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| 1 | Down-regulation of tyrosinase,TRP-1,TRP-2 and MITF expressions by citrus press-cakes in murine B16 F10 melanoma显示文摘Objective:To investigate the suitability of citrus-press cakes,by-products of the juice industry as a source for the whitening agents for cosmetic industry.Methods:Ethylacetate extracts of citrus-press cakes(CCE)were examined for their anti-melanogenic potentials in terms of the inhibition of melanin production and mechanisim of melanogenesis by using Western Blot analysis with tyrosinese,tyrosinase-related protein-1(TRP-1),TRP2,and microphthalmia-associated transcription factor(MITF)proteins.To apply the topical agents,citrus-press cakes was investigated the safety in human skin cell line.Finally flavonoid analysis of CCE was also determined by HPLC analysis.Results:Results indicated that CCE were shown to down-regulate melanin content in a dose-dependent pattern.The CCE inhibited tyrosinase,TRP-2,and MITF expressions in a dose-dependent manner.To test the applicability of CCE to human skin,we used MTT assay to assess the cytotoxic effects of CCE on human keratinocyte HaCaT cells.The CCE exhibited low cytotoxicity at 50μg/mL.Characterization of the citrus-press cakes for flavonoid contents using HPLC showed varied quantity of rutin,narirutin,and hesperidin.Conclusions:Considering the anti-melanogenic activity and human safety,CCE is considered as a potential anti-melanogenic agent and may be effective for topical application for treating hyperpigmentation disorders. | Sang Suk Kim Min-Jin Kim Young Hun Choi Byung Kuk Kim Kwang Sik Kim Kyung Jin Park Suk Man Park Nam Ho Lee Chang-Gu Hyun | 2013 | Asian Pacific Journal of Tropical Biomedicine2013，3，8： | 7 |
| 2 | Sensitivity Analysis in Parametrized Convex Vector Optimization显示文摘 | Hun Kuk Tetsuzo Tanino and Masahiro Tanaka | 1996 | Journal of Mathmatical Analysis and Applications1996，202，： | 1 |
| 3 | UV surface modification of waste tire powder: characterization and its influence on the properties of polypropylene/waste powder composites显示文摘 | Shanmugharaja A M Jin Kuk Kimh Sung Hun Ryua | 2005 | Polymer Testing2005，24，6： | 1 |
| 4 | UV Surface Modification of Waste Tire Powder: Characterization and Its Influence on the Properties of Polypropylene/Waste Powder Composites 显示文摘 | Shanmugharaja A M Jin Kuk Kimb Sung Hun Ryua | 2005 | Polymer Testing2005，24，6： | 1 |
| 5 | UV surface modification of waste tire powder:Characterization and its influence on the properties ofpolypropylene/waste powder composites显示文摘 | Shanmugharaja A M Jin Kuk Kimb Sung Hun Ryua | 2005 | Polymer Testing2005，24，6： | 1 |
| 6 | UV surface modification of waste tire powder:Characterization and its influence on the properties of polypropylene /waste powder composites显示文摘 | Shanmugharuja A M Jin Kuk Kimb Sung Hun Ryua | 2005 | Polymer Testing2005，24，6： | 1 |
| 7 | Sensitivity Analysis in Parametrized Convex Vector Optimization显示文摘 | Hun Kuk Tetsuzo Tanino and Masahiro Tanaka | 1996 | Journal of Mathmatical Analysis and Applications1996，，： | 1 |
| 8 | Blue electrophosphorescence from iridium complex covalently bonded to the poly(9-dodecyl-3-vinylcarbazole):Suppressed phase segregation and enhanced energy transfer显示文摘 | Youngmin You Se Hun Kim Ho Kuk Jung | 2006 | Macromolecules2006，39，： | 1 |
| 9 | Modification of rubber surface by UV surface grafting显示文摘 | A M Shanmugharaj Jin Kuk Kim Sung Hun Ryu | 2005 | Applied Surface Science2005，12，： | 1 |
| 10 | Modi- fication of rubber surface by UV surface grafting 显示文摘 | Shanmugharai A M Kim Jin Kuk Ryu Sung Hun | 2006 | Applied Sur- face Science2006，，： | 1 |
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