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| 1 | Autoimmune hepatitis and anti-tumor necrosis factor alpha therapy:A single center report of 8 cases显示文摘This article describes cases of anti-tumor necrosis factor(TNF)-α-induced autoimmune hepatitis and evaluates the outcome of these patients in relation to their immunosuppressive strategy. A retrospective analysis of medical records was performed in our center, in order to detect cases of autoimmune hepatitis(AIH) associated with anti-TNF biologic agents. We describe and analyze eight cases of AIH following anti-TNF therapy, 7 with infliximab and 1 with adalimumab. A distinction should be made between induction of autoimmunity and clinically evident autoimmune disease. Liver biopsy is useful in detecting the role of the TNF-α antagonist in the development of AIH. The lack of relapse after discontinuing immunosuppressive therapy favors, as in this case series, an immune-mediated drug reaction as most patients with AIH have a relapse after treatment is suspended. Although AIH related to anti-TNF therapy is rare, a baseline immunological panel along with liver function tests should be performed in all patients with autoimmune disease before starting biologics. | Susana Rodrigues Susana Lopes Fernando Magro Hélder Cardoso Ana Maria Horta e Vale Margarida Marques Eva Mariz Miguel Bernardes Joanne Lopes Fátima Carneiro Guilherme Macedo | 2015 | World Journal of Gastroenterology2015，21，24： | 9 |
| 2 | Management of autoimmune hepatitis:Focus on pharmacologic treatments beyond corticosteroids显示文摘In autoimmune hepatitis, patients who are intolerant or with toxicity experience, non-responders, relapsers or refractory are challenging. Non-standard drugs are being tried to preemptively avoid corticosteroid-related side effects. Prognosis and quality of life of life rely on treatment optimization. Recently, emergence of powerful immunosuppressive agents, mainly from liver transplantation, challenged the supremacy of the corticosteroid regime and promise greater immunosuppression than conventional medications, offer site-specific actions and satisfactory patient tolerance. Successes in experimental models of related diseases have primed these molecular interventions. We performed a literature review on alternative treatments. Azatioprine intolerance is the principal indication for mycophenolate use butit can be used as a front-line therapy. Cyclosporine A and tacrolimus have been tested for non-responders or relapsers. Rituximab may be used as salvage therapy. Anti-tumor necrosis factor-alpha agents may be used for incomplete responses or non-responders. Methotrexate is possibly an alternative for induction of remission and maintenance in refractory patients. Cyclophosphamide has been included in the induction regimen with corticosteroids. Ursodeoxycholic acid action is mainly immunomodulatory. Non-standard treatments are coming slowly to the attention, but its use should be cautious performed by experienced centers. | Marta Casal Moura Rodrigo Liberal Hélder Cardoso Ana Maria Horta e Vale Guilherme Macedo | 2014 | World Journal of Hepatology2014，6，6： | 2 |
| 3 | Macromolecular size of polyelectrolytes containing ammonium and sulfonic acid groups,as determined by light scattering显示文摘 | Rivas B L Pereira E D Horta A | 2004 | European Polymer Journal2004，40，： | 1 |
| 4 | Organic Personality Disorder after Traumatic Brain Injury显示文摘 | Franulic A Horta E Naturana R | 2000 | Brain Injury2000，14，5： | 1 |
| 5 | Organic Personality Disorder after Traumatic Brain Injury 显示文摘 | Franulic A Horta E Naturana R | 2000 | Brain Injury2000，14，5： | 1 |
| 6 | Turning Blood into Brain:Cell Bearing Neuronal Antigens Generated in Vivo from Bone Marrow显示文摘 | MEZEY E CHEVNDROSC KT HORTA G | 2000 | Science(S1705-2092)2000，290，5497： | 1 |
| 7 | Recent results from NASA's morphing project显示文摘 | MCGOWAN A-M R WASHBURN A E HORTA L G | | 0，，： | 1 |
| 8 | Altered expressions of MMP - 2, MMP - 9, and TIMP - 2 in placentas from women exposed to lead 显示文摘 | Gonzalez - Puebla E Gonz61ez - Horta C Infante - Ramirez R | 2012 | Hum Exp Toxicol2012，31，7： | 1 |
| 9 | In Situ Polymerization of N,N-Dimethylacrylamide in Aerosol OT-Water:Modified Lamellar Structure and Multiphase Separation显示文摘 | Pacios I E Renamayor C S Horta A | 2002 | Macromolecules2002，35，20： | 1 |
| 10 | Recent results from NASA's morphing project 显示文摘 | Mcgowan A M R Washburn A E Horta L G | 2002 | Proceedings of Spie2002，，： | 1 |
| 11 | Assessing potential protection effects on commercial fish species in a Cuban MPA显示文摘Cuba has been leading marine protected area(MPA)designation in the Caribbean region to ensure conservation of its valuable marine ecosystems.Yet,an efficient monitoring program for MPAs is still to be implemented and will benefit from pre-existing information.The highly regulated MPA of Punta Francés National Park is one of the first Cuban MPAs and was established mainly to protect species and ecosystems for tourism purposes.Monitoring of protection effects on commercial fish species was lacking in this MPA.This study aimed at increasing local scientific knowledge by providing a baseline study about the most commercially fished families(Haemulidae,Lutjanidae and Serranidae)around Punta Francés MPA.Data collected represent only a limited period but can be used as a base point to support future monitoring.Fish abundance in number and biomass,and size were collected to test for differences between inside and adjacent areas outside the Punta Francés MPA,in different coral reef types.The main result of this study was the significantly larger size and biomass of snappers and groupers outside the MPA where intense fisheries occur.An observation consistent with a large spawning aggregation was also recorded outside the MPA.Even with a limited set of data,these results suggest that,at least temporarily,the most targeted species[and sizes]are still highly vulnerable to fisheries.Relevant habitats in the adjacent area,that are apparently missing within the MPA,may support some of the results found.Extending the limits of the Punta Francés MPA to include those habitats outside may be critical to ensure the effectiveness of this MPA in contributing to protect the most commercial species of the region.This should be done together with efficient fisheries management measures in the region,such as the significantly increase of minimum legal sizes and temporal closures during spawning migrations. | Barbara Horta e Costa Jorge Angulo-Valdés Jorge M.S.Gonçalves Pedro Barros | 2020 | Aquaculture and Fisheries2020，5，5： | 0 |
| 12 | Fisher's perceptions about a marine protected area over time显示文摘The perceptions of fishers towards the Arrábida Marine Park,a marine protected area(MPA)in the west coast of Portugal,were studied through face-to-face interviews in two different moments of the MPA life cycle.Fishers'perceptions about the MPA and the impact it had on the fishing activity over time were identified just before the full implementation of the zoning and regulations of the management plan and 10 years later.This study aimed to investigate fishers'knowledge,acceptance and perceptions about the MPA changed with time,if support for the MPA was linked to the impact of the MPA on the fishing activity,and if fishers'perceptions about the impact of the MPA on the fishing activity match with local landings trends.Results show that although knowledge about the marine park significantly improved over time,fishers'acceptance did not.A decrease on fishers'support was not substantial but occurred.Issues such as the disagreement with regulations reinforced concerns raised during the implementation of the marine park,particularly in relation to the top-down decision-making,which commonly confers minor participation,recognition and legitimacy to fishers.Apparently,fisheries benefits were still not perceived by local fishers,though they are central for fishers'support.Further,the perceived negative impacts of the park seemed to be more related to social aspects and individual interests than to impacts on catches.Addressing adequate management,enforcement and participation of local fishers is still possible and are advocated here as to contribute to the expected socioecological outcomes and respective support,leading to the future successful performance of the Arrábida Marine Park.Assessing fishers’perceptions towards an MPA over time is central and should be included on periodical socioecological monitoring and inform an effective adaptive management. | Cristina Pita Barbara Horta e Costa Gustavo Franco Rui Coelho Inês Sousa Emanuel J.Gonçalves Jorge M.S.Gonçalves Karim Erzini | 2020 | Aquaculture and Fisheries2020，5，5： | 0 |
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