维普期刊资源整合服务平台（V6.5）

维普中文期刊产品整合服务

18篇 您的检索式：作者名="Hubens J"

选中清除导出查看参考文献查看引证文献引用追踪共1页首页上一页第1页下一页末页 /1 跳转

		题名	作者	年代	出处	被引量
	1	Tumor Antigen Specific Activation of Primary Human T-Cells Expressing a Virally Encoded Chimeric T-Cell Receptor Specific for p185HER2显示文摘We have developed and tested chimeric T-cell receptors (TCR) specific for p185HER2. In these experiments, retroviral vectors expressing the N29γ or N29ζ receptors were constructed in pRET6. Amphotropic viral producer cells were established in the GALV-based PG13 packaging cell line. Ficoll purified human peripheral blood lymphocytes (PBL) were virally transduced using an optimized protocol incorporating activation with immobilized anti-CD3/anti-CD28 monoclonal anti- bodies, followed by viral infection in the presence of fibronectin fragment CH296. Transduced cells were co-cultured with human tumor cell lines that overexpress (SK-OV-3) or underexpress (MCF7) p185HER2 to assay for antigen specific im- mune responses. Both CM+ and CD8+ T-cells transduced with the N29γ or N29ζ chTCR demonstrated HER2-specific anti- gen responses, as determined by release of Th1 like cytokines, and cellular cytotoxicity assays. Our results support the fea- sibility of adoptive immunotherapy with genetically modified T-cells expressing a chTCR specific for p185HER2.	杨建民 Michael S FRIEDMAN Christopher M REYNOLDS Marianne T HUBEN Lee WILKE Jennifer FULLER 李桥 Zelig ESHHAR James J MULE Kevin T MCDONAGH	2004	Journal of Microbiology and Immunology2004，2，4：	5
	2	In vivo anti-tumor activity of murine hematopoietic stem cells expressing a p185HER2-specific chimeric T-cell receptor gene显示文摘We have confirmed efficient anti-tumor activities of the peripheral lymphocytes transduced with a p185HER2-specific chimeric T-cell receptor gene both in murine and in human in our previous studies. To further test the feasibility of chimeric T-cell receptor in a bone marrow transplantation model, we first, made two murine tumor cell lines: MT901 and MCA-205, to express human p185HER2 by retroviral gene transduction. Murine bone marrow cells were retrovirally transduced to express the chimeric T-cell receptor and gene-modified bone marrow cells were transplanted into lethally irradiated mouse. Six months post transplantation, p185HER2-positive tumor cells:MT-901/HER2 or MCA-205/ HER2 was subcutaneously or intravenously injected to make mouse models simulating primary breast cancer or pulmonary metastasis. The in vivo anti-tumor effects were monitored by the size of the subcutaneous tumor or counting the tumor nodules in the lungs after India ink staining. The size of the subcutaneous tumor was significantly inhibited and the number of pulmonary nodules were significantly decreased in mouse recipients transplanted with chimeric T-cell receptor modified bone marrow cells compared with the control group. Our results suggest the efficient in vivo anti-tumor activities of chimeric T-cell receptor gene modified bone marrow cells.	JIAN MIN YANG MICHAEL S FRIEDMAN MARIANNE T HUBEN JENNIFER FULLER QIAO LI ALFRED E CHANG JAMES J MULE KEVIN T MCDONAGH	2006	Journal of Microbiology and Immunology2006，4，2：	3
	3	Laparoscopic treatment of nonparasitic liver cysts: adequate selection of patients and surgical technique显示文摘	Gigot J F Legrand M Hubens G	1996	World J Surg1996，20，：	1
	4	Implantation of colon cancers cells on intact and damaged colon mucosa and serosa: an experimental study in rat显示文摘	Huben J Lafullarde T Vermeulen P	1994	Acta Chir Belg1994，94，：	1
	5	Laparoscopic treatment of nonparasitic liver cysts:adequate selection of patients and surgical technigue显示文摘	GIGOT J F LEGRAND M HUBENS G	1996	World J Surg1996，20，5：	1
	6	An unstable shoe with a rocker bottom redistributes external work 显示文摘	Wurdeman S Yentes J Huben N	2012	Footwear Science2012，4，2：	1
	7	Malignant phyllodes tumor of prostate显示文摘	L(o)pez-Beltran A Gaeta J F Huben R	1990	Urology1990，35，2：	1
	8	Secondary urinoma mimicking reccurrent tumor as a cause of bilateral ureteral obstruction 显示文摘	ZEIN TA HUBEN RP PETREL N J	1987	J Surg Onco1987，34，：	1
	9	Malignant phyllodes tumor of prostate显示文摘	Lopez-Beltran A Gaeta J F Huben R Croghan G A	1990	Urology1990，35，2：	1
	10	Implantation of colon cancers cells on intact and damaged colonmucosa and serosa:an experimental study in rat显示文摘	Huben J Lafullarde T Vermeulen P		0，，：	1
	11	Implantation of colon cancers cells on intact and damaged colon cancers ceils on intact and damaged colonmucosa and serosa:an experimental study in rat 显示文摘	Hubens J Lafullarde T Van Marck E	1994	Acta Chir Belg1994，94，5：	1
	12	Laparoscopic treatment of nonparasitic liver cysts : adequate selection of patients and surgical technique woAd显示文摘	Gigot J F Legrand M Hubens G	1996	J Surg1996，20，5：	1
	13	Renal cortical tumors:Cytogenetic characterization显示文摘	Dal CP Gaeta J Huben R	1989	Am J Clin Pathol1989，92，：	1
	14	Effects of suramin on anastomotic colon tumors in a rat model显示文摘	Lauwers P Hubens G Hendriks J	1999	Eur Surg Res1999，31，4：	1
	15	The influence of cholecystectomy on the duodenogastric reflux of bile显示文摘	Hubens A Van de Kelft E Roland J	1989	Hepatogastroenterol1989，36，：	1
	16	Laparoscopic treatment of nonparasitic liver cysts; adequate selection of patients and surgicaltechnique显示文摘	GIOT J F LEGRAND M HUBENS G	1996	WorldJ Surg1996，20，：	1
	17	Implantation of colon cancer cells on intact and damaged colon mucosa and serosa:an experimental study in rat显示文摘	Huben J Lafullarde T Vermeulen P	1994	Acta Chir Belg1994，94，5：	1
	18	Laparoscopic treatment of nonparasitic liver cysts: adequate selection of patients and surgical technique显示文摘	Gigot J F Legrand M Hubens G	1996	World J Surg1996，20，5：	1

返回顶部每页显示：

共1页首页上一页第1页下一页末页 /1 跳转

goolge学术搜索-维普

网站首页 | 关于我们 | 联系我们 | 产品服务 | 客服中心 | 广告服务 | 版权声明 | 网站联盟 | 友情链接 | 售卡网点

版权所有© 渝B2-20050021-1　渝公网安备 50019002500403号　违法和不良信息举报中心

互联网出版许可证新出网证(渝)字10号全国400电话 - 免长途话费