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| 1 | Induction of Endoplasmic Reticulum Stress by Cadmium and Its Regulation on Nrf2 Signaling Pathway in Kidneys of Rats显示文摘Objective This study was conducted to investigate the regulation of endoplasmic reticulum stress on Nrf2 signaling pathway in the kidneys of rats. Methods Rats were divided into twelve groups of six animals each. Some groups were pre-administered with bacitracin or tauroursodeoxycholic acid(TUDCA), and all of them were treated with 5-20 μmol/kg cadmium(Cd) for 48 h. The oxidative stress levels were analyzed using kits. The mRNA and protein expression levels of endoplasmic reticulum stress-related factors and Nrf2 signaling pathway-related factors were determined using RT-PCR and western blot. Results Cd exposure resulted in oxidative stress in the kidneys of rats and upregulated the expression of endoplasmic reticulum stress(ERS)-related factors and Nrf2 signaling pathway-related factors, especially at doses of 10 and 20 μmol/kg Cd, and the expression changes were particularly obvious. Moreover, after pretreatment with bacitracin, Cd upregulated the expression of ERS-related factors to a certain extent and, at higher doses, increased the mRNA expression of Nrf2. After pretreatment with TUDCA, Cd reduced the level of ERS to a certain extent; however, at these doses, there were no significant changes in the expression of Nrf2. Conclusion Cadmium can result in ERS and oxidative stress in the kidneys of rats, activate Nrf2, and upregulate the transcriptional expression of phase II detoxification enzymes under these experimental conditions. ERS has a positive regulation effect on Nrf2 signaling pathway but has little effect on the negative regulation of Nrf2 signaling pathway in cadmium toxicity. | CHEN Zhi Jian CHEN Jia Xing WU Li Kang LI Bi Yun TIAN Ya Feng XIAN Min HUANG Zi Pei YU Ri An | 2019 | Biomedical and Environmental Sciences2019，32，1： | 6 |
| 2 | Oxygen Atom Exchange Mechanism in Reaction of OH Radical with AsO显示文摘Oxygen atom exchange reaction mechanism in the reaction of OH radicals with AsO was investigated by means of the density functional theory (DFT) with 6 311++G( 3df,3pd ) and 6 311++G( d,p ) basis sets. The calculated results suggest that the reaction between OH and AsO should make the oxygen atoms exchange rapidly because the barrier to isomerization is significantly less than the HO-AsO bond dissociation energy. | CHI Yu-juan 1, YU Hai tao 1,2** , FU Hong gang 1,2 HUANG Xu ri 2, LI Ze sheng 2 and SUN Chia chung 21. College of Chemistry and Chemical Engineering, Heilongjiang University, Harbin 150080, P. R. China 2. State Key Laboratory of T | 2002 | Chemical Research in Chinese Universities2002，18，3： | 3 |
| 3 | Upregulation of integrins alpha v beta 3 and alpha v beta 5 on human monocytes and T lymphocytes facilitates adenovirusmediated gene delivery显示文摘 | Huang S Endo RI Nemerow GR | 1995 | J Virol1995，69，4： | 1 |
| 4 | Raman micro- scopic analysis of single microbial cells 显示文摘 | Huang WE Griffiths RI Thompson IP | 2004 | Anal Chem2004，76，15： | 1 |
| 5 | Double perovskites as anode materials for solid - oxide fuel cells 显示文摘 | Huang YH Dass RI Xing ZL | 2006 | Science2006，312，： | 1 |
| 6 | Bmk1/erk5 is re-quired for cell proliferation induced by epidermal growth fac-tor显示文摘 | Kato Y Tapping RI Huang S | 1998 | Nature1998，395，6703： | 1 |
| 7 | Two Lower-barrier Channels in the Reaction of HF with HOBO显示文摘Two possible lower barrier reaction pathways in the reaction HF+HOBOH2O+FBO are predicated by means of MP2 and CCSD(T) (single-point) methods. In the two channels, two stable intermediates are located, and thus, they are multi-step channels, which are more favorable in energy than direct single-step reaction pathway predicated by previous theoretical study. Therefore, the two pathways should be main reaction channels in experiments. | Hai Tao YU Xu Ri HUANG 等 | 2003 | Chinese Chemical Letters2003，14，1： | 1 |
| 8 | Effect of General Relativity on a Near-Earth Satellite in the Geocentric and Barycentric Reference Frames显示文摘 | Huang C | 1988 | Phys Rev Lett1988，61，8： | 1 |
| 9 | Shale-to-well energy use and air pollutant emissions of shale gas production in China 显示文摘 | Chang Y Huang R Ries R J | 2014 | Applied Energy2014，125，： | 1 |
| 10 | Effect of polymerization on the antioxidant capacity of anthocyanins in Roselle显示文摘 | Ri Jen Tsai Hsiao-Ping Huang | 2004 | Food Research International2004，37，4： | 1 |
| 11 | Bmkl/Erk5 is required for cell proliferation induced by epidermal growth factor显示文摘 | KATO Y TAPPING RI HUANG S | 1998 | Nature1998，395，6703： | 1 |
| 12 | 11q13 allelic loss in pituitary tumors in patients with multiple endocrine neaplasia syndrome type 1 显示文摘 | Vortmeyer AO Huang S | 1998 | Clin Cancer Res1998，4，： | 1 |
| 13 | Prenatal diagnosis of ectopia cordis at 10 weeks of gestation using two-dimensional and three-dimensional ultrasonography显示文摘 | Liang RI Huang SE Chang FM | 1997 | Ultrasound Obstet Gynecol1997，10，2： | 1 |
| 14 | Bmk1/Erk5 is required for cell proliferation induced by epidermal growth factor显示文摘 | Kato Y Tapping RI Huang S | 1998 | Nature1998，395，： | 1 |
| 15 | Effects of Plant-derived Humic Acid Organic Fertilizer on Selenium Content of Rice in Northern Guangxi显示文摘This study was to find out the suitable application amount of plant-derived humic acid organic fertilizer for selenium-rich rice production in northern Guilin area by applying the fertilizer at different amounts.The results showed that plant-derived humic acid organic fertilizer could effectively activate selenium in selenium-rich soil,and then promote the uptake of selenium by rice.With costs,selenium enrichment and rice yield as the main evaluation indicators,A4 was chosen as the best treatment,that is,the application of 4 500 kg/hm^2 of plant-derived humic acid organic fertilizer as base fertilizer could achieve the best benefit. | Yunwei JIANG Lixiu HUANG Dongmei WANG Liping PAN Qianchi MO Ri MING Zongji ZHANG Jinping CHEN Hengzhi ZHAO Youxing YANG Xiongying JIANG Dayong FAN Yongxian LIU | 2019 | Agricultural Biotechnology2019，8，3： | 1 |
| 16 | Clinical manifestations of a cluster of rotavirus infection in young infants hospitalized in neo- natal care units 显示文摘 | Tai IC Huang YC Lien RI | 2012 | J Microbiol Immunol Infect2012，45，1： | 1 |
| 17 | Electro-generation of TGA by Ni-mSA-mCS bipolar membrane显示文摘Ni-mSA-mCS bipolar membrane (BM) was prepared by sodium alginate (SA) and chitosan (CS),which were modified by Ca^(2+) and glutaraldehyde as linking reagents,respectively,mSA-mCS membrane was characterized by FTIR,SEM,TG and used as a separator in the electrolysis cell to produce thioglycolic acid (TGA).The experiment results show that TGA was prepared effectively by electro-reduction of dithiodiglycolic acid (DTDGA) with the mixture of TGA and DTDGA in the cathodic chamber.The current efficiency was up to 66.7% at the room temperature (25℃) during the current density of 10 mA/cm^2.Compared with the traditional metal reduction method,the electro-reduction technology saves the zinc powder and eliminates the pollution to environment. (?)2007 Zhen Chen.Published by Elsevier B.V.on behalf of Chinese Chemical Society.All rights reserved. | Zhen Xia Huang Xi Zheng Ri Yao Chen Xiao Chen Zhen Chen | 2007 | Chinese Chemical Letters2007，18，11： | 1 |
| 18 | Efficacy of intracoronary nicardipine in the treatment of no-reflow during percutaneous coronary intervention显示文摘 | Huang RI Patel P Walinsky P | 2006 | Catheter Cardiovasc Interv2006，68，5： | 1 |
| 19 | Efficacy of intracoronary nicardipine in the treatment of no-rellow during percutaneous coronary intervention显示文摘 | Huang RI Palel P Walinsky P | 2006 | Catheter Cardiovasc Interv2006，68，： | 1 |
| 20 | Identification of Chemi- cal Compounds that Induce HIF-la Activity显示文摘 | Xia MH Huang RI Semenza GL | 2012 | Toxicological Sciences2012，112，1： | 1 |
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