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| 1 | Qualitative and quantitative analyses of the bifidobacterial microbiota in the colonic mucosa of patients with colorectal cancer, diverticulitis and inflammatory bowel disease显示文摘AIM: To characterize the bifidobacterial microbiota of the colonic mucosa in patients with colon cancer, inflammatory bowel disease or diverticulitis. METHODS: A sample of the distal colonic mucosa was taken during surgery from a total of 34 patients, twenty-one with diagnosed colorectal cancer, nine with diverticulitis and four with inflammatory bowel disease, requiring surgery for their condition. Bacterial DNA was extracted from the resected mucosal samples and bifidobacterial mucosa-associated microbiota was qualitatively and quantitatively determined by means of qualitative and quantitative PCR. RESULTS: Bifidobacteria were found in 100% of the samples from patients with diverticulitis or IBD and a 76% of those suffering colon cancer. The species B. longum and B. bifidum were the most widely found, followed by B. animalis, B. catenulatum and B. adolescentis. B. breve, B. dentium and B. angulatum were not detected in any sample. A significantly higher occurrence of B. longum was observed in patients with diverticulitis than in those with colon cancer or IBD (100%, 62% and 75%, respectively, P < 0.05). Similar results were obtained for B. animalis (56%, 0% and 25%, P < 0.05), while B. adolescentis was only found in the mucosa from patients with colon cancer (5 out of 21, 24%). At the quantitative level, patients with colon cancer or IBD showed lower counts of total Bifidobacterium (4.94 and 5.91 vs 6.96 log Cells/sample, respectively, P < 0.05) and of the species B. longum (4.05 and 4.79 vs 6.76, P < 0.05) than those with diverticulitis. CONCLUSION: Aberrancies in mucosa associated microbiota are present in different intestinal diseases. This may indicate a role of the microbiota in the pathogenesis of these diseases. | Miguel Gueimonde Arthur Ouwehand Heikki Huhtinen Eeva Salminen Seppo Salminen | 2007 | World Journal of Gastroenterology2007，13，29： | 25 |
| 2 | Pseudoclitocybaceae fam. nov. (Agaricales, Tricholomatineae), a new arrangement at family, genus and species level显示文摘A new classification of several clitocyboid taxa is here proposed to accommodate results from multigenic phylogenetic inference.The analysis of ITS rDNA as well as a combined dataset including 18S and 28S rDNA,tef1 and rpb2 data,support significantly a shared monophyletic origin of the genera Pseudoclitocybe,Musumecia and Pogonoloma,and the species Clitocybe alexandri and C.harperi.The new family Pseudoclitocybaceae is here proposed to name this clade,characterized by the presence of loop-like clamp connections in most species,absence of cystidia,and parallel hymenophoral trama with broad,cylindrical hyphae with intracellular granulations.The new genera Clitopaxillus and Harmajaea are proposed to accommodate the type species C.alexandri and H.harperi,as well as the combination H.wellsiae.In addition,two new species are described:C.fibulatus has a differential distribution of clamp connections in the basidiome,while H.guldeniae is,by now,an exclusively European taxon with brownish pileus,somewhat decurrent gills,ovoid spores and basidia longer than those of H.harperi.Finally,the species concept within Pseudoclitocybe and Pogonoloma is discussed and descriptions of the most representative species are provided. | Pablo Alvarado Pierre-Arthur Moreau Balint Dima Alfredo Vizzini Giovanni Consiglio Gabriel Moreno Ledo Setti Tapio Kekki Seppo Huhtinen Kare Liimatainen Tuula Niskanen | 2018 | Fungal Diversity2018，，3： | 2 |
| 3 | Serum HE4 concentration differentiates malignant ovarian tumours from ovarian endometriotic cysts显示文摘 | Huhtinen K Suvitie P Hiissa J | 2009 | Br J Cancer2009，100，8： | 1 |
| 4 | Serum HE4 concentration differentiates malignant ovarian tumours from ovarian endometriotic cysts显示文摘 | Huhtinen M Suitie P Hiissa J | | Br J Cancer0，100，8： | 1 |
| 5 | Adoption of self-expanding metallic stents in the palliative treatment of obstructive colorectal cancer-look out for perforations 显示文摘 | VARPE P HUHTINEN H RANTALA A | 2008 | Surg Laparosc Endosc Percutan Tech2008，18，4： | 1 |
| 6 | Serum HE4 concentration differentiates malignant ovarian tumours from ovarian endometriotic cysts 显示文摘 | Huhtinen K Suvitie P Hiissa J | 2009 | BrJ Cancer2009，100，8： | 1 |
| 7 | Serum HE4 concentration differentiates malignant ovarian turnouts from ovarian endometri- otic cysts显示文摘 | Huhtinen K Suvitie P Hiissa J | 2009 | Br J Cancer2009，100，8： | 1 |
| 8 | Serum HE4 concentration differentiates malignant ovarian tumours from ovarian endometriotic cysts显示文摘 | Huhtinen K Suvitie P Hiissa J | | 0，，08： | 1 |
| 9 | YBCO nanopowder: novel material for PLD preparation of thin films显示文摘 | Huhtinen H Laiho R Lahderanta E | 2000 | Physica C2000，341，： | 1 |
| 10 | Preparation of superconducting YBa2 Cu3 O7-x nanopowder by deoxydation in Ar before final oxygenation显示文摘 | Raittila J Huhtinen H Paturi P | 2002 | Physica C2002，，371： | 1 |
| 11 | Computational method to estimate single event upset rates in an accelerator environment 显示文摘 | Huhtinen M Faccio F | 2000 | Nuclear Instruments and Methods in Physics Research A2000，450，： | 1 |
| 12 | 显示文摘 | Raittila J Huhtinen H Paturi P | 2002 | Physica C2002，371，： | 1 |
| 13 | Sermn HE4 concentration differentiates malignant ovarian tumours from ovarian endometriotic cysts显示文摘 | Huhtinen K Suvitie P Hiissa J | 2009 | Br J Cancer2009，100，8： | 1 |
| 14 | Serum HE4 concentration differentiates malignant ovarian tumours from ovarian endometriotic cysts显示文摘 | Huhtinen K Suvitie P Hiissa J | 2009 | Br J Cancer2009，100，8： | 1 |
| 15 | YBCO nanopowder:novel material for PLD preparation of thin films显示文摘 | Huhtinen H Laiho R | 2000 | Physica C2000，，： | 1 |
| 16 | Serum HFA concentration differentiates malignant ovarian tumours from ovarian endometriotic cysts 显示文摘 | Huhtinen K Suvitie P Hiissa J | 2009 | BrJCancer2009，100，8： | 1 |
| 17 | Serum concentration differentiates malignant ovarian turnouts from ovarian endometriotic cysts 显示文摘 | Huhtinen K Suvitie P Hiissa J | 2009 | BrJ Cancer2009，100，8： | 1 |
| 18 | Activa tion of androgens by hydroxysteroid (17beta) dehy- drogenase 1 in vivo as a cause of prenatal masculiniza tion and ovarian benign serous cystadenomas显示文摘 | Saloniemi T Lamminen T Huhtinen K | 2007 | Mol Endocrinol2007，21，11： | 1 |
| 19 | Serum HE4 concen- tration differentiates malignant ovarian tumours from ovari- an endometriotic cysts 显示文摘 | Huhtinen K Suvitie P Hiissa J | 2009 | Br J Cancer2009，100，8： | 1 |
| 20 | Serum HE4 con-centration differentiates malignant ovarian tumours fromovarian endometriotic cysts显示文摘 | Huhtinen K Suvitie P Hiissa J | 2009 | Br J Cancer2009，100，8： | 1 |
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