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| 1 | LncRNAs-directed PTEN enzymatic switch governs epithelial–mesenchymal transition显示文摘Despite the structural conservation of PTEN with dual-specificity phosphatases,there have been no reports regarding the regulatory mechanisms that underlie this potential dual-phosphatase activity.Here,we report that K27-linked polyubiquitination of PTEN at lysines 66 and 80 switches its phosphoinositide/protein tyrosine phosphatase activity to protein serine/threonine phosphatase activity.Mechanistically,high glucose,TGF-β,CTGF,SHH,and IL-6 induce the expression of a long non-coding RNA,GAEA(Glucose Aroused for EMT Activation),which associates with an RNA-binding E3 ligase,MEX3C,and enhances its enzymatic activity,leading to the K27-linked polyubiquitination of PTEN.The MEX3C-catalyzed PTEN^K27-polyUb activates its protein serine/threonine phosphatase activity and inhibits its phosphatidylinositol/protein tyrosine phosphatase activity.With this altered enzymatic activity,PTEN^K27-polyUb dephosphorylates the phosphoserine/threonine residues of TWIST1,SNAI1,and YAP1,leading to accumulation of these master regulators of EMT.Animals with genetic inhibition of PTEN^K27-polyUb,by a single nucleotide mutation generated using CRISPR/Cas9(Pten^K80R/K80R),exhibit inhibition of EMT markers during mammary gland morphogenesis in pregnancy/lactation and during cutaneous wound healing processes.Our findings illustrate an unexpected paradigm in which the lncRNA-dependent switch in PTEN protein serine/threonine phosphatase activity is important for physiological homeostasis and disease development. | Qingsong Hu Chunlai Li Shouyu Wang Yajuan Li Bo Wen Yanyan Zhang Ke Liang Jun Yao Youqiong Ye Heidi Hsiao Tina K.Nguyen Peter K.Park Sergey D.Egranov David H.Hawke Jeffrey R.Marks Leng Han Mien-Chie Hung Bing Zhang Chunru Lin Liuqing Yang | 2019 | Cell Research2019，29，4： | 8 |
| 2 | In-situ oxygen profiling and lignin modification in guts of wood-feeding termites显示文摘 | Jing Ke Jian-Zhong Sun Hung D. Nguyen Deepak Singh Karmen C. Lee Haluk Beyenal Shu-Lin Chen | 2010 | Insect Science2010，17，3： | 5 |
| 3 | Noninferiority clinical trial comparing the bowel cleansing efficacy of sodium phosphate tablets(Quiklean®)with a polyethylene glycol/bisacodyl kit显示文摘BACKGROUND Efficient bowel cleansing is essential for a successful colonoscopy,but the ideal cleansing agent,volume,and pharmaceutical dosage form have yet to be determined.Small-volume cleansers enhance patient compliance.AIM To compare the bowel cleansing efficacy of 32-tablet sodium phosphate(Quiklean®)with 2-L polyethylene glycol(PEG)/bisacodyl(Klean-Prep/Dulcolax®)under identical dietary recommendations.METHODS This multicenter,randomized,parallel-group,noninferiority clinical trial enrolled 472 outpatients,randomized 456 subjects,and scheduled 442 subjects to undergo colonoscopy(Quiklean®=222 and Klean-Prep/Dulcolax®=220).After bowel preparation,a colonoscopist performed the colonoscopy with video recorded for rating.The primary efficacy endpoint was the bowel cleansing quality using the Aronchick Scale.The secondary endpoints were the bowel cleansing efficacy of three colon segments,tolerability and acceptability,safety using the Ottawa bowel preparation scale,questionnaires by subjects,and monitoring of adverse events.RESULTS Success rates(Excellent+Good)of the bowel cleansing quality by Aronchick Scale were 98.6%(n=205)and 97.6%(n=204)in the Quiklean®and Klean-Prep/Dulcolax®groups,respectively.Quiklean®demonstrated noninferiority over Klean-Prep/Dulcolax®in colon cleansing efficacy.Quicken showed better tolerability and acceptability in the overall experience(was rated as excellent;24.0%vs 17.2%;P=0.0016)and the taste of the study preparation(was rated as excellent,23.1%vs 13.4%;P<0.0001)than Klean-Prep/Dulcolax®.Safety profiles did not differ between the two groups.Our data indicate that Quiklean®is an adequate,well-tolerated bowel cleansing preparation compared with the standard comparator Klean-Prep/Dulcolax®.CONCLUSION Quiklean®is sodium phosphate tablets available on Taiwan’s market for bowel preparation;it potentially offers patients an alternative to standard large-volume bowel preparation regimens and may,therefore,increase positive attitudes toward colonoscopies and participation rates. | Shih-Ya Hung Hung-Chang Chen Tao-Wei Ke Jiann-Hwa Chen Koung-Hung Hsiao Hwei-Ming Wang Hua-Che Chiang Sheng-Chi Chang Yi-Chang Chen Ming-Hao Hsieh Yuan-Yao Tsai Yo-Wen Hsieh William Tzu-Liang Chen | 2021 | World Journal of Gastroenterology2021，27，5： | 4 |
| 4 | Protein - Protein Interac- tions in High Moisture - Extruded Meat Analogs and Heat - Induced Soy Protein Gels 显示文摘 | Ke Shun Liu Fu - Hung Hsieh | 2007 | Journal of the American Oil Chemists' Society2007，84，： | 1 |
| 5 | Foreign Investment Strategies and Sub - national Institutions in Emerging Markets: Evidence from Vietnam 显示文摘 | Meyer KE Hung VN | 2005 | Journal of Management Studies2005，42，01： | 1 |
| 6 | Preparation and application of partially porous poly(styrene-divinylbenzene) particles for lipase immobilization 显示文摘 | Hung F C Ke C H Lee W C | 2001 | Jounud of Applied Polymer Science2001，80，1： | 1 |
| 7 | Hydrodynamic focusing for a micromachined flow cytometer显示文摘 | Lee GB Hung CI Ke BJ | 2001 | ASME J Fluids Eng2001，123，3： | 1 |
| 8 | Comprehensive proteome analysis of an Ape mouse model uncovers proteins associated with intestinal tumorigenesis显示文摘 | Hung KE Faea V Song K | 2009 | Cancer Prey Res ( Phila Pa)2009，2，： | 1 |
| 9 | Development of a mouse model for sporadic and metastatic colon tumors and its use in assessing drug treatment 显示文摘 | Hung KE Maricevich MA Richard LG | 2010 | Proc Natl Acad Sci U S A2010，107，4： | 1 |
| 10 | Development of amouse model for sporadic and metastatic colon tumors and its usein assessing drug treatment显示文摘 | Hung KE Maricevich MA Richard LG | 2010 | Proc Natl Acad Sci U S A2010，10，： | 1 |
| 11 | Hydrodynamic Focusing for a Micromachined Flow Cytometer显示文摘 | Lee Gwo-Bin Hung Chen-I Ke Bin-Jo | 2001 | ASME J Fluids Eng2001，123，9： | 1 |
| 12 | Improvement of antioxidant activity of peptides with molecular weights ranging from 1 to 10<ce:hsp sp='0.25'/>kDa by PEF technology显示文摘 | Jia Wang Ke Wang Songyi Lin Ping Zhao Gregory Jones Hung Trang Jingbo Liu Haiqing Ye | 2012 | International Journal of Biological Macromolecules2012，，3： | 1 |
| 13 | Detection of proximal adeno- matous polyps with screening sigmoidoscopy: a systematic review and meta-analysis of screening colonoscopy 显示文摘 | Lewis JD Ng K Hung KE | 2003 | Arch Intern Med2003，163，4： | 1 |
| 14 | Metallothionein 3: An androgen‐upregulated gene enhances cell invasion and tumorigenesis of prostate carcinoma cells显示文摘 | Horng‐Heng Juang Li‐Chuan Chung Hsin‐Ching Sung Tsui‐Hsia Feng Yi‐Hua Lee Phei‐Lang Chang Ke‐Hung Tsui | 2013 | Prostate2013，，14： | 1 |
| 15 | THE EARLY EFFECT OF PELVIC FLOOR MUSCLE EXERCISE AFTER TRANSURETHRAL PROSTATECTOMY显示文摘 | PHEI LANG CHANG LI HUNY TSAI SHIH TSUNG HUANG TA MIN WANG MING LI HSIEH KE HUNG TSUI | 1998 | The Journal of Urology1998，，2： | 1 |
| 16 | Acute multiple sclerosis lesion: conversion of restricted diffusion due to vasogenic edema显示文摘 | Balashov KE hung LL Dhib- Jalbut S | 2011 | J Neuroimaging2011，21，2： | 1 |
| 17 | Comprehensive proteome analysis of an Apc mouse model uncovers proteins associated with intestinal tumorigenesis显示文摘 | Hung KE Faca V Song K | 2009 | Cancer Prey Res (Phila)2009，2，3： | 1 |
| 18 | Hy- drodynamic focusing for a micromachined Now cytome- ters 显示文摘 | LEE Gwo-Bin HUNG Chen-I KE Bin-Jo | 2001 | Journal of Fluids Engineering2001，123，： | 1 |
| 19 | Hydrodynamic focusing for a micromachined flow cytometer 显示文摘 | LEE G B HUNG C I KE B J | 2001 | Trans American Society of Mechanical Engineers J Fluids Engineering2001，123，3： | 1 |
| 20 | Proteomic approaches to Cancer Biomarkers显示文摘 | Hung KE Yu KH | | 0，，01： | 1 |
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