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| 1 | Ever-increasing diversity of drug-induced pancreatitis显示文摘With over 100000 hospital admissions per annum,acute pancreatitis remains the leading gastrointestinal cause of hospitalization in the United States and has farreaching impact well beyond.It has become increasingly recognized that druginduced pancreatitis(DIP),despite accounting for less than 3%of all cases,represents an important and growing though often inconspicuous cause of acute pancreatitis.Nevertheless,knowledge of DIP is often curtailed by the limited availability of evidence needed to implicate given agents,especially for nonprescription medications.Indeed,the majority of available data is derived from case reports,case series,or case control studies.Furthermore,the mechanism of injury and causality for many of these drugs remain elusive as a definitive correlation is generally not established(<10%of cases).Several classification systems have been proposed,but no single system has been widely adopted,and periodic updates are required in light of ongoing pharmacologic expansion.Moreover,infrequently prescribed medications or those available over-thecounter(including herbal and other alternative remedies)are often overlooked as a potential culprit of acute pancreatitis.Herein,we review the ever-increasing diversity of DIP and the potential mechanisms of injury with the goal of raising awareness regarding the nature and magnitude of this entity.We believe this manuscript will aid in increasing both primary and secondary prevention of DIP,thus ultimately facilitating more expedient diagnosis and a decrease in DIPrelated morbidity. | Simcha Weissman Muhammad Aziz Ryan B Perumpail Tej I Mehta Rutwik Patel James H Tabibian | 2020 | World Journal of Gastroenterology2020，26，22： | 8 |
| 2 | Impact of gut microbiome in the development and treatment of pancreatic cancer:Newer insights显示文摘The gut microbiome plays an important role in the variation of pharmacologic response.This aspect is especially important in the era of precision medicine,where understanding how and to what extent the gut microbiome interacts with drugs and their actions will be key to individualizing therapy.The impact of the composition of the gut microbiome on the efficacy of newer cancer therapies such as immune checkpoint inhibitors and chimeric antigen receptor T-cell treatment has become an active area of research.Pancreatic adenocarcinoma(PAC)has a poor prognosis even in those with potentially resectable disease,and treatment options are very limited.Newer studies have concluded that there is a synergistic effect for immunotherapy in combination with cytotoxic drugs,in the treatment of PAC.A variety of commensal microbiota can affect the efficacy of conventional chemotherapy and immunotherapy by modulating the tumor microenvironment in the treatment of PAC.This review will provide newer insights on the impact that alterations made in the gut microbial system have in the development and treatment of PAC. | Ayrton I Bangolo Chinmay Trivedi Ishan Jani Silvanna Pender Hirra Khalid Budoor Alqinai Alina Intisar Karamvir Randhawa Joseph Moore Nicoleta De Deugd Shaji Faisal SuchithBoodgere Suresh Parva Gopani Vignesh K Nagesh Tracy Proverbs-Singh Simcha Weissman | 2023 | World Journal of Gastroenterology2023，29，25： | 2 |
| 3 | Can stem cells cross lineage boundaries?显示文摘 | Anderson D J Gage F H Weissman I L | 2001 | Nat Med2001，7，： | 1 |
| 4 | Intramolecular energy transfer the fluores- cence of comples of europium 显示文摘 | Weissman S I | 1942 | J Chem Phys1942，10，4： | 1 |
| 5 | Titania-zirconia mixed oxide aerogels as supports for hydrotreating catalysts 显示文摘 | Weissman J G Ko E I Kaytal S | 1993 | Applied Catalysis A : General1993，94，1： | 1 |
| 6 | Cancer stem cells in bladdercancer: a revisited and evolving concept 显示文摘 | Chan KS Volkmer JP Weissman I | 2010 | Curr Opin Urol2010，20，5： | 1 |
| 7 | On the role of water contamination in rechargeable Li batteries显示文摘 | Aurbach D Weissman I Zaban A | 1999 | Electrochimica Acta1999，45，： | 1 |
| 8 | Hematopoietic stem cell and other hematopoietic cells show broad resistance to chemotherapeutic agents in vivo when overexpressing bcl-2显示文摘 | WEISSMAN I L | 2003 | Experimental Hematology2003，31，： | 1 |
| 9 | Nonaqueous Magnesium Electrochemistry and Its Application in Secondary Batteries显示文摘 | Aurbach D Weissman I Gofer Y | 2003 | Chem Rec2003，3，1： | 1 |
| 10 | Hematopoietic stem and progenitor cells: clinical and preclinical regeneration of the hematolymphoid system显示文摘 | Shizuru J A Negrin R S Weissman I L | 2005 | Annu Rev Med2005，56，1： | 1 |
| 11 | The high copper tolerance of Candida albicans is madiated by a P-type ATPase显示文摘 | WEISSMAN Z BERDICEVSKY I CAVARI B Z | 2000 | Proceedings of the National Academy of Sciences2000，97，5： | 1 |
| 12 | Reflection intensity optical fiber sensors for the mid-infrared显示文摘 | Tugendhaft I Bornstein A Weissman Y | 1997 | Applied Optics1997，36，6： | 1 |
| 13 | AML1/ETO-expressing nonleukemic stem cells in acute myelogenous leukemia with 8; 21 chromosomal translocation显示文摘 | MIYAMOTO T WEISSMAN I L AKASHI K | 2000 | Proc Natl Acad Sci USA2000，97，13： | 1 |
| 14 | A cell-surface moleculemvalved in organ-specific homing of lymphocytes 显示文摘 | Callatin V M Weissman I L Butcher E L | 1983 | Nature1983，304，： | 1 |
| 15 | Molecular identification of candida albicans显示文摘 | Weissman Z Berdicevsky I Cavari B | 1995 | J Med Vet Mycol1995，33，： | 1 |
| 16 | Prevention of programmed cell death in Caenorhabditis elegans by human bcl-2显示文摘 | Vaux D L Weissman I L Kim S K | 1992 | Science1992，258，5059： | 1 |
| 17 | Stem cells:units of development,units of regeneration,and units in evolution显示文摘 | WEISSMAN I L | 2000 | Cell2000，100，1： | 1 |
| 18 | The correlation between charge/discharge rates and morphology, surface chemistry, and performance of Li electrodes and the connection to cycle life of practical batteries显示文摘 | D Aurbach I Weissman H Yamin | 1998 | J Electrochem Soc1998，145，5： | 1 |
| 19 | Stem cells, cancer, and cancer stem cells显示文摘 | Reya T Morrison S J Clarke M F Weissman I L | 2001 | Nature2001，414，： | 1 |
| 20 | AML1/ETO-expressing nonleukemic stem cells in acute myelogenous leukemia with 8; 21 chromosomal translocation 显示文摘 | Miyamoto T Weissman I L Akashi K | 2000 | Proe Natl Acad Sci USA2000，97，： | 1 |
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