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| 1 | Metabolic syndrome and risk of subsequent colorectal cancer显示文摘The metabolic syndrome and visceral obesity have anincreasing prevalence and incidence in the generalpopulation. The actual prevalence of the metabolicsyndrome is 24% in US population and between24.6% and 30.9% in Europe. As demonstrated by many clinical trials (NAHANES , INTERHART) the metabolic syndrome is associated with an increased risk of both diabetes and cardiovascular disease. In addition to cardiovascular disease, individual components of the metabolic syndrome have been linked to the development of cancer, particularly to colorectal cancer. Colorectal cancer is an important public health problem; in the year 2000 there was an estimated total of 944 717 incident cases of colorectal cancer diagnosed world-wide. This association is sustained by many epidemiological studies. Recent reports suggest that individuals with metabolic syndrome have a higher risk of colon or rectal cancer. Moreover, the clusters of metabolic syndrome components increase the risk of associated cancer. The physiopathological mechanism that links metabolic syndrome and colorectal cancer is mostly related to abdominal obesity and insulin resistance. Population and experimental studies demonstrated that hyperinsulinemia, elevated C-peptide, elevated body mass index, high levels of insulin growth factor-1, low levels of insulin growth factor binding protein-3, high leptin levels and low adiponectin levels are all involved in carcinogenesis. Understanding the pathological mechanism that links metabolic syndrome and its components to carcinogenesis has a major clinical signifi cance and may have profound health benefi ts on a number of diseases including cancer, which represents a major cause of mortality and morbidity in our societies. | Raluca Pais Horatiu Silaghi Alina Cristina Silaghi Mihai Lucian Rusu Dan Lucian Dumitrascu | 2009 | World Journal of Gastroenterology2009，15，41： | 16 |
| 2 | Systemic lupus erythematosus and acute pancreatitis显示文摘 | Derk CT de Horatius RJ | 2004 | Clin Rheumatol (Belgium)2004，23，2： | 1 |
| 3 | Genetic fin- gerprint - innovative method for animal products traceability in the context of bio eeonomy 显示文摘 | Enache Mariana Sandu Horatiu Strasser | 2014 | Procedia Economies and Fi nanee2014，8，： | 1 |
| 4 | Pregnancy outcomes in female renal recipients : a comparison of systemic lupus erythematosus with other diagnoses显示文摘 | M C GRORY C H M C CLOSKEY L J DE HORATIUS RJ | 2003 | Am J Transplant2003，3，： | 1 |
| 5 | Subaraehnoid hemorrhage due to cerebral aneurysmal rupture during pregnancy 显示文摘 | Horatiu Roman Gérome Descargnes Manuel Lopes | 2004 | Aeta Obstet Gyneeol Seand2004，83，4： | 1 |
| 6 | Fever of un-know n origin-predictors of outcome a prospective Multi-center study on 164 patients显示文摘 | Baicus C Horatiu D Tanasescu C | 2003 | Eur J Intern Med2003，14，4： | 1 |
| 7 | Implementing Fast-Track Protocol for Colorectal Surgery: A Prospective Randomized Clinical Trial显示文摘 | Daniela Ionescu Cornel Iancu Daniela Ion Nadim Al-Hajjar Simona Margarit Lucian Mocan Teodora Mocan Delia Deac Raluca Bodea Horatiu Vasian | 2009 | World Journal of Surgery2009，，11： | 1 |
| 8 | Restoration of a peri-implant defect by platelet-rich fibrin显示文摘 | Jong-Won Lee Seong-Gon Kim Jwa-Young Kim Yong-Chan Lee Je-Yong Choi Rosca Dragos Horatiu Rotaru | 2012 | Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology2012，，： | 1 |
| 9 | Systemic lupuseryt hematosus and acute pancreatitis 显示文摘 | Derk CT de Horatius RJ | 2004 | Clin Rheumatol (Belgium)2004，23，2： | 1 |
| 10 | Cranioplasty With Custom-Made Implants: Analyzing the Cases of 10 Patients显示文摘 | Horatiu Rotaru Horatiu Stan Ioan Stefan Florian Ralf Schumacher Yong-Tae Park Seong-Gon Kim Horea Chezan Nicolae Balc Mihaela Baciut | 2012 | Journal of Oral and Maxillofacial Surgery2012，，2： | 1 |
| 11 | Public-Private: Public Sphere and Citizenship显示文摘 | Adrian Gorun Horatiu Tiberiu Gorun | 2011 | Journal of US-China Public Administration2011，8，3： | 0 |
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