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| 1 | Simultaneous in-situ determination of U-Pb age and trace elements in zircon by LA-ICP-MS in 20 μm spot size显示文摘Simultaneous in-situ determination of U-Pb ages and 20 trace elements of three international zircon standards(91500,GJ1 and TEMORA 1) and one laboratory zircon standard(SK10-2) separated from Cenozoic fine-grained gabbro was carried out on quadrupole ICP-MS equipped with 193 nm excimer laser in 20 μm spot size. The weighted mean 206Pb/238U ages of 91500,GJ1 and TEMORA 1 are 1064.4±4.8 Ma(2σ ),603.2±2.4 Ma(2σ ) and 418.2±2.4 Ma(2σ ),respectively. The relative standard de-viations(RSDs) of 206Pb/238U ages(2σ ) are less than 2.2% for single measurements and 0.6% for weighted means. The obtained weighted mean 206Pb/238U ages of three standard zircons agree with the recommended values within 2σ error. The weighted mean 206Pb/238U age of SK10-2 is 31.42±0.25 Ma(2σ ) and the RSDs of 206Pb/238U ages(2σ ) are between 2.4% and 5.7% for single measurements and less than 0.8% for weighted mean. The obtained weighted mean 206Pb/238U age is in good agreement with the age obtained by Yuan(2004). Trace element concentrations of NIST612 and NIST614 obtained under the same LA-ICP-MS operating conditions agree with the recommended values within analytical error. The results indicate that it is possible to measure U-Pb age and trace elements simultaneously by LA-ICP-MS in a small spot size of 20 μm. | LIU XiaoMing GAO Shan DIWU ChunRong YUAN HongLin HU ZhaoChu | 2007 | Chinese Science Bulletin2007，52，9： | 107 |
| 2 | Identification of 3.5 Ga detrital zircons from Yangtze craton in south China and the implication for Archean crust evolution显示文摘在 Yichang 在 Sanxia 区域从 Liantuo 形成的 Sinian 沙岩和 Nantuo 形成的 tillites 几百由岩屑形成的锆石谷物标明日期的 LA-ICP-MS U-Pb 识别了 3319-3508 妈锆石谷物。他们的 207Pb/206 Pb 和 206Pb/238 U 年龄显示出优秀同意(concordia 度 99%100%) 。他们的 CL 图象展出比率在 0.46-0.76 以内的开发得好的摆动的 zoning 和 Th/U,暗示他们是形成了在期间的火的锆石中间早太古代。这些锆石是在 Yangtze craton 发现直到现在的最旧的。然而,有比在 Kongling 组的变形岩石中的 3.3 Ga 旧的年龄的由岩屑形成的锆石没被进一步的调查发现,它在 Yangtze craton 建议比高级变形 Kongling 地面旧的外壳的存在。 | LIU Xiaoming GAO Shan LING Wenli YUAN Honglin HU Zhaochu | 2006 | Progress in Natural Science:Materials International2006，16，6： | 17 |
| 3 | Complete chloroplast genome sequence of Magnolia grandiflora and comparative analysis with related species显示文摘Magnolia grandiflora is an important medicinal,ornamental and horticultural plant species.The chloroplast(cp) genome of M.grandiflora was sequenced using a 454 sequencing platform and the genome structure was compared with other related species.The complete cp genome of M.grandiflora was 159623 bp in length and contained a pair of inverted repeats(IR) of 26563 bp separated by large and small single copy(LSC,SSC) regions of 87757 and 18740 bp,respectively.A total of 129 genes were successfully annotated,18 of which included introns.The identity,number and GC content of M.grandiflora cp genes were similar to those of other Magnoliaceae species genomes.Analysis revealed 218 simple sequence repeat(SSR) loci,most composed of A or T,contributing to a bias in base composition.The types and abundances of repeat units in Magnoliaceae species were relatively conserved and these loci will be useful for developing M.grandiflora cp genome vectors.In addition,results indicated that the cp genome size in Magnoliaceae species and the position of the IR border were closely related to the length of the ycf1 gene.Phylogenetic analyses based on 66 shared genes from 30 species using maximum parsimony(MP) and maximum likelihood(ML) methods provided strong support for the phylogenetic position of Magnolia.The availability of the complete cp genome sequence of M.grandiflora provides valuable information for breeding of desirable varieties,cp genetic engineering,developing useful molecular markers and phylogenetic analyses in Magnoliaceae. | LI XiWen GAO HuanHuan WANG YiTao SONG JingYuan HENRY Robert WU HeZhen HU ZhiGang YAO Hui LUO HongMei LUO Kun PAN HongLin CHEN ShiLin | 2013 | Science China(Life Sciences)2013，56，2： | 17 |
| 4 | Mutation profile and its correlation with clinicopathology in Chinese hepatocellular carcinoma patients显示文摘Background:Hepatocellular carcinoma(HCC)is one of the most common causes of cancer worldwide.Although many studies have focused on oncogene characteristics,the genomic landscape of Chinese HCC patients has not been fully clarified.Methods:A total of 165 HCC patients,including 146 males and 19 females,were enrolled.The median age was 55 years(range,27-78 years).Corresponding clinical and pathological information was collected for further analysis.A total of 168 tumor tissues from these patients were selected for next-generation sequencing(NGS)-based 450 panel gene sequencing.Genomic alterations including single nucleotide variations(SNV),short and long insertions and deletions(InDels),copy number variations,and gene rearrangements were analyzed.Tumor mutational burden(TMB)was measured by an algorithm developed in-house.The top quartile of HCC was classified as TMB high.Results:A total of 1,004 genomic alterations were detected from 258 genes in 168 HCC tissues.TMB values were identified in 160 HCC specimens,with a median TMB of 5.4 Muts/Mb(range,0-28.4 Muts/Mb)and a 75%TMB of 7.7 Muts/Mb.The most commonly mutated genes were TP53,TERT,CTNNB1,AXIN1,RB1,TSC2,CCND1,ARID1A,and FGF19.SNV was the most common mutation type and C:G>T:A and guanine transformation were the most common SNVs.Compared to wild-type patients,the proportion of Edmondson grade III-IV and microvascular invasion was significantly higher in TP53 mutated patients(P<0.05).The proportion of tumors invading the hepatic capsule was significantly higher in TERT mutated patients(P<0.05).The proportion of Edmondson grade I-II,alpha fetoprotein(AFP)<25μmg/L,and those without a history of hepatitis B was significantly higher in CTNNB1 mutated patients(P<0.05).CTNNB1 mutations were associated with TMB high in HCC patients(P<0.05).Based on correlation analysis,the mutation of TP53 was independently correlated with microvascular invasion(P=0.002,OR=3.096)and Edmondson grade III-IV(P=0.008,OR=2.613).The mutation of TERT was independently correlated with tumor invasion of the liver capsule(P=0.001,OR=3.030),and the mutation of CTNNB1 was independently correlated with AFP(<25μmg/L)(P=0.009,OR=3.414).Conclusions:The most frequently mutated genes of HCC patients in China were TP53,TERT,and CTNNB1,which mainly lead to the occurrence and development of HCC by regulating the P53 pathway,Wnt pathway,and telomere repair pathway.There were more patients with microvascular invasion and Edmondson III-IV grade in TP53 mutated patients and more patients with hepatic capsule invasion in TERT mutated patients,while in CTNNB1 mutated patients,there were more patients with Edmondson I-II grade,AFP<25μmg/L,and a non-hepatitis B background.Also,the TMB values were significantly higher in CTNNB1 mutated patients than in wild type patients. | Shuo Wang Huasheng Shi Tao Liu Manjiang Li Sanshun Zhou Xuan Qiu Zusen Wang Weiyu Hu Weidong Guo Xiaoqian Chen Honglin Guo Xiaoliang Shi Junping Shi Yunjin Zang Jingyu Cao Liqun Wu | 2021 | Hepatobiliary Surgery and Nutrition2021，10，2： | 8 |
| 5 | A Small-Scale Medication of Leflunomide as a Treatment of COVID-19 in an Open-Label Blank-Controlled Clinical Trial显示文摘We recently reported that inhibitors against human dihydroorotate dehydrogenase(DHODH)have broad-spectrum antiviral activities including their inhibitory efficacies on SARS-CoV-2 replication in infected cells.However,there are limited data from clinical studies to prove the application of DHODH inhibitors in Coronavirus disease 2019(COVID-19)patients.In the present study,we evaluated Leflunomide,an approved DHODH inhibitor widely used as a modest immune regulator to treat autoimmune diseases,in treating COVID-19 disease with a small-scale of patients.Cases of 10 laboratory-confirmed COVID-19 patients of moderate type with obvious opacity in the lung were included.Five of the patients were treated with Leflunomide,and another five were treated as blank controls without a placebo.All the patients accepted standard supportive treatment for COVID-19.The patients given Leflunomide had a shorter viral shedding time(median of5 days)than the controls(median of 11 days,P=0.046).The patients given Leflunomide also showed a significant reduction in C-reactive protein levels,indicating that immunopathological inflammation was well controlled.No obvious adverse effects were observed in Leflunomide-treated patients,and they all discharged from the hospital faster than controls.This preliminary study on a small-scale compassionate use of Leflunomide provides clues for further understanding of Leflunomide as a potential antiviral drug against COVID-19. | Ke Hu Mengmei Wang Yang Zhao Yunting Zhang Tao Wang Zhishui Zheng Xiaochen Li Shaolin Zeng Dong Zhao Honglin Li Ke Xu Ke Lan | 2020 | Virologica Sinica2020，35，6： | 7 |
| 6 | A survey of next generation mobile communications researchin China显示文摘With the rapid development of wireless communication networks, the fourth generation (4G) has emerged to move beyond the limitations of the third generation (3G), with increased bandwidth, enhanced quality of services, and reduced costs of resources. In this paper, we discuss the key technologies of 4G and focus on surveying the ongoing research in 4G communications in China. The 4G technologies under investigation include multicarrier transmission, multiple antenna techniques, carrier aggregation, relays, cognitive radio, distributed antenna systems, network convergence, and network self-optimization. These technologies are the building blocks of 4G and contribute largely to the requirements of International Mobile Telecommunications Advanced (IMT-Advanced). For each technology, its benefits, research topics, and some existing approaches are examined. Finally, we briefly discuss the challenges and future research issues in 4G systems. | TIAN JinFeng 1,2 , ZHENG XiaoYing 2,3 , HU HongLin 1,2 YOU XiaoHu 1,3 1 Shanghai Research Center for Wireless Communications (WiCO), Shanghai 200335, China 2 Shanghai Institute of Microsystem and Information Technology (SIMIT), Chinese Academy of Sciences (CAS), Shanghai 200050, China 3 National Mobile Communications Research Laboratory, Southeast University (SEU), Nanjing 210096, China | 2011 | Chinese Science Bulletin2011，56，27： | 6 |
| 7 | Transmit correlation effect on SIC-ZF receiver for V-BLAST system显示文摘It has been shown that transmit correlation causes a signal-to-noise ratio (SNR) loss in the zero forcing (ZF) receiver for V-BLAST (Vertical Bell LAbs LAyered Space-Time) system. In this paper, we investigate the transmit correlation effect on the ZF receiver with successive interference cancellation (SIC). We show that such an unfavorable condition leads to twofold effects on the performance degradation. In addition to the immediate SNR loss, the transmit correlation can increase the propagation factor to spread decision error significantly. These two effects are evaluated analytically. We derive the probability density function (pdf) of the effective SNR at each decoded stream, and hence accurately quantify the SNR loss. We also calculate the decision error propagation factor in terms of its second moment. In particular, we show that transmit correlation can cause a stable component of error propagation which does not decline during the SIC procedure. Finally, we conduct the simulation to verify the analytical results. | GUO HaiYou ZHOU ZhiGang HU HongLin | 2009 | Science in China(Series F)2009，52，12： | 3 |
| 8 | Layer-by-Layer Assembled Bacterial Cellulose/Graphene Oxide Hydrogels with Extremely Enhanced Mechanical Properties显示文摘Uniform dispersion of two-dimensional(2 D) graphene materials in polymer matrices remains challenging. In this work, a novel layer-by-layer assembly strategy was developed to prepare a sophisticated nanostructure with highly dispersed 2 D graphene oxide in a three-dimensional matrix consisting of onedimensional bacterial cellulose(BC) nanofibers. This method is a breakthrough, with respect to the conventional static culture method for BC that involves multiple in situ layer-by-layer assembly steps at the interface between previously grown BC and the culture medium. In the as-prepared BC/GO nanocomposites, the GO nanosheets are mechanically bundled and chemically bonded with BC nanofibers via hydrogen bonding,forming an intriguing nanostructure. The sophisticated nanostructure of the BC/GO leads to greatly enhanced mechanical properties compared to those of bare BC. This strategy is versatile, facile, scalable, and can be promising for the development of high-performance BC-based nanocomposite hydrogels. | Honglin Luo Jiaojiao Dong Fanglian Yao Zhiwei Yang Wei Li Jie Wang Xinhua Xu Jian Hu Yizao Wan | 2018 | Nano-Micro Letters2018，10，3： | 2 |
| 9 | Surface modification of self-healing poly(urea-formaldehyde) microcapsules using silane-coupling agent显示文摘 | Haiyan Li Rongguo Wang Honglin Hu Wenbo Liu | 2008 | Applied Surface Science2008，，5： | 2 |
| 10 | Analysis and prediction of 100 km-scale atmo-spheric duct interference in TD-LTE networks显示文摘Atmospheric ducts are horizontal layers that occur under certain weather conditions in the lower atmosphere.Radio signals guided in atmospheric ducts tend to experience less attenuation and spread much farther,i.e,hundreds of kilometers.In a large-scale deployed TD-LTE(Time Division Long Term Evolution)network,atmospheric ducts cause faraway downlink wireless signals to propagate beyond the designed protection distance and interfere with local uplink signals,thus resulting in a large outage probability.In this paper,we analyze the characteristics of ADI atmospheric duct interference(Atmospheric Duct Interference)by the use of real network-side big data from the current operated TD-LTE network owned by China Mobile.The analysis results yield the time varying and directional characteristics of ADI.In addition,we proposed an SVM(Support Vector Machine)-classi er based spacial prediction method of ADI by machine learning over combination of real network-side big data and real meteorological data.Furthermore,an implementation of ADMM(Alternating Direction Methods of Multipliers)framework is proposed to implement a distributed SVM prediction scheme,which reduces data exchange among di erent regions/cities,maintains similar prediction accuracy and is thus of a more practical use to operators. | Ting Zhou Tianyu Sun Honglin Hu Hui Xu Yang Yang Ilkka Harjula Yevgeni Koucheryavy | 2017 | Journal of Communications and Information Networks2017，2，1： | 2 |
| 11 | A new SSVEP-based BCI utilizing frequency and space to encode visual targets显示文摘Dear editor,Brain-computer interfaces(BCIs)based on steadystate visual evoked potential(SSVEP)have attracted considerable attention from researchers owing to their improved performance,such as their higher recognition accuracy,more reliable relation to stimuli,and higher information transfer rate(ITR),compared with other types of BCIs. | Min ZHANG Zhenyu WANG Honglin HU | 2020 | Science China(Information Sciences)2020，63，8： | 1 |
| 12 | Relay technologies for Wimax and LTE-advanced mobile systems 显示文摘 | Yang Yang Hu Honglin Xu Jing | 2009 | IEEE Communi- cations Magazines2009，47，10： | 1 |
| 13 | Characterization of TEMPO-oxidized bacterial cellulose scaffolds for tissue engineering applications显示文摘 | Luo Honglin Xiong Guangyao Hu Da | 2013 | Materials Chemistry and Physics2013，143，： | 1 |
| 14 | Determination of forty two major and trace elements in USGS and NIST SRM glasses by laser-ablation inductively coupled plasma-mass spectrometry 显示文摘 | Gao Shan Liu Xiaoming Yuan Honglin Hattendorf B Gunther D Chen Liang Hu Shenghong | 2002 | Geostand Geoanal Res2002，26，2： | 1 |
| 15 | Intracluster Device-to-decive Relay Algorithm with Optimal Resource Utilization 显示文摘 | ZHOU Bin HU Honglin HUANG Shengqiang | 2013 | IEEE transactions on Vehicular Technology2013，62，5： | 1 |
| 16 | Frequency Domain Discrete Fourier Transform Spread Generalized Multi-cartier System and its Performance Analysis 显示文摘 | RUI Yun HU Honglin YI Huiyue | 2009 | Computer Communications2009，32，3： | 1 |
| 17 | Selfconfigurationand self-optimization for LTE networks显示文摘 | HU Honglin ZHANG Jian ZHENG Xiaoying | 2011 | Communications Magazine IEEE2011，48，2： | 1 |
| 18 | In- tracluster device-to-device relay algorithm with optimal resource utilization显示文摘 | Zhou Bin Hu Honglin Huang Shengqiang | 2013 | IEEE Transacuons on Vehicu- lar Technology2013，62，5： | 1 |
| 19 | Characteriza- tion of TEMPO-oxidized bacterial cellulose scaffolds for tis- sue engineering applications 显示文摘 | Luo Honglin Xiong Guangyao Hu Da | 2013 | Mater Chem Phys2013，143，1： | 1 |
| 20 | Cooperative wireless networks for better green services显示文摘In order to guarantee the overall return on investment (ROI), improve user experience and quality of service (QoS), save energy, reduce electra magnetic interference (EMI) and radiation pollution, and enable the sustainable deployment of new profitable applications and services in heterogeneous wireless networks coexistence reality, this paper proposes a cross-network cooperation mechanism to effectively share network resources and infrastructures, and then adaptively control and match multi-network energy distribution characteristics according to actual user/service requirements in different geographic areas. Some idle or lightly-loaded base stations (BS or BSs) will be temporally turned off for saving energy and reducing EMI. Initial simulation results show that the proposed approach can significantly improve the overall energy efficiency and QoS performance across multiple cooperative wireless networks. | Yang Yang Zhang Wuxiong Hu Honglin Zhang Sihai Wang Xin Zhao Haitao Zhou Wuyang Wei Jibo | 2011 | Engineering Sciences2011，9，1： | 1 |
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