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| 1 | Intraoperative radiofrequency ablation with or without tumorectomy for hepatocellular carcinoma in locations difficult for a percutaneous approach显示文摘BACKGROUND:Although hepatic resection is widely accepted as a proper modality for treating hepatocellular carcinoma(HCC),a majority of patients are unable to undergo surgical resection due to various tumor and patient factors.Radiofrequency ablation(RFA)has mostly been used as a therapeutic alternative to resection for treating HCC.The objective of this study was to evaluate the results of intraoperative RFA for HCCs in locations difficult for a percutaneous approach.METHODS:Eight patients(male,seven;age,49-67 years) with 8 HCCs in difficult locations were treated by intraoperative RFA.Six of the patients had local tumor progression after initial transarterial chemoembolization or ultrasound(US)guided percutaneous RFA.The locations of the tumors were hepatic dome in six patients,posterior subcapsule in one,and caudate lobe in one.The tumor size was 2.0 to 6.4 cm(mean,3.9 cm).Intraoperative RFA was performed at the tumor itself and an anticipated resection line under US guidance with 3 cm monopolar single or clustered internally cooled electrodes.Tumor resection was performed in six patients.One month later,treatment response was assessed by contrast material-enhanced computed tomography(CT).CT studies were performed every 2 or 3 months after RFA.RESULTS:RFA was technically successful in all tumors,and the contrast-enhanced CT images acquired one month later showed complete disappearance of tumor enhancement.One pneumothorax occurred.After a median follow-up of 18 months(range,6-30 months),no tumors showed local progression.During the follow-up period,four new recurrent tumors were observed in three patients.Four patients were alive at the time of this report and the other four died of hepatorenal syndrome,liver failure,and progression of new recurrent tumors.CONCLUSION:Intraoperative RFA with tumor resection can be an alterative treatment option for HCC in locations difficult for a percutaneous approach. | Hyung Ook Kim Seung Kwon Kim Byung Ho Son Chang Hak Yoo Hyun Pyo Hong Yong Kyun Cho Byung Ik Kim | 2009 | Hepatobiliary & Pancreatic Diseases International2009，8，6： | 9 |
| 2 | New antireflux self‐expandable metal stent for malignant lower biliary obstruction: In vitro and in vivo preliminary study显示文摘 | Dong Uk Kim Chang‐Il Kwon Dae Hwan Kang Kwang Hyun Ko Sung Pyo Hong | 2012 | Digestive Endoscopy2012，，1： | 2 |
| 3 | Adding adefovir vs. switching to entecavir for lamivudine‐resistant chronic hepatitis B ( ACE study): a 2‐year follow‐up randomized controlled trial显示文摘 | Hyung Joon Yim Yeon Seok Seo Eileen L. Yoon Chang Wook Kim Chang Don Lee Sang Hoon Park Myung Seok Lee Choong Kee Park Hee Bok Chae Moon Young Kim Soon Koo Baik Yun Soo Kim Ju Hyun Kim Jung Il Lee Jin Woo Lee Sun Pyo Hong Soon Ho Um | 2013 | Liver Int2013，，2： | 2 |
| 4 | Adefovir and Lamivudine Combination Therapy in Patients with Entecavir-Resistant Chronic Hepatitis B: Antiviral Responses and Evolution of Mutations显示文摘 | Yim Hyung Joon Lee Hyun Jung Suh Sang Jun Seo Yeon Seok Kim Chang Wook Lee Chang Don Park Sang Hoon Lee Myung Seok Park Choong Kee Chae Hee Bok Kim Moon Young Baik Soon Koo Kim Yun Soo Kim Ju Hyun Lee Jung Il Lee Jin Woo Hong Sun Pyo Um | 2014 | Intervirology2014，，5： | 1 |
| 5 | Defect-Detection Model for Underground Parking Lots Using Image Object-Detection Method显示文摘The demand for defect diagnoses is gradually gaining ground owing to the growing necessity to implement safe inspection methods to ensure the durability and quality of structures.However,conventional manpower-based inspection methods not only incur considerable cost and time,but also cause frequent disputes regarding defects owing to poor inspections.Therefore,the demand for an effective and efficient defect-diagnosis model for concrete structures is imminent,as the reduction in maintenance costs is significant from a long-term perspective.Thus,this paper proposes a deep learning-based image objectidentification method to detect the defects of paint peeling,leakage peeling,and leakage traces that mostly occur in underground parking lots made of concrete structures.The deep learning-based object-detection method can replace conventional visual inspection methods.A faster region-based convolutional neural network(R-CNN)model was used with a training dataset of 6,281 images that utilized a region proposal network to objectively localize the regions of interest and detect the surface defects.The defects were classified according to their type,and the learning of each exclusive model was ensured through test sets obtained from real underground parking lots.As a result,average precision scores of 37.76%,36.42%,and 61.29%were obtained for paint peeling,leakage peeling,and leakage trace defects,respectively.Thus,this study verified the performance of the faster RCNN-based defect-detection algorithm along with its applicability to underground parking lots. | Hyun Kyu Shin Si Woon Lee Goo Pyo Hong Lee Sael Sang Hyo Lee Ha Young Kim | 2021 | Computers, Materials & Continua2021，，3： | 1 |
| 6 | Oxide properties and stress corrosion cracking behaviour for Alloy 600 in leaded caustic solutions at high temperature显示文摘 | Dong-Jin Kim Hyuk Chul Kwon Hyun Wook Kim Seong Sik Hwang Hong Pyo Kim | 2010 | Corrosion Science2010，，4： | 1 |
| 7 | A comparative study of volumetric analysis, histopathologic downstaging, and tumor regression grade in evaluating tumor response in locally advanced rectal cancer following preoperative chemoradiation显示文摘 | Nam Kyu Kim Seung Hyuk Baik Byung Soh Min Hong Ryull Pyo Yun Jung Choi Hogeun Kim Jinsil Seong Ki Chang Keum Sun Young Rha Hyun Cheol Chung | 2007 | International Journal of Radiation Oncology Biology Physics2007，，1： | 1 |
| 8 | Gastrointestinal Stromal Tumor of the Rectum: An Analysis of Seven Cases显示文摘 | Seung Hyuk Baik Nam Kyu Kim Chung Ho Lee Kang Young Lee Seung Kook Sohn Chang Hwan Cho Hoguen Kim Hong Ryull Pyo Sun Young Rha Hyun Cheol Chung | 2007 | Surgery Today2007，，6： | 1 |
| 9 | Promoter polymorphisms of pri - miR-34b/c are associated with hepatocellular carcinoma显示文摘 | Myung Su Son Moon Ju Jang Young Joo Jeon Won Hee Kim Chang-Il Kwon Kwang Hyun Ko Pil Won Park Sung Pyo Hong Kyu Sung Rim Sung Won Kwon Seong Gyu Hwang Nam Keun Kim | 2013 | Gene2013，，2： | 1 |
| 10 | Bio-sheet graft therapy for artificial gastric ulcer after endoscopic submucosal dissection: an animal feasibility study显示文摘 | Chang-Il Kwon Gwangil Kim Kwang Hyun Ko Yunho Jung Il-Kwun Chung Seok Jeong Don Haeng Lee Sung Pyo Hong Ki Baik Hahm | 2014 | Gastrointestinal Endoscopy2014，，： | 1 |
| 11 | Anti-inflammatory effects of schisandrin isolated from the fruit of Schisandra chinensis Baill显示文摘 | Lian Yu Guo Tran Manh Hung Ki Hwan Bae Eun Myoung Shin Hong Yu Zhou Yoo Na Hong Sam Sik Kang Hyun Pyo Kim Yeong Shik Kim | 2008 | European Journal of Pharmacology2008，，1： | 1 |
| 12 | Effect of music on colonoscopy performance: A propensity scorematched analysis显示文摘BACKGROUND Music has been used to reduce stress and improve task performance during medical therapy.AIM To assess the effects of music on colonoscopy performance outcomes.METHODS We retrospectively reviewed patients who underwent colonoscopy performed by four endoscopists with popular music.Colonoscopy performance outcomes,such as insertion time,adenoma detection rate(ADR),and polyp detection rate(PDR),were compared between the music and non-music groups.To reduce selection bias,propensity score matching was used.RESULTS After one-to-one propensity score matching,169 colonoscopies were selected from each group.No significant differences in insertion time(4.97 vs 5.17 min,P=0.795)and ADR(39.1%vs 46.2%,P=0.226)were found between the two groups.Subgroup analysis showed that the insertion time(3.6 vs 3.8 min,P=0.852)and ADR(51.1%vs 44.7%,P=0.488)did not significantly differ between the two groups in experts.However,in trainees,PDR(46.9%vs 66.7%,P=0.016)and ADR(25.9%vs 47.6%,P=0.006)were significantly lower in the music than in the nonmusic group.CONCLUSION The current study found that listening to music during colonoscopy did not affect procedure performance.Moreover,it suggested that music may distract trainees from appropriately detecting adenomas and polyps. | Eun Jeong Choi Sam Ryong Jee Sang Heon Lee Jun Sik Yoon Seung Jung Yu Jong Hyun Lee Han Byul Lee Sang Wook Yi Myeong Pyo Kim Byung Cheol Chung Hong Sub Lee | 2023 | World Journal of Gastrointestinal Endoscopy2023，15，5： | 0 |
| 13 | Curvature range measurements of the arcuate fasciculus using diffusion tensor tractography显示文摘Because Broca's area and Wernicke's area in the brain are connected by the arcuate fasciculus, understanding the anatomical location and morphometry of the arcuate fasciculus can help in the treatment of patients with aphasia. We measured the horizontal and vertical curvature ranges of the arcuate fasciculus in both hemispheres in 12 healthy subjects using diffusion tensor tractography. In the right hemisphere, the direct curvature range and indirect curvature range values of the arcuate fasciculus horizontal part were 121.13 ± 5.89 and 25.99 ± 3.01 degrees, respectively, and in the left hemisphere, the values were 121.83 ± 5.33 and 27.40 ± 2.96 degrees, respectively. In the right hemisphere, the direct curvature range and indirect curvature range values of the arcuate fasciculus vertical part were 43.97 ± 7.98 and 30.15 ± 3.82 degrees, respectively, and in the left hemisphere, the values were 39.39 ± 4.42 and 24.08 ± 4.34 degrees, respectively. We believe that the measured curvature ranges are important data for localization and quantitative assessment of specific neuronal pathways in patients presenting with arcuate fasciculus abnormalities. | Dong Hoon Lee Cheol Pyo Hong Yong Hyun Kwon Yoon Tae Hwang Joong Hwi Kim Ji Won Park | 2013 | Neural Regeneration Research2013，8，3： | 0 |
| 14 | Bulk-Si photonics technology for DRAM interface[Invited]显示文摘We present photonics technology based on a bulk-Si substrate for cost-sensitive dynamic random-access memory(DRAM)optical interface application.We summarize the progress on passive and active photonic devices using a local-crystallized Si waveguide fabricated by solid phase epitaxy or laser-induced epitaxial growth on bulk-Si substrate.The process of integration of a photonic integrated circuit(IC)with an electronic IC is demonstrated using a 65 nm DRAM periphery process on 300 mm wafers to prove the possibility of seamless integration with various complementary metal-oxide-semiconductor devices.Using the bulk-Si photonic devices,we show the feasibility of high-speed multidrop interface:the Mach–Zehnder interferometer modulators and commercial photodetectors are used to demonstrate four-drop link operation at 10 Gb∕s,and the transceiver chips with photonic die and electronic die work for the DDR3 DRAM interface at 1.6 Gb∕s under a 1∶4 multidrop configuration. | Hyunil Byun Jinkwon Bok Kwansik Cho Keunyeong Cho Hanmei Choi Jinyong Choi Sanghun Choi Sangdeuk Han Seokyong Hong Seokhun Hyun TJJeong Ho-Chul Ji In-Sung Joe Beomseok Kim Donghyun Kim Junghye Kim Jeong-Kyoum Kim Kiho Kim Seong-Gu Kim Duanhua Kong Bongjin Kuh Hyuckjoon Kwon Beomsuk Lee Hocheol Lee Kwanghyun Lee Shinyoung Lee Kyoungwon Na Jeongsik Nam Amir Nejadmalayeri Yongsang Park Sunil Parmar Junghyung Pyo Dongjae Shin Joonghan Shin Yong-hwack Shin Sung-Dong Suh Honggoo Yoon Yoondong Park Junghwan Choi Kyoung-Ho Ha Gitae Jeong | 2014 | Photonics Research2014，2，3： | 0 |
| 15 | A novel IRAK4/PIM1 inhibitor ameliorates rheumatoid arthritis and lymphoid malignancy by blocking the TLR/MYD88-mediated NF-κB pathway显示文摘Interleukin-1 receptor-associated kinase 4(IRAK4)is a pivotal enzyme in the Toll-like receptor(TLR)/MYD88 dependent signaling pathway,which is highly activated in rheumatoid arthritis tissues and activated B cell-like diffuse large B-cell lymphoma(ABC-DLBCL).Inflammatory responses followed by IRAK4 activation promote B-cell proliferation and aggressiveness of lymphoma.Moreover,proviral integration site for Moloney murine leukemia virus 1(PIM1)functions as an anti-apoptotic kinase in propagation of ABC-DLBCL with ibrutinib resistance.We developed a dual IRAK4/PIM1 inhibitor KIC-0101 that potently suppresses the NF-κB pathway and proinflammatory cytokine induction in vitro and in vivo.In rheumatoid arthritis mouse models,treatment with KIC-0101 significantly ameliorated cartilage damage and inflammation.KIC-0101 inhibited the nuclear translocation of NF-κB and activation of JAK/STAT pathway in ABC-DLBCLs.In addition,KIC-0101 exhibited an anti-tumor effect on ibrutinib-resistant cells by synergistic dual suppression of TLR/MYD88-mediated NF-κB pathway and PIM1 kinase.Our results suggest that KIC-0101 is a promising drug candidate for autoimmune diseases and ibrutinib-resistant B-cell lymphomas. | Sae-Bom Yoon Hyowon Hong Hee-Jong Lim Ji Hye Choi Yoon Pyo Choi Seong Wook Seo Hyuk Woo Lee Chong Hak Chae Woo-Kyu Park Hyun Young Kim Daeyoung Jeong Tran Quang De Chang-Seon Myung Heeyeong Cho | 2023 | Acta Pharmaceutica Sinica B2023，13，3： | 0 |
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