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| 1 | National trends in resection of the distal pancreas显示文摘AIM:To investigate national trends in distal pancreatectomy(DP) through query of three national patient care databases.METHODS:From the Nationwide Inpatient Sample(NIS,2003-2009),the National Surgical Quality Improvement Project(NSQIP,2005-2010),and the Surveillance Epidemiology and End Results(SEER,2003-2009) databases using appropriate diagnostic and procedural codes we identified all patients with a diagnosis of a benign or malignant lesion of the body and/or tail of the pancreas that had undergone a partial or distal pancreatectomy.Utilization of laparoscopy was defined in NIS by the International Classification of Diseases,Ninth Revision correspondent procedure code;and in NSQIP by the exploratory laparoscopy or unlisted procedure current procedural terminology codes.In SEER,patients were identified by the International Classification of Diseases for Oncology,Third Edition diagnosis codes and the SEER Program Code Manual,third edition procedure codes.We analyzed the databases with respect to trends of inpatient outcome metrics,oncologic outcomes,and hospital volumes in patients with lesions of the neck and body of the pancreas that underwent operative resection.RESULTS:NIS,NSQIP and SEER identified 4242,2681 and 11 082 DP resections,respectively.Overall,laparoscopy was utilized in 15%(NIS) and 27%(NSQIP).No significant increase was seen over the course of the study.Resection was performed for malignancy in 59%(NIS) and 66%(NSQIP).Neither patient Body mass index nor comorbidities were associated with operative approach(P = 0.95 and P = 0.96,respectively).Mortality(3% vs 2%,P = 0.05) and reoperation(4% vs 4%,P = 1.0) was not different between laparoscopy and open groups.Overall complications(10% vs 15%,P < 0.001),hospital costs [44 741 dollars,interquartile range(IQR) 28 347-74 114 dollars vs 49 792 dollars,IQR 13 299-73 463,P = 0.02] and hospital length of stay(7 d,IQR 4-11 d vs 7 d,IQR 6-10,P < 0.001) were less when laparoscopy was utilized.One and two year survival after resection for malignancy were unchanged over the course of the study(ductal adenocarinoma 1-year 63.6% and 2-year 35.1%,P = 0.53;intraductal papillary mucinous neoplasm and nueroendocrine 1-year 90% and 2-year 84%,P = 0.25).The majority of resections were performed in teaching hospitals(77% NIS and 85% NSQIP),but minimally invasive surgery(MIS) was not more likely to be used in teaching hospitals(15% vs 14%,P = 0.26).Hospitals in the top decile for volume were more likely to be teaching hospitals than lower volume deciles(88% vs 43%,P < 0.001),but were no more likely to utilize MIS at resection.Complication rate in teaching and the top decile hospitals was not significantly decreased when compared to non-teaching(15% vs 14%,P = 0.72) and lower volume hospitals(14% vs 15%,P = 0.99).No difference was seen in the median number of lymph nodes and lymph node ratio in N1 disease when compared by year(P = 0.17 and P = 0.96,respectively).CONCLUSION:There appears to be an overall underutilization of laparoscopy for DP.Centralization does not appear to be occurring.Survival and lymph node harvest have not changed. | Armando Rosales-Velderrain Steven P Bowers Ross F Goldberg Tatyan M Clarke Mauricia A Buchanan John A Stauffer Horacio J Asbun | 2012 | World Journal of Gastroenterology2012，18，32： | 8 |
| 2 | Celiac disease serology in patients with different pretest probabilities: Is biopsy avoidable?显示文摘AIM: To establish the diagnostic performance of sev-eral serological tests, individually and in combination, for diagnosing celiac disease (CD) in patients with different pretest probabilities, and to explore potential se- rological algorithms to reduce the necessity for biopsy. METHODS: We prospectively performed duodenal biopsy and serology in 679 adults who had either high risk (n = 161) or low risk (n = 518) for CD. Blood samples were tested using six assays (enzyme-linked immunosorbent assay) that detected antibodies to tissue transglutaminase (tTG) and deamidated gliadin peptide (DGP). RESULTS: CD prevalence was 39.1% in the high-risk population and 3.3% in the low-risk group. In high-risk patients, all individual assays had a high diagnostic efficacy [area under receiving operator characteristic curves (AU ROC): 0.968 to 0.999]. In contrast, assays had a lower diagnostic efficacy (AU ROC: 0.835 to 0.972) in the low-risk group. Using assay combinations, it would be possible to reach or rule out diagnosis of CD without biopsy in 92% of cases in both pretest populations. We observed that the new DGP/tTG Screen assay resulted in a surplus compared to more conventional assays in any clinical situation. CONCLUSION: The DGP/tTG Screen assay could be considered as the best initial test for CD. Combinations of two tests, including a DGP/tTG Screen, might be able to diagnose CD accurately in different clinical scenarios making biopsy avoidable in a high proportion of subjects. | Emilia Sugai María L Moreno Hui J Hwang Ana Cabanne Adriana Crivelli Fabio Nach-man Horacio Vázquez Sonia Niveloni Julio Argonz Roberto Mazure Graciela La Motta María E Caniggia Edgardo Smecuol Néstor Chopita Juan C Gómez Eduardo Maurińo Julio C Bai | 2010 | World Journal of Gastroenterology2010，16，25： | 4 |
| 3 | Total pancreatectomy: Short- and long-term outcomes at a high-volume pancreas center显示文摘AIM To identify the current indications and outcomes of total pancreatectomy at a high-volume center. METHODS A single institutional retrospective study of patients undergoing total pancreatectomy from 1995 to 2014 was performed.RESULTS One hundred and three patients underwent totalpancreatectomy for indications including: Pancreatic ductal adenocarcinoma(n = 42, 40.8%), intraductal papillary mucinous neoplasms(n = 40, 38.8%), chronic pancreatitis(n = 8, 7.8%), pancreatic neuroendocrine tumors(n = 7, 6.8%), and miscellaneous(n = 6, 5.8%). The mean age was 66.2 years, and 59(57.3%) were female. Twenty-four patients(23.3%) underwent a laparoscopic total pancreatectomy. Splenic preservation and portal vein resection and reconstruction were performed in 24(23.3%) and 18 patients(17.5%), respectively. The 90 d major complications, readmission, and mortality rates were 32%, 17.5%, and 6.8% respectively. The 1-, 3-, 5-, and 7-year survival for patients with benign indications were 84%, 82%, 79.5%, and 75.9%, and for malignant indications were 64%, 40.4%, 34.7% and 30.9%, respectively.CONCLUSION Total pancreatectomy, including laparoscopic total pancreatectomy, appears to be an appropriate option for selected patients when treated at a high-volume pancreatic center and through a multispecialty approach. | Hazem M Zakaria John A Stauffer Massimo Raimondo Timothy A Woodward Michael B Wallace Horacio J Asbun | 2016 | World Journal of Gastrointestinal Surgery2016，8，9： | 3 |
| 4 | Gastric cancer in young people under 30 years of age: worse prognosis, or delay in diagnosis?显示文摘 | Horacio N López-Basave Diaz Romero C Alejandro Padilla Rosciano Melchor Ruan J Silvio A. ?amendys-Silva Vela Sarmiento I Ruiz Molina JM Calderillo Ruiz G Flavia Morales-Vásquez Abelardo Meneses Garcia Angel Herrera-Gomez | 2013 | Cancer Management and Research (default)2013，，： | 2 |
| 5 | Role of PI3K signaling in survival and progression of prostate cancer cells to androgen refractory state显示文摘 | Horacio M Huang H J Lucy J | 2001 | Endocrinology2001，142，11： | 1 |
| 6 | Spectroelectrochemieal study of the oxidation of arninophenols on platinum electrode in acid medium显示文摘 | Horacio J Salavagione Joaquln Arias Pedro Garccs | 2004 | Journal of Eleetroanalytieal Chemistry2004，565，2： | 1 |
| 7 | Continuous-flow determination of reserpine by oxidation with periodate ion and catalysis by manganese(II) in solution or by an MnO2(s) reactor显示文摘 | VARMA S R MARTINEZ C J HORACIO A M | 1990 | Anal Chim Acta1990，233，： | 1 |
| 8 | Hypematrmia 显示文摘 | Horacio J Nieolaos E | 2000 | N Ensl J Med2000，342，20： | 1 |
| 9 | The state of the art on Wells-Dawson heteropoly-compounds:a review of their properties and applications显示文摘 | LAURA E B GRACIELA T B HORACIO J T | 2003 | Applied Catalysis A:General2003，256，： | 1 |
| 10 | Solvent - free catalytic preparation of 1,1 - diacetates from aldehydes using a wells - dawson acid (H6P2W18 O62 · 24H2O) 显示文摘 | GUSTAVO P R HORACIO J T GRACIELA T B | 2003 | Tetrahedrom Letters2003，44，1： | 1 |
| 11 | Synthesis of lanthanum nickelate perovskite nanotubes by using a template-inorganic precursor 显示文摘 | Mario Tagliazucchi Rodolfo D Sanchez Horacio E Troiani Emesto J Calvo | 2006 | Solid State Communications2006，137，： | 1 |
| 12 | Hyponatremia显示文摘 | Horacio J A Nicolaos E M | 2000 | N Engl J Med2000，342，： | 1 |
| 13 | Solvent-free catalytic preparation of 1,1-diacetates from aldehydes using a Wells-Dawson acid (H6P2W18 O62· 24H2O) 显示文摘 | Gustavo P Romanelli Horacio J Thomas Graciela T | 2003 | Tetrahedron Lett2003，44，3： | 1 |
| 14 | The state of the art on Wells - Dawson heteropoly - compounds: A review of their properties and applications 显示文摘 | Laura E B Graciela T B Horacio J T | 2003 | Applied Catalysis A :2003，256，： | 1 |
| 15 | IMC design for unstable processed with time delays 显示文摘 | Tan W Horacio J Marquez Chen T W | 2003 | J of Process Control2003，13，3： | 1 |
| 16 | Laparoscopic vs open pancreaticoduodenectomy:overall outcomes and severity of complications using the Accordion Severity Grading System 显示文摘 | Horacio J Asbun John A Stauffer | 2012 | J Am Coll Surg2012，215，： | 1 |
| 17 | Low Dialysate Decreases Efficiency of Hemodialysis and Increases Urea Rebound显示文摘 | George M Dolson A Horacio J | 1998 | J Am Soc Nephrol1998，9，： | 1 |
| 18 | Short RC columns under bilateral load histories显示文摘 | Kyuichi M Horacio R James O J | 1984 | Journal of Structural Engineering1984，110，1： | 1 |
| 19 | Decrease of exercise-induced microalbuminuria in patients with type I diabetes by means of angiotensinconverting enzyme inhibitor显示文摘 | INSERRA F HORACIO D IPPOLITO J L | 1996 | Am J Kidney Dis1996，27，： | 1 |
| 20 | Sodium and potassium in the pathogenesis of hypertension显示文摘 | Horacio J Adrogue Nicolaos E Madias | 2007 | New England Journal of Medcine2007，356，19： | 1 |
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