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| 1 | Liver transplantation for a giant mesenchymal hamartoma of the liver in an adult: Case report and review of the literature显示文摘Mesenchymal hamartomas of the liver(MHLs) in adults are rare and potentially premalignant lesions, which present as solid/cystic neoplasms. We report a rare case of orthotopic liver transplantation in a patient with a giant MHL. In 2013, a 34-year-old female sought medical advice after a 2-year history of progressive abdominal distention and respiratory distress. Physical examination revealed an extensive mass in the abdomen. Computed tomography(CT) of her abdomen revealed multiple liver cysts, with the diameter of largest cyst being 16 cm × 14 cm. The liver hilar structures were not clearly displayed. The adjacent organs were compressed and displaced. Initial laboratory tests, including biochemical investigations and coagulation profile, were unremarkable. Tumor markers, including levels of AFP, CEA and CA19-9, were within the normal ranges. The patient underwent orthotopic liver transplantation in November 2013, the liver being procured from a 40-year-old man after cardiac death following traumatic brain injury. Warm ischemic time was 7.5 min and cold ischemic time was 3 h. The recipient underwent classical orthotopic liver transplantation. The recipient operative procedure took 8.5 h, the anhepatic phase lasting for 1 h without the use of venovenous bypass. The immunosuppressive regimen includedintraoperative induction with basiliximab and high-dose methylprednisolone, and postoperative maintenance with tacrolimus, mycophenolate mofetil, and prednisone. The recipient's diseased liver weighed 21 kg(dry weight) and measured 41 cm × 32 cm × 31 cm. Histopathological examination confirmed the diagnosis of an MHL. The patient did not experience any acute rejection episode or other complication. All the laboratory tests returned to normal within one month after surgery. Three months after transplantation, the immunosuppressive therapy was reduced to tacrolimus monotherapy, and the T-tube was removed after cholangiography showed no abnormalities. Twelve months after transplantation, the patient remains well and is fulfilling all normal activities. Adult giant MHL is extremely rare. Symptoms, physical signs, laboratory results, and radiographic imaging are nonspecific and inconclusive. Surgical excision of the lesion is imperative to make a definite diagnosis and as a cure. Liver transplantation should be considered as an option in the treatment of a non-resectable MHL. | Jiang Li Jin-Zhen Cai Qing-Jun Guo Jun-Jie Li Xiao-Ye Sun Zhan-Dong Hu David KC Cooper Zhong-Yang Shen | 2015 | World Journal of Gastroenterology2015，21，20： | 3 |
| 2 | The effects of electrically assisted methods on transdermal delivery of nalbuphine benzoate and sebacoyl dinalbuphine ester from solutions and hydrogels 显示文摘 | Huang JF Sung KC Hu OYP | 2005 | Int J Pharm2005，297，12： | 1 |
| 3 | Pollutants in Hong Kong soils:polycyclic aromatic hydrocarbons显示文摘 | CHUNG MK HU R CHEUNG KC | | 0，，3： | 1 |
| 4 | Procalcitonin and C-reactive protein cannot differentiate bacterial or viral infection in COPDex- acerbation requiting emergency department visits显示文摘 | Chang CH Tsao KC Hu HC | 2015 | Int J Chron Obstruct Pulman Dis2015，10，4： | 1 |
| 5 | Outcome of herpes simplex encephalitis in children 显示文摘 | Hsieh WB Chiu NC Hu KC | 2007 | J Micro Immun Infect2007，40，1： | 1 |
| 6 | MicroRNA-328 may influence myopia development by mediating the PAX6 gene显示文摘 | Chen KC Hsi E Hu CY | 2012 | Invest Ophthalmol Vis Sci2012，53，6： | 1 |
| 7 | Findings and risk factors of early mortality of endoscopic retrograde in different cohorts of elderly patients 显示文摘 | Hu KC Chang WH Chu CH | 2009 | J Am Geriatr Soc2009，57，10： | 1 |
| 8 | Analvsis of die tenderisalion of jumbo squid (Dosidicus gigas )meat by ultrasonic treatment using lvsponse surface methodology 显示文摘 | Hu YQ Yu HX Dong KC el aI | 2014 | Food chemistl32014，160，10： | 1 |
| 9 | MicroRNA- 328 may influence myopia development by mediating the PAX6 gene显示文摘 | Chen KC Hsi E Hu CY | 2012 | Invest Ophthalmol Vis Sci2012，53，： | 1 |
| 10 | Risk factors for glioma in a- dultsa case-control study in northeast China显示文摘 | Hu J Johnson KC Mao Y | 1998 | Cancer Detect Prey1998，22，10： | 1 |
| 11 | The combined treatment of precutaneous cryoabiation and ethanol ablation for unresectable large Hepatocelluar carcinoma显示文摘 | Xu KC Niu LZ Hu YZ | 2007 | Techno cancer Resarch Treat2007，6，： | 1 |
| 12 | Acute ST-elevation myocardial infarction in young patients: 15 years of experience in a single center显示文摘 | Chua SK Hu IF Shyu KC | 2010 | Clin Cardil2010，33，3： | 1 |
| 13 | The expression of vascular endothelial growth factor in transitional cell carcinoma of urinary bladder is correlated with cancer progression显示文摘 | Yang CC Hu KC Yeh WL | 2004 | Urol Oncol2004，22，1： | 1 |
| 14 | Poor prognosis of intraoperative rupture of mature cystic teratoma with ma|ignant transformation 显示文摘 | Wen KC Hu WM Twu NF | 2006 | Taiwan J Obstet Gynecol2006，45，3： | 1 |
| 15 | The expression of vascular endothelial growth factor in transitional cell carcinoma of urinary bladder is correlated with cancer progression显示文摘 | YANG CC HU KC YEH WL | 2004 | Urol Oncol2004，22，1： | 1 |
| 16 | Soluble E-cadherin is a valid prognostie marker in gastric carcinoma显示文摘 | Chan AO Lam SK Chu KM Lam CM Kwok E Leung SY Yuen ST Law SY Hui WM Lai KC Wong CY Hu HC Lai CL Wong J | | 0，，： | 1 |
| 17 | The effects of electrically assisted methods on transdermal delivery of nalbuphine benzoate and sebacoyl dinalbuphine ester from solutions and hydrogels 显示文摘 | Huang JF Sung KC Hu OY | 2005 | IntJPharm2005，297，12： | 1 |
| 18 | Genomie analysis of bacteriophage AB1, a KMV-like virus infecting multidrug-resistant Acinetobacter baumannii显示文摘 | Chang KC Lin NT Hu A | 2011 | Genomics2011，97，4： | 1 |
| 19 | OxLDL up-regulates microRNA-29 b, leading to epigenetic modifications of MMP- 2/MMP-9 genes: a novel mechanism for cardiovascular dis- eases显示文摘 | Chen KC Wang YS Hu CY | 2011 | FASEB J2011，25，5： | 1 |
| 20 | ox-LDL up-regulates microRNA-29b, leading to epigenetic modifications of MMP-2/-9 genes: a novel mechanism for cardiovascular diseases显示文摘 | Chen KC Wang YS Hu CY | 2011 | Faseb J2011，25，5： | 1 |
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