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| 1 | Vertical Vibration of Moving Strip in Rolling Process Based on Beam Theory显示文摘The shape and thickness qualities of strip are influenced by the vibration of rolling mill.At present,the researches on the vibration of rolling mill are mainly the vertical vibration and torsional vibration of single stand mill,the study on the vibration of tandem rolling mill is rare.For the vibration of tandem rolling mill,the key problem is the vibration of the moving strip between stands.In this paper,considering the dynamic of moving strip and rolling theory,the vertical vibration of moving strip in the rolling process was proposed.Take the moving strip between the two mills of tandem rolling mill in the rolling process as subject investigated,according to the theory of moving beam,the vertical vibration model of moving strip in the rolling process was established.The partial differential equation was discretized by Galerkin truncation method.The natural frequency and stability of the moving strip were investigated and the numerical simulation in time domain was made.Simulation results show that,the natural frequency was strongly influenced by the rolling velocity and tension.With increasing of the rolling velocity,the first three natural frequencies decrease,the fourth natural frequency increases;with increasing of the unit tension,when the rolling velocity is high and low,respectively,the low order dimensionless natural frequency gradually decreases and increases,respectively.According to the stability of moving strip,the critical speed was determined,and the matching relationship of the tension and rolling velocity was also determined.This model can be used to study the stability of moving strip,improve the quality of strip and develop new rolling technology from the aspect of dynamics. | SUN Jianliang PENG Yan LIU Hongmin JIANG Guangbiao | 2009 | Chinese Journal of Mechanical Engineering2009，22，5： | 23 |
| 2 | Coupled Dynamic Modeling of Rolls Model and Metal Model for Four High Mill Based on Strip Crown Control显示文摘The crown is a key quality index of strip and plate,the rolling mill system is a complex nonlinear system,the strip qualities are directly affected by the dynamic characteristics of the rolling mil.At present,the studies about the dynamic modeling of the rolling mill system mainly focus on the dynamic simulation for the strip thickness control system,the dynamic characteristics of the strip along the width direction and that of the rolls along axial direction are not considered.In order to study the dynamic changes of strip crown in the rolling process,the dynamic simulation model based on strip crown control is established.The work roll and backup roll are considered as elastic continuous bodies and the work roll and backup roll are joined by a Winkler elastic layer.The rolls are considered as double freely supported beams.The change rate of roll gap is taken into consideration in the metal deformation,based on the principle of dynamic conservation of material flow,the two dimensional dynamic model of metal is established.The model of metal deformation provides exciting force for the rolls dynamic model,and the rolls dynamic model and metal deformation model couple together.Then,based on the two models,the dynamic model of rolling mill system based on strip crown control is established.The Newmark-β method is used to solve the problem,and the dynamic changes of these parameters are obtained as follows:(1) The bending of work roll and backup roll changes with time;(2) The strip crown changes with time;(3) The distribution of rolling force changes with time.Take some cold tandem rolling mill as subject investigated,simulation results and the comparisons with experimental results show that the dynamic model built is rational and correct.The proposed research provides effective theory for optimization of device and technological parameters and development of new technology,plays an important role to improve the strip control precision and strip shape quality. | SUN Jianliang PENG Yan LIU Hongmin | 2013 | Chinese Journal of Mechanical Engineering2013，26，1： | 10 |
| 3 | Self-supported CoMoS4 nanosheet array as an efficient catalyst for hydrogen evolution reaction at neutral pH显示文摘 | Xiang Ren Dan Wu Ruixiang Ge Xu Sun Hongmin Ma Tao Yan Yong Zhang Bin Du Qin Wei Liang Chen | 2018 | Nano Research2018，11，4： | 8 |
| 4 | Development of the triazole-fused pyrimidine derivatives as highly potent and reversible inhibitors of histone lysine specific demethylase1(LSD1/KDM1A)显示文摘Histone lysine specific demethylase 1(LSD1) has been recognized as an important modulator in post-translational process in epigenetics. Dysregulation of LSD1 has been implicated in the development of various cancers. Herein, we report the discovery of the hit compound 8 a(IC50=3.93 μmol/L) and further medicinal chemistry efforts, leading to the generation of compound 15 u(IC50=49 nmol/L, and Ki= 16 nmol/L), which inhibited LSD1 reversibly and competitively with H3 K4 me2, and was selective to LSD1 over MAO-A/B. Docking studies were performed to rationalize the potency ofcompound 15 u. Compound 15 u also showed strong antiproliferative activity against four leukemia cell lines(OCL-AML3, K562, THP-1 and U937) as well as the lymphoma cell line Raji with the IC50 values of 1.79, 1.30, 0.45, 1.22 and 1.40 μmol/L, respectively. In THP-1 cell line, 15 u significantly inhibited colony formation and caused remarkable morphological changes. Compound 15 u induced expression of CD86 and CD11 b in THP-1 cells, confirming its cellular activity and ability of inducing differentiation.The findings further indicate that targeting LSD1 is a promising strategy for AML treatment, the triazolefused pyrimidine derivatives are new scaffolds for the development of LSD1/KDM1 A inhibitors. | Zhonghua Li Lina Ding Zhongrui Li Zhizheng Wang Fengzhi Suo Dandan Shen Taoqian Zhao Xudong Sun Junwei Wang Ying Liu Liying Ma Bing Zhao Pengfei Geng Bin Yu Yichao Zheng Hongmin Liu | 2019 | Acta Pharmaceutica Sinica B2019，9，4： | 6 |
| 5 | The influence of intimacy on the ’iterative reactions’ during OX-ZEO process for aromatic production显示文摘The oxide-zeolite process provides a promising way for one-step production of aromatics from syngas,whereas the reasons for the dramatic effect of intimacy between oxide and zeolite in the composite catalyst on the product selectivity are still unclear. In order to explore the optimal intimacy and the essential influence factors, ZnCrOxcombined with ZSM-5 are employed to prepare the composite catalysts with different distances between the two components by changing the mixing methods. An aromatic selectivity of 74%(with CO conversion to be 16%) is achieved by the composite catalyst when the intimacy is in the range of nanometer. A so-called ‘iterative reactions’ mechanism of intermediates over oxides is then proposed and studied: the intermediate chemical can undergo a hydrogenation reaction on oxide.So the shorter the intermediates stay on oxide, the more of chance for C-C coupling takes place on zeolite to form aromatics. Moreover, the aero-environments of reaction is found to impact on the extent of iterative reaction as well. Therefore, when the intimacy between the two components changes, the extent of iterative reactions vary, resulting in alteration of product distribution. This work provides new insight in understanding the mechanisms during the complex process of OX-ZEO composite catalysis and sheds light to the design of a high-yield catalyst for synthetization of aromatics from syngas. | Xiaoli Yang Ting Sun Junguo Ma Xiong Su Ruifeng Wang Yaru Zhang Hongmin Duan Yanqiang Huang Tao Zhang | 2019 | Journal of Energy Chemistry2019，28，8： | 4 |
| 6 | A small molecule inhibitor of the UBE2F-CRL5 axis induces apoptosis and radiosensitization in lung cancer显示文摘Protein neddylation is catalyzed by a neddylation activating enzyme(NAE,E1),an E2 conjugating enzyme,and an E3 ligase.In various types of human cancers,the neddylation pathway is abnormally activated.Our previous study validated that the neddylation E2 UBE2F is a promising therapeutic target in lung cancer.Although the NAE inhibitor MLN4924/pevonedistat is currently under clinical investigation as an anti-cancer agent,there are no small molecules available that selectively target UBE2F.Here,we report,for the first time,the discovery,via structure-based virtual screen and chemical optimization,of such a small molecule,designated as HA-9104.HA-9104 binds to UBE2F,reduces its protein levels,and consequently inhibits cullin-5 neddylation.Blockage of cullin-5 neddylation inactivates cullin-RING ligase-5(CRL5)activity,leading to accumulation of the CRL5 substrate,NOXA,to induce apoptosis.Moreover,HA-9104 appears to form the DNA adduct via its 7-azaindole group to induce DNA damage and G2/M arrest.Biologically,HA-9104 effectively suppresses the growth and survival of lung cancer cells and confers radiosensitization in both in vitro cell culture and in vivo xenograft tumor models.In summary,we discovered a small molecule,designated HA-9104,that targets the UBE2F-CRL5 axis with anti-cancer activity alone or in combination with radiation. | Tiantian Xu Qisheng Ma Yanan Li Qing Yu Peichen Pan Yawen Zheng Zhijian Li Xiufang Xiong Tingjun Hou Bin Yu Hongmin Liu Yi Sun | 2022 | Signal Transduction and Targeted Therapy2022，7，11： | 2 |
| 7 | The Active Sites and Corresponding Stability Challenges of the M-N-C Catalysts for Proton Exchange Membrane Fuel Cell显示文摘Proton exchange membrane fuel cells(PEMFCs)as promising alternatives to traditional internal combustion engines have attracted massive concerns to promote their wide application in society.However,the biggest challenge to the commercialization of PEMFCs remains the high cost due to the adoption of the platinum group metal(PGM)catalysts in the cathode. | Ruolin Peng Zhongkun Zhao Hongmin Sun Yongping Yang Tinglu Song Yao Yang Jiankun Shao Haibo Jin Hongtao Sun Zipeng Zhao | 2023 | Chinese Journal of Chemistry2023，41，6： | 1 |
| 8 | Statistical Analysis of Dangerous Chemical Accidents in China显示文摘 | Kang Sun Hongmin Yang | 2012 | Fire Technology2012，48，2： | 1 |
| 9 | Shape-selective alkylation of benzene with ethylene over a core–shell ZSM-5@MCM-41 composite material显示文摘A series of ZSM-5@MCM-41 core-shell composite materials prepared via a multi-cycle-sol-gel coating strategy is investigated as the catalyst for benzene alkylation with ethylene,in which both ethylbenzene and para-diethylbenzene(p-DEB)are aimed as the target products.With multi-cycle-sol-gel coating,the external acid sites on the samples are gradually passivated by the inert MCM-41 shell.As a result,the shape selectivity to p-DEB is greatly enhanced.Nevertheless,the coating of mesoporous MCM-41 shell on ZSM-5 accelerates deactivation of the catalyst only due to the dilution effect of ZSM-5 content in the catalyst at the same space velocity,which is a reason that core-shell ZSM-5@MCM-41 will potentially be a practical catalyst in shape selective alkylation of benzene.In order to enhance the yield of p-DEB on ZSM-5@MCM-41,the reaction conditions at the fixed bed reactor including temperature,the molar rate of benzene to ethylene and GHSV,are also optimized. | Zhenhao Shen Chongwei Ma Darui Wang Junlin He Hongmin Sun Zhirong Zhu Weimin Yang | 2021 | Chinese Journal of Chemical Engineering2021，34，9： | 1 |
| 10 | Statistical analysis of dangerous chemical accidents in China显示文摘 | SUN Kang YANG Hongmin | 2012 | Fire Technology2012，48，2： | 1 |
| 11 | Establishment Method of Shape Standard Curve Based on Stepwise Optimization and Its Compensation Models显示文摘There are very few researches on the shape standard curve currently,and they merely remain on the level of description of the general concept and production experiences,lacking of the in-depth theoretical analysis,and the concrete principle,method and steps for determining the shape standard curve are not put forward,therefore,they are not applicable in industrial production.This is the weakest spot in the research on the basic shape theory.In this paper,the basic shape standard curve and the transverse distribution curve of the exit thickness are attained with stepwise optimization,which is based on the theoretical calculation method of the shape standard curve of strip mills proposed by authors.By calculating the shape discrimination model and the shape forecast model separately,the simultaneous iterative calculation by the previous method is avoided,and the speed and stability of calculation are improved.The compensation models of the transverse temperature difference of the strip,the shape detection roller deflection and the shape of the strip coil are established,respectively,meantime,the basic shape standard curves are compensated,and the relatively perfect theoretical establishment method of the shape standard curve is formed.The simulation and calculation are done on a 1 220 mm five-stand cold strip tandem mill.The simulation and calculation result shows that the principle,method and steps for determining the shape standard curve are correct and feasible,and the correctness of theoretical analysis and calculation is verified.This paper proposes an idea and a method for the establishment of the shape standard curve in the rolling processes of cold strip mills,which develop the theory and model of the shape standard curve and improve the quality and efficiency of the shape control in the rolling processes of cold strip mills. | SUN Yabo LIU Hongmin PENG Yan | 2011 | Chinese Journal of Mechanical Engineering2011，24，1： | 1 |
| 12 | REE bound polysaccharides in leaves of Dicranopteris dichotoma by MAA显示文摘 | Yuqi Wang Jingxin Sun Hongmin Chen Fanqing Guo Lei Xu Guoyin Cao | 1998 | Science in China Series B: Chemistry1998，，3： | 1 |
| 13 | Fibroblast growth factor 9 promotes kidney cell proliferation via WNT signaling-mediated activation of ANXA4显示文摘Fibroblast growth factors(FGFs)play pivotal roles in cell migration and proliferation.However,the identity of the FGF that plays a dominant role in kidney cell proliferation remains unclear.Therefore,in this study,we investigated the dominant FGF among all FGFs.To this end,RNA-sequencing,qRT-PCR,western blotting,and ChIP assays were performed.FGF9 showed the highest expression among all FGFs,and its overexpression significantly promoted proliferation in the mouse kidney cell line C57BL/6 and increased JNK and AKT phosphorylation levels.Further,RNA-seq analysis identified 365 upregulated and 276 downregulated genes in FGF9-overexpressed cells.These differentially expressed genes were classified primarily into 20 biological pathways and were enriched in 31 gene ontology terms.qRT-PCR revealed that the expression of WNT and NF-κB signaling genes,as well as ANXA4 expression patterns,correlated with the RNA-seq data,while FGF9-overexpressed cells accumulated moreβ-catenin,a key WNT signaling protein,compared to control cells.Moreover,downregulation of the gene that encodesβ-catenin or ANXA4 inhibited C57BL/6 cell proliferation.Additionally,the expression of ANXA4 was lower in CTNNB1-knockdown cells than in the control group.Additionally,the ChIP assay revealed that a transcription factor complex containing TCF4 andβ-catenin directly binds to the ANXA4 promoter.Taken together,these results suggest a role of FGF9 in the regulation of kidney cell migration.These findings may prove useful in the development of future therapies. | TING LI XINHUI SUN NANNAN LI HONGMIN GUO | 2021 | BIOCELL2021，45，4： | 1 |
| 14 | Three-party Encrypted Key Exchange Without Server Public-key显示文摘 | Lin Chunli Sun Hongmin Steiner M | 2001 | IEEE Communi- cations Letters2001，5，12： | 1 |
| 15 | Advances in development and industrial application of ethylbenzene process显示文摘 | Yang Weimin Wang Zhengdong Sun Hongmin | 2016 | Chin J Catal2016，37，1： | 1 |
| 16 | Plasma-tungsten interactions in experimental advanced superconducting tokamak(EAST)显示文摘Tungsten(W)is used as the armor material of the International Thermonuclear Experimental Reactor(ITER)divertor and is regarded as the potential first wall material of future fusion reactors.One of the key challenges for the successful application of W in fusion devices is effective control of W at an extremely low concentration in plasma.Understanding and control of W erosion are not only a prerequisite for W impurity control,but also vital concerns to plasma-facing component(PFC)lifetime.Since the application of ITER-like water-cooled full W divertor in EAST in 2014,great efforts were made to inves-tigate W erosion by experiment and simulation.A spectroscopic system was developed to provide a real-time measurement of W sputtering source.Both experiment and simulation results indicate that carbon(C)is the dominant impurity causing W sputtering in L-mode plasmas,which comes from the erosion of C plasma-facing material(PFM)in the lower divertor and the main chamber limiters.The mixture layer on the surface of W PFCs formed through redeposition or the wall coating can effectively suppress W erosion.Increasing the plasma density and radiation can reduce incident ion energy,thus alleviating W sputtering.In H-mode plasmas,control of edge localized mode(ELM)via resonant magnetic perturbation(RMP)proves to be capable of suppressing intra-ELM W erosion.The experiences and lessons from the EAST W divertor are beneficial to the design,manufacturing and operation of ITER and beyond. | Fang Ding Guang-Nan Luo Xiahua Chen Hai Xie Rui Ding Chaofeng Sang Hongmin Mao Zhenhua Hu Jing Wu Zhen Sun Liang Wang Youwen Sun Jiansheng Hu 无 | 2019 | Tungsten2019，1，2： | 1 |
| 17 | 吉西他滨联合卡铂作为诱导方案治疗老年不可手术的非小细胞肺癌(英文)显示文摘Objective:The purpose of this study was to evaluate the efficacy and safety of gemcitabine(GEM) and carboplatin(CBP) used as induction regimen in the treatment of elderly patients with locally advanced unresectable non-small cell lung cancer(NSCLC).Methods:Seventy-eight cases of elderly patients have been cytologically and pathologically confirmed with locally advanced unresectable NSCLC,the age of the patients ranged from 65 to 75 years.The patients were treated with the combined regimen of gemcitabine and cisplatin.GEM 1000 mg/m2 intravenously injected by drip on the 1st,8th day and the dosage of CBP was AUC 4 that was used on the 1st day,21 days apart to each cycle,most patients received 2 cycles.Treatment response was evaluated according to the criteria of RECIST(Response Evaluation Criteria in Solid Tumor),the side effect of the regimen was judged based on WHO criteria.Results:Seventy-eight patients were evaluated and received a total of 156 cycles chemotherapy.There were no complete regression that could be observed,but 32 cases had partial regression(PR),37 cases with no change(NC) and 9 cases with progression disease(PD).The overall response rate was 41.0%.The main side effects were hematological toxicity.Conclusion:The GC regimen could be used as induction treatment for elderly patients with locally advanced unresectable NSCLC,and the regimen could be well tolerated and is safe in terms of side effects. | Zhihua Sun Hongmin Zheng Linyun Zhang | 2011 | The Chinese-German Journal of Clinical Oncology2011，10，2： | 0 |
| 18 | Regulating Li transport in Li-magnesium alloy for dendrite free Li metal anode显示文摘Li metal has become a strong candidate for anode due to its high theoretical specific capacity and lowest electrochemical potential.However,the poor reversibility caused by continuous chemical and electrochemical degradation hinders the practical application of Li metal.Solid-solution-based metal alloy phases have been proposed as hosts for regulating the non-dendrite electrodeposition,but the fundamental understanding remains unclear due to the drastically different deposition behaviors of Li on them.Here we found the difference in the diffusion coefficient of Li atoms on solid-solution-based metal alloy phases(Li-Mg and Li-Ag alloys)was a major contributor to the different deposition behaviors.The low Li atom diffusion coefficient of Li-Mg alloy showed a preferential Li accumulation on the upper surface rather than the inward-growth plating of Li atoms into alloy foil in Li-Ag alloy.By the process of secondary recrystallization,we improved the diffusion coefficient of Li atoms in Li-Mg alloy that facilitates the inward transfer rather than surface plating of Li atoms.In this case,the recrystallized Li-Mg alloy underwent a solidsolution phase change in the delithiation-lithiation cycles which yielded a high Coulombic efficiency of 99.3%with a reversible gravimetric capacity of 2,874 mAh·g−1 and superior cycling stability over 5,000 h without dendrite growth. | Jinxi Wang Yadong Ye Hongmin Zhou Wei Zhang Zhaowei Sun Jiawen Zhu Hongchang Jin Huanyu Xie Haoliang Huang Yi Cui Rong Huang Zezhong Li Song Jin Hengxing Ji | 2023 | Nano Research2023，16，6： | 0 |
| 19 | Multi-Omics-Guided Discovery of Omicsynins Produced by Streptomyces sp.1647:Pseudo-Tetrapeptides Active Against Influenza A Viruses and Coronavirus HCoV-229E显示文摘Many microorganisms have mechanisms that protect cells against attack from viruses.The fermentation components of Streptomyces sp.1647 exhibit potent anti-influenza A virus(IAV)activity.This strain was isolated from soil in southern China in the 1970s,but the chemical nature of its antiviral substance(s)has remained unknown until now.We used an integrated multi-omics strategy to identify the antiviral agents from this streptomycete.The antibiotics and Secondary Metabolite Analysis Shell(antiSMASH)analysis of its genome sequence revealed 38 biosynthetic gene clusters(BGCs)for secondary metabolites,and the target BGCs possibly responsible for the production of antiviral components were narrowed down to three BGCs by bioactivity-guided comparative transcriptomics analysis.Through bioinformatics analysis and genetic manipulation of the regulators and a biosynthetic gene,cluster 36 was identified as the BGC responsible for the biosynthesis of the antiviral compounds.Bioactivity-based molecular networking analysis of mass spectrometric data from different recombinant strains illustrated that the antiviral compounds were a class of structural analogues.Finally,18 pseudo-tetrapeptides with an internal ureido linkage,omicsynins A1–A6,B1–B6,and C1–C6,were identified and/or isolated from fermentation broth.Among them,11 compounds(omicsynins A1,A2,A6,B1–B3,B5,B6,C1,C2,and C6)are new compounds.Omicsynins B1–B4 exhibited potent antiviral activity against IAV with the 50%inhibitory concentration(IC_(50))of approximately 1μmol·L^(-1)and a selectivity index(SI)ranging from 100 to 300.Omicsynins B1–B4 also showed significant antiviral activity against human coronavirus HCoV-229E.By integrating multi-omics data,we discovered a number of novel antiviral pseudo-tetrapeptides produced by Streptomyces sp.1647,indicating that the secondary metabolites of microorganisms are a valuable source of novel antivirals. | Hongmin Sun Xingxing Li Minghua Chen Ming Zhong Yihua Li Kun Wang Yu Du Xin Zhen Rongmei Gao Yexiang Wu Yuanyuan Shi Liyan Yu Yongsheng Che Yuhuan Li Jian-Dong Jiang Bin Hong Shuyi Si | 2022 | Engineering2022，，9： | 0 |
| 20 | Design of distance teaching platform based on Agent technology显示文摘The computer network technology and multi-media technology offer a new teaching mode for the distance education. Now there are still many problems in modem distance education such as weak generality,flexibility and intelligence,etc.This paper brought up a design mode of distance teaching platform based on Agent mechanism and the concrete implementation method through analyzing the characteristic and structure of Agent technology. | LI Xiaoming SUN Hongmin WU Wansheng | 2007 | Journal of Northeast Agricultural University(English Edition)2007，14，2： | 0 |
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