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| 1 | Effect of TGF-131 antisense oligodeoxynucleotide on renal function in chronic renal failure rats显示文摘目的:学习是调查转变生长因素( TGF )贝它 1 反的有效性的礼品的目的在改善察觉到 oligodeoxynucleotides ( ODN )在有 导致puromycin 的长期的肾衰竭( CRF )的老鼠的败坏的肾功能 .Methods :盐,嘌呤霉素,puromycin+TGF贝它 1 反感觉 ODN 或 puromycin+scrambled ODN 予被以单方地 nephrecto-mized 老鼠。肾的血液动力学、分泌的大小在经历了外科的 procedure.Results 的使麻木的老鼠被拿:在 CRF 老鼠,在肾的血流( RBF )有显著减小,这被观察, glomerular 率( GFR ),严重蛋白尿,并且几乎6褶层在控制老鼠作为与那相比增加了钠( FE Na^+)的部分排泄(所有 P < 0.05 )。在 CRF 老鼠,有 1 反察觉到的 TGF 贝它的处理,然而并非爬的 ODN,显著地稀释了 RBF, GFR,和蛋白尿的减小并且显著地阻止了 FE Na^+ 的增加,这进一步被观察(所有 P < 0.05 ) 。另外,在 CRF 的肾的肥大组织(P < 0.05 对非肾的失败控制) 是有 TGF-1 反感觉 ODN 的显著地稀释的术后疗法(P < 0.05 ) 。焦点的部分肾小球硬化症在未经治疗、爬的对待 ODN 的 CRF 组仅仅是明显的。这研究的有趣的观察在 CRF 老鼠是那,尽管有显著 attenuating 和TGF贝它的预防效果败坏的肾的功能上的 1 反感觉 ODN ,反感觉处理没在TGF贝它的肾的表示引起任何显著变化 1 在蛋白质 level.Conclusion :一起,获得的数据建议 1 反感觉 ODN 拥有的那TGF贝它在 导致puromycin 的长期的肾衰竭的有益的效果并且在形态学的恶化和处于这个病理学的状态的损害肾的功能部分地依赖于TGF贝它的行动 1 在肾以内。 | Law Chung HIONG Kiew Lik VOON Nor Azizan ABDULLAH Munavvar A SATTAR Nazarina Abdul RAHMAN Abdul Hye KHAN4, Edward James JOHNS | 2008 | Acta Pharmacologica Sinica2008，29，4： | 7 |
| 2 | Prognostic implication of isolated tumor cells and micrometastases in regional lymph nodes of gastric cancer显示文摘AIM: To determine the prognostic significance of isolated tumor cells (ITCs) and lymph node micrometastases in gastric cancer.METHODS: Hematoxylin and eosin-stained slides of lymph node dissections of 632 consecutive gastric cancers were reviewed. Cytokeratin immunostaining was performed in 280 node-negative cases and 5 cases indefinite for lymph node metastases. Lymph node metastases were divided into ITC s, micrometastases, or macrometastases, according to the sizes of tumor deposits in largest dimension. ITCs were further classified into four groups according to metastasis pattern.RESULTS: Lymph node metastases were identified by immunostaining in 58 of 280 node-negative cases (20.7%)and were not significantly associated with patient survival (P = 0.3460). After cytokeratin immunostaining, 196 cases were classified as pN1, which consisted of 20 cases with micrometastases detected by immunostaining (pN1mi(i+)),34 cases with only micrometastases (pN1mi), and 142 cases with pN1 with one or more macrometastases (pN1).Cases with pN1mi and pN1mi(i+) had a significantly better prognosis than the cases with pN1 (P = 0.0037). ITCs were found in 38 of these 58 cases, and could be divided into four groups: 12 cases with only a single cell pattern,7 cases with multiple individual cells, 5 cases with single small cluster, and 14 cases with multiple small clusters.Among these four groups, cases with ITCs of multiple individual cell pattern showed the worst survival (median survival: 28 mo, P<0.0001).CONCLUSION: Both size and pattern of lymph node metastases can give prognostic information on the survival of gastric cancer patients. | Hye Seung Lee Min A Kim Han-Kwang Yang Byung Lan Lee Woo Ho Kim | 2005 | World Journal of Gastroenterology2005，11，38： | 5 |
| 3 | Capacity fading of spinel phase LiMn2O4 with cycling显示文摘 | Myong Y S Dong S A Hye R P | 1999 | J Power Sources1999，83，： | 2 |
| 4 | Flexible OLED encapsulated with gas barrier film and adhesive gasket显示文摘 | A Ra Cho Eun Hye Kim Soo Young Park Lee Soon Park | 2014 | Synthetic Metals2014，，： | 2 |
| 5 | Caveolin 1 Expression Correlates with Poor Prognosis and Focal Adhesion Kinase Expression in Gastric Cancer显示文摘 | Nam Kyung Han Lee Byung Lan Park Joo Hyun Kim Jin Han Nayoung Lee Hee Eun Kim Min A Lee Hye Seung Kim Woo Ho | 2012 | Pathobiology2012，，2： | 2 |
| 6 | Cancer-associated fibroblast-derived secreted phosphoprotein 1 contributes to resistance of hepatocellular carcinoma to sorafenib and lenvatinib显示文摘Background:Cancer-associated fibroblasts(CAFs)play an important role in the induction of chemo-resistance.This study aimed to clarify the mechanism underlying CAF-mediated resistance to two tyrosine kinase inhibitors(TKIs),sorafenib and lenvatinib,and to identify a novel therapeutic target for overcoming TKI resistance in hepatocellular carcinoma(HCC).Methods:We performed a systematic integrative analysis of publicly available gene expression datasets and whole-transcriptome sequencing data from 9 pairs of CAFs and para-cancer fibroblasts isolated from human HCC and para-tumor tissues,respectively,to identify key molecules that might induce resistance to TKIs.We then performed in vitro and in vivo experiments to validate selected targets and related mechanisms.The associations of plasma secreted phosphoprotein 1(SPP1)expression levels before sorafenib/lenvatinib treatment with progression-free survival(PFS)and overall survival(OS)of 54 patients with advanced HCC were evaluated using Kaplan-Meier and Cox regression analysis.Results:Bioinformatic analysis identified CAF-derived SPP1 as a candidate molecule driving TKI resistance.SPP1 inhibitors reversed CAF-induced TKI resistance in vitro and in vivo.CAF-derived SPP1 activated rapidly accelerated fibrosarcoma(RAF)/mitogen-activated protein kinase(MAPK)and phosphatidylinositol 3-kinase(PI3K)/protein kinase B(AKT)/mammalian target of rapamycin(mTOR)through the integrin-protein kinase C-alpha(PKCα)signaling pathway and promoted epithelial-to-mesenchymal transition(EMT).A high plasma SPP1 level before TKI treatment was identified as an independent predictor of poor PFS(P=0.026)and OS(P=0.047)in patients with advanced HCC after TKI treatment.Conclusions:CAF-derived SPP1 enhances TKI resistance in HCC via bypass activation of oncogenic signals and EMT promotion.Its inhibition represents a promising therapeutic strategy against TKI resistance inHCC.Moreover,plasma SPP1 level before TKI treatment represents a potential biomarker for treatment response prediction. | JungWoo Eun Jung Hwan Yoon Hye Ri Ahn Seokhwi Kim Young Bae Kim Su Bin Lim Won Park TaeWook Kang Geum Ok Baek Moon Gyeong Yoon Ju A Son Ji HyangWeon Soon Sun Kim Hyo Jung Cho Jae Youn Cheong | 2023 | Cancer Communications2023，43，4： | 2 |
| 7 | Glycogen synthase kinase-3 is increased in white cells early in Alzheimer's disease 显示文摘 | Hye A Kerr F Archer N | 2005 | Neurosci Len2005，373，1： | 1 |
| 8 | New CT response criteria in non-small cell lung cancer: Proposal and application in EGFR tyrosine kinase inhibitor therapy显示文摘 | Ho Yun Lee Kyung Soo Lee Myung-Ju Ahn Hye Sun Hwang Ju Won Lee Keunchil Park Jin Seok Ahn Tae Sung Kim Chin A Yi Myung Jin Chung | 2010 | Lung Cancer2010，，： | 1 |
| 9 | Economic growth, energy consumption, financial development, interna- tional trade and CO2 emissions in Indonesia 显示文摘 | Shahbaz M Hye Q M A Tiwari A K Leito N C | 2013 | Renewable and Sustainable Energy Reviews2013，，25： | 1 |
| 10 | Homocysteine and the risk of isehemie stroke in a triethnie cohort the northern manhattan study 显示文摘 | Ralph L Kishlay A Hye Seung L | 2004 | Stroke2004，35，22： | 1 |
| 11 | White blood cell count and abdominalfat distribution in female obese adolescents 显示文摘 | K1M J A HYE S P | 2008 | Metabolismclinical & Experimental2008，57，10： | 1 |
| 12 | Plasma biomarkers of brain atrophy in Alzheimer's disease显示文摘 | Thambisetty M Simmons A Hye A | | PLoS One0，，： | 1 |
| 13 | Determination of carbamate pesticides by a cholinesterase-based flow injection biosensor显示文摘 | Hye S L Kim Y A Chuang D H | 2001 | International Journal of Food Science and Technology2001，36，： | 1 |
| 14 | Recreational benefits from the dartmoor national park 显示文摘 | C Liston-Heyes A Hyes | 1995 | Journal of Environmental Management1995，，55： | 1 |
| 15 | Recreational benefits from the dartmoornafional park 显示文摘 | C Liston - Heyes A Hyes | 1995 | Journal of Environmental Management1995，，55： | 1 |
| 16 | Mixed lineage kinase 3 connects reac- tive oxygen species to c-Jun NH2-terminal kinase induced mitochondrial apoptosis in genipin- reated PC3 humanprostate cancer cells 显示文摘 | Hye A Byung AB | 2007 | Biochemical and Biophysical Research Communications2007，，362： | 1 |
| 17 | Recreational benefits from the dartmoor national park显示文摘 | C L Heyes A Hyes | 1995 | Journal of Environmental Management1995，，55： | 1 |
| 18 | Glycogen synthase kinase-3 is increased in white cells early in Alzheimer's diseas显示文摘 | Hye A Kerr F Archer N | 2005 | Neurosci Lett2005，373，1： | 1 |
| 19 | Proteome-based plasma biomarkers for Alzheimer′s disease显示文摘 | Hye A Lynham S Thambisetty M | | 0，，11： | 1 |
| 20 | Cisplatin-induced nephrotoxicity causes altered renal hemodynamics in Wistar Kyoto and spontaneously hypertensive rats:role of augmented renal alpha-adrenergic responsiveness显示文摘 | HYE KHAM M A ABDUL SATTAR M ABDULLAH N A | | 0，，3： | 1 |
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