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| 1 | 半边旗提取物5F对非小细胞肺癌NCI-H460细胞生长的抑制作用显示文摘目的研究半边旗提取物5F对非小细胞肺癌NCI-H460细胞生长的抑制作用。方法MTT法检测5F对NCI-H460细胞的生长抑制作用;用PI-Hoechst荧光双染法和TUNEL法检测细胞凋亡;流式细胞仪检测5F对DNA含量的影响。结果5F抑制NCI-H460细胞的生长,其效果与5F的浓度和作用时间相关,24、48、72h的IC50分别为:21.40、4.52、1.02μg/ml;荧光双染色法显示经5F作用后细胞出现变形,染色质浓缩,产生凋亡小体;细胞被阻滞在G2/M期。结论5F在体外能有效地抑制NCI-H460细胞的生长,其作用可能是通过诱导其凋亡产生的。 | 刘义 吴科锋 李立 George G CHEN Michael KY HSIN Malcolm J UNDERWOOD 梁念慈 | 2009 | 肿瘤防治研究2009，36，1： | 9 |
| 2 | 半边旗活性物质5F对非小细胞肺癌NCI-H460细胞IκKβ、IκB、p65及p50 mRNA表达的影响显示文摘目的从NF-κB信号通路着手探讨半边旗活性物质5F诱导非小细胞肺癌NCI-H460细胞凋亡发生的机制。方法MTT法检测5F对NCI-H460细胞的生长抑制作用;用半定量RT-PCR方法检测NCI-H460细胞IκKβ、IκB、p65及p50mRNA表达水平的变化。结果5F抑制NCI-H460细胞的生长,其效果与5F的质量浓度和作用时间相关,24、48、72h的IC50分别为:21.40、4.52、1.02μg/mL;100μg/mL5F作用NCI-H460细胞6h后能引起IκKβ和IκBmRNA表达水平显著降低(P<0.05);p65和p50mRNA水平在作用3h就发生明显减少(P<0.05)。结论5F诱导NCI-H460细胞凋亡的机制可能是通过抑制核因子-κB(NF-κB)信号通路来实现的。 | 刘义 CHEN George G 吕应年 HSIN Michael K Y UNDERWOOD Malcolm J 梁念慈 | 2010 | 中草药2010，41，3： | 3 |
| 3 | Transoral endoscopic CO2 laser microsurgery for early laryngeal cancers 显示文摘 | Hsin L J Fang T J Chang K P | 2009 | Chang Gung Med J2009，32，5： | 1 |
| 4 | Piezoelectric gated diode of a single ZnO nanowire显示文摘 | He J H Hsin C L Liu J | 2007 | Adv Mater2007，19，： | 1 |
| 5 | A new measure to compare the hedging effectiveness of foreign currency futures versus options显示文摘 | Kuo J Lee C F | 1994 | Journal of Futures Markets1994，，14： | 1 |
| 6 | Improving abnormal hemorheological parameters in aging guinea pigs by water-soluble extracts of Salvia miltiorrhiza Bunge显示文摘 | Wen C H Hsin S T Hong J L | | 0，，03： | 1 |
| 7 | A nu- merical comparison of end-plate effect propellers and conventional propellers 显示文摘 | CHENG H J CHIEN Y C HSIN C Y | 2010 | Journal of Hydrodynam- ics2010，22，5： | 1 |
| 8 | Inhibition of the cyclic adenosine monophosphate pathway attenuates neuropathic pain and reduces phosphorylation of cyclic adenosine monophosphate response element-binding in the spinal cord after partial sciatic nerve ligation in rats显示文摘 | Liou J T Liu F C Hsin S T | 2007 | Anesth Analg2007，105，6： | 1 |
| 9 | Robust Image Watermarking Based on Multiple Description Vector Quantisation显示文摘 | Pan J S Hsin Y C Huang H C | 2004 | Electronics Letters2004，40，22： | 1 |
| 10 | Randomized, double blind, placebo-controlled trial of fish-oil-based lipid emulsion infusion for treatment of critically Ⅲ patients with severe sepsis显示文摘 | BOON S K SHIUMN J L HSIN C S | 2011 | Asian J Surg2011，34，1： | 1 |
| 11 | Impairment of NK cell function by NKG2D modulation in NOD mice显示文摘 | Hamerman J A Hsin H | 2003 | Immunity2003，18，1： | 1 |
| 12 | Low Frequency Noise Properties of SiGe Hetero-junction Bipolar Transistors显示文摘 | Hsieh M W Hsin Y M Chan Y J | 2007 | Japanese Journey of Applied Physics2007，49，7： | 1 |
| 13 | A new measure to compare the hedging effectiveness of foreign currency futures ver- sus options显示文摘 | Hsin C W Kuo J Lee C F | 1994 | The Journal of Futures Markets1994，14，： | 1 |
| 14 | Lateral Self-aligned p-type In2O3 Nanowire Arrays Epitaxially Grown on Si Substrates 显示文摘 | Hsin C L He J H Lee C Y | 2007 | Nano Letters2007，7，6： | 1 |
| 15 | Effect of neuromuscular elec- trical stimulation in a patient with Sjogren syndrome with dyspha- gia: a real time videofluoroscopic swallowing study 显示文摘 | Cheung SM Chen C J Hsin YJ | 2010 | Chang Gung Med J2010，33，3： | 1 |
| 16 | Application of GaInP/GaAs DHBTs to power amplifiers for wireless communications 显示文摘 | CHEN P F HSIN Y M T WELTY R J | 1999 | IEEE Trans on MTT1999，47，8： | 1 |
| 17 | New oral anticoagulants for atrial fibrillation:a review of clinical trials显示文摘 | O’Dell KM Igawa D Hsin J | 2012 | Clin Ther2012，34，4： | 1 |
| 18 | Effects of chronic epilepsy on heart rate variability A case-control study显示文摘BACKGROUND: Dysfunctional autonomic cardiac regulation is thought to be associated with high mortality in epileptic patients.OBJECTIVE: To explore changes in sympathetic and parasympathetic activities in epileptic patients with repetitive generalized tonic-clonic seizures by observing interictal heart rate.DESIGN,TIME AND SETTING: A case-control study was performed at the Buddhist Tzu Chi General Hospital from July 2006 to May 2009.PARTICIPANTS: A total of 30 patients,comprising 15 males and 15 females,who presented with chronic epilepsy and repetitive generalized tonic-clonic seizures according to International League Against Epilepsy guidelines (ILAE,1989),were selected.In addition,30 matched,healthy volunteers were selected as controls.METHODS: Lead I electrocardiogram was performed in the epilepsy and control groups for 5 minutes during a daytime interictal period.Frequency-domain analysis of heart rate variability was performed using fast Fourier transformation.MAIN OUTCOME MEASURES: Heart rate interval,high frequency (HF;0.15–0.45 Hz) power,low frequency (LF;0.04–0.15 Hz) power,and LF/(HF + LF) expressed in normalized units (LF%).RESULTS: Compared with the control group,the epilepsy group exhibited a significantly lower mean heart rate interval and HF power,but a significantly greater LF% (P < 0.01).There was no significant difference in LF power between the groups (P = 0.17).CONCLUSION: Patients with chronic epilepsy exhibited faster heart rates during interictal periods,which could contribute to higher sympathetic and lower parasympathetic activities. | Yueloong Hsin Cheryl C H Yang Terry B J Kuo Tomor Harnod | 2010 | Neural Regeneration Research2010，5，2： | 1 |
| 19 | Efficient exact test for rate monotonic schedulability using large period-dependent initial values 显示文摘 | Lu Wanchen Lin Kwei J Wei Hsin W | 2008 | IEEE Transactions on Computers2008，57，5： | 1 |
| 20 | Effect of aristolochic acid on intracellular calcium concentration and its links with apoptosis in renal tubular cells显示文摘 | HSIN Y H CHENG C H TZEN J T | 2006 | Apoptosis2006，11，12： | 1 |
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