P>0.05).CONCLUSION: Sijunzi decoction improved pathological changes in muscle mitochondria and NMJ,enhanced the amount of ATP in gastrocnemius muscle mitochondria, and improved the activities of respiratory chain complexes I, Ⅱ, Ⅲ, and Ⅳ(especially I and Ⅲ) of the EAMG rats. | HaibinWu Shifeng She Youzhang Liu Wensheng Xiong Yalei Guo Huansong Fang Hong Chen Jia Li | 2013 | Journal of Traditional Chinese Medicine2013，33，5： | 3 |
| 13 | Effect of Chronic Noise Exposure on Expression of N-Methyl-D-Aspartic Acid Receptor 2B and Tau Phosphorylation in Hippocampus of Rats显示文摘Objective To study the effect of chronic noise exposure on expression of N-methyl-D-aspartic acid receptor 2B (NR2B) and tau phosphorylation in hippocampus of rats. Methods Twenty-four male SD rats were divided in control group and chronic noise exposure group. NR2B expression and tau phosphorylation in hippocampus of rats were detected after chronic noise exposure (100 dB SPL white noise, 4 h/d×30d) and their mechanisms underlying neuronal apoptosis in hippocampus of rats with TUNEL staining. Results The NR2B expression decreased significantly after chronic noise exposure which resulted in tau hyperphosphorylation and neural apoptosis in hippocampus of rats. Immunohistochemistry showed that the tau hyperphosphorylation was most prominent in dentate gyrus (DG) and CA1 region of rat hippocampus. Conclusion The abnormality of neurotransmitter system, especially Glu and NR2B containing NMDA receptor, and tau hyperphosphorylation in hippocampus of rats, may play a role in chronic noise-induced neural apoptosis and cognition impairment. | CUI Bo WU Ming Quan ZHU Li Xing SHE Xiao Jun MA Qiang LIU Hong Tao | 2013 | Biomedical and Environmental Sciences2013，26，3： | 3 |
| 14 | Microstructures and mechanical properties of titanium-reinforced magnesium matrix composites: Review and perspective显示文摘Currently, many gratifying signs of progress have been made in magnesium(Mg) matrix composites(MMCs) by virtue of their high mechanical properties both at room and elevated temperatures. Although the commonly used reinforcements in MMCs are ceramic particles,they often provide improved yield and ultimate stresses by a significant loss in ductility. Therefore, hard metallic phases were introduced as alternative candidates for the manufacturing of MMCs, especially titanium(Ti). It has a high melting point, high Young’s modulus, high plasticity, low level of mutual solubility with Mg matrix, and closer thermal expansion coefficient to that of Mg metal than that of ceramic particles. It is highly preferable to provide both high ultimate stress and ductility in Mg matrix. However, many critical challenges for the fabrication of Ti-reinforced MMCs remain, such as Ti’s homogeneity, low recovery rate, and the optimization of interfacial bonding strength between Mg and Ti, etc. Meanwhile, different fabrication methods have various effects on the microstructures, mechanical properties, and the interfacial strength of Ti-reinforced MMCs. Hence, this review placed emphasis on the microstructural characteristics and mechanical properties of Ti-reinforced MMCs fabricated by different techniques. The influencing factors that govern the strengthening mechanisms were systematically compared and discussed. Future research trends, key issues, and prospects were also proposed to develop Ti-reinforced MMCs. | Hong Yang Xianhua Chen Guangsheng Huang Jiangfeng Song Jia She Jun Tan Kaihong Zheng Yiming Jin Bin Jiang Fusheng Pan | 2022 | Journal of Magnesium and Alloys2022，10，9： | 2 |
| 15 | Orthotopic liver transplantation from a donor with Schistosoma japonicum显示文摘To the Editor:Despite of the rapid increase of donation after cardiac death(DCD)in China,the shortage of organs continues to be a major problem.Every organ procured is so valu able that it should never be discarded easily,especially a liver that could save a patient’s life in an emergency.This leads to the use of grafts from donors with unrecognized and unusual diseases,including schistosomiasis.[1]Here we reported a case of orthotopic liver | Bo Peng Xing-Guo She Ke Cheng Hong Liu Ying Niu Ying-Zi Ming | 2017 | Hepatobiliary & Pancreatic Diseases International2017，16，3： | 2 |
| 16 | Sensitivity of P300 auditory event-related potentials for assessing cognitive impairment in elderly type 2 diabetic patients显示文摘BACKGROUND:In previous studies, cognitive function in elderly type 2 diabetic patients was evaluated by psychometric tests. These studies have confirmed that P300 event-related potential is an objective way of assessing cognitive function. OBJECTIVE: To analyze the objectivity of P300 for assessment of cognitive function in elderly type 2 diabetic patients. DESIGN, TIME AND SETTING: This case-control experiment was performed at the Department of Endocrinology of the Fourth Affiliated Hospital, Guangxi Medical University from January 2004 to December 2006. PARTICIPANTS: Seventy-two patients (38 males and 34 females) with type 2 diabetes mellitus were enrolled in this study. The patients were divided according to those with diabetes alone (diabetes alone group) (n=38) and those with diabetes and cerebral ischemia (diabetes and cerebral ischemia group) (n=34). A further 31 healthy individuals (16 males and 15 females), who received health examinations over the same period, were included as normal controls (normal control group). METHODS: All subjects were assessed by Mini-Mental State Examination (MMSE). Abnormalities in cognitive functions were identified by analyzing the auditory P300 event-related potentials. MAIN OUTCOME MEASURES: Auditory event-related potentials and MMSE scores. Multiple linear regression analysis was conducted using the 'enter method' with the 72 elderly patients with type 2 diabetes mellitus. P3 latency, P3 amplitude and N2 latency served as dependent variables. Age, sex, education, course of the disease, glycosylated hemoglobin, and ischemic brain damage were used as independent variables. RESULTS: No significant difference in scores of MMSE was detected between the diabetes alone and normal control groups (P > 0.05). MMSE score was significantly lower in the diabetes and cerebral ischemia group (P < 0.01) than in the normal control group. N2 and P3 latencies of auditory event-related potential were significantly longer, and P3 amplitude was significantly lower in the diabetes alone and diabetes and cerebral ischemia groups (P < 0.01) than in the normal control group. N2 and P3 latencies were significantly longer in the diabetes and cerebral ischemia group than in the diabetes alone group (P < 0.01), but amplitude was not significantly different. N2 and P3 latencies were negatively correlated with MMSE score in elderly type 2 diabetic patients (r=–0.421, –0.604; both P < 0.01). P3 amplitude was positively related to the score of MMSE (r =0.517; P < 0.01). P3 latency was positively associated with age, course of disease, glycosylated hemoglobin and ischemic brain damage in elderly type 2 diabetic patients (t=2.186 to 3.490; all P < 0.05). P3 amplitude was negatively correlated with age, course of disease and glycosylated hemoglobin (t=–2.220, –2.491, and –2.024, respectively; all P < 0.05). N2 latency was positively correlated with age, course of disease and ischemic brain damage (t=2.946, 2.511, and 2.331, respectively; P < 0.05). CONCLUSION: The course of disease, glycosylated hemoglobin and ischemic brain damage are key influential factors for cognitive impairment in elderly type 2 diabetic patients. The P300 event-related potential is a sensitive index for objective assessment of cognitive impairment in elderly diabetic patients. | Hong Yang Junhong She Xianfu Lu Rihong Peng | 2008 | Neural Regeneration Research2008，3，8： | 2 |
| 17 | Magnesium bistrifluoromethanesulfonimide as an efficient catalyst for the hydroalkylation of aromatic olefins with 1,3-diketones under solvent-free conditions显示文摘有效的镁 bistrifluoromethanesulfonimide [Mg (NTf2 ) 2 ] 有在没有溶剂的条件下面的 1,3-diketones 的芳香的石蜡的催化 hydroalkylation 被开发了。反应顺利继续在短反应时间在好收益给需要的产品。 | Hong She Wang Wei Xing Zhao | 2011 | Chinese Chemical Letters2011，22，8： | 2 |
| 18 | Iodine catalyzed efficient synthesis of symmetrical diaryl sulfoxides from arenes and thionyl chloride under solvent-free conditions显示文摘从 arenes 和 thionyl 氯化物的对称的 diaryl sulfoxides 的合成面对在在没有溶剂的条件下面的房间温度的碘的催化数量被描述。温和反应条件,容易的工作在上面,高收益,和容易可得到的催化剂是这个方法的重要特征。 | Hong She Wang Jun E. Zeng | 2007 | Chinese Chemical Letters2007，18，12： | 2 |
| 19 | Lung cancer in china:chal- lenges and interventions显示文摘 | SHE J YANG P HONG Q | 2013 | Chest2013，143，11： | 1 |
| 20 | Lung cancer in China: challengesand interventions显示文摘 | She J Yang P Hong Q | 2013 | Chest2013，143，4： | 1 |
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