|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Novel Recombinant Seneca Valley Virus Isolated from Slaughtered Pigs in Guangdong Province显示文摘Dear Editor,Since the first outbreak in Brazil in 2015,Seneca Valley virus(SVV)associated with porcine idiopathic vesicular disease,has shown increasing geographic distribution.Cases of SVV have been reported from several countries including the United States(US),Colombia,Thailand,Canada,and China(Pasma et al.2008;Zhang et al.2015;Sun et al.2017;Wu et al.2017;Liu et al.2018;Saeng-Chuto et al.2018).SVV was first identified in the US in 2002 and is the only member of the genus Senecavirus in the family Picomaviridae(Hales et al.2008;Leme et al.2017).The SVV genome contains a large open reading frame(ORF)encoding a polyprotein,which is cleaved into various mature viral proteins including the leader protein(L),structural proteins(VP1,VP2,VP3,and VP4),and non-structural proteins(2A,2B,2C,3A,3B,3C,and 3D)(Hales et al 2008).Structural proteins bind to their receptor,anthrax toxin receptor 1,to mediate viral invasion and stimulate specific immunity of the host(Jayawardena et al.2018).Non-structural proteins such as 3C suppress innate immune responses by degrading interferon regulatory factor 3(IRF 3)and IRF7 and inhibit the activation of RIG-1,TBK1,and TRAF3 through deubiquitination(Xue et al 2018). | Jianxin Liu Yunfeng Zha Huizi Li Yanwei Sun Fuguang Wang Rong Lu Zhangyong Ning | 2019 | Virologica Sinica2019，34，6： | 7 |
| 2 | Specific Recognition of Breast Cancer Cells In Vitro Using Near Infrared-Emitting Long-Persistence Luminescent Zn_3Ga_2Ge_2O_(10):Cr^(3+)Nanoprobes显示文摘In this paper, near-infrared emitting long-persistence luminescent Zn3Ga2Ge2O10:Cr3?(ZGG) nanoparticles with diameters of 30–100 nm and bright luminescence were prepared by a sol–gel synthesis method. After the surface amination, the nanoparticles were further bioconjugated with breast cancer-specific monoclonal antibody(anti-Ep CAM) to form ZGG-Ep CAM nanoprobes which can specifically target breast cancer cell lines(MCF7) in vitro. The results of in vitro images show that the luminescence signals from the cells treated with ZGG-Ep CAM nanoprobes are stronger than those from cells treated with ZGG-unconjugated antibody, indicating that the prepared ZGG-Ep CAM nanoprobes possessed excellent specific recognition capability. Furthermore, due to their long afterglow properties, the imaging could persist more than 1 h. Therefore, these nanoprobes could not only provide a high specificity detection method for cancer cells but also realize the long-time monitoring. Developed near-infrared emitting long-persistence luminescent nanoprobes will be expected to find new perspectives for cell therapy research and diagnosis applications. | Jinlei Li Junpeng Shi Jiangshan Shen Huizi Man Mingxi Wang Hongwu Zhang | 2015 | Nano-Micro Letters2015，7，2： | 4 |
| 3 | DNA methylation downregulated mir-10b acts as a tumor suppressor in gastric cancer显示文摘 | Zheng Li Huizi Lei Min Luo Yi Wang Lei Dong Yanni Ma Changzheng Liu Wei Song Fang Wang Junwu Zhang Jianxiong Shen Jia Yu | 2015 | Gastric Cancer2015，，1： | 2 |
| 4 | Ratiometric sensing lysosomal pH in inflammatory macrophages by a BODIPY-rhodamine dyad with restrained FRET显示文摘Inflammation,as the pathophysiological response of body to harmful stimuli,leads to changes in cellular microenvironment.To research pH changes in lysosomes of macrophages during inflammation,we designed a FRET(F(o|')rster resonance energy transfer)based probe,BDP-RhB.The probe showed good lysosome targeting ability,wide response range of pH from 8.0 to 4.0 with significant ratio(I582/I518)change from 0.6 to 3.4,and good reversibility and sustainability.By applying BDP-RhB,we found a decrease of lysosomal pH of macrophages during inflammation. | Yu Yan Xiaodong Zhang Xinfu Zhang Ning Li Huizi Man Lingcheng Chen Yi Xiao | 2020 | Chinese Chemical Letters2020，31，5： | 2 |
| 5 | A Novel Transfer Hydrogenation with High Hydrogen Utilization for the Hydrogenation of Halogenated Nitrobenzene without Hydrodehalogenation显示文摘 | Li Zhou Huizi Gu Xinhuan Yan | 2009 | Catalysis Letters (-)2009，，12： | 1 |
| 6 | Anti-inflammatory and analgesic effects of Daphne retusa Hemsl显示文摘 | Xiaojia Hu Huizi Jin Wenzheng Xu Wei Zhang Xiaohua Liu Shikai Yan Ming Chen Jianqiang Li Wei-dong Zhang | 2008 | Journal of Ethnopharmacology2008，，1： | 1 |
| 7 | Study on Family Carbon Emissions Assessment and Optimization 显示文摘 | Li Huizi | 2011 | Procedia Environmental Sciences2011，，11： | 1 |
| 8 | Two new phenolic amides from Allium chinense显示文摘Objective: To isolate the phenolic amides from the dried bulbs of Allium chinense and investigate their myocardium protective activities.Methods: The chemical constituents were isolated and purified by combining with silica gel column,Sephadex LH-20 column, HPLC and other chromatography techniques. Their structures were elucidated by NMR techniques and mass spectrometry. The isolated compounds were evaluated to determine their protective effect for myocardium cells in vitro.Results: Two new phenolic amides, namely, alichinemide Ⅰ(1) and alichinemide Ⅱ(2), and six konwn amides were isolated from the dried bulbs of A. chinense. The structures of compounds 3–8 were identified as 3-indolcarbaldehyde(3), 1-(2-aminophenyl)urea(4), 2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylic acid(5), N-trans-feruloyltyramine(6), N-trans-p-coumaroyltyramine(7), and N-(3,4-dimethoxyphenethyl) acetamide(8). Compound 3(50 μmol/L) showed significant inhibitory effect on the damage of H9c2 myocardial cells induced by H2O2in vitro.Conclusion: Compounds 1 and 2 were new phenolic amides. Compound 3 could be one of the potential myocardium protective constituents of A. chinense. | Xiaoqing Li Shikai Yan Jihong Lu Rui Wang Xianpeng Ma Xue Xiao Yan Zhang Huizi Jin | 2023 | Chinese Herbal Medicines2023，15，4： | 0 |
| 9 | A new strategy for high-throughput identification of human gut microbiota containing specific monosaccharide显示文摘Dear Editor,The human gastrointestinal tract is colonized by trillions of microorganisms,the majority of which cannot be cultured (Wu et al.,2018).Numerous glycans are expressed on the surface of gut microbiota that are characteristic of different strains,and the diversity of these glycans is partially attributed to variations in their monosaccharides. | Qizheng Wu Fang Liu Yu Song Qingyun Meng Xunlian Zhang Huizi Li Jingyu Sun Hongqi Gao Peng George Wang Yun Kong Min Chen | 2019 | Science China(Life Sciences)2019，62，7： | 0 |
| 10 | A novelα-ketoamide reactivity-based two-photon fluorogenic probe for visualizing peroxynitrite in Parkinson's disease models显示文摘Peroxynitrite(ONOO^(-))contributes to oxidative stress and neurodegeneration in Parkinson's disease(PD).Developing a peroxynitrite probe would enable in situ visualization of the overwhelming ONOO^(-)flux and understanding of the ONOO^(-)stress-induced neuropathology of PD.Herein,a novelα-ketoamide-based fluorogenic probe(DFlu)was designed for ONOO^(-)monitoring in multiple PD models.The results demonstrated that DFlu exhibits a fluorescence turn-on response to ONOO^(-)with high specificity and sensitivity.The efficacy of DFlu for intracellular ONOO^(-)imaging was demonstrated systematically.The results showed that DFlu can successfully visualize endogenous and exogenous ONOO^(-)in cells derived from chemical and biochemical routes.More importantly,the two-photon excitation ability of DFlu has been well demonstrated by monitoring exogenous/endogenous ONOO^(-)production and scavenging in live zebraflsh PD models.This work provides a reliable and promisingα-ketoamide-based optical tool for identifying variations of ONOO^(-)in PD models. | Tao Shao Xianning Xu Lan Wang Yu Shen Jun Zhao Huizi Li Duoteng Zhang Wei Du Hua Bai Bo Peng Lin Li | 2023 | Journal of Innovative Optical Health Sciences2023，16，4： | 0 |
| 11 | Regulation of 2-acetyl-1-pyrroline and grain quality in early-season indica fragrant rice by nitrogen and silicon fertilization under different plantation methods显示文摘Fragrant rice has a high market value,and it is a popular rice type among consumers owing to its pleasant flavor.Plantation methods,nitrogen(N)fertilizers,and silicon(Si)fertilizers can affect the grain yield and fragrance of fragrant rice.However,the core commercial rice production attributes,namely the head rice yield(HRY)and 2-acetyl-1-pyrroline(2-AP)content of fragrant rice,under various nitrogen and silicon(N-Si)fertilization levels and different plantation methods remain unknown.The field experiment in this study was performed in the early seasons of 2018 and 2019 with two popular indica fragrant rice cultivars(Yuxiangyouzhan and Xiangyaxiangzhan).They were grown under six N-Si fertilization treatments(combinations of two levels of Si fertilizer,0 kg Si ha^(−1)(Si0)and 150 kg Si ha^(−1)(Si1),and three levels of N fertilizer,0 kg N ha^(−1)(N0),150 kg N ha^(−1)(N1),and 220 kg N ha^(−1)(N2))and three plantation methods(artificial transplanting(AT),mechanical transplanting(MT),and mechanical direct-seeding(MD)).The results showed that the N-Si fertilization treatments and all the plantation methods significantly affected the HRY and 2-AP content and related parameters of the two different fragrant rice cultivars.Compared with the Si0N0 treatment,the N-Si fertilization treatments resulted in higher HRY and 2-AP contents.The rates of brown rice,milled rice,head rice,and chalky rice of the fragrant rice also improved with the N-Si fertilization treatments.The N-Si fertilization treatments increased the activities of N metabolism enzymes and the accumulation of N and Si in various parts of the fragrant rice,and affected their antioxidant response parameters.The key parameters for the HRY and 2-AP content were assessed by redundancy analysis.Furthermore,the structural equation model revealed that the Si and N accumulation levels indirectly affected the HRY by affecting the N metabolism enzyme activity,N use efficiency,and grain quality of fragrant rice.Moreover,high N and Si accumulation directly promoted the 2-AP content or affected the antioxidant response parameters and indirectly regulated 2-AP synthesis.The interactions of the MT method with the N-Si fertilization treatments varied in the fragrant rice cultivars in terms of the HRY and 2-AP content,whereas the MD method was beneficial to the 2-AP content in both fragrant rice cultivars under the N-Si fertilization treatments. | Yongjian Chen Lan Dai Siren Cheng Yong Ren Huizi Deng Xinyi Wang Yuzhan Li Xiangru Tang Zaiman Wang Zhaowen Mo | 2024 | Journal of Integrative Agriculture2024，23，2： | 0 |
| 12 | Zircon U-Pb age and geochemical characteristics of granodiorites from the western Qilian block显示文摘1 Introduction Qilian Block is located in between the South China Craton and the North China Craton and the Tarim Craton(Fig.1a),which is one of the key area to study the tectonic evolution of China.The Phanerozoic tectonic | OUYANG Huizi LI Zhiwu ZHU Lidong YANG Wenguang TAO Gang | 2017 | Acta Geologica Sinica(English Edition)2017，91，S1： | 0 |
| 13 | Propionate stimulates the secretion of satiety hormones and reduces acute appetite in a cecal fistula pig model显示文摘Short-chain fatty acids(SCFA)can regulate appetite by stimulating the secretion of satiety hormones.However,the impact of short-chain fatty acid propionate on the release of gut satiety hormones and appetite regulation in pigs is not completely understood.In this study,16 pigs were infused with saline or sodium propionate through a fistula in the caecum during a 28-day experimental period.We characterized the effects of propionate administration on peptide YY(PYY)and glucagon-like peptide 1(GLP-1)secretion from colonic tissue,and investigated the role of propionate infusion on the expression of appetite-related genes in the colon and hypothalamus.Further,the direct impact of propionate administration on the expression of orexigenic neuropeptide agouti-related protein(AgRP)in hypothalamic N38 cells was also examined.The results showed that intra-cecal infusion of propionate reduced the short-term feed intake(P<0.05)but not the long-term feed intake in pigs(P>0.05).Propionate administration stimulated PYY and GLP-1 release from colon tissue in vivo and ex vivo(P<0.05).It also upregulated PYY expression in the colonic mucosa(P<0.05).Meanwhile,the GLP-1 and PYY levels in the blood were increased after intra-cecal infusion of propionate at d 28(P<0.05).Additionally,intra-cecal infusion of propionate upregulated the mRNA and protein expression of free fatty acid receptor 2/3(FFAR2/FFAR3)in the colonic mucosa(P<0.05).Propionate infusion also downregulated the orexigenic AgRP mRNA expression(P<0.05)and upregulated the anorexigenic cocaine-and amphetamine-regulated transcript(CART)mRNA expression(P=0.09)in the hypothalamus.Moreover,propionate administration directly downregulated AgRP expression in hypothalamic N38 cells in a dose-dependent manner(P<0.05).Collectively,these findings demonstrated that cecal propionate stimulated colonic secretion of satiety hormones and suppressed appetite to reduce the short-term feed intake in pigs.This study highlights that microbial-derived propionate exerts an important role in regulating the physical functions of the host. | Yanan Zhang Xuan Li Guowen Huang Haifeng Wang Huizi Chen Yong Su Kaifan Yu Weiyun Zhu | 2022 | Animal Nutrition2022，，3： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员