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| 1 | 难治性类风湿关节炎的临床特点:一项国际问卷调查研究显示文摘目的尽管按照目前欧洲抗风湿联盟(EULAR)的推荐对类风湿关节炎(rheumatoid arthritis,RA)患者进行治疗,难治性RA患者的临床症状却仍然没有得到完全控制,目前EULAR指南主要关注的是RA的早期治疗和药物治疗。本研究的目的在于分析难治性RA患者的临床特点,以及在患者管理中需要探索然而现有EULAR指南并未涉及的问题。方法对多个国家的风湿科医生进行问卷调查,分析难治性RA的临床特点。问卷包括多选题以及开放性问题,从开放性问题的回答中发现需要进一步阐明的问题以及现有EULAR指南需要增加的内容。结果410名受访者完成了调查问卷,关于难治性RA的特点:50%受访者认为基于28个关节评估的疾病活动评分(disease activity score assessing 28 joints,DAS28)>3.2或存在疾病活动的征象;42%受访者认为疲劳是其特点;48%认为至少两种传统合成改变病情抗风湿药(DMARDs)以及使用至少两种生物制剂或靶向合成DMARDs治疗失败;89%认为糖皮质激素不能减量到5 mg/天或泼尼松不能减量到10 mg/天或同等剂量的其他激素。另外,现有EULAR指南中应增加合并症和关节外表现的干预以及多种药物联合治疗等重要内容。结论目前风湿科医生对难治性RA的定义有很大争议。难治性RA患者的很多重要问题目前EULAR指南中均没有涉及。 | Nadia MT Roodenrijs Maria J H de Hair Marlies C van der Goes Johannes WG Jacobs Paco MJ Welsing Désirée van der Heijde Daniel Aletaha Maxime Dougados Kimme L Hyrich Iain B McInnes Ulf Mueller-Ladner Ladislav Senolt Zoltan Szekanecz Jacob Mvan Laar Nagy Gyorgy 黄艳荣(译) 张卓莉(审校) | 2019 | 英国医学杂志中文版2019，22，2： | 1 |
| 2 | Assessment of eccentric exercise-induced muscle damage of the elbow flexors by tensiomyography 显示文摘 | Angus M Hunter Stuart D R Galloway Iain J S | 2012 | Journal of Electromyography and Kinesiology2012，22，3： | 1 |
| 3 | Heavy metal distribution in sediment profiles of the Pearl River estuary, South China显示文摘 | Li X D Onyx W H Wai Y S Lia Bma3- J Colesb Michael H Ramseyb Iain Thornton | 2000 | Applied Geochemistry2000，15，5： | 1 |
| 4 | Stimulus-driven and goal-driven control over visual selection显示文摘 | Casimor J H Ludwig Iain D Gilchrist | 2002 | Journal of Experimental Psychology:Human Perception and Performance2002，28，4： | 1 |
| 5 | Chemical partitioning of trace and major elements in soils contaminated by mining and smelting acativities 显示文摘 | Li X D Iain Thornton | 2001 | Applied Geochemistry2001，16，： | 1 |
| 6 | A review and analysis of current computer-aided fixture design approaches 显示文摘 | BOYLE Iain RONG Y BROWN D C | 2011 | Robotics and Computer Integrated Manufacturing2011，，27： | 1 |
| 7 | Effective leadership and decision-making in animal groups on the move显示文摘 | Iain D C Krause J Simon A L | 2005 | Nature2005，433，7025： | 1 |
| 8 | Momentum and heat transfer in a laminar boundary layer with slip flow显示文摘 | Michael J M Iain D B | 2006 | Journal of Thermophysics and Heat Transfer2006，20，4： | 1 |
| 9 | Collective memory and spafial sorting in animal groups显示文摘 | Iain D C Jens K Richard J | 2002 | Journal of Theory Biology2002，218，： | 1 |
| 10 | Analysis of mannose se- lection used for transformation of sugar beet显示文摘 | MORTEN J IAIN D JETTE K | 1998 | Mol Breed1998，4，2： | 1 |
| 11 | Predicting failure of the continuum fluid equations in transitional hypersonic flows 显示文摘 | Boyd Iain D Gang Chen | 1995 | Phys Fluids1995，7，1： | 1 |
| 12 | Quantitative risk assessment of human infection from Escherichia coli 0157 associated with recreational use of animal pasture显示文摘 | NORVAL J C STRACHAN GEOFFEY M DUNN IAIN D OGDEN | 2002 | International Journal of Food Microbiology2002，75，： | 1 |
| 13 | Collective memory and spatial sorting in animal groups显示文摘 | Iain D C Jens K Richard J | 2002 | Journal of Theoretical Biology2002，218，： | 1 |
| 14 | A new histological grading system to assess response of breast cancers to primary chemotherapy: prognostic significance and survival显示文摘 | Keith N Ogston Iain D Miller Simon Payne Andrew W Hutcheon Tarun K Sarkar Ian Smith A Schofield Steven D Heys | 2003 | The Breast2003，，5： | 1 |
| 15 | Effective leadership and decision-making in animal groups on the move显示文摘 | Iain D C Jens K Nigel R F | 2005 | Nature2005，433，： | 1 |
| 16 | Do open access articles have greater citation impact? : A critical review of the literature 显示文摘 | Craig Iain D Plume Andrew M McVeigh Marie E | 2007 | Journal of Informetrics2007，1，3： | 1 |
| 17 | Analysis of mannose selection used fortrans{ormation of sugar beet显示文摘 | JOERSBO M Iain D Jette K | 1998 | Molecular Breeding1998，4，： | 1 |
| 18 | A new histological grading system to assess response of breast cancers to primary chemotherapy: prognostic significance and survival显示文摘 | Keith N Ogston Iain D Miller Simon Payne Andrew W Hutcheon Tarun K Sarkar Ian Smith A Schofield Steven D Heys | 2003 | The Breast2003，，5： | 1 |
| 19 | Adapting to unknown smoothness via wavelet shrinkage显示文摘 | Donoho D L Johnstone Iain M | 1995 | Journal of the America Statistical Association1995，90，432： | 1 |
| 20 | Ideal spatial adaptation by wavelet shrinkage显示文摘 | Donoho D Johnstone Iain M | 1994 | Biometrika1994，81，3： | 1 |
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