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| 1 | Differential expression of interleukin-1/Toll-like receptor signaling regulators in microscopic and ulcerative colitis显示文摘AIM:To investigate Toll-like receptor(TLR)signaling regulators in microscopic and ulcerative colitis patients.METHODS:Total RNA and microRNA were isolated from fresh frozen colonic biopsies of non-inflamed controls and patients with active or in-remission collagenous colitis(CC),lymphocytic colitis(LC),or ulcerative colitis(UC).We compared expressions of interleukin-1receptor-associated kinase(IRAK)-2,IRAK-M,interleukin(IL)-37,microRNA(miR)-146a,miR-155,and miR-21 using quantitative real time reverse transcription polymerase chain reaction.RESULTS:IRAK-M expression was increased in LC patients with active disease in histopathological remission(LC-HR;P=0.02)and UC patients(P=0.01),but no differences in IRAK-2 expression were detected compared to controls.miR-146a,-155 and-21 expressions were increased in LC-HR(P=0.04,0.07,and 0.004)and UC(P=0.02,0.04 and 0.03)patients.miR-146a and miR-21 expressions were significantly enhanced in UC patients compared to UC remission(UC-R;P=0.01and 0.04).Likewise,active CC patients showed significantly increased expression of miR-155(P=0.003)and miR-21(P=0.006).IL-37 expression was decreased in both CC(P=0.03)and LC(P=0.04)patients with a similar trend in UC patients but not statistically significant,whilst it was increased in UC-R patients compared to controls(P=0.02)and active UC(P=0.001).CONCLUSION:The identification of differentially expressed miRNAs,IL-37,and IRAK-M suggests different pathophysiologic mechanisms in various disease stages in LC,CC,and UC. | Sezin Gunaltay Nils Nyhlin Ashok Kumar Kumawat Curt Tysk Johan Bohr Olof Hultgren Elisabeth Hultgren Hornquist | 2014 | World Journal of Gastroenterology2014，20，34： | 11 |
| 2 | Clinical and immunologic effects of faecal microbiota transplantation in a patient with collagenous colitis显示文摘One to six percent of patients with microscopic colitis are refractory to medical treatment. The effect of faecal microbiota transplantation(FMT) in active collagenous colitis(CC) has, to the best of our knowledge, never been reported before. Here, we report the effect of repeated FMT in a patient with CC. The patient presented with severe symptoms including profuse diarrhea and profound weight loss. Although she responded to budesonide in the beginning, she became gradually refractory to medical treatment, and was therefore treated with FMT. The patient remained in remission for 11 mo after the third faecal transplantation. The immunomodulatory effect of the therapy was evaluated using flow cytometry, which showed alterations in the profile of intraepithelial and lamina propria lymphocyte subsets after the second transplantation. Our observations indicate that FMT can have an effect in CC, which support the hypothesis that luminal factors, influencing the intestinal microbiota, are involved in the pathogenesis of CC. | Sezin Günaltay Lech Rademacher Elisabeth Hultgren Hornquist Johan Bohr | 2017 | World Journal of Gastroenterology2017，23，7： | 4 |
| 3 | Interaction of Bordetella pertussis with mast cells,modulation of cytokine secretion by pertussis toxin显示文摘 | Mielcarek N Hornquist EH Johansson BR | 2001 | Cell Microbiol2001，3，3： | 1 |
| 4 | Quality of life: Concept and assessment显示文摘 | Hornquist JO | 1990 | Scandinavian Journal of Social Medicine1990，18，1： | 1 |
| 5 | The concept of quality of life显示文摘 | Hornquist JO | 1982 | Scand J Soc Med1982，10，： | 1 |
| 6 | Quality of life : Status and change( QLsc ) reliability, validity and sensitivity of a generic assessment approach tailored for diabetes显示文摘 | Hornquist JO Wikby A Hansson B | 1993 | Qua Life Res1993，2，4： | 1 |
| 7 | Dietary antigen- specific T-cell responses: switch from an interleukin- 10-dominated response in normalmice to a Thelper 1 cytokine profile in Galphai-2-deficient mice prior to co- litis显示文摘 | BjurstenM Hultgren Hornquist E | 2005 | Scandinavian Journal of Immunology2005，61，1： | 1 |
| 8 | The concept of quality of life显示文摘 | Hornquist JO | 1982 | Scand J Soc Med1982，10，2： | 1 |
| 9 | Quality of life: concept and assessment显示文摘 | Hornquist JO | 1990 | Scand J Soc Med1990，18，1： | 1 |
| 10 | Quality of life concept and assessments显示文摘 | Hornquist JO | 1990 | Scand J Soc Med1990，18，1： | 1 |
| 11 | Quality of life:status and change(QLsc)reliability,valiability,validity and sensitivity of a generic assessment approach tailored for diabetes显示文摘 | Hornquist J O Wikby A Hansson B | 1993 | Qual Life Res1993，2，4： | 1 |
| 12 | Controllability analysis of networks显示文摘 | Lombardi A Hornquist M | 2007 | Physical Review E2007，75，05： | 1 |
| 13 | Three-dimensional variational data assimilation for a limited area model 显示文摘 | Gustafsson N Berre L Hornquist S | 2001 | Tellus2001，53，： | 1 |
| 14 | The concept of quality of life显示文摘 | Hornquist JO | 1982 | Scand J Soc Med1982，10，： | 1 |
| 15 | Quality of life concept and assessments显示文摘 | Hornquist JO | 1990 | Scand J Soc Med1990，18，1： | 1 |
| 16 | Quality of life:concept and assessment显示文摘 | Hornquist JO | 1990 | Scand J Soc Med1990，18，1： | 1 |
| 17 | Psychological outcomes in Swedish and Icelandic parents following a child' s cancer-in the light of site-related differences显示文摘 | Gudmundsdottir E Hornquist L Boman K K | 2013 | Supportive Care in Cancer2013，21，6： | 1 |
| 18 | Lack of local suppression in orally tolerant CD8-Deficient mice reveals a critical regulatory role of CD8+T cells in the normal gut mucosa显示文摘 | Grdic D Hornquist E Kjerrulf M | | 0，，02： | 1 |
| 19 | Quality of life compept and assessments显示文摘 | Hornquist Jo | | 0，，01： | 1 |
| 20 | Quality of life:concept and assessment显示文摘 | Hornquist J O | 1990 | Scand J Soc Med1990，18，1： | 1 |
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