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| 1 | The wonders of BMP9:From mesenchymal stem cell differentiation,angiogenesis,neurogenesis,tumorigenesis,and metabolism to regenerative medicine显示文摘Although bone morphogenetic proteins(BMPs)initially showed effective induction of ectopic bone growth in muscle,it has since been determined that these proteins,as members of the TGF-b superfamily,play a diverse and critical array of biological roles.These roles include regulating skeletal and bone formation,angiogenesis,and development and homeostasis of multiple organ systems.Disruptions of the members of the TGF-b/BMP superfamily result in severe skeletal and extra-skeletal irregularities,suggesting high therapeutic potential from understanding this family of BMP proteins.Although it was once one of the least characterized BMPs,BMP9 has revealed itself to have the highest osteogenic potential across numerous experiments both in vitro and in vivo,with recent studies suggesting that the exceptional potency of BMP9 may result from unique signaling pathways that differentiate it from other BMPs.The effectiveness of BMP9 in inducing bone formation was recently revealed in promising experiments that demonstrated efficacy in the repair of critical sized cranial defects as well as compatibility with bone-inducing bio-implants,revealing the great translational promise of BMP9.Furthermore,emerging evidence indicates that,besides its osteogenic activity,BMP9 exerts a broad range of biological functions,including stem cell differentiation,angiogenesis,neurogenesis,tumorigenesis,and metabolism.This review aims to summarize our current understanding of BMP9 across biology and the body. | Sami Mostafa Mikhail Pakvasa Elam Coalson Allen Zhu Alex Alverdy Hector Castillo Jiaming Fan Alex Li Yixiao Feng Di Wu Elliott Bishop Scott Du Mia Spezia Alissa Li Ofir Hagag Alison Deng Winny Liu Mingyang Li Sherwin S·Ho Aravind Athiviraham Michael J·Lee Jennifer Moriatis Wolf Guillermo A·Ameer Hue H·Luu Rex C·Haydon Jason Strelzow Kelly Hynes Tong-Chuan He Russell R·Reid | 2019 | Genes & Diseases2019，6，3： | 15 |
| 2 | Integrins: Verastility, modulation and signaling in cell adhesion显示文摘 | Hynes R O | 1992 | Cell1992，69，1： | 1 |
| 3 | Out- comes of cataract surgery in children with chronic uveitis显示文摘 | Quinones K Cervantes-Castaneda R A Hynes A Y | 2009 | J Cataract Refract Surg2009，35，4： | 1 |
| 4 | Amphibians and agricultural chemicals:Review of the risks in a cmplex environment 显示文摘 | MANN R M HYNE R V CHOUNG C B | 2009 | Environ Pollut2009，157，11： | 1 |
| 5 | Nephronophthisis: a genetically diverse ciliopathy 显示文摘 | SIMMS R J HYNES A M ELEY L | 2011 | Int J Nephrol2011，2011，52： | 1 |
| 6 | Synergistic effects of L - and P - selectin in facilitating tumor metastasis can involve non - mucin ligands and implicate leukocytes as enhancers of metastasis 显示文摘 | Borsig L Wong R Hynes RO | 2002 | Proc Natl Acad Sci USA2002，99，4： | 1 |
| 7 | Photovoltaie solar cells : an overview of state-of-the-art cell development and environmental issues 显示文摘 | MILES R W HYNES K M FORBES I | 2005 | Progress in Crystal Growth and Characterization of Materials2005，51，13： | 1 |
| 8 | lnlegrins: bidirectional allosteric sigaling machines 显示文摘 | Hynes R | 2002 | Celt2002，110，6： | 1 |
| 9 | Cell adhesion events mediated by alpha 4 integrins are essential in placental and cardiac development显示文摘 | Yang J T Rayburn H Hynes R O | 1995 | Development1995，121，2： | 1 |
| 10 | Amphibians and Agricultural Chemicals: Review of the Risks in a Complex Environment显示文摘 | Mann R M Hyne R V Choung C B | 2009 | Environmental Pollution2009，157，11： | 1 |
| 11 | Photovoltaic solar cells: an overview of state-of-the-art cell development and environmental issues显示文摘 | MILES R W HYNES K M FORBES I | 2005 | Progress in Crystal Growth and Characterization of Materials2005，51，13： | 1 |
| 12 | Trans- formed mammalian cells secrete specific proteins and phosphoprot eins显示文摘 | SENC-ER D R WIRTH D F HYNES R O | 1979 | Cell1979，16，： | 1 |
| 13 | Foliar application of fungal biocontrol agents for the control of white mold of dry beans caused by Sclerotinia sclerotiorum 显示文摘 | Huang H C Bremer E Hynes R K | 2000 | Biological Control2000，18，： | 1 |
| 14 | Multivariate analy-sis of proteolysis patterns differentiated the impact of six strains of probiotic bacteria on a semi-hard cheese显示文摘 | Bergamini C V Hynes E R Candioti M C | | 0，，06： | 1 |
| 15 | Integrinsbidirectional allosteric signaling machines 显示文摘 | Hynes R O | 2002 | Cell2002，110，6： | 1 |
| 16 | Photovoltaic solar ceils: An overview of state of the art cell development and environmental issues显示文摘 | Miles R W Hynes K M Forbes I | 2005 | Prog Crystal Growth Charact Ma- ter2005，51，123： | 1 |
| 17 | Development of highnutrient-dense, low-pollution diets and prediction of aquaculture wastes using biological approaches 显示文摘 | Cho C Y Hynes J D Wood K R | 1994 | Aquaculture1994，124，： | 1 |
| 18 | Shock-tube study of the pyrolysis of the halon replacement molecule CF3CHFCF3显示文摘 | HYNES R G MACKIE J C MASRI A R | 1999 | Journal of Physical Chemistry A1999，103，1： | 1 |
| 19 | Ab initio model study of the mechanism of chlorine nitrate hydrolysis on ice显示文摘 | BIANCO R HYNES J T | 1998 | Phys Chem A1998，102，： | 1 |
| 20 | A novel, tissue-specific integrin subunit, beta nu, expressed in the midgut of Drosophila melonogaster显示文摘 | Yee G H Hynes R O | 1993 | Development1993，118，3： | 1 |
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