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| 1 | Ethanol extract of Chondracanthus tenellus(Harvey)Hommersand attenuates lipopolysaccharide-induced inflammatory and oxidative response by blocking the NF-κB,MAPKs,and PI3K/Akt signaling pathways显示文摘Objective:To investigate whether the ethanol extract of Chondracanthus tenellus(Harvey)Hommersand,a type of red algae,could exhibit anti-inflammatory potential in lipopolysaccharide(LPS)-stimulated macrophages.Methods:The ethanol extract of Chondracanthus tenellus was applied to 100 ng/mL LPS-stimulated RAW 264.7 cells,and cell viability,phagocytic ability,levels of pro-inflammatory factors,and the production of reactive oxygen species were measured.To identify the underlying mechanism of the ethanol extract of Chondracanthus tenellus,the expression of inflammation-regulated genes was estimated.Results:The ethanol extract of Chondracanthus tenellus had no cytotoxic effect at concentrations below 300μg/mL,and reduced the LPS-induced production of inflammatory mediators including nitric oxide(NO)and prostaglandin E2.Furthermore,the extract markedly suppressed the expression of inducible NO synthase and cyclooxygenase-2,as well as the production of reactive oxygen species.The LPS-induced up-regulation of pro-inflammatory cytokines was attenuated by treatment with the ethanol extract of Chondracanthus tenellus,reducing their extracellular secretion.The Chondracanthus tenellus extract also inhibited LPS-mediated activation of nuclear factor-kappa B(NF-κB).In addition,the phosphorylation of mitogen activated protein kinases(MAPKs)and phosphatidylinositol 3 kinase(PI3K)/Akt was markedly increased by LPS,which was significantly abolished by the Chondracanthus tenellus extract.Conclusions:Our findings indicate that the ethanol extract of Chondracanthus tenellus exhibited potential anti-inflammatory and antioxidant effects through downregulating the NF-κB,MAPKs,and PI3K/Akt signaling pathways in LPS stimulated RAW 264.7 macrophages.tenellus extract.Conclusions:Our findings indicate that the ethanol extract of Chondracanthus tenellus exhibited potential anti-inflammatory and antioxidant effects through downregulating the NF-κB,MAPKs,and PI3K/Akt signaling pathways in LPS stimulated RAW 264.7 macrophages. | Da Hye Kwon Cheol Park Hyesook Lee Su Hyun Hong Gi-Young Kim Hee-Jae Cha Suhkmann Kim Heui-Soo Kim Hye-Jin Hwang Yung Hyun Choi | 2021 | Asian Pacific Journal of Tropical Biomedicine2021，11，10： | 4 |
| 2 | Implications of repeat visitor patterns:The Cheju island case 显示文摘 | SungSoo P JaeHo S HyeSook C (1998) | 1998 | Tourism Analysis1998，，： | 1 |
| 3 | Effect of partial gelatinization and retrogradation on the enzymatic digestion of waxy rice starch显示文摘 | Hyun- Jung Chung Hyesook Son Lim Seung- Talk Lim | 2006 | Journal of Cereal Science2006，43，3： | 1 |
| 4 | Effect of partial gelatinization and retrogradation on the enzymatic di- gestion of waxy rice starch显示文摘 | Hyun-Jung C Hyesook SL Seung-Taik L | 2006 | Journal of Cereal Science2006，43，3： | 1 |
| 5 | Isolation of Sorangium cellulosum carrying epothilone gene clusters显示文摘 | Hyesook H Chung J Kim J | | 0，，8： | 1 |
| 6 | Pasting and rheological behavior of soy protein-based pudding 显示文摘 | Hyesook SLim Ganesan Narsimhan | 2006 | LWT-Food Science and Technology2006，39，4： | 1 |
| 7 | Heavy metal contamination and health risk assessment in the vicinity of the abandoned songcheon Au, Ag mine in Korea显示文摘 | Lim Hyesook Lee Jinsoo Chon Hyotaek | 2008 | Journal of Geochemical Exploration2008，96，23： | 1 |
| 8 | Immunostimulatory effect of ethanol extract of Chondracanthus tenellus in RAW 264.7 macrophages in vitro显示文摘Objective:To investigate whether ethanol extracts of Chondracanthus tenellus(EECT)could improve immunomodulatory property of murine monocyte/macrophage RAW 264.7 cells.Methods:Cell viability,phagocytic ability,and nitric oxide were measured.The levels of prostaglandin E2 and cytokines were determined using enzyme-linked immunosorbent assay kits.Expression of immunoregulatory response protein was detected by Western blotting assay.Results:As the concentration of EECT increased,the morphology of the cells changed to a typical active macrophage shape,and the phagocytic activity increased significantly.EECT also effectively enhanced the production and secretion of immunomodulatory mediators,such as nitric oxide and prostaglandin E2,and cytokines.In addition,compared with the control group,EECT markedly stimulated the expression of Toll-like receptor 4(TLR4)and myeloid differentiation factor 88,one of the TLR4 adapter molecules.Furthermore,EECT promoted the nucleus translocation of nuclear factor-kappa B(NF-κB)by increasing the phosphorylation and degradation of the inhibitor of NF-κB-α,indicating activation of the NF-κB signaling pathway.Meanwhile,similar trends were found in cells treated with lipopolysaccharide as a positive control.Conclusions:Taken together,the results indicate that EECT has an immunomodulatory effect by increasing the production of immunomodulatory mediators and cytokines through activation of the TLR4/NF-κB signaling pathway.EECT could be used as a potential candidate for medication or dietary supplements to increase immune activity. | Cheol Park Da Hye Kwon Hyesook Lee Su Hyun Hong Gi-Young Kim Hee-Jae Cha Do-Hyung Kim Suhkmann Kim Heui-Soo Kim Hye-Jin Hwang Yung Hyun Choi | 2021 | Asian Pacific Journal of Tropical Biomedicine2021，11，6： | 1 |
| 9 | Sei- zure exacerbation and hormonal cycles in women with epilep- sy显示文摘 | Geon Ha Kim Hyang Woon Lee Hyesook Park | 2010 | Epilepsy Res2010，90，3： | 1 |
| 10 | Isolation of Sorangium cellulosum car-rying epothilone gene clusters显示文摘 | Hyesook H Chung J Kim J | | 0，，08： | 1 |
| 11 | Com- bined effects of noise and mixed solvents exposure on the hear- ing function among workers in the aviation industry 显示文摘 | JEONGYOUN K HYESOOK P EUNHEE H A | 2005 | Ind Health2005，43，： | 1 |
| 12 | Survey and proposal on binary search algorithms for longest prefix match显示文摘 | Hyesook Lim Nara Lee | 2012 | IEEE Communications Surveys & Tutorials2012，14，4： | 1 |
| 13 | Individuals with type 2 diabetes and depressive symptoms exhibited lower adherence with self care 显示文摘 | Hyesook Park Youngsun Hong Hye Jin Lee | 2004 | Journal of Clinical Epidemiology2004，57，9： | 1 |
| 14 | On adding Bloom filters to longest prefix matching algorithms 显示文摘 | LIM Hyesook LIM Kyuhee LEE Nara | 2014 | IEEE Transactions on Computers2014，63，2： | 1 |
| 15 | Rhamnetin and Cirsiliol Induce Radiosensitization and Inhibition of Epithelial-Mesenchymal Transition (EMT) by miR-34a-mediated Suppression of Notch-1 Expression in Non-small Cell Lung Cancer Cell Lines显示文摘 | JiHoon Kang EunGi Kim Wanyeon Kim Ki Moon Seong HyeSook Youn Jung Woo Kim Joon Kim BuHyun Youn | 2013 | Journal of Biological Chemistry2013，，： | 1 |
| 16 | Effect of partial gelatinization and retrogradation on the enzymatic digestion of waxy rice starch显示文摘 | Hyun-Jung C Hyesook S L Seung-Taik L | 2006 | Journal of Cereal Science2006，43，： | 1 |
| 17 | Psoralidin, a dual inhibitor of COX-2 and 5-LOX, regulates ionizing radiation (IR)-induced pulmonary inflammation显示文摘 | Hee Jung Yang HyeSook Youn Ki Moon Seong Young Ju Yun Wanyeon Kim Young Ha Kim Ji Young Lee Cha Soon Kim Young-Woo Jin BuHyun Youn | 2011 | Biochemical Pharmacology2011，，5： | 1 |
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