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| 1 | Household air pollution and lung cancer in China:a review of studies in Xuanwei显示文摘Over half of the world's population is exposed to household air pollution from the burning of solid fuels at home. Household air pollution from solid fuel use is a leading risk factor for global disease and remains a major public health problem, especially in low- and mid-income countries. This is a particularly serious problem in China, where many people in rural areas still use coal for household heating and cooking. This review focuses on several decades of research carried out in Xuanwei County, Yunnan Province, where household coal use is a major source of household air pollution and where studies have linked household air pollution exposure to high rates of lung cancer. We conducted a series of case-control and cohort studies in Xuanwei to characterize the lung cancer risk in this population and the factors associated with it. We found lung cancer risk to vary substantially between different coal types, with a higher risk associated with smoky(i.e., bituminous) coal use compared to smokeless(i.e., anthracite) coal use. The installation of a chimney in homes resulted in a substantial reduction in lung cancer incidence and mortality. Overall, our research underscores the need among existing coal users to improve ventilation, use the least toxic fuel, and eventually move toward the use of cleaner fuels, such as gas and electricity. | Wei Jie Seow Wei Hu Roel Vermeulen H.Dean Hosgood III George S.Downward Robert S.Chapman Xingzhou He Bryan A.Bassig Christopher Kim Cuiju Wen Nathaniel Rothman Qing Lan | 2014 | Chinese Journal of Cancer2014，33，10： | 15 |
| 2 | Curbing the burden of lung cancer显示文摘肺癌症实质地作出贡献到疾病和保健费用的全球负担。用低剂量的计算机化的断层摄影术的新屏蔽形式为导致药品外科的早察觉正在答应工具。然而,屏蔽和这些技术的诊断过程可以是的后续昂贵。集中于预防是一个重要因素减少屏蔽,处理,和肺癌症死亡的负担。当开发预防策略时,为关于癌症的研究的国际机构识别了几肺致癌物,我们相信罐头它被认为可起诉。限制肺癌症的社会负担,保健资源需要集中于早察觉并且屏蔽并且在减轻一个人的暴露到已知的肺致癌物上例如活跃烟草吸烟,家庭空气污染(幸运) ,和室外的空气污染。证据也建议了这些已知的肺致癌物可以与基因倾向被联系,支持归因于不同暴露的肺癌症可能从归因于兴趣的暴露的唯一的内在的基因机制开发了的假设。例如, smokingattributed 肺癌症与归因幸运的肺癌症相比包含风险的新奇基因标记。因此,基因风险标记可以在风险层化被使用识别在为得归因于给定的暴露的肺癌症的更高的风险的 subpopulations。如此的指向的预防策略建议精确预防策略以后可能是可能的;然而,许多工作被需要决定这些策略是否将是可行的。 | Alexandra Urman H. Dean Hosgood | 2016 | Frontiers of Medicine2016，10，2： | 3 |
| 3 | 1400W reduces ischemia reperfusion injury in an ex-vivo porcine model of the donation after circulatory death kidney donor显示文摘AIM: To investigate the effects of 1400W-a selective inducible nitric oxide synthase(iN OS) inhibitor in a model of donation after circulatory death(DCD) kidneys. METHODS: Porcine kidneys were retrieved after 25 min warm ischemia. They were then stored on ice for 18 h before being reperfused ex vivo with oxygenated autologous blood on an isolated organ perfusion system. The selective i NOS inhibitor 1400W(10 mg/kg) was administered before reperfusion(n = 6) vs control group(n = 7). Creatinine(1000 μmol/L) was added to the system, renal and tubular cell function and the level of ischemia reperfusion injury were assessed over 3 h of reperfusion using plasma, urine and tissue samples. RESULTS: Kidneys treated with 1400 W had a higher level of creatinine clearance(CrC l) [area under the curve(AUC) CrC l: 2.37 ± 0.97 mL /min per 100 g vs 0.96 ± 0.32 mL /min per 100 g, P = 0.004] and urine output [Total: 320 ± 96 mL vs 156 ± 82 mL, P = 0.008]. There was no significant difference in levels of fractional excretion of sodium(AUC, Fr ex Na+: Control, 186.3% ± 81.7%.h vs 1400 W, 153.4% ± 12.1%.h, P = 0.429). Levels of total protein creatinine ratio were significantly lower in the 1400 W group after 1 h of reperfusion(1h Pr/Cr: 1400 W 9068 ± 6910 mg/L/mmol/L vs Control 21586 ± 5464 mg/L/mmol/L, P = 0.026). Levels of 8-isoprostane were significantly lower in the 1400 W group [8-iso/creatinine ratio: Control 239 ± 136 pg/L/mmol/L vs 1400 W 139 ± 47 pg/L/mmol/L, P = 0.041].CONCLUSION: This study demonstrated that 1400 W reduced ischaemia reperfusion injury in this porcine kidney model of DCD donor. Kidneys had improved renal function and reduced oxidative stress. | Sarah A Hosgood Phillip J Yates Michael L Nicholson | 2014 | World Journal of Transplantation2014，4，4： | 2 |
| 4 | The role of perfluorocarbon in organ preservation显示文摘 | Hosgood SA Nicholson ML | 2010 | Transplantation2010，89，10： | 1 |
| 5 | The two layer method does not improve the preservation of porcine kidneys 显示文摘 | Hosgood SA Mohamed IH Nicholson ML | 2011 | Med Sci Monit2011，17，1： | 1 |
| 6 | Evaluation of hemorrhage, sample size, and collateral damage for {ire hepatic biopsy methods in dogs 显示文摘 | Vasanj ee S C Bubenik L J Hosgood G | 2006 | Vet Surg2006，35，1： | 1 |
| 7 | The first clinical case of intermediate ex vivo normothermic perfusion in renal transplantation显示文摘 | Hosgood SA Nicholson ML | 2014 | Am J Transplant2014，14，7： | 1 |
| 8 | Effects of dietary supplementation with fish oil on in vivo production of inflammatory mediators in clirilcally normal dogs 显示文摘 | LeBlanc C J Horohov DW Bauer JE Hosgood G Mauldin GE | 2008 | Am J Vet Res2008，69，4： | 1 |
| 9 | Mitochonclrial DNA copy number and lung cancer risk in a prospective cohort study显示文摘 | Hosgood HD 3rd Liu CS Rothman N | 2010 | Carcinogenesis2010，31，5： | 1 |
| 10 | A comparison of hypothermic machine perfusion versus static cold storage in an experimental model of renal ischemia reperfusion injury 显示文摘 | Hosgood SA Yang B Bagul A | 2010 | Transplantation2010，89，7： | 1 |
| 11 | A comparison of hypothermic machine perfusion versus static cold storage in an experimental model of renal ischemia reperfusion injury显示文摘 | Hosgood SA YangB Bagul A | 2010 | Transplantation2010，89，7： | 1 |
| 12 | A pilot study assessing the feasibility of a short period of normothermic preservation in an experimental model of non heart beating donor kidneys显示文摘 | Hosgood SA Barlow AD Yates PJ | 2011 | J Surg Res2011，171，1： | 1 |
| 13 | Renal transplantation after ex vivo normothermic perfusion: the first clinical stody显示文摘 | Nicholson ML Hosgood SA | 2013 | Am J Transplant2013，13，5： | 1 |
| 14 | Normothermic versus hypothermic ex vivo flush using a novel phosphate-free preservation solution(AQIX)in porcine kidneys显示文摘 | Kay MD Hosgood SA Harper SJ | 2011 | J Surg Res2011，171，1： | 1 |
| 15 | First in man renal transplantation after ex vivo normothermic perfusion 显示文摘 | Hosgood SA Nicholson ML | 2011 | Transplantation2011，92，7： | 1 |
| 16 | A comparison of hypothermic machine perfusion versus static cold storage in an experimental model of renal ischemia reperfusion injury 显示文摘 | Hosgood S A Yang B Bagul A | 2010 | Transplantation2010，89，7： | 1 |
| 17 | The effect of inhalant anestheticand body temperature on peri-anesthetic serum concentra-tions of transdermally administered fentanyl in dogs显示文摘 | Pettifer GR Hosgood G | 2004 | Vet Anaesth Analg2004，31，2： | 1 |
| 18 | The conditioning effect of ex vivo normothermic perfusion in an experimental kidney model显示文摘 | Hosgood SA Patel M Nicholson ML | 2013 | J Surg Res2013，182，1： | 1 |
| 19 | The role of perfluorocarbon in organ preservation 显示文摘 | HOSGOOD S A NICHOLSON M L | 2010 | Transplantation2010，89，10： | 1 |
| 20 | Experimental renal preservation by normothermic resuscitation perfusion with autologous blood显示文摘 | Bagul A Hosgood SA Kaushik M | 2008 | Br J Surg2008，95，1： | 1 |
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