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| 1 | Electroporative interleukin-10 gene transfer ameliorates carbon tetrachlo-ride-induced murine liver fibrosis by MMP and TIMP modulation显示文摘瞄准:肝纤维变性代表响应长期的肝损伤愈合并且结疤的一个过程。为肝纤维变性的有效治疗正在缺乏。Interleukin-10 (IL-10 ) 是 cytokine 下面调整支持 inflammatory 回答并且在肝的纤维发生上有调节效果。这研究的目的是调查 electroporative IL-10 基因治疗是否在老鼠上有肝的 fibrolytic 效果。方法:肝的纤维变性被在老鼠管理四氯化碳(CCl4 ) 10 个星期导致。在肝的纤维变性被建立以后,人的 IL-10 表示原生质标志经由 electroporation 被交付。组织病理学说,反向的抄写聚合酶链反应(RT-PCR ) ,弄污的免疫,和明胶 zymography 被用来调查 IL-10 的行动的可能的机制。结果:人的 IL-10 基因治疗在老鼠颠倒了导致 CCl4 的肝纤维变性。RT-PCR 表明那 IL-10 基因治疗稀释了肝 TGF-beta1,骨胶原 alpha1, fibronectin,和房间粘附分子在规定上面的 mRNA。后面的基因转移,两个都, alpha 光滑的肌肉肌动朊和 cyclooxygenase-2 的激活显著地被稀释。而且, IL-10 显著地禁止了矩阵 metalloproteinase-2 (MMP-2 ) 和矩阵 metalloproteinase (TIMP ) 的织物禁止者在 CCl4 沉醉以后的激活。结论:我们证明那 IL-10 基因治疗在老鼠稀释了导致 CCl4 的肝纤维变性。在调整 fibrogenic 和支持 inflammatory 基因回答上面阻止的 IL-10。它的溶胶原效果可以被归因于 MMP 和 TIMP 调整。IL-10 基因治疗可以是对有潜在的临床的使用的肝纤维变性的一种有效治疗学的形式。 | Wen-ying CHOU Cheng-nan LU Tsung-hsing LEE Chia-ling WU Kung-sheng HUNG Allan M CONCEJERO Bruno JAWAN Cheng-haung WANG | 2006 | Acta Pharmacologica Sinica2006，27，4： | 25 |
| 2 | Insulin resistance is associated with hepatocellular carcinoma in chronic hepatitis C infection显示文摘AIM:To elucidate the role of insulin resistance(IR) and serum adiponectin level in hepatocellular carcinoma(HCC) associated with chronic hepatitis C.METHODS:Clinical and biochemical characteristics were collected from 165 consecutive patients with newly diagnosed HCC.Homeostasis model assessment of IR(HOMA-IR) and serum adiponectin level were investigated in 188 patients with different stages of hepatitis C virus(HCV) infection.RESULTS:Among HCC patients,type 2 diabetics(DM) was more prevalent in HCV subjects(35.6%,n = 59) compared to hepatitis B virus(HBV;12.7%,n = 63) or non-HBV,non-HCV cases(7.1%,n = 28).In patients with chronic hepatitis C,HCC subjects had higher blood sugar(P < 0.001),insulin level(P = 0.003) and HOMAIR(P = 0.018) than those with chronic hepatitis and advanced fibrosis.Age,male sex and body mass index were significantly associated with serum adiponectin level,whereas HOMA-IR was not.Based on stepwise logistic regression analysis,age(OR:1.124,P < 0.001),serum insulin level(OR:1.585,P < 0.001),HOMA-IR(OR:0.495,P = 0.001),DM(OR:11.601,P = 0.002) and male sex(OR:3.877,P = 0.016) were independently associated with HCC.This result was similar even if the diabetic subjects were excluded for analysis.CONCLUSION:Insulin resistance measured by HOMAIR,regardless of the presence of diabetes,is significantly associated with HCC development in patients with chronic HCV infection. | Chao-Hung Hung Jing-Houng Wang Tsung-Hui Hu Chien-Hung Chen Kuo-Chin Chang Yi-Hao Yen YuanHung Kuo Ming-Chao Tsai Chuan-Mo Lee | 2010 | World Journal of Gastroenterology2010，16，18： | 18 |
| 3 | Hepatitis B virus coinfection in human immunodeficiency virus-infected patients: A review显示文摘Hepatitis B virus(HBV)infection is a leading cause of chronic hepatitis,liver cirrhosis,and hepatocellular carcinoma worldwide.Due to the shared modes of transmission,coinfection with HBV and human immunodeficiency virus(HIV)is not uncommon.It is estimatedthat 10%of HIV-infected patients worldwide are coinfected with HBV.In areas where an HBV vaccination program is implemented,the HBV seroprevalence has declined significantly.In HIV/HBV-coinfected patients,HBV coinfection accelerates immunologic and clinical progression of HIV infection and increases the risk of hepatotoxicity when combination antiretroviral therapy(cART)is initiated,while HIV infection increases the risk of hepatitis events,cirrhosis,and end-stage liver disease related to chronic HBV infection.With the advances in antiviral therapy,concurrent,successful longterm suppression of HIV and HBV replication can be achieved in the cART era.To reduce the disease burden of HBV infection among HIV-infected patients,adoption of safe sex practices,avoidance of sharing needles and diluent,HBV vaccination and use of cART containing tenofovir disoproxil fumarate plus emtricitabine or lamivudine are the most effective approaches.However,due to HIV-related immunosuppression,using increased doses of HBV vaccine and novel approaches to HBV vaccination are needed to improve the immunogenicity of HBV vaccine among HIV-infected patients. | Hsin-Yun Sun Wang-Huei Sheng Mao-Song Tsai Kuan-Yeh Lee Sui-Yuan Chang Chien-Ching Hung | 2014 | World Journal of Gastroenterology2014，20，40： | 17 |
| 4 | SARS-CoV-2 infects human neural progenitor cells and brain organoids显示文摘Dear Editor,Coronavirus disease 2019(COVID-19)caused by the novel severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)1 has resulted in over 13 million confirmed cases and more than 580,045 deaths across 218 countries and geographical regions as of July 16,2020.This novel coronavirus primarily causes respiratory illness with clinical manifestations largely resembling those of SARS.However,neurological symptoms including headache,anosmia,ageusia,confusion,seizure,and encephalopathy have also been frequently reported in COVID-19 patients. | Bao-Zhong Zhang Hin Chu Shuo Han Huiping Shuai Jian Deng Ye-fan Hu Hua-rui Gong Andrew Chak-Yiu Lee Zijiao Zou Thomas Yau Wutian Wu Ivan Fan-Ngai Hung Jasper Fuk-Woo Chan Kwok-Yung Yuen Jian-Dong Huang | 2020 | Cell Research2020，30，10： | 8 |
| 5 | Poorly expandable common bile duct with stones on endoscopic retrograde cholangiography显示文摘AIM:To describe characteristics of a poorly expandable(PE) common bile duct(CBD) with stones on endoscopic retrograde cholangiography.METHODS:A PE bile duct was characterized by a rigid and relatively narrowed distal CBD with retrograde dilatation of the non-PE segment.Between 2003 and 2006,endoscopic retrograde cholangiography(ERC) images and chart reviews of 1213 patients with newly diagnosed CBD stones were obtained from the computer database of Therapeutic Endoscopic Center in Chang Gung Memorial Hospital.Patients with characteristic PE bile duct on ERC were identified from the database.Data of the patients as well as the safety and technical success of therapeutic ERC were collected and analyzed retrospectively.RESULTS:A total of 30 patients with CBD stones and characteristic PE segments were enrolled in this study.The median patient age was 45 years(range,20 to 92 years);66.7% of the patients were men.The diameters of the widest non-PE CBD segment,the PE segment,and the largest stone were 14.3 ± 4.9 mm,5.8 ± 1.6 mm,and 11.2 ± 4.7 mm,respectively.The length of the PE segment was 39.7 ± 15.4 mm(range,12.3 mm to 70.9 mm).To remove the CBD stone(s) completely,mechanical lithotripsy was required in 25(83.3%) patients even though the stone size was not as large as were the difficult stones that have been described in the literature.The stone size and stone/PE segment diameter ratio were associated with the need for lithotripsy.Post-ERC complications occurred in 4 cases:pancreatitis in 1,cholangitis in 2,and an impacted Dormia basket with cholangitis in 1.Two(6.7%) of the 28 patients developed recurrent CBD stones at follow-up(50 ± 14 mo) and were successfully managed with therapeutic ERC.CONCLUSION:Patients with a PE duct frequently require mechanical lithotripsy for stones extraction.To retrieve stones successfully and avoid complications,these patients should be identified during ERC. | Chi-Liang Cheng Yung-Kuan Tsou Cheng-Hui Lin Jui-Hsiang Tang hien-Fu Hung Kai-Feng Sung Ching-Song Lee Nai-Jen Liu | 2012 | World Journal of Gastroenterology2012，18，19： | 7 |
| 6 | Characteristics of vertical ozone distribution in the lower troposphere in the Yangtze River Delta at Lin'an in the spring of 2001显示文摘We analyzed vertical distributions of ozone (O3) in the lower troposphere (< 5 km above ground) at Lin’an (119.75°E, 30.30°N), Zhejiang Province using electrochemical concen- tration cell (ECC) ozonesonde data obtained from February 21 to April 13, 2001. The results showed that the vertical O3 distributions are controlled by metrological conditions and the char- acteristics of O3 profiles are related to those of wet bulb potential temperature and wind field. O3 below 2 km showed that the strongest variability and enhanced O3 mixing ratios were associated with easterly winds that blow pollutants from the upwind source region of the Yangtze River Delta (YRD) region. Vertical O3 profiles below 5 km can be grouped into 5 categories: (1) peak mixing ratio type, (2) well-mixed type, (3) layered-structure type, (4) episodic pollution type and (5) alti- tudinal increasing type. Vertical distributions of O3 affected by regional transport of polluted air masses were investigated. Transport of polluted air from high latitudes of northern China, ac- companying subsiding motion of air and stagnant atmospheric conditions are important factors that lead to high mixing ratios of O3 at Lin’an. The stagnant atmospheric conditions associated with a continental high pressure system and pollution plume transported from the YRD and cen- tral-eastern China also lead to regional accumulation of O3 and high O3 mixing ratio at Lin’an. Long-range transport of O3 and pollutants from the Pearl River Delta in South China and in-situ O3 formation also resulted in elevated O3 mixing ratios at around 1 km altitudes and layered O3 distribution in the lower troposphere. | ZHENG Xiangdong1, CHAN Chuenyu2, CUI Hong2, QIN Yu3, CHAN Loyan2, ZHENG Yongguang3 & LEE Yusiang2 1. Chinese Academy of Meteorological Sciences, Beijing 100081, China 2. Department of Civil and Structural Engineering, Hong Kong Polytechnic University, Hung Hom, Hong Kong, China 3. Department of Atmospheric Sciences, Peking University, Beijing 100871, China | 2005 | Science China Earth Sciences2005，48，9： | 6 |
| 7 | Serum hepatitis B surface antigen levels predict treatment response to nucleos(t)ide analogues显示文摘Quantification of hepatitis B surface antigen(HBsAg)has been suggested to be helpful in the management of chronic hepatitis B(CHB)patients.Nucleos(t)ide analogs(NAs)are the therapy of choice for CHB and are used in the majority of CHB patients.NAs are able to induce hepatitis B virus(HBV)viral suppression,normalization of alanine aminotransferase(ALT)levels,and improvement in liver histology.Automated quantitative assays for serum HBsAg have recently become available,facilitating standardized quantification of serum HBsAg.This has led to increased interest in the clinical application of quantitative serum HBsAg for predicting therapeutic response to NAs.Recent studies have shown that a decline in serum HBsAg levels in patients receiving peginterferon may signal successful induction of immune control over HBV,and can therefore be used to predict therapeutic response.NA treatment typically induces a less rapid decline in HBsAg than interferon treatment;it has been estimated that full HBsAg clearance can require decades of NA treatment.However,a rapid HBsAg decline during NA therapy may identify patients who will show clearance of HBsAg.Currently,there is no consensus on the clinical utility of serum HBsAg monitoring for evaluating patient responses to NA therapy.This review focuses on recent findings regarding the potential application of HBsAg quantification in the management of CHB patients receiving NA therapy. | Chien-Hung Chen Yi-Chun Chiu Sheng-Nan Lu Chuan-Mo Lee Jing-Houng Wang Tsung-Hui Hu Chao-Hung Hung | 2014 | World Journal of Gastroenterology2014，20，24： | 6 |
| 8 | In-situ oxygen profiling and lignin modification in guts of wood-feeding termites显示文摘 | Jing Ke Jian-Zhong Sun Hung D. Nguyen Deepak Singh Karmen C. Lee Haluk Beyenal Shu-Lin Chen | 2010 | Insect Science2010，17，3： | 5 |
| 9 | Hepatitis A virus infection and hepatitis A vaccination in human immunodeficiency virus-positive patients: A review显示文摘Hepatitis A virus(HAV)is one of the most common infectious etiologies of acute hepatitis worldwide.The virus is known to be transmitted fecal-orally,resulting in symptoms ranging from asymptomatic infection to fulminant hepatitis.HAV can also be transmitted through oral-anal sex.Residents from regions of low endemicity for HAV infection often remain susceptible in their adulthood.Therefore,clustered HAV infections or outbreaks of acute hepatitis A among men who have sex with men and injecting drug users have been reported in countries of low endemicity for HAV infection.The duration of HAV viremia and stool shedding of HAV may be longer in human immunodeficiency virus(HIV)-positive individuals compared to HIV-negative individuals with acute hepatitis A.Current guidelines recommend HAV vaccination for individuals with increased risks of exposure to HAV(such as from injecting drug use,oral-anal sex,travel to or residence in endemic areas,frequent clotting factor or blood transfusions)or with increased risks of fulminant disease(such as those with chronic hepatitis).The seroconversion rates following the recommended standard adult dosing schedule(2doses of HAVRIX 1440 U or VAQTA 50 U administered6-12 mo apart)are lower among HIV-positive individuals compared to HIV-negative individuals.While the response rates may be augmented by adding a booster dose at week 4 sandwiched between the first dose and the 6-mo dose,the need of booster vaccination remain less clear among HIV-positive individuals who have lost anti-HAV antibodies. | Kuan-Yin Lin Guan-Jhou Chen Yu-Lin Lee Yi-Chia Huang Aristine Cheng Hsin-Yun Sun Sui-Yuan Chang Chun-Eng Liu Chien-Ching Hung | 2017 | World Journal of Gastroenterology2017，23，20： | 5 |
| 10 | Role of modern radiotherapy in managing patients with hepatocellular carcinoma显示文摘Hepatocellular carcinoma(HCC)is the most common type of primary liver cancer.Several treatment options are available for managing HCC patients,classified roughly as local,local-regional,and systemic therapies.The high postmonotherapy recurrence rate of HCC urges the need for the use of combined modalities to increase tumor control and patient survival.Different international guidelines offer treatment recommendations based on different points of view and classification systems.Radiotherapy(RT)is a well-known local-regional treatment modality for managing many types of cancers,including HCC.However,only some of these treatment guidelines include RT,and the role of combined modalities is rarely mentioned.Hence,the present study reviewed clinical evidence for the use of different combined modalities in managing HCC,focusing on modern RT's role.Modern RT has an increased utility in managing HCC patients,mainly due to two driving forces.First,technological advancement(e.g.,stereotactic body radiotherapy and advanced proton-beam therapy)enables precise delivery of radiation to increase tumor control and reduce side effects in the surrounding normal tissue.Second,the boom in developing target therapies and checkpoint-blockade immunotherapy prolongs overall survival in HCC patients,re-emphasizing the importance of local tumor control.Remarkably,RT combines with systemic therapies to generate the systemic therapy augmented by radiotherapy effect,a benefit now being actively investigated. | Liang-Cheng Chen Hon-Yi Lin Shih-Kai Hung Wen-Yen Chiou Moon-Sing Lee | 2021 | World Journal of Gastroenterology2021，27，20： | 5 |
| 11 | Seasonal and geographical distribution of bacillary dysentery(shigellosis)and associated climate risk factors in Kon Tum Province in Vietnam from 1999 to 2013显示文摘Background:Bacillary dysentery(BD)is an acute bacterial infection of the intestine caused by Shigella spp.,with clinical symptoms ranging from fever to bloody diarrhoea to abdominal cramps to tenesmus.In Vietnam,enteric bacterial pathogens are an important cause of diarrhoea and most cases in children under 5 years of age are due to Shigella strains.The serogroups S.flexneri and S.sonnei are considered to be the most common.The main objective of this study was to,for the first time,assess the seasonal patterns and geographic distribution of BD in Vietnam,and to determine the climate risk factors associated with the incidence of BD in Kon Tum Province,where the highest rate of bacillary dysentery was observed from 1999 to 2013.Methods:The seasonal patterns and geographic distribution of BD was assessed in Vietnam using a seasonaltrend decomposition procedure based on loess.In addition,negative binomial regression models were used to determine the climate risk factors associated with the incidence of BD in Kon Tum Province,from 1999 to 2013.Results:Overall,incidence rates of BD have slightly decreased over time(except for an extremely high incidence in 2012 in the north of Vietnam).The central regions(north/south central coast and central highlands)had relatively high incidence rates,whereas the northwest/east and Red River Delta regions had low incidence rates.Overall,seasonal plots showed a high peak in the mid-rainy reason and a second smaller peak in the early or late rainy season.The incidence rates significantly increased between May and October(“wet season”)across the country.In Kon Tum Province,temperature,humidity,and precipitation were found to be positively associated with the incidence of BD.Conclusions:Our findings provide insights into the seasonal patterns and geographic distribution of BD in Vietnam and its associated climate risk factors in Kon Tum Province.This study may help clinicians and the general public to better understand the timings of outbreaks and therefore equip them with the knowledge to plan better interventions(such as improving water,sanitation,and hygiene conditions)during peak seasons.This can,in turn,prevent or reduce outbreaks and onwards transmission during an outbreak. | Hu Suk Lee TTHa Hoang Phuc Pham-Duc Mihye Lee Delia Grace Dac Cam Phung Vu Minh Thuc Hung Nguyen-Viet | 2017 | Infectious Diseases of Poverty2017，6，1： | 5 |
| 12 | Tyrosine 370 phosphorylation of ATM positively regulates DNA damage response显示文摘混乱毛细管扩张变异(ATM ) 调停由控制导致照耀的 foci 形成,房间周期检查点,和 apoptosis 的 DNA 损坏反应。然而,在上游的发信号怎么调整 ATM,完全没被理解。这里,我们证明在照耀刺激之上, ATM 与联系并且在 DNA 双海滨裂缝的地点在 Tyr370 (Y370 ) 是由表皮的生长因素受体(EGFR ) 的 phosphorylated。内长的 EGFR 的弄空损害调停 ATM 的 foci 形成,相应再结合,和 DNA 修理。而且,有一个 EGFR kinase 禁止者, gefitinib,块 EGFR 和 ATM 协会的预告的处理,妨碍 CHK2 激活和随后的 foci 形成,和增加放射敏感度。因此,我们揭示 EGFR 直接在 DNA 损坏反应由调整 ATM 激活的批评机制,并且我们的结果建议 ATM Y370 phosphorylation 的地位有潜力用作 biomarker 成层为独自一个的任何一个放射疗法或在有 EGFR 抑制的联合的病人。 | Hong-Jen Lee Li Lan Guang Peng Wei-Chao Chang Ming-Chuan Hsu Ying-Nai Wang Chien-Chia Cheng Leizhen Wei Satoshi Nakajima Shih-Shin Chang Hsin-Wei Liao Chung-Hsuan Chen Martin Lavin K Kian Ang Shiaw-Yih Lin Mien-Chie Hung | 2015 | Cell Research2015，25，2： | 4 |
| 13 | Identification and Characterization of Tumorigenic Liver Cancer Stem/Progenitor Cells显示文摘 | Stephanie Ma Kwok–Wah Chan Liang Hu Terence Kin–Wah Lee Jana Yim–Hung Wo Irene Oi–Lin Ng Bo–Jian Zheng Xin–Yuan Guan | 2007 | Gastroenterology2007，，7： | 4 |
| 14 | Initial experience in children using conventional laparoscopic instruments in single-incision laparoscopic surgery显示文摘 | Yuk Him Tam Kim Hung Lee Jennifer Dart Yin Sihoe Kin Wai Chan Sing Tak Cheung Kristine Kit Yi Pang | 2010 | Journal of Pediatric Surgery2010，，12： | 4 |
| 15 | Therapeutic effect of Guijiajiao (Colla Carapacis et Plastri) on bone regeneration in rats and zebrafish显示文摘OBJECTIVE:To investigate the effect of Guijiajiao(Colla Carapacis et Plastri, CCP), the glue of tortoise shell, on bone regeneration in zebrafish and male Wistar rats.METHODS: In this study, we applied in vitro and in vivo models, tissue section analysis, and quantitative polymerase chain reaction to assess the effects of CCP on bone repair. MG-63 cells were used in alkaline phosphatase(ALP) activity and mineralization assays. Zebrafish and male Wistar rats were used to evaluate the effects of CCP on bone repair in vivo.RESULTS: A simple preparation of CCP promoted osteogenesis in vivo and in vitro, and promoted MG-63 cell proliferation as well as ALP activity and mineralization. In addition, CCP activated Akt and extracellular signaling-regulated kinase pathways and significantly increased the expression of ossification-related genes and proteins such as runt-related transcription factor-2, osteocalcin, and osteopontin. The in vivo results revealed promotion of osteogenesis by immersing zebrafish in CCP for 72 h.An oral dose of 1.25 g/kg CCP significantly improved skull defects in rats, which was accompanied by an increase in serum ALP levels.CONCLUSION: One of the ingredients of Guilu Erxianjiao(tortoise shell and deer horn formula) pro-vides a practical alternative therapy for bone regeneration. | Su Weiyang Feng Chienwei Tseng Chungchih Hung Hanchun Chen Zhicheng Lee Hsinpai Jean Yenhsuan Wu Shingyi Sean Wen Zhihong | 2018 | Journal of Traditional Chinese Medicine2018，38，2： | 3 |
| 16 | Changes in Serum Levels of HBV DNA and Alanine Aminotransferase Determine Risk for Hepatocellular Carcinoma显示文摘 | Chuen–Fei Chen Wen–Chung Lee Hwai–I. Yang Hung–Chuen Chang Chin–Lan Jen Uchenna H. Iloeje Jun Su Chuhsing K. Hsiao Li–Yu Wang San–Lin You Sheng–Nan Lu Chien–Jen Chen | 2011 | Gastroenterology2011，，4： | 3 |
| 17 | Cystic meconium peritonitis with jejunoileal atresia:Is it associated with unfavorable outcome?显示文摘AIM To compare the outcome between patients with jejunoileal atresia(JIA) associated with cystic meconium peritonitis(CMP) and patients with isolated JIA(JIA without CMP).METHODS A retrospective study was conducted for all neonates with JIA operated in our institute from January 2005 to January 2016.Demographics including the gestation age,sex,birth weight,age at operation,the presence of associated syndrome was recorded.Clinical outcome including the type of operation performed,operative time,the need for reoperation and mortality were studied.The demographics and the outcome between the 2 groups were compared.RESULTS During the study period,53 neonates had JIA underwent operation in our institute.Seventeen neonates(32%) were associated with CMP.There was no statistical difference on the demographics in the two groups.Patients with CMP had earlier operation than patients with isolated JIA(mean 1.4 d vs 3 d,P = 0.038).Primaryanastomosis was performed in 16 patients(94%) with CMP and 30 patients(83%) with isolated JIA(P = 0.269).Patients with CMP had longer operation(mean 190 min vs 154 min,P = 0.004).There were no statistical difference the need for reoperation(3 vs 6,P = 0.606) and mortality(2 vs 1,P = 0.269) between the two groups.CONCLUSION Primary intestinal anastomosis can be performed in94% of patients with JIA associated with CMP.Although patients with CMP had longer operative time,the mortality and reoperation rates were low and were comparable to patients with isolated JIA. | Kin Wai Edwin Chan Kim Hung Lee Hei Yi Vicky Wong Siu Yan Bess Tsui Yuen Shan Wong Kit Yi Kristine Pang Jennifer Wai Cheung Mou Yuk Him Tam | 2017 | World Journal of Clinical Pediatrics2017，6，1： | 3 |
| 18 | Features of Ciguatera Fish Poisoning Cases in Hong Kong 2004-2007显示文摘Objective To review the clinical features and laboratory investigations of ciguatera patients in Hong Kong between 2004 and 2007 in order to show the timely sampling of implicated fish from ciguatera victims and application of validated mouse bioassay for confirming suspected clinical cases of ciguatera. Methods Diagnosis of the ciguatera victims was based on history of coral fish consumption and clinical presentations stated in official guidelines for clinical diagnosis of ciguatera fish poisoning in Hong Kong. Food remnants of coral fish samples were collected swiftly from ciguatera victims between 2004 and 2007 for ciguatoxins (CTXs) analysis. Results Major clinical symptoms in ciguatera patients included gastrointestinal and neurological effects including limb numbness and diarrhoea, which developed at 0.5 to 15 hours after consumption of fish. In most cases, neurological symptoms were more common than gastrointestinal symptoms. A broad range of attack rate (10%-100%) was observed in each ciguatera outbreak. Validated mouse bioassay on ether extracts of the food remnant samples confirmed that all were CTXs-positive (<0.5 – 4.3 MU/20 mg ether extract) and directly linked to the corresponding ciguatera cases. Conclusion Consistency between clinical and laboratory analysis for ciguatera poisoning illustrates the application of laboratory mouse bioassay in a timely fashion for confirming ciguatera poisoning cases and implementing effective public health measures. With further improvement in laboratory techniques, features of ciguatera fish poisoning cases can be better defined. Further studies are needed to determine the risk of each class of CTXs (Pacific-, Indian- and Caribbean-CTXs) in Hong Kong. | CHUN-KWAN WONG PATRICIA HUNG KELLIE L. H. LEE TINA MOK THOMAS CHUNG KAI-MAN KAM | 2008 | Biomedical and Environmental Sciences2008，21，6： | 3 |
| 19 | Entecavir vs. lamivudine in chronic hepatitis B patients with severe acute exacerbation and hepatic decompensation显示文摘 | Chien-Hung Chen Chih-Lang Lin Tsung-Hui Hu Chao-Hung Hung Po-Lin Tseng Jing-Houng Wang Juan-Yu Chang Sheng-Nan Lu Rong-Nan Chien Chuan-Mo Lee | 2014 | Journal of Hepatology2014，，： | 3 |
| 20 | Colonoscopy in Hong Kong Chinese children显示文摘AIM:To investigate the safety and diagnostic yield of colonoscopy in Chinese children in whom the procedure is not often done.METHODS:We conducted a retrospective review of all colonoscopies in consecutive children who underwent their fi rst diagnostic colonoscopy from Jan 2003 to 2008.RESULTS:Seventy-nine children (48 boys,31 girls;mean age 9.2 ± 4.2 years) were identified and reviewed with a total of 82 colonoscopies performed.Successful caecal and ileal intubation rates were 97.6% and 75.6% respectively.Forty patients (50.6%) had a positive diagnosis made in colonoscopy and that included colonic polyps (23),Crohn's disease (12),ulcerative colitis (1),and miscellaneous causes (4).80% of polyps were in the rectosigmoid colon.All but one were juvenile hamartomatous polyps.The exceptionwas an adenomatous polyp.The mean ages for children with inflammatory bowel disease (IBD) and polyps were 11.3 and 4.3 years respectively.There was no procedure-related complication.CONCLUSION:Colonoscopy is a safe procedure in our Chinese children.The increasing diagnosis of IBD in recent decades may reflect a rising incidence of the disease in our children. | Yuk Him Tam Kim Hung Lee Kin Wai Chan Jennifer Dart Yin Sihoe Sing Tak Cheung Jennifer Wai Cheung Mou | 2010 | World Journal of Gastroenterology2010，16，9： | 3 |
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