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| 1 | Inhibition of the B7-H3 immune checkpoint limits tumor growth by enhancing cytotoxic lymphocyte function显示文摘在肿瘤和免疫系统之间的相互作用仍然糟糕被理解。重要临床的回答在对 CTLA4 和 PD-1/PD-L1 检查点与抗体对待的癌症病人被完成了;然而,仅仅病人的小部分对治疗作出回应,显示需要探索为癌症治疗的另外的 co 禁止的分子。B7-H3, B7 总科的一个成员,被我们以前显示出禁止 T 房间激活和 autoimmunity。在这研究,我们在肿瘤免疫分析了 B7-H3 的功能。B7-H3 的表示在多重肿瘤线,渗入肿瘤的树枝状的房间,和巨噬细胞被发现。与对抗抗体对待到 B7-H3 的 B7-H3-deficient 老鼠或老鼠显示出多重肿瘤的减少的生长,它取决于 NK 和 CD8 + T 房间。与细胞毒素的淋巴细胞表示的通常认为的受体, B7-H3 禁止了他们的激活,并且它的缺乏在忍受肿瘤的鼠标导致了增加的细胞毒素的淋巴细胞功能。B7-H3 和 PD-1 的联合封锁导致了迟了阶段的肿瘤的进一步提高的治疗学的控制。一起拿,我们的结果显示 B7-H3 检查点可以对癌症为免疫疗法用作一个新奇目标。 | Young-hee Lee Natalia Martin-Orozco Peilin Zheng Jing Li Peng Zhang Haidong Tan Hyun Jung Park Mira Jeong Seon Hee Chang Byung-Seok Kim Wei Xiong Wenjuan Zang Li Guo Yang Liu Zhong-jun Dong Willem W Overwijk Patrick Hwu Qing Yi Larry Kwak Zhiying Yang Tak W Mak Wei-Li Laszlo G Radvanyi Ling Ni Dongfang Liu Chen Dong | 2017 | Cell Research2017，27，8： | 29 |
| 2 | Pathological characterization and molecular analysis of Elsinoe iso lates causing scab diseases of citrus in jeju island in korea显示文摘 | Hyun J W Timmer L W Lee S C | 2001 | Plant disease2001，85，9： | 1 |
| 3 | Evaluation of recovery characteristic of acidic and alkaline solutions from NaNO3 using conventional eleetrodialysis and eleetrodialysis with bipolar membranes显示文摘 | KIM K W HYUN J T LEE K Y | 2013 | Korean Journal of Chemical Engineering2013，30，9： | 1 |
| 4 | Trapdoor security in a search- able public-key encryption scheme with a designated tester显示文摘 | Hyun S R Jong H P Susilo W | 2010 | Jour- nal of Systems and Software2010，83，5： | 1 |
| 5 | Flue gas treatment using pulsed corona discharge generated by magnetic pulse compression modulator 显示文摘 | MOK Y S LEE H W HYUN Y J | 2001 | Journal of Electrostatics2001，53，3： | 1 |
| 6 | A novel control method for three-phase PWM rectifiers using a single current sen- sor显示文摘 | LEE W C HYUN D S LEE T K | 2000 | IEEE Transactions on Power Electronics2000，15，5： | 1 |
| 7 | Synthesis and electrochemical characteristics of Al2O3-coated LiNi1/3Co1/3Mn1/3O2 cathode materials for lithium ion batteries显示文摘 | Youngsik Kima Hyun Soo Kimb Steve Martin W | | 0，，03： | 1 |
| 8 | Source identification of nitrate on Cheju Island, South Korea 显示文摘 | Spalding R F U Z K Hyun S W | 2001 | Nutrient Cycling in Agroecosystems2001，61，3： | 1 |
| 9 | A Genetic Algoritm-based Heuristic for the Dynamic Integrated Forward/Reverse Logistics Network for 3 PLs 显示文摘 | Hyun H J Evans G W | 2007 | Computers & Operations Research2007，24，2： | 1 |
| 10 | Comparison of singlesensor current control in the DC link for three phase voltage-source PWM converters显示文摘 | LEE W C LEE T K HYUN D S | 2001 | IEEE Transactions on Industrial Electronics2001，48，3： | 1 |
| 11 | Evomonoside:the cytotoxic cardiac glycoside from Lepidium apetalum显示文摘 | Hyun J W Shin J E Lim K H | | 0，，03： | 1 |
| 12 | An electronic nose system to diagnose illness 显示文摘 | JULIAN W GARDNER J HYUN W | 2000 | Sens Actuators B2000，，19： | 1 |
| 13 | Antitumor components of Agrocybe cylindracea显示文摘 | HYUN N JIN W CHAE K K | 1996 | Actives of Pharmacal Research1996，19，3： | 1 |
| 14 | Synthesis and characterization of tin oxide/carbon aerogel composite electrodes for electrochemical supercapacitors显示文摘 | Hwang S W Hyun S H | 2007 | J Power Sources2007，172，： | 1 |
| 15 | A genetic algorithm-based heuristic for the dynamic integrated forward/reverse logistics network for 3PLs显示文摘 | Hyun Jeung Ko Gerald W Evans | 2007 | Computers & Operations Research2007，34，： | 1 |
| 16 | Antitumor components of Agrocybe cylindracea 显示文摘 | HYUN J W KIM C K PARK S H | 1996 | Arch Pharm Res1996，19，3： | 1 |
| 17 | A simplified subspace fitting method for estimating shape of a towed array显示文摘 | Hee Y P Ki M K Hyun W K | 2008 | IEEE J Ocean Eng2008，33，2： | 1 |
| 18 | Production of ribonucleotides by autolysis of pichiaanomala mutant and some physiological activities 显示文摘 | LEE J S HYUN K W JEONG S C | 2004 | Can J Microbiol2004，50，7： | 1 |
| 19 | Effects of Opuntia ficus-indica var Saboten stem on gastric damages in rats显示文摘 | E B Lee J E Hyun D W Li Y I Moon | 2002 | Arch Pharm Res2002，25，： | 1 |
| 20 | A genetic algorithm-based heuristic for the dynamic integrated forward/reverse logistics network for 3PLs显示文摘 | HYUN JEUNG K EVANS G W | 2007 | Computers & Operations Research2007，34，2： | 1 |
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