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| 1 | A human circulating immune cell landscape in aging and COVID-19显示文摘Age-associated changes in immune cells have been linked to an increased risk for infection.However,a global and detailed characterization of the changes that human circulating immune cells undergo with age is lacking.Here,we combined scRNA-seq,mass cytometry and sCATAC-seq to compare immune cell types in peripheral blood collected from young and old subjects and patients with COVID-19.We found that the immune cell landscape was reprogrammed with age and was characterized by T cell polarization from naive and memory cells to effector,cytotoxic,exhausted and reg-ulatory cells,along with increased late natural killer cells,age-associated B cells,inflammatory monocytes and age-associated dendritic cells.In addition,the expression of genes,which were implicated in coron-avirus susceptibility,was upregulated in a cell subtype-specific manner with age.Notably,COVID-19 promoted age-induced immune cell polarization and gene expression related to inflammation and cellular senes-cence.Therefore,these findings suggest that a dysreg-ulated immune system and increased gene expression associated with SARS-CoV-2 susceptibility may at least partially account for COVID-19 vulnerability in the elderly. | Yingfeng Zheng Xiuxing Liu Wenqing Le Lihui Xie He Li Wen Wen Si Wang Shuai Ma Zhaohao Huang Jinguo Ye Wen Shi Yanxia Ye Zunpeng Liu Moshi Song Weiqi Zhang Jing-Dong J.Han Juan Carlos lzpisua Belmonte Chuanle Xiao Jing Qu Hongyang Wang Guang-Hui Liu Wenru Su | 2020 | Protein & Cell2020，11，10： | 10 |
| 2 | Synergistic effects in Mn-Co mixed oxide supported on cordierite honeycomb for catalytic deep oxidation of VOCs显示文摘A series of Co-Mn mixed oxide catalyst supported on a cordierite monolith was facilely synthesized by ultrasonic impregnation.Its catalytic performance was evaluated in the combustion of toluene,ethyl acetate and its mixture.It was observed that with incorporating Mn into Co_(3)O_(4),the formation of solid solution with spinel structure could significantly improve the catalytic activity of pure phase Co_(3)O_(4).And the monolithic Co_(0.67)Mn_(0.33)O_(x) catalyst showed the best catalytic performance in the catalytic oxidation of toluene and ethyl acetate which could be completely oxidized at 220 and 180℃ respectively under the reaction velocity(WHSV)about 45,000 m L/(g·hr)and pollutant concentration of 500 ppm V.The total conversion temperature of the VOCs mixture was at 230℃(500 ppm V toluene and 500 ppm V ethyl acetate)and determined by the temperature at which the most difficult molecule was oxidized.The excellent catalytic performance of monolithic Co_(0.67)Mn_(0.33)O_(x) was attributed to the higher content of Mn^(3+),Co^(3+),surface adsorbed oxygen and better redox ability.The prepared catalyst showed the good mechanical stability,reaction stability,and good adaptability to different reaction conditions. | Hongyang Zhao Hui Wang Zhenping Qu | 2022 | Journal of Environmental Sciences2022，34，2： | 4 |
| 3 | The protective role of hydrogen-rich saline in experimental liver injury in mice显示文摘 | HanYong Sun Lei Chen WeiPing Zhou Liang Hu Liang Li QianQian Tu YanXin Chang Qu Liu XueJun Sun MengChao Wu HongYang Wang | 2010 | Journal of Hepatology2010，，3： | 2 |
| 4 | All in one theranostic nanoplatform enables efficient anti-tumor peptide I delivery for triple-modal imaging guided cancer therapy显示文摘Developing a reliable system to efficiently and safely deliver peptide drugs into tumor tissues still remains a great challenge since the instability of peptide drugs and low ability to traverse the cell membrane. Herein, we constructed a multifunctional nanoplatform based on porous europium/gadolinium (Eu/Gd)-doped NaLa(MoO4)2 nanoparticles (NLM NPs) to deliver antitumor peptide of B-cell lymphoma/leukemia-2-like protein 11 (BIM) for cancer therapy. The porous NLM NPs exhibited inherent photoluminescent, magnetic and X-ray absorbable properties, which enable them for triple-modal bioimaging, including fluorescence, magnetic resonance imaging (MRI) and computed tomography (CT). This triple-modal bioimaging can contribute to monitoring NLM NPs biodistribution and guiding therapy in vitro and in vivo. Furthermore, the NLM NPs showed negligible cytotoxicity in vitro and tissue toxicity in vivo. Importantly, NLM NPs could load the antitumor peptide of BIM and efficiently improve the resistance of peptide drugs to proteolysis. The BIM peptide was efficiently delivered into the tumor cells by NLM NPs, which can inhibit the growth and promote the apoptosis of cancer cells in vitro, significantly inhibit the tumor growth in vivo. Notably, NLM-BIM theranostic nanoplatform exhibits low systemic toxicity and fewer side effects in vivo. The NLM NPs can serve as a promising multifunctional peptide delivery nanoplatform for multi-modal bioimaging and cancer therapy. | Xiaoyan Qu Zhengqing Liu Bohan Ma Na Li Hongyang Zhao Tian Yang Yumeng Xue Xiaozhi Zhang Yongping Shao Ying Chang Jun Xu Bo Lei Yaping Du | 2019 | Nano Research2019，12，3： | 2 |
| 5 | Communicative commitments: Model chec- king and complexity analysis显示文摘 | Jamal Bentahar Mohamed E1-Menshawy Hongyang Qu | 2012 | Knowledge-based sys- tems2012，35，： | 1 |
| 6 | Communicative commitments: Model checking and com- plexity analysis显示文摘 | BENTAHAR J EL-MENSHAWY M QU Hongyang | 2012 | Knowledge-based systems2012，35，： | 1 |
| 7 | Improving BDD-based attractor detection for synchronous Boolean networks显示文摘Boolean networks are an important formalism for modelling biological systems and have attracted much attention in recent years. An important challenge in Boolean networks is to exhaustively find attractors,which represent steady states of a biological network. In this paper, we propose a new approach to improve the efficiency of BDD-based attractor detection. Our approach includes a monolithic algorithm for small networks,an enumerative strategy to deal with large networks, a method to accelerate attractor detection based on an analysis of the network structure, and two heuristics on ordering BDD variables. We demonstrate the performance of our approach on a number of examples and on a realistic model of apoptosis in hepatocytes. We compare it with one existing technique in the literature. | Qixia YUAN Hongyang QU Jun PANG Andrzej MIZERA | 2016 | Science China(Information Sciences)2016，59，8： | 0 |
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