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| 1 | Endoscopic submucosal dissection for premalignant lesions and noninvasive early gastrointestinal cancers显示文摘AIM: To investigate the indication, feasibility, safety, and clinical utility of endoscopic submucosal dissection (ESD) in the management of various gastrointestinal pathologies. METHODS: The medical records of 60 consecutive patients (34 female, 26 male) who underwent ESD at the gastroenterology department of Kocaeli University from 2006-2010 were examined. Patients selected for ESDhad premalignant lesions or non-invasive early cancers of the gastrointestinal tract and had endoscopic and histological diagnoses. Early cancers were considered to be confined to the submucosa, with no lymph node involvement by means of computed tomography and endosonography. RESULTS: Sixty ESD procedures were performed. The indications were epithelial lesions (n = 39) (33/39 adenoma with high grade dysplasia, 6/39 adenoma with low grade dysplasia), neuroendocrine tumor (n = 7), cancer (n = 7) (5/7 early colorectal cancer, 2/7 early gastric cancer), granular cell tumor (n = 3), gastrointestinal stromal tumor (n = 2), and leiomyoma (n = 2). En bloc and piecemeal resection rates were 91.6% (55/60) and 8.3% (5/60), respectively. Complete and incomplete resection rates were 96.6% (58/60) and 3.3% (2/60), respectively. Complications were major bleeding [n = 3 (5%)] and perforations [n = 5 (8.3%)] (4 colon, 1 stomach). Two patients with colonic perforations and two patients with submucosal lymphatic and microvasculature invasion (1 gastric carcinoid tumor, 1 colonic adenocarcinoma) were referred to surgery. During a mean follow-up of 12 mo, 1 patient with adenoma with high grade dysplasia underwent a second ESD procedure to resect a local recurrence. CONCLUSION: ESD is a feasible and safe method for treatment of premalignant lesions and early malignant gastrointestinal epithelial and subepithelial lesions. Successful en bloc and complete resection of lesions yield high cure rates with low recurrence. | Sadettin Hulagu Omer Senturk Cem Aygun Orhan Kocaman Altay Celebi Tolga Konduk Deniz Koc Goktug Sirin Ugur Korkmaz Ali Erkan Duman Neslihan Bozkurt Gokhan Dindar Tan Attila Yesim Gurbuz Orhan TarcinDivision of Gastroenterology Derince State Hospital Kocaeli 41900 Turkey Cem Kalayci | 2011 | World Journal of Gastroenterology2011，17，13： | 23 |
| 2 | Effects of dexmedetomidine and dexketoprofen on the conduction block of rat sciatic nerve显示文摘Dexmedetomidine is a selective α2-adrenoceptor agonist that is used because of its sedative,anxiolytic,and analgesic effects.Dexketoprofen,which is used as an analgesic,is a nonselective nonsteroidal anti-inflammatory drug (NSAID).The use of dexmedetomidine and dexketoprofen as adjuvants to local anesthetics for the peripheral nerve is gradually increasing.In this study,we aimed to investigate the effects of different doses of dexmedetomidine and dexketoprofen on conduction block of rat sciatic nerve.The isolated sciatic nerve from adult rats was transferred to a nerve chamber.The compound action potentials (CAPs) were recorded from stimulated nerve with electrophysiological methods.Dexmedetomidine (n = 8) and dexketoprofen (n = 8) were administered in the chamber with cumulative concentrations of 10–9 to 10–5 M,and the CAPs were recorded for 5 and 10 minutes.The CAP parameters were calculated.Both dexmedetomidine and dexketoprofen significantly depressed all CAP parameters in a dose-dependent manner compared with the control group,i.e.,the group in which rats did not receive treatment.CAP parameters showed there was no significant difference in nerve conduction inhibition between dexmedetomidine and dexketoprofen.Higher doses of dexmedetomidine suppressed the conduction in the fast-conducting fibers;however,dexketoprofen was found to suppress the conduction in the slow-conducting fibers in a time-dependent manner and suppress the conduction in the medium- and slow-conducting fibers in a dose-dependent manner.These findings suggest that dexmedetomidine and dexketoprofen exhibit better anesthetic effects on peripheral nerve through different ways of action.The experimental procedures were approved by the Necmettin Erbakan University on January 30,2013 (approval No.2013-024). | Sengal Bagci Taylan Hulagu Bariskaner | 2020 | Neural Regeneration Research2020，15，5： | 8 |
| 3 | Association of Apolipoprotein E Polymorphisms in Patients with Non-Alcoholic Steatohepatitis显示文摘 | Ali Sazci Gurler Akpinar Cem Aygun Emel Ergul Omer Senturk Sadettin Hulagu | 2008 | Digestive Diseases and Sciences2008，，12： | 3 |
| 4 | Serum levels of hepatoprotective peptide adiponectin in non-alcoholic fatty liver disease显示文摘 | Cem Aygun Omer Senturk Saadettin Hulagu Suleyman Uraz Altay Celebi Tolga Konduk Birsen Mutlu Zeynep Canturk | 2006 | European Journal of Gastroenterology & Hepatology2006，，2： | 2 |
| 5 | Serum levels of hepatoprotective peptide adiponectin in non-alcoholic fatty liver disease显示文摘 | Aygun C Senturk O Hulagu S | 2006 | Eur J Gastroenterol Hepatol2006，18，2： | 1 |
| 6 | Entecavir resist- ance in entecavir naive lamivudine treated chronic hepatitis B pa- tients显示文摘 | SAYAN M HULAGU S AKHAN SC | 2009 | Mikrobiyol Bul2009，43，3： | 1 |
| 7 | Serum levels of he-patoprotective peptide adiponectin in non-alcoholic fatty liver disease显示文摘 | Aygun C Senturk O Hulagu S | 2006 | Eur J Gastroenterol Hepatol2006，18，2： | 1 |
| 8 | Role of Ursodeoxycholic Acid in Prevention of Methotrexate-induced Liver Toxicity显示文摘 | Suleyman Uraz Veysel Tahan Cem Aygun Fatih Eren Goksenin Unluguzel Meral Yuksel Omer Senturk Erol Avsar Goncagul Haklar Cigdem Celikel Sadettin Hulagu Nurdan Tozun | 2008 | Digestive Diseases and Sciences2008，，4： | 1 |
| 9 | Evaluation of Metabolic Syndrome Frequency and Carotid Artery Intima-media Thickness as Risk Factors for Atherosclerosis in Patients with Nonalcoholic Fatty Liver Disease显示文摘 | Cem Aygun Orhan Kocaman Tayfun Sahin Suleyman Uraz Ahmet T. Eminler Altay Celebi Omer Senturk Sadettin Hulagu | 2008 | Digestive Diseases and Sciences2008，，5： | 1 |
| 10 | Serum levels of hepatoprotective peptide adiponectin in non-alcoholic fatty liver disease 显示文摘 | Aygun C Senturk O Hulagu S | 2006 | Eur J Gastroenterol Hepatol2006，18，2： | 1 |
| 11 | Serum levels of hepatoprotecrive peptide adiponectin in non - alcoholic fatty liver disease 显示文摘 | Aygun C Senturk O Hulagu S | 2006 | Eur J Gastroenterol Hepatol2006，18，： | 1 |
| 12 | Serum levels of hepatoprotective peptide adiponectin in non-alcoholic fatty liver disease显示文摘 | Aygun C Senturk O Hulagu S | 2006 | Eur J Gastroenterol Hepatol2006，18，2： | 1 |
| 13 | Endothe- lial dysfunction in Turkish patients with non-alcoholic fat- ty liver disease显示文摘 | SENTURK O KOCAMAN O HULAGU S | 2008 | Intern Med J2008，38，： | 1 |
| 14 | Serum levels of hepatopro-tective peptide adiponectin in non-alcoholic fatty liver disease显示文摘 | Aygun C Senturk O Hulagu S | 2006 | Eur J Gastroenterol Hepatol2006，18，2： | 1 |
| 15 | Serum levels of hepatoprotective peptide adiponectin in non-alcoholic fatty liver disease 显示文摘 | Aygun C Senturk O Hulagu S | 2006 | Eur J Gastroenterol Hepatol2006，18，： | 1 |
| 16 | Serum levels of hepatoprotective peptide adiponectin in non-alcoholic fatty liver disease显示文摘 | Aygun C Senturk O Hulagu S | 2006 | Eur J Gastroenterol Hepatol2006，18，2： | 1 |
| 17 | Clinical Characteristics of Inflammatory Bowel Disease in Turkey: A Multicenter Epidemiologic Survey显示文摘 | Nurdan Tozun Ozlen Atug Nese Imeryuz Hulya O. Hamzaoglu Arzu Tiftikci Erkan Parlak Ulku Dagli Aysel Ulker Sadettin Hulagu Hale Akpinar Candan Tuncer Inci Suleymanlar Oya Ovunc Fatih Hilmioglu Serap Aslan Kursat Turkdogan Halil Ibrahim Bahcecioglu Cihan Yu | 2009 | Journal of Clinical Gastroenterology2009，，1： | 1 |
| 18 | Serum levels of hepatoprotective peptide adiponectin in non-alcoholic fatty liver disease显示文摘 | Aygun C Senturk O Hulagu S | 2006 | Eur J Gastroenterol Hepatol2006，18，2： | 1 |
| 19 | Serum levels of hepatoprotective peptide adiponectin in non-alcoholic fatty liver disease显示文摘 | Aygun C Senturk O Hulagu S | 2006 | Eur J Gastroenterol Hepatol2006，18，2： | 1 |
| 20 | "Green Urban Transport" Modes and Arrangements" A Case Study on Authorities and Responsibilities of Local Governments in Turkey显示文摘 | Hulagu Kaplan Zümrüt ōzbahar | 2016 | Journal of US-China Public Administration2016，13，8： | 0 |
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