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| 1 | Gastric cancer in a Caucasian population: Role of pepsinogen C genetic variants显示文摘瞄准:在胃蛋白酶原 C (PGC ) 基因学习插入 / 删除多型性的角色,为胃粘膜的终端区别的一个有效标记,在到胃的损害的开发的危险性。方法:没有肿瘤的疾病的证据,学习与已知的胃的损害的 99 件样品和 127 件样品被执行。PCR 被采用, 6 多态的等位基因被放大:等位基因 1 (510 bp ) ,等位基因 2 (480 bp ) ,等位基因 3/4 (450/460 bp ) ,等位基因 5 (400 bp ) 并且等位基因 6 (310 bp ) 。结果:我们的结果表明等位基因 6 搬运人似乎对任何胃的损害的发展有保护(或 = 0.34;P<0.001 ) ,与象萎缩或肠的组织变形那样的胃的腺癌联系的 non-dysplastic 损害(或 = 0.28;P<0.001 ) 或侵略 GC (或 = 0.39;P = 0.004 ) 。结论:我们的学习表明等位基因 6 搬运人地位在胃的损害的发展有一个保护的角色,可能由于它有 PGC 的更高的表示的协会。而且,在控制组的等位基因 6 搬运人的频率比在亚洲人口获得了高是远的,它可能代表在白种人和亚洲人口之间的基因差距。 | Ana L Pinto-Correia Hugo Sousa Maria Fragoso Luís Moreira-Dias Carlos Lopes Rui Medeiros Mário Dinis-Ribeiro | 2006 | World Journal of Gastroenterology2006，12，31： | 6 |
| 2 | Epstein-Barr virus is associated with gastric carcinoma: The question is what is the significance?显示文摘AIM: To examine the possible role of the Epstein- Barr Virus (EBV) in the development of gastric adenocarcinoma (GC). It is unclear whether EBV is involved in GC development or is a consequence of gastric inflammation secondary to immunosuppressive treatments. METHODS: A systematic review was carried out of all published observational studies on the temporal association between EBV and GC, with a view to determine a causal relationship. RESULTS: The present study showed that the worldwide crude prevalence of EBV in gastric adenocarcinoma was 8.29%. The prevalence varied from 7.08% for intestinal type and 9.82% for diffuse type of GC. It was observed that Western and Central Asian countries had a significantly higher frequency of EBV positive cases compared to South-Eastern countries. America had the highest EBV-GC prevalence whereas Europe had the lowest. CONCLUSION: The present review has demonstrated a high prevalence of EBV in gastric adenocarcinoma. However, studies designed to assess a temporal relationship and histological association using sensitive techniques should be carried out to establish the role of EBV in GC carcinogenesis. | Hugo Sousa Ana L Pinto-Correia Rui Medeiros Mario Dinis-Ribeiro | 2008 | World Journal of Gastroenterology2008，14，27： | 4 |
| 3 | Influence of different second generation antipsychotics on the QTc interval: A pragmatic study显示文摘AIM To investigate whether differential influence on the QTc interval exists among four second generation antipsychotics(SGAs) in psychosis.METHODS Data were drawn from a pragmatic, randomized headto-head trial of the SGAs risperidone, olanzapine, quetiapine, and ziprasidone in acute admissions patients with psychosis, and with follow-up visits at discharge or maximally 6-9 wk, 3, 6, 12 and 24 mo. Electrocardiograms were recorded on all visits. To mimic clinical shared decision-making, the patients were randomized not to a single drug, but to a sequenceof the SGAs under investigation. The first drug in the sequence defined the randomization group, but the patient and/or clinician could choose an SGA later in the sequence if prior negative experiences with the first one(s) in the sequence had occurred. The study focuses on the time of, and actual use of the SGAs under investigation, that is until treatment discontinuation or change, in order to capture the direct medication effects on the QTc interval. Secondary intention-to-treat(ITT) analyses were also performed. RESULTS A total of 173 patients, with even distribution among the treatment groups, underwent ECG assessments. About 70% were males and 43% had never used antipsychotic drugs before the study. The mean antipsychotic doses in milligrams per day with standard deviations(SD) were 3.4(1.2) for risperidone, 13.9(4.6) for olanzapine, 325.9(185.8) for quetiapine, and 97.2(42.8) for ziprasidone treated groups. The time until discontinuation of the antipsychotic drug used did not differ in a statistically significant way among the groups(Log-Rank test: P = 0.171). The maximum QTc interval recorded during follow-up was 462 ms. Based on linear mixed effects analyses, the QTc interval change per day with standard error was-0.0030(0.0280) for risperidone;-0.0099(0.0108) for olanzapine;-0.0027(0.0170) for quetiapine, and-0.0081(0.0229) for ziprasidone. There were no statistically significant differences among the groups in this regard. LME analyses based on ITT groups(the randomization groups), revealed almost identical slopes with-0.0063(0.0160) for risperidone,-0.0130(0.0126) for olanzapine,-0.0034(0.0168) for quetiapine, and-0.0045(0.0225) for ziprasidone. CONCLUSION None of the SGAs under investigation led to statistically significant QTc prolongation. No statistically significant differences among the SGAs were found. | Roy E Olsen Rune A Kroken Sigmund Bj?rhovde Kristina Aanesen Hugo A J?rgensen Else-Marie L?berg Erik Johnsen | 2016 | World Journal of Psychiatry2016，6，4： | 2 |
| 4 | Naming and outline of Dothideomycetes-2014 including proposals for the protection or suppression of generic names显示文摘Article 59.1,of the International Code of Nomenclature for Algae,Fungi,and Plants(ICN;Melbourne Code),which addresses the nomenclature of pleomorphic fungi,became effective from 30 July 2011.Since that date,each fungal species can have one nomenclaturally correct name in a particular classification.All other previously used names for this species will be considered as synonyms.The older generic epithet takes priority over the younger name.Any widely used younger names proposed for use,must comply with Art.57.2 and their usage should be approved by the Nomenclature Committee for Fungi(NCF).In this paper,we list all genera currently accepted by us in Dothideomycetes(belonging to 23 orders and 110 families),including pleomorphic and nonpleomorphic genera.In the case of pleomorphic genera,we follow the rulings of the current ICN and propose single generic names for future usage.The taxonomic placements of 1261 genera are listed as an outline.Protected names and suppressed names for 34 pleomorphic genera are listed separately.Notes and justifications are provided for possible proposed names after the list of genera.Notes are also provided on recent advances in our understanding of asexual and sexual morph linkages in Dothideomycetes.A phylogenetic tree based on four gene analyses supported 23 orders and 75 families,while 35 families still lack molecular data. | Nalin N.Wijayawardene Pedro W.Crous Paul M.Kirk David L.Hawksworth Saranyaphat Boonmee Uwe Braun Dong-Qin Dai Melvina J.D’souza Paul Diederich Asha Dissanayake Mingkhuan Doilom Singang Hongsanan E.B.Gareth Jones Johannes Z.Groenewald Ruvishika Jayawardena James D.Lawrey Jian-Kui Liu Robert Lücking Hugo Madrid Dimuthu S.Manamgoda Lucia Muggia Matthew P.Nelsen Rungtiwa Phookamsak Satinee Suetrong Kazuaki Tanaka Kasun M.Thambugala Dhanushka N.Wanasinghe Saowanee Wikee Ying Zhang Andre Aptroot H.A.Ariyawansa Ali H.Bahkali D.Jayarama Bhat Cécile Gueidan Putarak Chomnunti G.Sybren De Hoog Kerry Knudsen Wen-Jing Li Eric H.C.McKenzie Andrew N.Miller Alan J.L.Phillips Marcin Piatek Huzefa A.Raja Roger S.Shivas Bernad Slippers Joanne E.Taylor Qing Tian Yong Wang Joyce H.C.Woudenberg Lei Cai Walter M.Jaklitsch Kevin D.Hyde | 2014 | Fungal Diversity2014，，6： | 2 |
| 5 | The PLAGL1 gene is down-regulated in human extraskeletal myxoid chondrosarcoma tumors显示文摘 | Hugo P Yves L | 2005 | Cancer Letters2005，227，： | 1 |
| 6 | Epithelial-mesenchymal and mesenehymal-epithelial transitions in carcinoma progression显示文摘 | Hugo H Ackland M L Blick T | 2007 | J Cell Phys-iol2007，213，2： | 1 |
| 7 | endothelial dysfunction in lacunar stroke: a systematic review显示文摘 | Iris LH Hugo TC Jan L | 2009 | Cerebrovasc Dis2009，27，5： | 1 |
| 8 | Highly sensitive in-fiber interferometric refractometer with temperature and axial strain compensation显示文摘 | JEREMIE H PING L HUGO L | 2013 | Optics Express2013，21，10： | 1 |
| 9 | Patient participation:current knowledge and applicability to patient safety 显示文摘 | Yves L Hugo S Lucian LL | 2010 | Mayo Clin Proe2010，85，1： | 1 |
| 10 | Healthy Hearts-A community-based primary prevention to reduce coronary heart disease 显示文摘 | Gill R Hugo C W Lucy M et a l | 2008 | BMC Cardio- vascular Disorders2008，26，8： | 1 |
| 11 | Black,Reminiscences 显示文摘 | Hugo L | 1965 | Alabama Law Review1965，18，1： | 1 |
| 12 | Rapid and efficient purification of hepatitis A virus from cell culture显示文摘 | Bishop N E Hugo D L Borovec S V | 1994 | J Virol Method1994，47，： | 1 |
| 13 | Glucocorticoid receptor counteracts tumorigenic activity of Akt in skin through interference with the phosphatidylinsitol3-kinase signaling pathway 显示文摘 | Hugo L Angnstias P Angel R | 2004 | Mol Endocrinol2004，18，2： | 1 |
| 14 | Universal Definition of Myocardial Infarction显示文摘 | Kristian Thygesen Joseph S. Alpert Harvey D. White Kristian Thygesen (Denmark) Joseph S. Alpert (USA) Harvey D. White (New Zealand) Allan S. Jaffe Fred S. Apple (USA) Marcello Galvani (Italy) Hugo A. Katus (Germany) L Kristin Newby (USA) Jan Ravkilde (Den | 2007 | Circulation2007，，22： | 1 |
| 15 | Rapid and efficient purification of hepatitis A virus from cell culture 显示文摘 | Bishop N E Hugo D L Borovec S V | 1994 | J Virol Method1994，47，： | 1 |
| 16 | Epi thelial mesenchymal and mesenchymal epithelial tran sitions in carcinoma progression显示文摘 | HUGO H ACKLAND M L BLICK T | 2007 | J Cell Physiol2007，213，： | 1 |
| 17 | Pavement response and rutting for full scale and scaled AP'I'显示文摘 | MARTIN A E WALUBITA L F HUGO F | 2003 | Journal of Transportation Engineering2003，129，4： | 1 |
| 18 | Residence time, groundwater age, and solute output in steady-state groundwater systems显示文摘 | Hugo A L | 2004 | Advances in Water Resources2004，27，： | 1 |
| 19 | Wear particle classifier system based on an artificial neural network显示文摘 | GONCALVES V D ALMEIDA L F HUGO M | 2010 | Journal of Mechanical Engineering2010，56，4： | 1 |
| 20 | Universal Definition of Myocardial Infarction显示文摘 | Kristian Thygesen Joseph S. Alpert Harvey D. White Kristian Thygesen (Denmark) Joseph S. Alpert (USA) Harvey D. White (New Zealand) Allan S. Jaffe Fred S. Apple (USA) Marcello Galvani (Italy) Hugo A. Katus (Germany) L Kristin Newby (USA) Jan Ravkilde (Den | 2007 | Circulation2007，，22： | 1 |
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