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| 1 | The Deep-Time Digital Earth program:data-driven discovery in geosciences显示文摘Current barriers hindering data-driven discoveries in deep-time Earth(DE)include:substantial volumes of DE data are not digitized;many DE databases do not adhere to FAIR(findable,accessible,interoperable and reusable)principles;we lack a systematic knowledge graph for DE;existing DE databases are geographically heterogeneous;a significant fraction of DE data is not in open-access formats;tailored tools are needed.These challenges motivate the Deep-Time Digital Earth(DDE)program initiated by the International Union of Geological Sciences and developed in cooperation with national geological surveys,professional associations,academic institutions and scientists around the world.DDE’s mission is to build on previous research to develop a systematic DE knowledge graph,a FAIR data infrastructure that links existing databases and makes dark data visible,and tailored tools for DE data,which are universally accessible.DDE aims to harmonize DE data,share global geoscience knowledge and facilitate data-driven discovery in the understanding of Earth’s evolution. | Chengshan Wang Robert MHazen Qiuming Cheng Michael HStephenson Chenghu Zhou Peter Fox Shu-zhong Shen Roland Oberhansli Zengqian Hou Xiaogang Ma Zhiqiang Feng Junxuan Fan Chao Ma Xiumian Hu Bin Luo Juanle Wang Craig M.Schiffries | 2021 | National Science Review2021，8，9： | 14 |
| 2 | Channel Modeling and Performance Analysis for UAV Relay Systems显示文摘In this paper, a multi-hop relay channel model based on unmanned aerial vehicles(UAVs) is established by taking into account of the propagation loss, shadowing, and multi-path fading. Based on the proposed channel model, the cascaded propagation loss of relay link and the cascaded probability density function(PDF) of channel fading are derived. Moreover, the theoretical performance of the UAV-based relay system, i.e., the outage probability, bit error rate(BER), and channel capacity, is also analysed and derived. Simulation results show agreement with theoretical results for the hill, mountain, and sea scenarios, indicating the accuracy of both the simulations and derivations. | Xiaomin Chen Xujun Hu Qiuming Zhu Weizhi Zhong Bin Chen | 2018 | China Communications2018，15，12： | 8 |
| 3 | Geoscience knowledge graph in the big data era显示文摘Since the beginning of the 21 st century,the geoscience research has been entering a significant transitional period with the establishment of a new knowledge system as the core and with the drive of big data as the means.It is a revolutionary leap in the research of geoscience knowledge discovery from the traditional encyclopedic discipline knowledge system to the computer-understandable and operable knowledge graph.Based on adopting the graph pattern of general knowledge representation,the geoscience knowledge graph expands the unique spatiotemporal features to the Geoscience knowledge,and integrates geoscience knowledge elements,such as map,text,and number,to establish an all-domain geoscience knowledge representation model.A federated,crowd intelligence-based collaborative method of constructing the geoscience knowledge graph is developed here,which realizes the construction of high-quality professional knowledge graph in collaboration with global geo-scientists.We also develop a method for constructing a dynamic knowledge graph of multi-modal geoscience data based on in-depth text analysis,which extracts geoscience knowledge from massive geoscience literature to construct the latest and most complete dynamic geoscience knowledge graph.A comprehensive and systematic geoscience knowledge graph can not only deepen the existing geoscience big data analysis,but also advance the construction of the high-precision geological time scale driven by big data,the compilation of intelligent maps driven by rules and data,and the geoscience knowledge evolution and reasoning analysis,among others.It will further expand the new directions of geoscience research driven by both data and knowledge,break new ground where geoscience,information science,and data science converge,realize the original innovation of the geoscience research and achieve major theoretical breakthroughs in the spatiotemporal big data research. | Chenghu ZHOU Hua WANG Chengshan WANG Zengqian HOU Zhiming ZHENG Shuzhong SHEN Qiuming CHENG Zhiqiang FENG Xinbing WANG Hairong LV Junxuan FAN Xiumian HU Mingcai HOU Yunqiang ZHU | 2021 | Science China Earth Sciences2021，64，7： | 4 |
| 4 | by thermogravimetry (TG) and in a fixed bed reactor显示文摘 | MENG Meng HU Haoquan ZHANG Qiuming Pyrolysis behaviors of Tumuji oil sand | 2007 | Energy & Fuels2007，21，4： | 1 |
| 5 | Rapid Preparation, Characterization and Hydrogen Storage Properties of Pure and Metal Ions Doped Mesoporous MCM-41显示文摘 | Wu Chundong Gao Qiuming Hu Juan | 2009 | Microporous Mesoporous Mater2009，117，： | 1 |
| 6 | Porous car- bons prepared by using metal - organic framework as the precursor for supercapacitors显示文摘 | Juan Hu Huanlei Wang Qiuming Gao | 2010 | Carbon2010，48，： | 1 |
| 7 | Multifractal Characterization of Urban Residential Land Price in Space and Time显示文摘 | HU Shougeng CHENG Qiuming WANG Le | 2012 | Applied Geography2012，34，： | 1 |
| 8 | High hydrogen storage capacity of porous carbons prepared by using activated carbon 显示文摘 | Wang Huanlei Gao Qiuming Hu Juan | 2009 | Journal of the American Chemical Society2009，131，20： | 1 |
| 9 | High hydrogen storage capacity of porous carbons prepared by using activated carbon显示文摘 | Huanlei Wang Gao Qiuming Juan Hu | 2009 | J Am Chem Soc2009，131，： | 1 |
| 10 | Research of Technique for Synthesizing Carbonyl Diethyl Malonate显示文摘Diethyl malonate being an initial raw material,processed with chlorination-replacement-desalination-vacuum rectification,is used to produce carbonyl diethyl malonate.An experiment for optimization determines that the best reaction condition was:① reaction for 7 h at 10 ℃ with mole-ratio being 2.4︰1 between chloride and raw material(diethyl malonate);② reaction for 4.5 h at 118 ℃ with mole-ratio being 1.2︰1 between the anhydrous sodium acetate and intermediate Ⅰ.The final product carbonyl diethyl malonate recovery ratio reaches up to as high as 79.12% with a purity of 96.4%,which meets the market requirement.This synthesis technique has the advantages of simple process,moderate reaction conditions,high yield and low cost,being suitable for industrial scale production. | GUI Houying DONG Liuyu ZHOU Qiuming HU Xinming | 2011 | Wuhan University Journal of Natural Sciences2011，16，3： | 0 |
| 11 | A New Technique for Synthesis of 2,4-Dichloro-Thieno[3,2-d]Pyrimidine显示文摘3-Amino-2-methoxycarbonylthiophene used as the main raw material,an intermediate(thiofuran siamese) 2,4-dichloro-thieno[3,2-d]pyrimidine was synthesized.The prod-uct was characterized by nuclear magnetic resonance(NMR).The first step yield was 84%(190 ℃) and the second step yield was 81.4%(105 ℃,m(intermediate):m(phosphorus oxychloride) = 1:6.4).The raw product was refined with a unique refining process,which can enhance the purity up to 99.5% to meet the requirement of condi-tions for the development and research of thiofuran siamese as a new medicine of anticarcinogen.Contrasted with the traditional technique,this process featured with cheap raw materials,possible for solvent recovery and reuse,low comprehensive cost,and suit-able for production on certain scale. | DONG Liuyu GUI Houying ZHOU Qiuming HU Xinming GUI Shaoyong | 2012 | Wuhan University Journal of Natural Sciences2012，17，2： | 0 |
| 12 | Study on The Whitening Effect of a Composite Plant Extract显示文摘By compounding the cranberry extract,lavender flower extract,Kakadu plum extract,edelweiss flower/leaf extract and aloe vera extract into a composite plant extract(BIRC-Rosée WT100),the whitening effects of this composite plant extract in antioxidation,anti-inflammation,skin barrier maintenance,and inhibition of melanin production and transport were evaluated.By comparing the inhibitory effects on tyrosinase activity between the composite plant extract andα-arbutin,and then analyzing the decline of apparent chromaticity,apparent brightness and melanin content through 3D melanin skin model platform,the comprehensive whitening effect was evaluated and compared with that of kojic acid.The results showed that,the composite plant extract(BIRC-Rosée WT100)had a tyrosinase inhibition rate of 98.99%at the original concentration,which was much higher than that ofα-arbutin.In 3D melanin skin model,the apparent chromaticity and brightness could be effectively improved,and moreover,the total amount of melanin in the skin could be reduced,showing remarkable whitening effect. | Zhang Hao Tang Wendi Hu Qiuming Zhong Meiying Li Yan Wang Yan | 2023 | China Detergent & Cosmetics2023，8，3： | 0 |
| 13 | Dissecting the novel abilities of aripiprazole: The generation of anti-colorectal cancer effects by targeting Gαq via HTR2B显示文摘Colorectal cancer(CRC)is a type of malignant tumor that seriously threatens human health and life,and its treatment has always been a difficulty and hotspot in research.Herein,this study for the first time reports that antipsychotic aripiprazole(Ari)against the proliferation of CRC cells both in vitro and in vivo,but with less damage in normal colon cells.Mechanistically,the results showed that5-hydroxytryptamine 2B receptor(HTR2B)and its coupling protein G protein subunit alpha q(Gaq)were highly distributed in CRC cells.Ari had a strong affinity with HTR2B and inhibited HTR2B downstream signaling.Blockade of HTR2B signaling suppressed the growth of CRC cells,but HTR2B was not found to have independent anticancer activity.Interestingly,the binding of Gaq to HTR2B was decreased after Ari treatment.Knockdown of Gaq not only restricted CRC cell growth,but also directly affected the antiCRC efficacy of Ari.Moreover,an interaction between Ari and Gaq was found in that the mutation at amino acid 190 of Gaq reduced the efficacy of Ari.Thus,these results confirm that Gaq coupled to HTR2B was a potential target of Ari in mediating CRC proliferation.Collectively,this study provides a novel effective strategy for CRC therapy and favorable evidence for promoting Ari as an anticancer agent. | Haowei Liu Qiuming Huang Yunqi Fan Bo Li Xuemei Liu Changhua Hu | 2023 | Acta Pharmaceutica Sinica B2023，13，8： | 0 |
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