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| 1 | Mechanisms of hepatocellular carcinoma progression显示文摘Hepatocellular carcinoma(HCC) is the most common primary malignancy of the liver. It is the second leading cause of cancer-related deaths worldwide, with a very poor prognosis. In the United States, there has been only minimal improvement in the prognosis for HCC patients over the past 15 years. Details of the molecular mechanisms and other mechanisms of HCC progression remain unclear. Consequently, there is an urgent need for better understanding of these mechanisms. HCC is often diagnosed at advanced stages, and most patients will therefore need systemic therapy, with sorafenib being the most common at the present time. However, sorafenib therapy only minimally enhances patient survival. This review provides a summary of some of the known mechanisms that either cause HCC or contribute to its progression. Included in this review are the roles of viral hepatitis, non-viral hepatitis, chronic alcohol intake, genetic predisposition and congenital abnormalities, toxic exposures, and autoimmune diseases of the liver. Well-established molecular mechanisms of HCC progression such as epithelial-mesenchymal transition, tumor-stromal interactions and the tumor microenvironment, cancer stem cells, and senescence bypass are also discussed. Additionally, we discuss the roles of circulating tumor cells,immunomodulation, and neural regulation as potential new mechanisms of HCC progression. A better understanding of these mechanisms could have implications for the development of novel and more effective therapeutic and prognostic strategies, which are critically needed. | Olorunseun O Ogunwobi Trisheena Harricharran Jeannette Huaman Anna Galuza Oluwatoyin Odumuwagun Yin Tan Grace X Ma Minhhuyen T Nguyen | 2019 | World Journal of Gastroenterology2019，25，19： | 21 |
| 2 | Ex vivo cytokine and memory T cell responses to the 42-kDa fragment of Phismodium falciparum merozoite surface protein-1 in vaccinated volunteers 显示文摘 | Huaman MC Martin LB Malkin E | 2008 | J Immunol2008，180，3： | 1 |
| 3 | Transcriptional Activation of Apolipoprotein CIII Expression by Glucose May Contribute to Diabetic Dyslipidemia显示文摘 | Sandrine Caron An Verrijken Ilse Mertens Carolina Huaman Samanez Gisèle Mautino Joel T. Haas Daniel Duran-Sandoval Janne Prawitt Sven Francque Emmanuelle Vallez Anne Muhr-Tailleux Isabelle Berard Folkert Kuipers Jan A. Kuivenhoven Sudha B. Biddinger Marja | 2011 | Arteriosclerosis Thrombosis and Vascular Biology2011，，3： | 1 |
| 4 | Microstructure, heat treatment and pitting corrosion of 13CrNiMo plate and weld metals显示文摘 | BILMES P D LLORENTE C L SAIRE HUAMAN L | 2009 | Cor- rosion Science2009，51，4： | 1 |
| 5 | Microstructure and pitting corrosion of 13CrNiMo weld metals显示文摘 | BILMES P D LLORENTE C L SAIRE HUAMAN L | 2006 | Corrosion Science2006，48，10： | 1 |
| 6 | In vitro conser- vation of potato germplasm at the international potato center 显示文摘 | LIZARRAGA R HUAMAN A DODDS J H | 1989 | American Potato Journal1989，66，： | 1 |
| 7 | Control of the es- trous cycle in guinea-pig (Cavia porcellus) 显示文摘 | Gregoire A AHard A Huaman E | 2012 | Theriogenolo- gy2012，78，4： | 1 |
| 8 | Water consumption in eucalypt plantation:part 1 determination ofstomatal conductance in irrigated and non-irrigated treatments显示文摘 | Carneiro RLC Ribeiro A Martinez y Huaman CA | 2008 | Revistarvore2008，32，1： | 1 |
| 9 | Biosorption of cadmiumby green coconut shell powder显示文摘 | Gabriela Huaman Pino Luciana Mafia Souza de Mesquita Mauricio Lconardo Totem | 2006 | Minerals Engineering2006，19，5： | 1 |
| 10 | Optimal sampling strategy and core collection size of Andean tetraploid potato based on isozyme data A simulation study显示文摘 | Chandra S Huaman Z Krislma Haft S | 2002 | Theoretical and Applied Genetics2002，104，： | 1 |
| 11 | A retrospective randomly selected cohort study of D-penicillamine treatment in rapidly progressive diffuse cutaneous systemic sclerosis of recent onset显示文摘 | Derk CT Huaman G Jimenez SA | 2008 | Br J Dermatol2008，158，5： | 1 |
| 12 | Selecting a Peruvian sweet potato core collection on the basis of morphological,cogeographical,and disease and pest reaction data显示文摘 | HUAMAN Z AGUILAR C ORTIZ R | 1999 | Theor Appl Genet1999，98，： | 1 |
| 13 | Optimal sampling strategy and core collection size of Andean tetraploid potato based on isozyme data-a simulation study显示文摘 | CHANDRA S HUAMAN Z HARI Krishna S | 2002 | Theor Appl Genet2002，104，： | 1 |
| 14 | Peruvian scientific production in medicine and collaboration networks, analysis of the Science Citation Index 2000-2009显示文摘 | Huamaní C Mayta-Tristán P | 2010 | Revista Peruana de Medicina Experimentaly Salud Publica2010，27，3： | 1 |
| 15 | Microstructure and pitting corrosion of 13CrNiMo weld metals 显示文摘 | Bilmes P D Llorente C L Saire Huaman L | 2006 | Corrosion Science2006，48，： | 1 |
| 16 | A retrospective randomly selectedcohort study of D-penicillamine treatment in rapidly progressive dif-fuse cutaneous systemic sclerosis of recent onset 显示文摘 | Derk CT Huaman G Jimenez SA | 2008 | Br J Dermatol2008，158，： | 1 |
| 17 | Selecting a Peruvian sweetpotato core collection on the basis of morphological,eco-geographical,and disease and pest reaction data 显示文摘 | Huaman Z Aguilar C Ortiz R | 1999 | Theoretical and Applied Genetics1999，98，5： | 1 |
| 18 | A synopsis of Ipomoea (Convolvulaceae) in the Americas显示文摘 | AUSTIN DF HUAMAN Z | 1996 | Taxon1996，45，1： | 1 |
| 19 | Implications of fires on carbon budgets in Andean cloud montane forest: The importance of peat soils and tree resprouting显示文摘 | R.M. Román-Cuesta N. Salinas H. Asbjornsen I. Oliveras V. Huaman Y. Gutiérrez L. Puelles J. Kala D. Yabar M. Rojas R. Astete D.Y. Jordán M. Silman R. Mosandl M. Weber B. Stimm S. Günter T. Knoke Y. Malhi | 2011 | Forest Ecology and Management2011，，11： | 1 |
| 20 | Genetic diversity and geographic pattern in early South American cotton domestication 显示文摘 | Westengen O T Z Huaman M Heum | 2005 | Theor Appl Genet2005，110，： | 1 |
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