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| 1 | Controlling hypoxia-inducible factor-2α is critical for maintaining bone homeostasis in mice显示文摘Pathological bone loss is caused by an imbalance between bone formation and resorption.The bone microenvironments are hypoxic,and hypoxia-inducible factor (HIF) is known to play notable roles in bone remodeling.However,the relevant functions of HIF-2α are not well understood.Here,we have shown that HIF-2α deficiency in mice enhances bone mass through its effects on the differentiation of osteoblasts and osteoclasts.In vitro analyses revealed that HIF-2α inhibits osteoblast differentiation by targeting Twist2 and stimulates RANKL-induced osteoclastogenesis via regulation of Traf6.In addition,HIF-2α appears to contribute to the crosstalk between osteoblasts and osteoclasts by directly targeting RANKL in osteoprogenitor cells.Experiments performed with osteoblast- and osteoclast-specific conditional knockout mice supported a role of HIF-2α in this crosstalk.HIF-2α deficiency alleviated ovariectomy-induced bone loss in mice,and specific inhibition of HIF-2α with ZINC04179524 significantly blocked RANKLmediated osteoclastogenesis.Collectively,our results suggest that HIF-2α functions as a catabolic regulator in bone remodeling,which is critical for the maintenance of bone homeostasis. | Sun Young Lee Ka Hyon Park Hyung-Gu Yu Eunbyul Kook Won-Hyun Song Gyuseok Lee Jeong-Tae Koh Hong-In Shin Je-Yong Choi Yun Hyun Huh Je-Hwang Ryu | 2019 | Bone Research2019，7，2： | 5 |
| 2 | 微波辐射辅助柠檬酸络合法制备的Ho^(3+)/Tm^(3+)/Yb^(3+)共掺杂CaWO_4的白光性能(英文)显示文摘采用微波辐射辅助柠檬酸络合法制备Ho3+/Tm3+/Yb3+共掺杂CaWO4纳米晶升频转换荧光粉。将柠檬酸络合物前驱体在300~700°C热处理3 h。Ho3+/Tm3+/Yb3+共掺杂CaWO4C在400°C时开始结晶,在600°C时结晶完成。经600°C热处理的Ho3+/Tm3+/Yb3+共掺杂CaWO4主要呈球形,且形态均匀。在980 nm的激光激发下,Ho3+/Tm3+/Yb3+共掺杂CaWO4纳米晶出现肉眼可见的明亮的白色升频转换发射,这种现象来自Tm3+的475 nm蓝光发射以及Ho3+的543 nm绿光和651 nm红光发射。通过调整Tm3+和Ho3+的浓度可以控制Ho3+/Tm3+/Yb3+共掺杂CaWO4的CIE色度图从冷到暖白色之间变化。讨论了Tm3+和Ho3+浓度对升频转换光性能的影响以及与激光泵功率相关的影响机制。 | Hyun CHO Seok Min HWANG Jae Bin LEE Dong Hyun KA Tae Wan KIM Bo Seul LEE Ji Young LEE Jung-Il LEE Jeong Ho RYU | 2014 | Transactions of Nonferrous Metals Society of China2014，24，S1： | 2 |
| 3 | Role of dorsomedial hypothalamic neuropeptide Y in modulating food intake and energy balance显示文摘 | YANG L Scott KA Hyun J | 2009 | 1 Neurosci2009，29，17： | 1 |
| 4 | Phylogenetic relationships of Korean Sparassis latifolia based on morphological and ITS rDNA characteristics显示文摘 | Rhim Ryoo Hong-Duck Sou Kang-Hyeon Ka Hyun Park | 2013 | Journal of Microbiology2013，，1： | 1 |
| 5 | Association between bacterial vaginosis and cervical intraepithelial neoplasia 显示文摘 | Ka Hyun Nam Young Tae Kim Soo Rim Kim | 2009 | J Gynecol Oncol2009，20，1： | 1 |
| 6 | Dynamic changes of soil physicochemical properites in the fairy - rings of Tricholoma matsutake 显示文摘 | Hur Tae Chul Park Hyun Ka ng Hyeon Joo Sung Hyun | 2004 | Journal of Korean Forestry Society2004，93，1： | 1 |
| 7 | Running wheel aetivity prevents hyperphagia and obesity in otsuka long-evans tokushima fatty rats : role of hypothalamic signaling 显示文摘 | Bi S Scott KA Hyun J el al | 2005 | Endocrinology2005，146，4： | 1 |
| 8 | Continuous labeling of circu- lating tumor cells with microbeads using a vortex micromixer for highly selective isolation 显示文摘 | Lin MX Hyun KA Moon HS | 2013 | Biosensors and Bioelectronics2013，40，1： | 1 |
| 9 | Effect of overexpression of Bcl-2 on cellular oxidative damage, nitric oxide production, antioxidant defenses, and the proteasome显示文摘 | Lee M Hyun DH Marshall KA | 2001 | Free Radic Biol Med2001，31，12： | 1 |
| 10 | Running wheel activity prevents hyperphagia and obesity in otsuka long-evans tokushima fatty rats : Role of hypothalamic signaling显示文摘 | Bi S Scott KA Hyun J | 2005 | Endocrinology2005，146，4： | 1 |
| 11 | Microfluidic flow fractionation device for label-free isolation of circulating tumor cells (CTCs) from breast cancer patients显示文摘 | Hyun KA Kwon K Han H | 2013 | Biosensors and Bioelectronics2013，40，1： | 1 |
| 12 | Negative enrichment of circulating tumor cells using a geometrically activated surface interaction chip显示文摘 | Hyun KA Lee TY Jung HI | 2013 | Anal Chem2013，85，9： | 1 |
| 13 | Association be-tween bacterial vaginosis and cervical intraepithelial neoplasia 显示文摘 | Ka Hyun Nam Young Tae Kim Soo Rim Kim | 2009 | J Gynecol 0ncol2009，20，1： | 1 |
| 14 | Effect of overexpression of Bcl-2 on cellular oxidative damage,nitric oxide production,antioxidant defenses,and the proteasome显示文摘 | Lee M Hyun DH Marshall KA | 2001 | Free Radic Biol Med2001，31，12： | 1 |
| 15 | Running wheel activity pre- vents hyperphagia and obesity in Otsuka long-evans Tokushima Fatty rats: role of hypothalamic signaling 显示文摘 | BI S SCOTT KA HYUN J | 2005 | Endocrinology2005，146，4： | 1 |
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