|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Methylation-dependent loss of RIP3 expression in cancer represses programmed necrosis in response to chemotherapeutics显示文摘交往受体的蛋白质 kinase-3 (RIP3 或 RIPK3 ) 是执行 “ 的细胞的机械的必要部分; programmed”或 “ regulated”坏死。这里,我们证明那规划坏死响应许多化学疗法的代理人被激活并且贡献导致化疗的房间死亡。然而,我们证明那 RIP3 表情经常在化学疗法的死亡期间由于它的 transcriptional 开始地点, MLKL 的这样 RIP3 依赖的激活和下游地规划的坏死附近的 genomic methylation 是在癌症房间的 silenced 大部分被镇压。不过,有 hypomethylating 代理人的治疗恢复 RIP3 表示,并且从而以一种 RIP3 依赖的方式把敏感提升到 chemotherapeutics。RIP3 表示在 85% 乳癌病人与正常织物相比在肿瘤被减少,建议那 RIP3 缺乏断然在肿瘤生长 / 发展期间被选择。因为 hypomethylating 代理人在病人是相当容忍得好的,我们建议病人们可以从收到 hypomethylating 代理人与常规 chemotherapeutics 在治疗以前导致 RIP3 表示有益于的那 RIP3 缺乏的癌症。 | Gi-Bang Koo Michael J Morgan Da-Gyum Lee Woo-Jung Kim Jung-Ho Yoon Ja Seung Koo Seung I1 Kim Soo Jung Kim Mi Kwon Son Soon Still Hong Jean M Mulcahy Levy Daniel A Pollyea Craig T Jordan Pearlly Yan David Frankhouser Deedra Nicolet Kati Maharry Guido Marcucci Kyeong Sook Choi Hyeseong Cho ndrew Thorbum You-Sun Kim | 2015 | Cell Research2015，25，6： | 20 |
| 2 | Effect of serum testosterone and percent tumor volume on extra-prostatic extension and biochemical recurrence after laparoscopic radical prostatectomy显示文摘几研究表明了外科手术前的浆液睾丸激素和百分比肿瘤体积(PTV ) 在激进的前列腺切除术以后预言 extra-prostatic 扩展(EPE ) 和生物化学的复发(BCR ) 。这研究在 laparoscopic 激进分子前列腺切除术(LRP ) 以后在与 EPE 和 BCR 的关系调查了浆液睾丸激素和 PTV 的预示的意义。我们考察了经历了在 2004 和 2012 之间的 LRP 的 520 个病人。PTV 在每节作为所有视觉上估计的肿瘤 foci 的和被决定。BCR 被定义为手术后的前列腺特定的抗原(PSA ) 的二连续增加 > 0.2 ng ml 1 。为浆液总数睾丸激素的阀值是 3.0 ng ml 1 。Multivariate 逻辑回归被用来在 EPE 和 BCR 的风险上定义变量的效果。低浆液睾丸激素(< 3.0 ng ml 1) 与高浆液 PSA,格利森分数,前列腺活体检视的积极核心百分比, PTV,和所有病理学的变量被联系。在 multivariate 分析上,类似于以前的研究,浆液 PSA,活体检视积极核心百分比,格利森分数,和病理学的变量预言了 EPE 和 BCR。另外,低浆液睾丸激素(< 3.0 ng ml 1 ,调整或, 8.52;95% CI, 5.04-14.4, P= 0.001 ) 预言的 EPE 和 PTV (调整或, 1.02;95% CI, 1.01-1.05, P= 0.046 ) 预言的 BCR。除了 EPE 和 BCR 的以前的预言者,低浆液睾丸激素和 PTV 在 LRP 以后是 EPE 和 BCR 的珍贵预言者。 | Eu Chang Hwang Seong Hyeon Yu Yang Hyun Jo Seung I1 Jung Taek Won Kang Dong Deuk Kwon Chan Choi Suk Hee Heo Jun Eul Hwang Sung-Hoon Jung Tae-Young Jung | 2016 | Asian Journal of Andrology2016，18，1： | 3 |
| 3 | 'Cervia II Working Group Report 2006' : guidelines on diagnosis and treatment of Helicobacter pylori infection in Italy显示文摘 | Working Group of the Cervia I1 Meeting | 2007 | Dig Liver Dis2007，39，8： | 1 |
| 4 | Effects of preoperative oral melatonin medication on postoperative analgesia, sleep quality, and sedation in patients undergoing elective prostatectomy: a ran- domized clinical trial显示文摘 | Borazan I1 Tuncer S Yalcin N | 2010 | J Anesth2010，24，2： | 1 |
| 5 | The utility of endoscopic radical resection with microdissection electrodes for lingual thyroglossal duct cysts 显示文摘 | Jung - Hae Cho Won - Sang Jung Dong - I1 Sun | 2014 | The Journal of craniofacial surgery2014，25，2： | 1 |
| 6 | Poly(DM AEMA- NVP)- b-PEG- galactose as gene delivery vector for hepatocytes显示文摘 | Dong Woo L Young I1 Y Tae Gwan P | 2000 | Bioconjugate Chem2000，11，： | 1 |
| 7 | Molecular characterization of the plasmid-encoded eps gene clusler essential for exopolysaccharide biosynthesis in Lactococcus lactis显示文摘 | Van Kranenburg R Marugg JD van Swam I1 | 1995 | Mol Microbiol1995，24，： | 1 |
| 8 | Permanent venovenous hemofihration in the complex therapy of se- vere acute pancreatitis显示文摘 | Aleksandrova IV I1 inskii ME Rei SI | 2011 | Anesteziol Reanimatol2011，，3： | 1 |
| 9 | The role of bone cement augmentation in the treatment of chronic symp- tomatic osteoporotic compression fracture显示文摘 | Hyeun Sung Kim Sung Hoon Kim Chang I1 J | 2010 | J Korean Neurosurg Soc2010，48，： | 1 |
| 10 | Fully aliphatic polyimides from adamantane-based diamines for enhanced thermal stability,solubility,transparency,and low dielectric constant显示文摘 | Anu Stella Mathews I1 Kim Chang-Sik Ha | | 0，，： | 1 |
| 11 | Modeling andsimula- tion for the methane steam reforming enhanced by in situ CO2 re- moval utilizing the CaO carbonation for 1t2 produetion显示文摘 | Deuk Ki Lee I1 Hyun Baek Wang Lai Yoon | 2009 | Chemi- cal Engineering Science2009，59，4： | 1 |
| 12 | Lactulose in treatment of hepatic encephalopathy in patient with liver cirrhosis显示文摘 | Shuliat'ev IS I1'chenko Llu Vinnitskaia EV | 2002 | Eksp Klin Gastroenterol2002，，5： | 1 |
| 13 | Sesquiterpene Furan Compound CJ-01,a Novel Chitin Synthase 2 Inhibitor from Chloranthus japonicus SIEB显示文摘 | Nam Hui YIM Eui I1 HWANG Bong Sik YUN | | 0，，05： | 1 |
| 14 | Prostate target volume variations during a course of radiotherapy 显示文摘 | Antolak JA Rosen I1 Childress CH | 1998 | Int J Radiat Oncol Biol Phys1998，42，3： | 1 |
| 15 | Microstructural interpretation of the effect of various matrices on the ablation properties of carbon fiber reinforced composites显示文摘 | Donghwan Cho Byung I1 Yoon | 2001 | Composites Science and Technology2001，61，： | 1 |
| 16 | ViTa: prediction of host mieroRNAs targets on viruses 显示文摘 | Hsu PW Lin I1 Hsu SD | 2007 | Nucleic Acids Res2007，35，1： | 1 |
| 17 | Determination of 1 -phenylazo- 2 - naphthol (Sudan I) in chillipowder and in chilli -containing food products by GPC clean - up and HPLC with LC/MS confirmation显示文摘 | Mazzetti M1 Fascioli R1 Mazzoncini I1 | 2004 | Food Additives & Contaminants2004，21，10： | 1 |
| 18 | The Anti-influenza virus effect of Phellinus igniarius extract显示文摘 | Sangmoo Lee Jin I1 Kim Jun Heo | 2013 | Journal of Micro- biology2013，51，5： | 1 |
| 19 | Specific microbiota direct Ihe differentiation of IL-17-producing T-helper cells in the mucosa of the small imestine显示文摘 | IVANOV I1 FRUTOS RDE L MANEL N | 2008 | Cell Host Micrebe2008，4，4： | 1 |
| 20 | Removal efficieneies of PCDDs/PCDFs by air pollution control devices in municipal solid waste incinerators 显示文摘 | Sam C K Hwan J S I1 R J et at | 2001 | Chemosphere2001，43，4： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员