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| 1 | Effect of Annealing Temperature on the Precipitation Behavior and Texture Evolution in a Warm-Rolled P-Containing Interstitial-Free High Strength Steel显示文摘By using transmission electron microscopy and electron back-scattered diffraction, the effect of annealing temperature on the precipitation behavior and texture evolution in a warm-rolled interstitial-free high strength steel was studied. The results indicated that fine FeTiP could precipitate at 650 °C, and the number of those precipitates increased greatly with the increasing annealing temperature until 800 °C. Furthermore, the nucleation of FeTiP was influenced by the precipitation of TiC and(Ti, Nb) C. The near absence of FeTiP and a large volume fraction of TiC and(Ti, Nb) C in matrix are envisaged to be primarily responsible for the sharp c-fiber texture. As the boundary pinning effect caused by FeTiP is weak and there are less interstitial C atoms in matrix. Thus, annealing at 800 °C leads to the highest intensity of c-fiber texture. | Jiecen Zhang Yu Cao Guangwei Jiang Hongshuang Di | 2014 | Acta Metallurgica Sinica(English Letters)2014，27，3： | 3 |
| 2 | Inflammation-induced inhibition of chaperone-mediated autophagy maintains the immunosuppressive function of murine mesenchymal stromal cells显示文摘Macroautophagy has been implicated in modulating the therapeutic function of mesenchymal stromal cells(MSCs).However,the biological function of chaperone-mediated autophagy(CMA)in MSCs remains elusive.Here,we found that CMA was inhibited in MSCs in response to the proinflammatory cytokines interferon-γ(IFN-γ)and tumor necrosis factor-α(TNF-α).In addition,suppression of CMA by knocking down the CMA-related lysosomal receptor lysosomal-associated membrane protein 2(LAMP-2A)in MSCs significantly enhanced the immunosuppressive effect of MSCs on T cell proliferation,and as expected,LAMP-2A overexpression in MSCs exerted the opposite effect on T cell proliferation.This effect of CMA on the immunosuppressive function of MSCs was attributed to its negative regulation of the expression of chemokine C-X-C motif ligand 10(CXCL10),which recruits inflammatory cells,especially T cells,to MSCs,and inducible nitric oxide synthase(iNOS),which leads to the subsequent inhibition of T cell proliferation via nitric oxide(NO).Mechanistically,CMA inhibition dramatically promoted IFN-γplus TNF-α-induced activation of NF-κB and STAT1,leading to the enhanced expression of CXCL10 and iNOS in MSCs.Furthermore,we found that IFN-γplus TNF-α-induced AKT activation contributed to CMA inhibition in MSCs.More interestingly,CMA-deficient MSCs exhibited improved therapeutic efficacy in inflammatory liver injury.Taken together,our findings established CMA inhibition as a critical contributor to the immunosuppressive function of MSCs induced by inflammatory cytokines nd highlighted a previously unknown function of CMA. | Jie Zhang Jiefang Huang Yuting Gu Mingxing Xue Fengtao Qian Bei Wang Wanlin Yang Hongshuang Yu Qiwei Wang Xin Guo Xinyuan Ding Jina Wang Min Jin Yanyun Zhang | 2021 | Cellular & Molecular Immunology2021，18，6： | 3 |
| 3 | An electron backscattered diffraction study on the dynamic recrystallization behavior of a nickel–chromium alloy (800H) during hot deformation显示文摘 | Yu Cao Hongshuang Di Jingqi Zhang Jiecen Zhang Tianjun Ma R.D.K. Misra | 2013 | Materials Science & Engineering A2013，，： | 2 |
| 4 | Evolution of deformation and annealing textures in Incoloy 800H/HT via different rolling paths and strains 显示文摘 | Cao Yu Di Hongshuang Misra R D K | 2014 | Materials Science & Engineering A2014，33，5： | 1 |
| 5 | Constitutive analysis of the hot deformation behavior of Fe–23Mn–2Al–0.2C twinning induced plasticity steel in consideration of strain显示文摘 | Jingqi Zhang Hongshuang Di Xiaoyu Wang Yu Cao Jiecen Zhang Tianjun Ma | 2013 | Materials and Design2013，，： | 1 |
| 6 | Orientation-Dependent Characteristics for Residual Grains during Hot Deformation of Nickel-Based Alloy 925显示文摘In the present work, the orientation characteristics of residual grains during hot deformation of an age-hardening Ni-Fe-Cr alloy(Alloy 925) at different conditions were systematically analyzed through high-resolution electron back-scatter diffraction. Based on the measurement of the kernel average misorientation, the density of geometrical necessary dislocations(GNDs) was further calculated. The orientation-dependent deformation mechanism of the residual grains was also discussed using Schmid factor difference ratio(SFDR) analysis. The results show that the deformed microstructure features typical 'necklace' structures. Many distorted twin boundaries can be observed within the residual grains at 950 ℃. When the deformation temperature increases to 1150 ℃, the volume fraction of dynamic recrystallization(DRX) increases, leading to the extensive formation of primary Σ3 twin boundaries. Additionally, the GNDs are widely distributed in the residual grains, while they are rare for the recrystallized grains. The maximum GND density value can be obtained at the interface of 'soft–hard' grains. The GND density also increases at higher strain rates, and the number of DRX grains significantly affects the distribution of the GND density. Moreover, based on the calculations and SFDR analysis, it can be summarized that the {100} and {111} grains are prone to deform in the uniserial slip mode and the multiple slip mode, respectively. | Yulong Zhu Yu Cao Rui Luo Cunjian Liu Hongshuang Di Gang Shu Guangjie Huang Qing Liu | 2021 | Acta Metallurgica Sinica(English Letters)2021，34，9： | 0 |
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