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| 1 | Chronic Epstein-Barr virus-related hepatitis in immunocompetent patients显示文摘AIM: To investigate reactivated Epstein-Barr virus (EBV) infection as a cause for chronic hepatitis. METHODS: Patients with occasionally established elevated serum aminotransferases were studied. HIV, HBV and HCV-infections were excluded as well as any other immunosuppressive factors, metabolic or toxic disorders. EBV viral capsid antigen (VCA) IgG and IgM, EA-R and EA-D IgG and Epstein-Barr nuclear antigen (EBNA) were measured using IFA kits. Immunophenotyping of whole blood was performed by multicolor flow cytometry. CD8+ T cell responses to EBV and PHA were determined according to the intracellular expression of IFN-γ. RESULTS: The mean alanine aminotransferase (ALT) and gamma glutamyl transpeptidase (GGTP) values exceeded twice the upper normal limit, AST/ALT ratio < 1. Serology tests showed reactivated EBV infection in all patients. Absolute number and percentages of T, B and NK cells were within the reference ranges. Fine subset analysis, in comparison to EBV+ healthy carriers, revealed a significant decrease of naive T cells (P < 0.001), accompanied by increased percentage of CD45RA- (P < 0.0001), and terminally differentiated CD28-CD27- CD8+ T cells (P < 0.01). Moderately elevated numbers of CD38 molecules on CD8+ T cells (P < 0.05) proposed a low viral burden. A significantly increased percentage of CD8+ T cells expressing IFN-γ in response to EBV and PHA stimulation was registered in patients, as compared to controls (P < 0.05). Liver biopsy specimens from 5 patients revealed nonspecific features of low-grade hepatitis.CONCLUSION: Chronic hepatitis might be a manifestation of chronic EBV infection in the lack of detectable immune deficiency; the expansion of CD28- CD27- and increase of functional EBV-specific CD8+ T cells being the only surrogate markers of viral activity. | Mihaela Petrova Maria Muhtarova Maria Nikolova Svetoslav Magaev Hristo Taskov Diana Nikolovska Zahariy Krastev | 2006 | World Journal of Gastroenterology2006，12，35： | 6 |
| 2 | Efficient IL-2R signaling differentially affects the stability,function,and composition of the regulatory T-cell pool显示文摘Signaling via interleukin-2 receptor(IL-2R)is a requisite for regulatory T(Treg)cell identity and function.However,it is not completely understood to what degree IL-2R signaling is required for Treg cell homeostasis,lineage stability and function in both resting and inflammatory conditions.Here,we characterized a spontaneous mutant mouse strain endowed with a hypomorphic Tyr129His variant of CD25,theα-chain of IL-2R,which resulted in diminished receptor expression and reduced IL-2R signaling.Under noninflammatory conditions,Cd25Y129H mice harbored substantially lower numbers of peripheral Treg cells with stable Foxp3 expression that prevented the development of spontaneous autoimmune disease.In contrast,Cd25^(Y^(129H))Treg cells failed to efficiently induce immune suppression and lost lineage commitment in a T-cell transfer colitis model,indicating that unimpaired IL-2R signaling is critical for Treg cell function in inflammatory environments.Moreover,single-cell RNA sequencing of Treg cells revealed that impaired IL-2R signaling profoundly affected the balance of central and effector Treg cell subsets.Thus,partial loss of IL-2R signaling differentially interferes with the maintenance,heterogeneity,and suppressive function of the Treg cell pool. | Marc Permanyer Berislav Bošnjak Silke Glage Michaela Friedrichsen Stefan Floess Jochen Huehn Gwendolyn E.Patzer Ivan Odak Nadine Eckert Razieh Zargari Laura Ospina-Quintero Hristo Georgiev Reinhold Förster | 2021 | Cellular & Molecular Immunology2021，18，2： | 2 |
| 3 | Reduction of Listeria monocytogenes on frankfurters treated with lactic acid solutions of various temperatures显示文摘 | BYELASHOV OLEKSANDR A DASKALOV HRISTO GEORNARAS IFIGENIA | 2010 | Food Microbiology2010，27，： | 1 |
| 4 | A study on the two phase flow in a stirred tank reactor agitated by a gas-inducing turbine显示文摘 | Hristov Hristo Vesselinov Boden Stephan Hampel Uwe | 2008 | Chemical Engineering Research and Design2008，86，： | 1 |
| 5 | Embryonic stem cell-specific microRNAs显示文摘 | Hristo BH Michael FM Phillip AS | 2003 | Deve Cell2003，5，： | 1 |
| 6 | Enhancement of acid proteinase production by the fungus Humicola lutea 120-5 immobilized in crosslinked poly(vinyl alcohol) mixed with poly(ethylene glycol)显示文摘 | Penka A Elka P Hristo K | 1998 | Process Biochemistry1998，33，7： | 1 |
| 7 | A Review of Electromagnetic Scattering Analysis for Inlets, Cavities, and Open Ducts显示文摘 | Hristos T Anastassiu | 2003 | IEEE Antennas and Propagation Magazine2003，45，6： | 1 |
| 8 | A survey on distributed access control sys- tems for Web business processes显示文摘 | Hristo K | 2009 | International Journal of Network Security2009，9，1： | 1 |
| 9 | A Survey on distributed access control systems for Web business processes显示文摘 | Hristo K | 2009 | International Journal of Network Security2009，9，1： | 1 |
| 10 | The Effects of System Parameters on In Vivo Injection Performance of a Needle-Free Injector in Human Volunteers显示文摘 | Lawrence Linn Brooks Boyd Hristo Iontchev Toby King Stephen J. Farr | 2007 | Pharmaceutical Research2007，，8： | 1 |
| 11 | Complete mathematical analysis of predator - prey models with linear prey growth and Beddington - DeAngelis functional response显示文摘 | Dobromir T D Hristo V K | 2005 | Appl Math Comp2005，162，2： | 1 |
| 12 | A negotiation scheme for access rights establishment in autonomic communication 显示文摘 | Hristo K Fabio M | 2007 | Journal of Network and Systems Management2007，15，1： | 1 |
| 13 | Economic openness andtechnical efficiency:A case study of Chinese manufacturing in- dustries显示文摘 | SUN H S PHILLIP H HRISTOS D | 1999 | Economics of Transition1999，7，3： | 1 |
| 14 | Economical, social and ecological demands towards Bulgarian forestry 显示文摘 | Hristo Tsakov Alexander Alexandrov | 2004 | Forest Academy Finland2004，，6： | 1 |
| 15 | The freter model:a simple model of biofilm formation显示文摘 | KOJOUHAROV HRISTO V LE DUNG | 2003 | Mathematical Biology2003，47，： | 1 |
| 16 | The importance of Aeromonas hydrophila in food safety 显示文摘 | Hristo D | 2006 | Food Control2006，17，： | 1 |
| 17 | The importance of Aeromonas hydrophila in food safety显示文摘 | HRISTO D | 2006 | Food Control2006，17，： | 1 |
| 18 | A regional analysis of technical change in Australian manufacturing显示文摘 | Hristos Doucouliagos | 2000 | Tech- nical Changes in Australian manufacturing2000，，7： | 1 |
| 19 | A Survey on Distributed Access Control Systems for Web Business Proeesses 显示文摘 | Hristo K | 2009 | International Journal of Network Security2009，9，1： | 1 |
| 20 | Democracyand Economic Growth:A Meta-Analysis显示文摘 | Hristos Doucouliagos Mehmet Ali Ulubasoglu | | 0，，1： | 1 |
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