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| 1 | Scaffold design and fabrication technologies for engineering tissues 显示文摘 | Hutmacher D W | 2001 | J Biomater Sci Polym Edn2001，，12： | 2 |
| 2 | An alginate-based hybrid system for growth factor delivery in the functional repair of large bone defects显示文摘 | Yash M. Kolambkar Kenneth M. Dupont Joel D. Boerckel Nathaniel Huebsch David J. Mooney Dietmar W. Hutmacher Robert E. Guldberg | 2010 | Biomaterials2010，，1： | 2 |
| 3 | Engineering osteoblastic metastases to delineate the adaptive response of androgen-deprived prostate cancer in the bone metastatic microenvironment显示文摘While stromal interactions are essential in cancer adaptation to hormonal therapies,the effects of bone stroma and androgen deprivation on cancer progression in bone are poorly understood.Here,we tissue-engineered and validated an in vitro microtissue model of osteoblastic bone metastases,and used it to study the effects of androgen deprivation in this microenvironment.The model was established by culturing primary human osteoprogenitor cells on melt electrowritten polymer scaffolds,leading to a mineralized osteoblast-derived microtissue containing,in a 3D setting,viable osteoblastic cells,osteocytic cells,and appropriate expression of osteoblast/osteocyte-derived mRNA and proteins,and mineral content.Direct co-culture of androgen receptordependent/ independent cell lines (LNCaP,C4-2B,and PC3) led cancer cells to display functional and molecular features as observed in vivo.Co-cultured cancer cells showed increased affinity to the microtissues,as a function of their bone metastatic potential.Cocultures led to alkaline phosphatase and collagen-I upregulation and sclerostin downregulation,consistent with the clinical marker profile of osteoblastic bone metastases.LNCaP showed a significant adaptive response under androgen deprivation in the microtissues,with the notable appearance of neuroendocrine transdifferentiation features and increased expression of related markers (dopa decarboxylase,enolase 2).Androgen deprivation affected the biology of the metastatic microenvironment with stronger upregulation of androgen receptor,alkaline phosphatase,and dopa decarboxylase,as seen in the transition towards resistance.The unique microtissues engineered here represent a substantial asset to determine the involvement of the human bone microenvironment in prostate cancer progression and response to a therapeutic context in this microenvironment. | Nathalie Bock Ali Shokoohmand Thomas Kryza Joan Rohl Jonelle Meijer Phong A. Tran Colleen C. Nelson Judith A. Clements Dietmar W. Hutmacher | 2019 | Bone Research2019，7，2： | 2 |
| 4 | Individually CAD-CAM technique designed,bioresorbable 3-dimensional polycaprolactone framework for experimental reconstruction of craniofacial defects in the pig显示文摘 | ROHNER D HUTMACHER D W SEE P | 2002 | Mund Kiefer Gesichtschir2002，6，3： | 1 |
| 5 | A tissue engineered cell-occlusive device for hard tissue regeneration--a preliminary report显示文摘 | Hutmacher DW Kirsch A Ackermann KL | | 0，，： | 1 |
| 6 | Fused dep- osition modeling of novel scaffold architectures for tissue engi- neering applieations 显示文摘 | ZEIN I HUTMACHER D W TAN K C | 2002 | Biomaterials2002，23，4： | 1 |
| 7 | Biomatofials offer cancer research the third dimension显示文摘 | Hutmacher DW | 2010 | Nat Mater2010，9，2： | 1 |
| 8 | Individually CAD-CAM technique designed, bioresorbable 3-dimensional polycaprolactone framework for experimental reconstruction of craniofacial defects in the pig显示文摘 | Rohner D Hutmacher DW See P | 2002 | Mund Kiefer Gesichtschir2002，6，3： | 1 |
| 9 | Scaffolds in tissue engineering bone and cartilage显示文摘 | Hutmacher DW | 2000 | Biomaterials2000，21，24： | 1 |
| 10 | The return of a forgotten polymer- Polycaprolactone in the 21st century 显示文摘 | Woodruff/VIA Hutmacher DW | 2010 | Prog Polym Sci2010，35，10： | 1 |
| 11 | Direct writing by way of melt electrospinning显示文摘 | Brown T D Dalton P D Hutmacher D W | 2011 | Advanced Materials2011，23，47： | 1 |
| 12 | Melt electrospinning显示文摘 | Hutmacher D W Dalton P D | 2011 | Chemistry an Asian journal2011，6，1： | 1 |
| 13 | Scaffold based tissue engineering: rationale for computer-aided design and solid free-form fabrication systems显示文摘 | Hutmacher DW Sittinger M Risbud MV | 2004 | Trends Biotechnol2004，22，7： | 1 |
| 14 | The return of a for- gotten polymer-polycaprolactone in the 21 st century 显示文摘 | Woodruff M A Hutmacher D W | 2010 | Progress in Polymer Science2010，35，10： | 1 |
| 15 | Scaffolds in tissue engineering bone and cartilage显示文摘 | Hutmacher DW | | 0，，24： | 1 |
| 16 | Exposure-Response Analysis in Patients With Schizophrenia to Assess the Effect of Asenapine on QTc Prolongation显示文摘 | Sunny Chapel Matt M. Hutmacher George Haig Howard Bockbrader Rik de Greef Sheldon H. Preskorn Richard L. Lalonde | 2009 | Journal of Clinical Pharmacology2009，，： | 1 |
| 17 | Water fertilizer management of processing tomatoes 显示文摘 | PHENE C J HUTMACHER R B DAVIS K R | 1990 | Acta Hort1990，277，： | 1 |
| 18 | Scaffolds in tissue engineering bone and cartilage 显示文摘 | Hutmacher D W | 2000 | Biomaterials2000，，21： | 1 |
| 19 | Water fertilizer management of processing tomatoes 显示文摘 | Phene C J Hutmacher R B Davisk R | 1990 | Acta Hort1990，277，： | 1 |
| 20 | Scaffolds in tissue engineering bone and cartilage 显示文摘 | | 2000 | Biomaterials2000，21，24： | 1 |
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