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| 1 | Lipid-dependent conformational dynamics underlie the functional versatility of T-cell receptor显示文摘T 房间 receptor-CD3 建筑群(TCR ) 是能基于 CD3 细胞质的领域的各种各样的生物化学的变化开始抗原特定的有免疫力的回答的一台万用的发信号机器,但是内在的结构的基础留下逃犯。这里,我们开发了生物物理的途径学习 CD3 细胞质的领域的 conformational 动力学(CD3 CD ) 。在单个分子的水平,我们发现那 CD3 CD 能与三个功能的主题的不同坦诚有多重 conformational 状态,即, ITAM, BRS 和 PRS。因为,这些符合构造被产生 CD3 CD 有异构的类脂化合物绑定性质因此有异构的动力学。实时房间的成像实验证明不同抗原刺激能稳定 CD3 在不同符合构造的 CD 。类脂化合物依赖者 conformational 动力学因此为 TCR 的万用的发信号性质提供结构的基础。 | Xingdong Guo Chengsong Yan Hua Li Wenmao Huan Xiaoshan Shi Min Huang Yingfang Wang Weiling Pan Mingjun Cai Lunyi Li Wei Wu Yibing Bai Chi Zhang Zhijun Liu Xinyan Wang Xiaohui F Zhang Chun Tang Hongda Wang Wanli Liu Bo Ouyang Catherine C Wong Yi Cao Chenqi Xu | 2017 | Cell Research2017，27，4： | 5 |
| 2 | Characterization of the chemical fungicides-responsive and bacterial pathogen-preventing Bacillus licheniformis in rice spikelet显示文摘Seed-borne bacterial pathogens cause severe yield loss and biotoxin contamination in rice,leading to increasing concern on the global food supply and environmental safety.Plant native microbes play an important role in defending against diseases,but their actions are often influ-enced by the chemical fungicides applied in the field.Here,Bacillus licheniformis mmj was isolated from rice spikelet,which uniquely showed not only fungicide-responsiveness but also broad-spectrum antimicrobial activity against major rice bacterial pathogens including Xanthomonas oryzae pv.oryzae,Burkholderia plantari and Burkholderia glumae.To understand the hallmark underlying the environmental adaptation and anti-microbial activity of B.licheniformis mmj,the genome sequence was determined by SMRT and subjected to bioinformatics analysis.Genome sequence analysis enabled the identification of a set of antimicrobial-resistance and antibacterial activity genes together with an array of harsh environment-adaptive genes.Moreover,B.licheniformis mmj metabolites were analyzed with gas chromatography coupled to triple quadrupole mass spectrometry,and the volatile components that were linked with the antimicrobial activity were preliminarily profiled.Collectively,the present findings reveal the genomic and metabolic landscapes underlying fungicide-responsive B.licheniformis,which offers a new opportunity to design harsh environment-adaptive biopesticides to cope with prevalent bacterial phytopathogens. | Chengfang Zhan Mengchen Wu Hongda Fang Xiaoyu Liu Jiuyue Pan Xiaoyan Fan Mengcen Wang Haruna Matsumoto | 2023 | Food Quality and Safety2023，7，2： | 1 |
| 3 | Guanine nucleotide-binding protein subunit beta-4 promotes gastric cancer progression via activating Erk1/2显示文摘Gastric cancer(GC)is one of the most comm on and lethal malig nancies worldwide,and its poor prognosis is mainly due to the rapid tumor progression including tumor invasion,distant metastasis,etc.Understanding the molecular mechanisms regulating GC progression lays the basis for the development of targeted therapeutic agents.Increasing evidence suggests that guanine nucleotide-binding protein subunit beta-4(GNB4),a key subunit of heterotrimeric G protein,plays a crucial role in the initiation and progression of multiple malignancies.However,whether and how GNB4 promotes GC progression are still unknown.In this study,we found that GNB4 was highly expressed in GC tissues compared to that in non-tumor tissues and was significantly associated with tumor invasion depth,pathological stage and poor survival rate of GC patients.Both gain-of-function and loss-of-function studies revealed that GNB4 significantly enhanced GC cell growth and motility both in vitro and in vivo.Further studies revealed that GNB4 overexpression induced G1-S transition and promoted the process of epithelial-mesenchymal transformation.These tumor promoting effects were mediated by GNB4 which activates the Erk1/2 pathway through upregulating Erk1/2 phosphorylation,as U0126,an Erk1/2 phosphorylation inhibitor,could sigrdficantly inhibit GNB4-mediated cell proliferation,migration and invasion.In summary,GNB4 contributes to the proliferation and metastasis of GC cells by activating the Erk1/2 signaling pathway,and it may serve as a potential therapeutic target of GC. | Jianpeng Gao Hongda Pan Zhenglun Zhu Teng Yu Binhao Huang Ye Zhou | 2020 | Acta Biochimica et Biophysica Sinica2020，52，9： | 0 |
| 4 | Analysis of optical coupling behavior in twodimensional implant-defined coherently coupled vertical-cavity surface-emitting laser arrays显示文摘Optical coupling behavior and associated effects in two-dimensional implant-defined coherently coupled verticalcavity surface-emitting laser(VCSEL) arrays are studied via both experiments and theoretical calculations.Experiments show that optical coupling between array elements can enhance the array's output power.Additionally, optical coupling via leaky optical fields can provide extra optical gain for the array elements, which can then reduce the thresholds of these elements. Elements can even be pumped without current injection to emit light by receiving a strong leaky optical field from other array elements. Optical coupling can also cause unusual phenomena: the central elements in large-area coherently coupled VCSEL arrays that lase prior to the outer elements when the arrays are biased, or the average injection current required for each element to lase, which is much lower than the threshold for a single VCSEL. Theoretical calculations are performed to explain the experimental | GUANZHONG PAN YIYANG XIE CHEN XU YIBO DONG JUN DENG HONGDA CHEN JIE SUN | 2018 | Photonics Research2018，，11： | 0 |
| 5 | Revealing the Cell Entry Dynamic Mechanism of Single Rabies Virus Particle显示文摘The rabies virus is a neurotropic virus that causes fatal diseases in humans and animals.Although studying the interactions between a single rabies virus and the cell membrane is necessary for understanding the pathogenesis,the internalization dynamic mechanism of single rabies virus in living cells remains largely elusive.Here,we utilized a novel force tracing technique based on atomic force microscopy(AFM)to record the process of single viral entry into host cell.We revealed that the force of the rabies virus internalization distributed at(65±25)pN,and the time was identified by two peaks with spacings of(237.2±59.1)and(790.3±134.4)ms with the corresponding speed of 0.12 and 0.04µm/s,respectively.Our results provide insight into the effects of viral shape during the endocytosis process.This report will be meaningful for understanding the dynamic mechanism of rabies virus early infection. | LI Siying PAN Yangang TENG Honggang SHAN Yuping YANG Guocheng WANG Hongda | 2022 | Chemical Research in Chinese Universities2022，38，3： | 0 |
| 6 | Analysis of bitcoin backbone protocol in the non-flat model显示文摘Owing to the novel proof-of-work based consensus algorithm,bitcoin has been the most successful decentralized cryptocurrency so far.In bitcoin system,parties(miners)compete to create blocks by doing publicly verifiable proofs of sequential work(proof-of-work)and the probability that a party wins the competition is proportional to the amount of computational power that he has invested.Note that its security holds under honest majority assumption in terms of the amount of computational power.In this paper,we provide the formal analysis of bitcoin backbone protocol in the non-flat model.Precisely,we rethink and redefine the model of computing puzzles to capture the real-world protocol execution,where each party owns different amount of computational power and does sequential computations towards a puzzle independently.Fortunately,our work obtains the better results in analyzing the security of bitcoin backbone protocol,which can reflect the real-world protocol execution better,without any additional assumptions but the honest majority assumption.Finally,we show that a robust public transaction ledger can be built on top of bitcoin backbone protocol in our model securely. | Peifang NI Hongda LI Dongxue PAN | 2020 | Science China(Information Sciences)2020，63，3： | 0 |
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