5篇
您的检索式：作者名="Hongbao Sun"
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| 1 | Facile synthesis of functionalized spiropyrrolizidine ox- indoles via a three-component tandem cycloaddition re- action显示文摘 | XIE Yongmei YAO Yuqin SUN Hongbao | 2011 | Molecules2011，16，12： | 1 |
| 2 | The impact of the dosage to the shrinkage-compensating concrete 显示文摘 | AN Yaqiang LOU Zongke SUN Hongbao | 2014 | Applied Mechanics and Materials Progress in Industrial and Civil Engineering III2014，，： | 1 |
| 3 | Diversification of pharmaceutical molecules via late-stage C(sp^(2))–H functionalization显示文摘C–H late-stage functionalization has gradually become a powerful approach for the rapid optimization of lead compounds’bioactivity.Significant advances in this field have been achieved in the past few years,mainly,the C–H functionalization system in(hetero)aryl C–H activation owing to the importance of(hetero)aryl moiety in pharmaceutical.In this review,we described the selected recent examples of how developed intermolecular C(sp^(2))–H functionalization methodologies involving diverse techniques diversify pharmaceutical molecules in the late stage. | Weidong Shang Hongbao Sun Wei Chen Jie Liu | 2023 | Green Synthesis and Catalysis2023，4，2： | 0 |
| 4 | Derivatization based on tetrazine scaffolds:synthesis of tetrazine derivatives and their biomedical applications显示文摘Bioorthogonal chemistry is widely used in biological systems and has been trialed in patients,attracting a lot of attention in this century.Tetrazine-based bioorthogonal reactions are essential in chemical biology applications,including cellular labeling,live-cell imaging,diagnosis,drug release,and oncotherapy,due to their tunable rapid reaction kinetics and unique fluorogenic characteristics.However,the scope of de novo tetrazine synthesis is restricted due to the limited supply of commercial starting materials.Therefore,derivatization based on tetrazine scaffolds has been used to synthesize various tetrazine derivatives to enhance the applications of tetrazine bioorthogonal reactions.Herein,the recent advances in tetrazine scaffold-based derivatizations,including tetrazine skeletons,aromatic substituents and alkyl substituents of tetrazines,have been summarized.The advantages and limitations of the derivatization methods and applications of the developed tetrazine derivatives in bioorthogonal chemistry have also been highlighted. | Hongbao Sun Qinghe Xue Chang Zhang Haoxing Wu Ping Feng | 2022 | Organic Chemistry Frontiers2022，9，2： | 0 |
| 5 | Difluorocarbene-derived rapid late-stage trifluoromethylation of 5-iodotriazoles for the synthesis of^(18)F-labeled radiotracers显示文摘Difluorocarbene has emerged as a valuable intermediate to synthesize fluorides.However,difluorocarbene-derived synthesis of^(19)F/^(18)F-trifluoromethyl triazoles has not been explored.Herein,we reported the Cu(I)-promoted difluorocarbene-derived^(19)F/^(18)F-trifluoromethylation of iodotriazoles using KF/K^(18)F as the fluorine source.This approach rapidly generated a wide range of 5-trifluoromethyl-1,2,3-triazoles in good yields showing high functional group compatibility.The reaction was effective for late-stage functionalization of bioactive molecules and^(18)F-trifluoromethylation of iodotriazoles.This work provides a practical synthetic methodology for the development of triazole drugs and^(18)F-radiotracers for positron emission tomography. | Fang Yuan Hongbao Sun Cheng Yang Haojie Yang Lili Pan Xiaoyang Zhang Rong Tian Lingjun Li Wei Chen Xiaoai Wu Haoxing Wu | 2023 | Chinese Chemical Letters2023，34，6： | 0 |
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