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| 1 | Update on Anti-Saccharomyces cerevisiae antibodies, anti-nuclear associated anti-neutrophil antibodies and antibodies to exocrine pancreas detected by indirect immunofluorescence as biomarkers in chronic inflammatory bowel diseases: Results of a multicent显示文摘AIM: Anti-Saccharomyces cerevisiae antibodies (ASCA), anti-nuclear associated anti-neutrophil antibodies (NANA) and antibodies to exocrine pancreas (PAB), are serological tools for discriminating Crohn’s disease (CrD) and ulcerative colitis (UC). Like CrD, coeliac disease (CoD) is an inflammatory bowel disease (IBD) associated with (auto) antibodies. Performing a multicenter study we primarily aimed to determine the performance of ASCA, NANA and PAB tests for IBD diagnosis in children and adults, and secondarily to evaluate the prevalence of these markers in CoD. METHODS: Sera of 109 patients with CrD, 78 with UC, 45 with CoD and 50 healthy blood donors were retrospectively included. ASCA, NANA and PAB were detected by indirect immunofluorescence (IIF). RESULTS: ASCA+/NANA- profile displayed a positive predictive value of 94.2% for CrD. Detection of ASCA was correlated with a more severe clinical profile of CrD and treatment of the disease did not influence their serum levels. ASCA positivity was found in 37.9% of active CoD.PAB were found in 36.7% CrD and 13.3% CoD patients and were not correlated with clinical features of CrD, except with an early onset of the disease. Fifteen CrD patients were ASCA negative and PAB positive. CONCLUSION: ASCA and PAB detected by IIF are specific markers for CrD although their presence does not rule out a possible active CoD. The combination of ASCA, NANA and PAB tests improves the sensitivity of immunological markers for CrD. Repeating ASCA, NANA, and PAB testing during the course of CrD has no clinical value. | S Desplat-Jégo C Johanet A Escande J Goetz N Fabien N Olsson E Ballot J Sarles JJ Baudon JC Grimaud M Veyrac P Chamouard RL Humbel | 2007 | World Journal of Gastroenterology2007，13，16： | 24 |
| 2 | The amino acid sequence of human insulin-like growth factor 1 and its structural homology with proinsulin显示文摘 | Rinderknecht E Humbel R E | 1978 | J Biol Chem1978，253，： | 1 |
| 3 | Primary structure of human insulin-like growth factor 11 显示文摘 | RINDERKNECHT E HUMBEL R E | 1978 | FEBS Lett1978，89，2： | 1 |
| 4 | Combined structural and chemical analysis of the anammoxosome: A membrane-bounded intracytoplasmic compartment in anammox bacteria显示文摘 | Laura van Niftrik Willie J.C. Geerts Elly G. van Donselaar Bruno M. Humbel Alevtyna Yakushevska Arie J. Verkleij Mike S.M. Jetten Marc Strous | 2007 | Journal of Structural Biology2007，，3： | 1 |
| 5 | The amino acid sequence of human insulin-like growth factor Ⅰ and its structural homology with proinsulin显示文摘 | Rinderknecht E Humbel R E | 1978 | J Biol Chem1978，253，8： | 1 |
| 6 | Primary structure of human insulin-like growth factor Ⅱ 显示文摘 | Rinderknecht E Humbel R E | 1978 | FEBS Lett1978，89，2： | 1 |
| 7 | The amino acid sequence of human insulin-like growth factor Ⅰ and its structural homology with pro-insulin显示文摘 | Rinderknecht E Humbel R E | 1978 | Biol Chem1978，253，8： | 1 |
| 8 | Insulin-like growth factor I and II 显示文摘 | Humbel R E | 1990 | European Journal of Biochemistry1990，190，： | 1 |
| 9 | Primary structure of human insulin-like growth factor Ⅱ显示文摘 | Rinderknecht E Humbel R E | 1978 | FEBS Lett1978，89，2： | 1 |
| 10 | Insulin-like growth factor-1 and 2 显示文摘 | Humbel R E | 1990 | Eur J Biochem1990，190，3： | 1 |
| 11 | The epidermal growth factor显示文摘 | Boonstra J Rijken P Humbel B | 1995 | Cell Biol Int1995，19，5： | 1 |
| 12 | Why is fast recovery diode plasma-engineering with ion-irradiation superior to that with emitter efficiency reduction显示文摘 | Galster N Dalibor T | 2003 | IEEE Transactions on Power Electronics2003，18，1： | 1 |
| 13 | The Amino Acid Sequence of Human Insulin-like Growth Factor 1 and its Structural Homology with Proinsulin显示文摘 | RINDERKNECHT E HUMBEL R E | 1978 | J Biol Chem1978，253，8： | 1 |
| 14 | The ep- idermal growth factor 显示文摘 | BOONSTRA J RIJKEN P HUMBEL B | 1995 | Cell Biology International1995，19，5： | 1 |
| 15 | The amino acid sequence of human insulin-like growth factor-Ⅰ and its structural homology with proinsulin显示文摘 | Rindderkneeht E Humbel R E | 1978 | The journal of biological chemistry1978，253，8： | 1 |
| 16 | The epidermal Growth factor 显示文摘 | Rijken P Humbel B | 1995 | Cell Biology International1995，19，5： | 1 |
| 17 | Tertiary structures,receptor binding,and antigenicity of insulin-like growth factors显示文摘 | Blundell T L Bedarkar S Humbel R E | 1983 | Fed Procm1983，42，： | 1 |
| 18 | Polypeptides with non suppressible insulin - like and cell - growth promoting activities in human serum : isolation, chemical characterization, and some biological properties of form I and II显示文摘 | Rinderknecht E Humbel R E | 1976 | Biology Chemistry1976，73，7： | 1 |
| 19 | Insulin-like growth factor 1 and 2显示文摘 | Humbel RE | 1990 | Eur J Biochem1990，190，3： | 1 |
| 20 | The epidermal growth factor显示文摘 | Boonstra J Rijken P Humbel B | 1995 | Cell Biol Int1995，19，5： | 1 |
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