|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | PD-1 blockade-unresponsive human tumor-infiltrating CD8^(+)T cells are marked by loss of CD28 expression and rescued by IL-15显示文摘Blockade of programmed death-1(PD-1)reinvigorates exhausted CD8^(+)T cells,resulting in tumor regression in cancer patients.Recently,reinvigoration of exhausted CD8^(+)T cells following PD-1 blockade was shown to be CD28-dependent in mouse models.Herein,we examined the role of CD28 in anti-PD-1 antibody-induced human T cell reinvigoration using tumor-infiltrating CD8^(+)T cells(CD8^(+)TILs)obtained from non-small-cell lung cancer patients.Single-cell analysis demonstrated a distinct expression pattern of CD28 between mouse and human CD8^(+)TILs.Furthermore,we found that human CD28^(+)CD8^(+)but not CD28^(–)CD8^(+)TILs responded to PD-1 blockade irrespective of B7/CD28 blockade,indicating that CD28 costimulation in human CD8^(+)TILs is dispensable for PD-1 blockade-induced reinvigoration and that loss of CD28 expression serves as a marker of anti-PD-1 antibody-unresponsive CD8^(+)TILs.Transcriptionally and phenotypically,PD-1 blockade-unresponsive human CD28^(–)PD-1^(+)CD8^(+)TILs exhibited characteristics of terminally exhausted CD8^(+)T cells with low TCF1 expression.Notably,CD28^(–)PD-1^(+)CD8^(+)TILs had preserved machinery to respond to IL-15,and IL-15 treatment enhanced the proliferation of CD28^(–)PD-1^(+)CD8^(+)TILs as well as CD28^(+)PD-1^(+)CD8^(+)TILs.Taken together,these results show that loss of CD28 expression is a marker of PD-1 blockade-unresponsive human CD8^(+)TILs with a TCF1–signature and provide mechanistic insights into combining IL-15 with anti-PD-1 antibodies. | Kyung Hwan Kim Hong Kwan Kim Hyung-Don Kim Chang Gon Kim Hoyoung Lee Ji Won Han Seong Jin Choi Seongju Jeong Minwoo Jeon Hyunglae Kim Jiae Koh Bo Mi Ku Su-Hyung Park Myung-Ju Ahn Eui-Cheol Shin | 2021 | Cellular & Molecular Immunology2021，18，2： | 6 |
| 2 | High- throughput and low-complexity BCH decoding architec- ture for solid-state drives显示文摘 | Youngjoo Lee Hoyoung Yoo Injae Yoo | 2014 | IEEE Transactions on Very Large Scale Integration (VLSI) Systems2014，22，5： | 1 |
| 3 | High- throughput and low-complexity BCH decoding architec- ture for solid-state drives显示文摘 | Youngjoo Lee Hoyoung Yoe Injae Yoo | 2014 | IEEE Transactions on Very Large Scale Integration (VLSI) Systems2014，22，5： | 1 |
| 4 | A study on the force balance of an unbalanced globe valve显示文摘 | Taik-Dong Cho Sang-Min Yang HoYoung Lee and Sung-Ho Ko | 2007 | Journal of Mechanical Science and Technology2007，21，5： | 1 |
| 5 | Development of photocatalytic TiO 2 nanofibers by electrospinning and its application to degradation of dye pollutants显示文摘 | Seok Joo Doh Cham Kim Se Geun Lee Sung Jun Lee Hoyoung Kim | 2007 | Journal of Hazardous Materials2007，，1： | 1 |
| 6 | Optimum conditions for S -allyl-(L)-cysteine accumulation in aged garlic by RSM显示文摘 | Soo Hyun Park Hoyoung Lee Hak Sung Kim Yong-Ro Kim Sang Ha Noh | 2014 | Food Science and Biotechnology2014，，3： | 1 |
| 7 | Increased type III interferons and NK cell functions in SARS-CoV-2-infected children显示文摘Dear Editor,Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)infection is more likely to progress to severe disease in the elderly,and the rates of hospitalization for coronavirus disease 2019(COVID-19)increase with age.1,2 Herein,we comprehensively compared adaptive and innate immune responses between children and adults infected with SARS-CoV-2. | Seong Dong Jeong Hoyoung Lee Ju Young Chang Seong Yong Lee Ji Eun Choi Eunmi Yang Hye Won Jeong Jae-Phil Choi Mi Seon Han Eui-Cheol Shin | 2023 | Signal Transduction and Targeted Therapy2023，8，3： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员