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| 1 | Exosomal PD-L1 harbors active defense function to suppress T cell killing of breast cancer cells and promote tumor growth显示文摘 | Yi Yang Chia-Wei Li Li-Chuan Chan Yongkun Wei Jung-Mao Hsu Weiya Xia Jong-Ho Cha Junwei Hou Jennifer L. Hsu Linlin Sun Mien-Chie Hung | 2018 | Cell Research2018，28，8： | 35 |
| 2 | Correlation between fragmented QRS and the short-term prognosis of patients with acute myocardial infarction显示文摘研究目的:探讨碎裂QRS波对急性心肌梗死患者的短期预后评估的价值,及其对ST段抬高和非ST段抬高型心肌梗死(STEMI和NSTEMI)患者不同的预测价值。创新要点:证实了碎裂QRS波对急性心肌梗死尤其是ST段抬高型心肌梗死的短期预后价值,对早期再灌注治疗有指导意义。研究方法:通过对碎裂QRS波发生及持续时间的详细记录(见图1、2),评价出现碎裂QRS波的STEMI及NSTEMI患者住院期间发生恶性心律失常、泵功能衰竭及住院死亡的风险(见图3;表3–5),并观察早期经皮冠状动脉介入治疗(PCI)对预后的不同影响(见表6)。重要结论:1.急性心肌梗死(尤其是STEMI)患者心电图出现碎裂QRS波短期内易发生恶性心律失常、左心室功能不全及死亡;2.对出现碎裂QRS波的急性心肌梗死患者,早期PCI再灌注治疗可改善患者短期预后。 | Qin-hui SHENG Chih-Chi HSU Jian-ping LI Tao HONG Yong HUO | 2014 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2014，15，1： | 19 |
| 3 | Palmitoylation stabilizes PD-L1 to promote breast tumor growth显示文摘Dear Editor,PD-L1 is a well-known transmembrane protein, which is highly expressed on many types of cancer cells. By binding to its receptor PD-1 on T cells, PD-L1 significantly inhibits T cells activation and activity, and thus plays a pivotal role in driving the escape of tumor cells from immune surveillance.^1. | Yi Yang Jung-Mao Hsu Linlin Sun Li-Chuan Chan Chia-Wei Li Jennifer L. Hsu Yongkun Wei Weiya Xia Junwei Hou Yufan Qiu Mien-Chie Hung | 2019 | Cell Research2019，29，1： | 14 |
| 4 | Thymoquinone suppresses migration of Lo Vo human colon cancer cells by reducing prostaglandin E2 induced COX-2 activation显示文摘AIM To identify potential anti-cancer constituents in natural extracts that inhibit cancer cell growth and migration.METHODS Our experiments used high dose thymoquinone(TQ) as an inhibitor to arrest Lo Vo(a human colon adenocarcinoma cell line) cancer cell growth, which was detected by cell proliferation assay and immunoblotting assay. Low dose TQ did not significantly reduce Lo Vo cancer cell growth. Cyclooxygenase 2(COX-2) is an enzyme that is involved in the conversion of arachidonic acid into prostaglandin E2(PGE2) in humans. PGE2 can promote COX-2 protein expression and tumor cell proliferation and was used as a control.RESULTS Our results showed that 20 μmol/L TQ significantly reduced human LoV o colon cancer cell proliferation. TQ treatment reduced the levels of p-PI3 K, p-Akt, p-GSK3β, and β-catenin and thereby inhibited the downstream COX-2 expression. Results also showed that the reduction in COX-2 expression resulted in a reduction in PGE2 levels and the suppression of EP2 and EP4 activation. Further analysis showed that TG treatment inhibited the nuclear translocation of β-catenin in LoV o cancer cells. The levels of the cofactors LEF-1 and TCF-4 were also decreased in the nucleus following TQ treatment in a dose-dependent manner. Treatment with low dose TQ inhibited the COX-2 expression at the transcriptional level and the regulation of COX-2 expression efficiently reduced LoV o cell migration. The results were further verified in vivo by confirming the effects of TQ and/or PGE2 using tumor xenografts in nude mice.CONCLUSION TQ inhibits LoV o cancer cell growth and migration, and this result highlights the therapeutic advantage of using TQ in combination therapy against colorectal cancer. | Hsi-Hsien Hsu Ming-Cheng Chen Cecilia Hsuan Day Yueh-Min Lin Shin-Yi Li Chuan-Chou Tu Viswanadha Vijaya Padma Hui-Nung Shih Wei-Wen Kuo Chih-Yang Huang | 2017 | World Journal of Gastroenterology2017，23，7： | 12 |
| 5 | Evaluation of remediation process with soapberry derived saponin for removal of heavy metals from contaminated soils in Hai-Pu, Taiwan显示文摘The use of a biodegradable natural plant-based surfactant extracted from soapberry is proposed for the remediation of Ni,Cr and Mn from industrial soil site in Hai-Pu,Taiwan.Batch experiments were performed under variation of fundamental factors(saponin concentration,pH,and incubation time) for metal remediation.Removal of Ni and Mn were increased with increasing saponin concentration(0.015-0.150 g/L),whereas the removal of Cr was increased upto 0.075 g/L saponin.The Ni,Cr and Mn were removed significantly(p ≤ 0.05) at near to the neutral and slightly acidic(pH 5 to 8) conditions.Removal efficiency of Ni(99%) from the soil was found to be greater than that of Cr(73%) or Mn(25%) in the presence of saponin at a concentration of 0.150 g/L at pH 5.The removal percentage increased with incubation time where the removal of Ni was faster than that of Cr and Mn.The result indicates the feasibility of eco-friendly removal of heavy metal(Ni,Cr and Mn) from industrial soil by soil washing process in presence of plant derived saponin. | Jyoti Prakash Maity Yuh Ming Huang Cheng-Wei Fan Chien-Cheng Chen Chun-Yi Li Chun-Mei Hsu Young-Fo Chang Ching-I Wu Chen-Yen Chen Jiin-Shuh Jean | 2013 | Journal of Environmental Sciences2013，25，6： | 11 |
| 6 | Relationship Between Measured Friction Coefficients and Two Tread Groove Design Parameters for Footwear Pads显示文摘The shoe sole geometrical design parameters are believed to be important factors affecting the coefficient of friction (COF) between the shoe/floor interface. This study is concerned with the relationship between the measured COF and the tread groove orientation and width on the footwear pad. Friction meas-urements using the Brungraber Mark Ⅱ slipmeter were conducted. Six tread groove width/orientations de-signs on the footwear pads under 27 footwear material/floor/contamination conditions were tested. The re-sults show that tread orientation and width affect the measured COF significantly. Wider grooved footwear pads result in higher COF values and footwear pads with tread grooves perpendicular to the friction meas-urement direction have higher COF values. A regression model using measured COF as the dependent variable and tread groove width, groove orientation, footwear material, floor, and contamination conditions as independent variables was established. The models are significant at p<0.0001 with R2 of 0.97, which may be used in predicting the COF at the shoe-floor interface. | LI Kai Way CHEN Chin Jung LIN Ching-Hua HSU Yao Wen | 2006 | Tsinghua Science and Technology2006，11，6： | 11 |
| 7 | Consumption of purple sweet potato leaves modulates human immune response: T-lymphocyte functions, lytic activity of natural killer cell and antibody production显示文摘AIM: To study the immunological effects of physiological doses of purple sweet potato leaves(PSPL). METHODS: The randomized crossover study(two periods, each lasting for 2 wk) involved 16 healthy non-smoking adults of normal weight. The 6-wk study consisted of a run-in(wk 1) PSPL diet(daily consumption of 200 g PSPL) or a control diet(low polyphenols, with the amount of carotenoids adjusted to the same level as that of PSPL)(wk 2-3), washout diet(wk 4), and switched diet(wk 5-6). Fasting blood was collected weekly in the morning. T-lymphocyte function was assessed via the proliferation and secretion of immunoreactive cytokines. Salivary IgA secretion and the specific cytotoxic activities of cytotoxic T lymphocytes and natural killer(NK) cells were determined. RESULTS: The plasma β-carotene level increased with time in both groups, while the plasma polyphenol level decreased in the control group, and no significant difference was detected between the two groups. Although plasma polyphenol levels did not significantly increase in the PSPL group at the end of the study, they were significantly elevated in urine. PSPL consumption produced a significant increase in proliferation responsiveness of peripheral blood mononuclear cells(PBMC) and their secretion of immunoreactive IL-2 and IL-4. As well, lytic activity in NK cells was elevated in a time-dependent fashion. Salivary IgA secretion significantly decreased in control group after 2 wk, and returned to baseline following dietary switch to PSPL. CONCLUSION: Consumption of PSPL modulates various immune functions including increased proliferation responsiveness of PBMC, secretion of cytokines IL-2 and IL-4, and the lytic activity of NK cells. The responsible determinants of PSPL remain to be elucidated, as does the biological significance of the present observations. | Chiao-Ming Chen Sing-Chung Li Ya-Ling Lin Ching-Yun Hsu Ming-Jer Shieh Jen-Fang Liu | 2005 | World Journal of Gastroenterology2005，11，37： | 10 |
| 8 | Use of percutaneous nephrostomy and ureteral stenting in management of ureteral obstruction显示文摘The management options for ureteral obstruction are diverse, including retrograde ureteral stent insertion or antegrade nephrostomy placement, with or without eventual antegrade stent insertion. There is currently no consensus on the ideal treatment or treatment pathway for ureteral obstruction owing, in part, to the varied etiologies of obstruction and diversity of institutional practices. Additionally, different clinicians such as internists, urologists, oncologists and radiologists are often involved in the care of patients with ureteral obstruction and may have differing opinions concerning the best management strategy. The purpose of this manuscript was to review available literature that compares percutaneous nephrostomy placement vs ureteral stenting in the management of ureteral obstruction from both benign and malignant etiologies. | Linda Hsu Hanhan Li Daniel Pucheril Moritz Hansen Raymond Littleton James Peabody Jesse Sammon | 2016 | World Journal of Nephrology2016，5，2： | 9 |
| 9 | MULTIPLICITY OF POSITIVE SOLUTIONS FOR SINGULAR ELLIPTIC SYSTEMS WITH CRITICAL SOBOLEV-HARDY AND CONCAVE EXPONENTS显示文摘In this paper,we consider a singular elliptic system with both concave non-linearities and critical Sobolev-Hardy growth terms in bounded domains.By means of variational methods,the multiplicity of positive solutions to this problem is obtained. | Tsing-San Hsu Huei-Lin Li | 2011 | Acta Mathematica Scientia2011，31，3： | 9 |
| 10 | 碎裂QRS波联合TIMI危险评分预测急性心肌梗死患者的短期预后(英文)显示文摘目的:探讨碎裂QRS波(fQRS)联合心肌梗死溶栓治疗临床试验(TIMI)危险评分对急性心肌梗死(AMI)患者短期预后的评估价值。创新点:TIMI危险评分常用于AMI患者入院即刻的风险评估,TIMI评分<4分的患者被评定为中危组。本研究发现,无论TIMI评分如何,出现fQRS而未行经皮冠状动脉介入治疗(PCI)的患者,其死亡率均显著升高。fQRS联合TIMI危险评分更利于AMI患者的预后评估,TIMI评分<4分但同时合并fQRS的患者,可以从早期PCI介入治疗获益。方法:回顾300例AMI患者的临床资料及院内诊治经过,记录分析患者fQRS出现的时间、部位及其他临床转归,评价fQRS联合TIMI危险评分与患者临床预后的关系。结论:(1)fQRS联合TIMI危险评分可提高恶性心律失常、左室收缩功能不全(LVSD)和死亡预测的敏感度和特异度;(2)fQRS阳性的AMI患者,进行早期血运重建可降低患者心血管事件发生率,fQRS可能作为TIMI评分<4分患者早期介入治疗的指征。 | Qin-hui SHENG Chih Chi HSU Jian-ping LI Tao HONG Yong HUO | 2018 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2018，19，5： | 8 |
| 11 | Impact of disease severity on gastric residual volume in critical patients显示文摘AIM: To investigate whether illness severity has an impact on gastric residual volume (GRV) in medical critically ill patients. METHODS: Medical intensive care unit (ICU) patients requiring nasogastric feeding were enrolled. Sequential Organ Failure Assessment (SOFA) score was assessed immediately preceding the start of the study. Acute Physiology and Chronic Health Evaluation (APACHE) Ⅱ scores were recorded on the first, fourth, seventh, and fourteenth day of the study period. GRV was measured every 4 h during enteral feeding. The relationship be-tween mean daily GRV and SOFA scores and the correlation between mean daily GRV and mean APACHE Ⅱ score of all patients were evaluated and compared. RESULTS: Of the 61 patients, 43 patients were survivors and 18 patients were non-survivors. The mean daily GRV increased as SOFA scores increased (P < 0.001, analysis of variance). Mean APACHE Ⅱ scores of all patients correlated with mean daily GRV (P = 0.011, Pearson correlation) during the study period. Patients with decreasing GRV in the first 2 d had better survival than patients without decreasing GRV (P = 0.017, log rank test). CONCLUSION: GRV is higher in more severely ill medical ICU patients. Patients with decreasing GRV had lower ICU mortality than patients without decreasing GRV. | Chien-Wei Hsu Shu-Fen Sun David Lin Lee Shoa-Lin Lin Kam-Fai Wong Hsiu-Hua Huang Hung-Ju Li | 2011 | World Journal of Gastroenterology2011，17，15： | 8 |
| 12 | A population-based cohort study of symptomatic gallstone disease in diabetic patients显示文摘AIM:To investigate the prevalence of gallstone dis-ease(GSD) and to evaluate the risk of symptomatic GSD among diabetic patients.METHODS:The study was conducted by analyzing the National Health Research Institutes(NHRI) dataset of ambulatory care patients,inpatient claims,and the updated registry of beneficiaries from 2000 to 2008.A total of 615 532 diabetic patients without a prior history of hospital treatment or ambulatory care visits for symptomatic GSD were identified in the year 2000.Age-and gender-matched control individuals free from both GSD and diabetes from 1997 to 1999 were randomly selected from the NHIR database(n = 614 871).The incidence densities of symptomatic GSD were estimated according to the subjects' diabetic status.The distributions of age,gender,occupation,income,and residential area urbanization were compared between diabetic patients and control subjects using Cox proportion hazards models.Differences between the rates of selected comorbidities were also assessed in the two groups.RESULTS:Overall,60 734 diabetic patients and 48 116 control patients developed symptomatic GSD and underwent operations,resulting in cumulative operation rates of 9.87% and 7.83%,respectively.The age and gender distributions of both groups were similar,with a mean age of 60 years and a predominance of females.The diabetic group had a significantly higher prevalence of all comorbidities of interest.A higher incidence of symptomatic GSD was observed in females than in males in both groups.In the control group,females under the age of 64 had a significantly higher incidence of GSD than the corresponding males,but this difference was reduced with increasing age.The cumulative incidences of operations for symptomatic GSD in the diabetic and control groups were 13.06 and 9.52 cases per 1000 person-years,respectively.Diabetic men exhibited a higher incidence of operations for symptomatic GSD than did their counterparts in the control group(12.35 vs 8.75 cases per 1000 person-years).CONCLUSION:The association of diabetes with increased symptomatic GSD may provide insight to the treatment or management of diabetes in clinical settings. | Chi-Ming Liu Chung-Te Hsu Chung-Yi Li Chu-Chieh Chen Meng-Lun Liu Jorn-Hon Liu | 2012 | World Journal of Gastroenterology2012，18，14： | 7 |
| 13 | Cross-cultural adaption and psychometric properties of the Chinese version of the Diabetes Behavior Rating Scale: a pilot study显示文摘Self-care behavior plays a major role in diabetic management. However, in China, a satisfactory instrument has not yet been developed to evaluate the compliance of self-care behavior for young patients with type 1 diabetes mellitus(T1 DM). The Diabetes Behavior Rating Scale(DBRS) has a potential to be the first mature instrument. The purpose of this study is to cross-culturally adapt the DBRS, and preliminarily evaluate its psychometric properties. The instrument translation included translation, back translation and culture adaptation. Psychometric properties were assessed in a sample of 116 young patients with T1 DM adapting insulin injection therapy. The Chinese version of the DBRS was divided to four subscales. Cronbach's α for the total scale was 0.92. The mean inter-item and item-total correlations were 0.35 and 0.54 respectively. Test-retest reliability showed good temporal stability(r=0.81, P=0.001). Negative correlations were found between DBRS scores with the Diabetes Distress Scale scores(r=.0.32, P=0.003) and hemoglobin A1 c(HbA1 c) levels(r=.0.36, P=0.002). Higher DBRS scores correlated with better glycemic control. The Chinese insulin injection therapy version of the DBRS is well translated and culturally adapted. It shows good overall reliability and validity and appears to be a valuable tool for assessing the diabetic self-care behaviors for young patients with T1 DM. | Jing Zhu Jingjing Xu Yang Chen Yong Gu Li Ji Yufeng Zhou Min Zhu Hsiang-Ting Hsu Xiaoping Huang Cuiping Yuan Yun Shi Dan Yan Lili Xie Shuang Chen Tao Yang Wei He | 2018 | Science China(Life Sciences)2018，61，3： | 6 |
| 14 | A pair of transposon-derived proteins function in a histone acetyltransferase complex for active DNA demethylation显示文摘Transposons 被 epigenetic 机制通常包括 DNA methylation 使沉默。这里,我们识别了一双先驱导出 transposon 的蛋白质(HDP ) , HDP1 和 HDP2,在 Arabidopsis 的反沉默因素。hdp1 和 hdp2 异种显示了 transgenes 和某 transposons 的提高的 silencing。种系发生的分析表明 HDP1 和 HDP2 分别地从先驱编码 transposon 的 transposase 和 DNA 有约束力的蛋白质被共同驯养。HDP1 在原子核与 HDP2 交往,类似于他们的 transposon 对应物。而且, HDP1 和 HDP2 与组成在 DNA demethylation 工作的 histone acetyltransferase 建筑群的 IDM1, IDM2, IDM3 和 MBD7 被联系。HDP2 和 methyl-DNA-binding 蛋白质 MBD7 分享普通 genomic 绑定地点的一个大集合,显示他们联合决定 histone acetyltransferase 建筑群的目标特性。因此,我们的数据表明 HDP1 和 HDP2 组成被招募了到 histone acetyltransferase 建筑群阻止 DNA hypermethylation 和 epigenetic silencing 的一个功能的模块。 | Cheng-Guo Duan Xingang Wang Shaojun Xie Li Pan Daisuke Miki Kai Tang Chuan-Chih Hsu Mingguang Lei Yingli Zhong Yueh-Ju Hou ZhijuanWang Zhengjing Zhang Satendra K Mangrauthia Huawei Xu Heng Zhang Brian Dilkes W Andy Tao Jian-Kang Zhu | 2017 | Cell Research2017，27，2： | 6 |
| 15 | Mesenchymal VEGFA induces aberrant differentiation in heterotopic ossification显示文摘Heterotopic ossification(HO)is a debilitating condition characterized by the pathologic formation of ectopic bone.HO occurs commonly following orthopedic surgeries,burns,and neurologic injuries.While surgical excision may provide palliation,the procedure is often burdened with significant intra-operative blood loss due to a more robust contribution of blood supply to the pathologic bone than to native bone.Based on these clinical observations,we set out to examine the role of vascular signaling in HO.Vascular endothelial growth factor A(VEGFA)has previously been shown to be a crucial pro-angiogenic and pro-osteogenic cue during normal bone development and homeostasis.Our findings,using a validated mouse model of HO,demonstrate that HO lesions are highly vascular,and that VEGFA is critical to ectopic bone formation,despite lacking a contribution of endothelial cells within the developing anlagen. | Charles Hwang Simone Marini Amanda KHuber David MStepien Michael Sorkin Shawn Loder Chase APagani John Li Noelle DVisser Kaetlin Vasquez Mohamed AGarada Shuli Li Jiajia Xu Ching-Yun Hsu Paul BYu Aaron WJames Yuji Mishina Shailesh Agarwal Jun Li Benjamin Levi | 2019 | Bone Research2019，7，4： | 4 |
| 16 | Low-lying-implantation ectopic pregnancy: A cluster of cesarean scar, cervico-isthmus, and cervical ectopic pregnancies in the first trimester显示文摘 | Shih-Wei Tsai Kuan-Hui Huang Yu-Che Ou Te-Yao Hsu Chen-Bin Wang Ming-Shan Chang Ko-Hsin Li Fu-Tsai Kung | 2013 | Taiwanese Journal of Obstetrics & Gynecology2013，，： | 4 |
| 17 | Tyrosine 370 phosphorylation of ATM positively regulates DNA damage response显示文摘混乱毛细管扩张变异(ATM ) 调停由控制导致照耀的 foci 形成,房间周期检查点,和 apoptosis 的 DNA 损坏反应。然而,在上游的发信号怎么调整 ATM,完全没被理解。这里,我们证明在照耀刺激之上, ATM 与联系并且在 DNA 双海滨裂缝的地点在 Tyr370 (Y370 ) 是由表皮的生长因素受体(EGFR ) 的 phosphorylated。内长的 EGFR 的弄空损害调停 ATM 的 foci 形成,相应再结合,和 DNA 修理。而且,有一个 EGFR kinase 禁止者, gefitinib,块 EGFR 和 ATM 协会的预告的处理,妨碍 CHK2 激活和随后的 foci 形成,和增加放射敏感度。因此,我们揭示 EGFR 直接在 DNA 损坏反应由调整 ATM 激活的批评机制,并且我们的结果建议 ATM Y370 phosphorylation 的地位有潜力用作 biomarker 成层为独自一个的任何一个放射疗法或在有 EGFR 抑制的联合的病人。 | Hong-Jen Lee Li Lan Guang Peng Wei-Chao Chang Ming-Chuan Hsu Ying-Nai Wang Chien-Chia Cheng Leizhen Wei Satoshi Nakajima Shih-Shin Chang Hsin-Wei Liao Chung-Hsuan Chen Martin Lavin K Kian Ang Shiaw-Yih Lin Mien-Chie Hung | 2015 | Cell Research2015，25，2： | 4 |
| 18 | Alendronate inhibits cell invasion and MMP-2 secretion in human chondrosarcoma cell line显示文摘目的: 软骨肉瘤是对化疗和放射治疗糟糕作出回应的一个恶意的主要骨头肿瘤。现在的学习的目的是调查 alendronate 的效果, bisphosphonate ,在人的软骨肉瘤房间( JJ012 )的侵略和迁居上 .Methods : JJ012 房间为一个指定时期与各种各样的集中的 alendronate 被对待直到 100mu mol/L ,然后明胶 zymography 和 matrigel 侵略试金被执行在矩阵 metalloproteinase ( MMP )上学习 alendronate 的效果 -2 活动和 JJ012 房间的侵略能力, respectively.Results :我们的数据证明 alendronate 施加了 adose --并且时间依赖者 JJ012cells.Furthermore 的侵略和迁居上的禁止的效果,明胶 zymography 和 RT-PCR 证明 alendronate 处理减少了在集中依赖者 manner.Conclusion 的 MMP-2 的活动和 mRNA 层次:我们的调查结果建议 alendronate 可以在 transcriptional 和翻译层次减少 MMP-2 分泌物,并且禁止软骨肉瘤的侵略房间。因此, alendronate 可以是软骨肉瘤,以及另外的恶意的疾病的全身的治疗的一个潜在的候选人。 | Te-jen Lai Sheng-feng HSU Te-mao li Horng-chaung HSU Juang-geng lIn Chin-jung HSU Ming-chih CHOU Meng-chih LEE Shun-fa yang Yi-chin FONG | 2007 | Acta Pharmacologica Sinica2007，28，8： | 4 |
| 19 | A B-la cell subset induces Foxp3- T cells with regulatory activity through an IL-10-independent pathway显示文摘规章的 T (Treg ) 房间在忍耐的维护起一个关键作用。B-1a 房间属于通过 IL-10 的生产施加它的规章的角色的一个特定、机能上地重要的 B 房间子集。当 IL-10 与类型 1 Treg (Tr1 ) 房间或象 Tr1 一样房间的正式就职被相关时, IL-10-producing B-1a 房间是否能导致 Treg 房间,特别 Tr1 系,糟糕被理解。我们表明了那,类似于报导 B-2 房间, B-1a 房间能变换 naï ve CD4 + CD25 − T 房间进 T 房间与的一个子集镇压工作,我们把它称为 ‘ Treg-of-B1a' 房间。Treg-of-B1a 房间不表示 Foxp3,而是 upregulate Treg 标记 OX40,规划了死亡 1 (PD-1 ) ,可诱导的 costimulator (ICOS ) 和 IL-10R。而且, Treg-of-B1a 房间不表示 Foxp3 并且生产 IFN-γ 的高水平;并且 IL-4 的 IL-10,而是最小的数量;因此,他们类似于 Tr1 房间。然而,利用 IL-10 −/− 老鼠,我们证明 IL-10 不涉及 Treg-of-B1a 房间的正式就职。相反,调停 CD86 的 costimulation 是必要的让 B-1a 房间驾驶 Treg-of-B1a 房间的正式就职。最后,我们表明了那,与调停的 B-2 房间产生的 Treg 房间相对照接触依赖者抑制, Treg-of-B1a 房间通过 secreting 压制可溶的因素。当 Tr1 房间调停时主要通过 IL-10 或 TGF-β 的抑制;分泌物, Treg-of-B1a 房间调停通过 IL-10- 和 TGF-β 的抑制;独立小径。一起,这些调查结果建议 B-1a 房间导致对报导 Foxp3 + Treg 或 Tr1 房间不一样的一张机能上地并且 phenotypically 不同的 Treg 人口。 | Ling-Hui Hsu Kun-Po Li Kuan-Hua Chu Bor-Luen Chiang | 2015 | Cellular & Molecular Immunology2015，12，3： | 4 |
| 20 | Improving stability of MXenes显示文摘Due to their superior hydrophilicity and conductivity,ultra-high volumetric capacitance,and rich surface-chemistry properties,MXenes exhibit unique and excellent performance in catalysis,energy storage,electromagnetic shielding,and life sciences.Since they are derived from ceramics(MAX phase)through etching,one of the challenges in MXenes preparation is the inevitable exposure of metal atoms on their surface and embedding of anions and cations.Because the as-obtained MXenes are always in a thermodynamically metastable state,they tend to react with trace oxygen or oxygen-containing groups to form metal oxides or degrade,leading to sharply declined activity and impaired performance.Therefore,improving the stability of MXenesbased materials is of practical significance in relevant applications.Unfortunately,there lacks a comprehensive review in the literature on relevant topics.To help promote the wide applications of MXenes,we review from the following aspects:(i)insights into the factors affecting the stability of MXenes-based materials,including oxidation of MXenes flakes,stability of MXenes colloidal solutions,and swelling and degradation of MXenes thin-film,(ii)strategies for enhancing the stability of MXenes-based materials by optimizing MAX phase synthesis and modifying the MXenes preparation,and(iii)techniques for further increasing the stability of freshly prepared MXenes-based materials via controlling the storage conditions,and forming shielding on the surface and/or edge of MXenes flakes.Finally,some outlooks are proposed on the future developments and challenges of highly active and stable MXenes.We aim to provide guidance for the design,preparation,and applications of MXenes-based materials with excellent stability and activity. | Jizhou Jiang Saishuai Bai Jing Zou Song Liu Jyh-Ping Hsu Neng Li Guoyin Zhu Zechao Zhuang Qi Kang Yizhou Zhang | 2022 | Nano Research2022，15，7： | 4 |
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