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| 1 | 脑缺血后N-myc下游调控基因2保护血脑屏障完整性显示文摘脑缺血后血脑屏障(BBB)的破坏与外周细胞向脑内浸润、病孔损形成与进展、以及临床病程恶化密切相关。目前BBB完整性的调控机制,尤其是在永久性缺血后的调控机制尚未明确。本研究使用小鼠永久性脑缺血模型进行相关研究,结果显示,星形胶质细胞N-myc下游调控基因2(NDRG2)可能是缺血性脑卒中后BBB通透性的调控分子,该分子与分化和应激相关。免疫组化显示,在永久性大脑中动脉闭塞(MCAO)后,NDRG2在星形胶质细胞中的表达显著增加。敲除NDRG2基因,脑梗死体积增加,免疫细胞在缺血同侧大脑半球积聚增加。MCAO后,NDRG2基因敲除小鼠缺血侧皮质的缺血灶内及灶周血管周围区域内的血清蛋白(包括纤维蛋白原和免疫球蛋白)的外渗增强此之,MCAO后NDRG2基因敲除小鼠体内基质金属蛋白酶(MMPs)的表达也显著增加。在细胞培养中,NDRG2-/-星形胶质细胞中MMP-3的表达和分泌增加,这种增加可被腺病毒介导的NDRG2再表达所逆转。综上所述,脑缺血后,星形胶质细胞内的NDRG2可能通过调节MMP的表达,而在BBB通透性的调节和免疫细胞浸润中起到重要作用。 | Takarada-Iemata M Yoshikawa A Ta HM Okitani N Nishiuchi T Aida Y Kamide T Hattori T Ishii H Tamatani T Le TM Roboon J Kitao Y Matsuyama T Nakada M Hori O 聂昊 | 2018 | 神经损伤与功能重建2018，13，4： | 4 |
| 2 | 普萘洛尔治疗婴幼儿血管瘤:对血浆血管内皮细胞生长因子的作用显示文摘普萘洛尔治疗婴幼儿血管瘤(IH)效果显著,但其发病机制及其对血管内皮细胞生长因子(VEGF)的作用尚不清楚。该文旨在明确普萘洛尔的疗效和评估IH患者治疗后血浆VEGF的变化。35例IH患儿被纳入研究。口服普萘洛尔2.0 mg/kg·d,3次/d。以病变大小和颜色的视觉模拟量表(VAS)变化评估疗效。血浆VEGF浓度采用酶联免疫吸附试验测定,各组间进行比较。 | Ozeki M Nozawa A Hori T | 2017 | 中国口腔颌面外科杂志2017，15，1： | 3 |
| 3 | 显示文摘 | Hashimoto Y Horie Y Hayashi M | 2000 | Tetrahedron:Asymmetry2000，11，10： | 2 |
| 4 | Autoradiography of keen joint after intra-articular administration of 14Csodium hyaluronate (14C-SL-1010) in rabbits显示文摘 | Hori K Kikkawa M Takaichi M | | Japanese Pharmacology and Therapeutics0，，： | 2 |
| 5 | Small hypervascular hepatocellular carcinoma revealed by double arterial phase CT per formed with single breath-hold scanning and automatic bolus tracking 显示文摘 | Kim T Murakami T Hori M etal | 2002 | AJR Am J Roentgenol2002，178，4： | 1 |
| 6 | Phenol oxidation kinetics in supercritical water 显示文摘 | Oshima Y Hori K Toda M | 1998 | Journal of super-critical fluids1998，13，2： | 1 |
| 7 | Insulin-mediated growth in aortic smooth muscle and the vascular renin-angiotensin system显示文摘 | Hori M T Zhu J H | 1998 | Hypertension1998，32，3： | 1 |
| 8 | Different profiles of Ca^2+ responses to endothelin-I and PDGF in liver myofibroblasts during the process of cell differentiation 显示文摘 | Kojima N Hori M Murata T | 2007 | Br J Pharmacol2007，151，6： | 1 |
| 9 | Effect of beta-agonists on production of cytokines by activated T cells obtained from asthmatic patients and normal subjects显示文摘 | Aihara M Dobashi K Horie T | 1999 | J Asthma1999，36，7： | 1 |
| 10 | Overexpression of ornithine decarboxylase enhances endothelial proliferation by suppressing endostatin expression显示文摘 | Nemoto T Hori H Yoshimoto M | 2002 | Blood2002，99，4： | 1 |
| 11 | Studies of methyl 2-nitroimidazole-l-acetohydroxam-ate (KIN 804) 2: effect on certain antioxidant enzyme systems in mice bearing ehrlich ascites carcinoma显示文摘 | Abu Zeid M Hori H Nagasawa H | 2000 | Biol Pharm Bull2000，23，2： | 1 |
| 12 | Stellettamide-A, a novel inhibitor of calmodulin, isolated from a marine sponge显示文摘 | Abe Y Saito S Hori M etal | 1997 | Br J Pharmacol1997，121，： | 1 |
| 13 | Voltammograms of Stepped and Kinked Stepped Surfaces of Palladium : Pd (S) - and Pd(S) - 显示文摘 | Hoshi N Kuroda M Hori Y | 2002 | J Electroanal Chem2002，521，： | 1 |
| 14 | Treatment of intraeranial dural arteriovenous fistulas:current strategies based on location and hemodynamics,and alternative techniques of trans-catheter embolization显示文摘 | Kiyosue H Hori Y Okahara M | 2004 | Radiographics2004，24，6： | 1 |
| 15 | Determination of macrolide antibiotics in meat and fish by liquid chromatography electrospray mass spectrometry显示文摘 | Horie M Takegami H Toya K | 2003 | Anal Chim Acta2003，492，12： | 1 |
| 16 | Fish and omega-3 polyun- saturated fatty acids in relation to risk of cardiovascular disease显示文摘 | Yamagishi K Hori M Iso H | 2013 | Nihon Rinsho2013，71，9： | 1 |
| 17 | HRS/EHRA/ APHRS expert consensus statement on the diagnosis and management of patients with inherited primary arrhythmia syndromes: document endorsed by HRS, EHRA, and APHRS in May 2013 and by ACCF, AHA, PACES, and AEPC in June 2013显示文摘 | PRIORI S G WILDE A A HORIE M | 2013 | Heart Rhythm2013，10，12： | 1 |
| 18 | lntrahepatic biliary cysts in children with biliary atresia who have had a Kasai operation显示文摘 | M Watanabe TM Hori H Komuro | 2007 | J pediatr Surg2007，42，7： | 1 |
| 19 | IL-1 beta inhibits intestinal smooth muscle proliferation in an organ culture system:involvement of COX-2 and iNOS induction in muscularis resident macrophages 显示文摘 | Ohama T Hori M Momotani E | 2007 | Am J Physiol Gast rointest Liver Physiol2007，292，5： | 1 |
| 20 | A numerical study of structural damage detection using changes in the rotation of mode shapes 显示文摘 | Abdo M A B Hori M | 2002 | Journal of Sound and Vibration2002，251，2： | 1 |
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