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| 1 | Targeting collagen expression in alcoholic liver disease显示文摘Alcoholic liver disease(ALD)is a leading cause of liver disease and liver-related deaths globally,particularly in developed nations.Liver fibrosis is a consequence of ALD and other chronic liver insults,which can progress to cirrhosis and hepatocellular carcinoma if left un-treated.Liver fibrosis is characterized by accumulation of excess extracellular matrix components,including typeⅠcollagen,which disrupts liver microcirculation and leads to injury.To date,there is no therapy for the treatment of liver fibrosis;thus treatments that either prevent the accumulation of typeⅠcollagen or hasten its degradation are desirable.The focus of this review is to examine the regulation of typeⅠcollagen in fibrogenic cells of the liver and to discuss current advances in therapeutics to eliminate excessive collagen deposition. | Kyle J Thompson Iain H McKillop Laura W Schrum | 2011 | World Journal of Gastroenterology2011，17，20： | 7 |
| 2 | Tenascin C upregulates interleukin-6 expression in human cardiac myofibroblasts via toll-like receptor 4显示文摘AIM:To investigate the effect of Tenascin C(TNC)on the expression of pro-inflammatory cytokines and matrixmetalloproteinases in human cardiac myofibroblasts(CMF).METHODS:CMF were isolated and cultured from patients undergoing coronary artery bypass grafting.Cultured cells were treated with either TNC(0.1μmol/L,24 h)or a recombinant protein corresponding to different domains of the TNC protein;fibrinogen-like globe(FBG)and fibronectin typeⅢ-like repeats(TNⅢ5-7)(both 1μmol/L,24 h).The expression of the proinflammatory cytokines;interleukin(IL)-6,IL-1β,TNFαand the matrix metalloproteinases;MMPs(MMP1,2,3,9,10,MT1-MMP)was assessed using real time RT-PCR and western blot analysis.RESULTS:TNC increased both IL-6 and MMP3(P<0.01)mR NA levels in cultured human CMF but had no significant effect on the other markers studied.The increase in IL-6 mR NA expression was mirrored by an increase in protein secretion as assessed by enzymelinked immunosorbant assay(P<0.01).Treating CMF with the recombinant protein FBG increased IL-6mR NA and protein(P<0.01)whereas the recombinant protein TNⅢ5-7 had no effect.Neither FBG nor TNⅢ5-7 had any significant effect on MMP3 expression.The expression of toll-like receptor 4(TLR4)in human CMF was confirmed by real time RT-PCR,western blot and immunohistochemistry.Pre-incubation of cells with TLR4neutralising antisera attenuated the effect of both TNC and FBG on IL-6 mR NA and protein expression.CONCLUSION:TNC up-regulates IL-6 expression in human CMF,an effect mediated through the FBG domain of TNC and via the TLR4 receptor. | Azhar Maqbool Emma J Spary Iain W Manfield Michaela Ruhmann Lorena Zuliani-Alvarez Filomena O Gamboa-Esteves Karen E Porter Mark J Drinkhill Kim S Midwood Neil A Turner | 2016 | World Journal of Cardiology2016，8，5： | 4 |
| 3 | Field evaluation of FR5 glass optical current transducer显示文摘 | N Pawel M W Craig M W Iain | 2000 | SPIE Proc2000，4074，： | 1 |
| 4 | A Reviewand Analysis of Current Computer-Aided Fixture DesignApproaches 显示文摘 | B O Y L E Iain R O N G Yiming B R O W N David C | 2011 | Robotics and Computer-Integrated Manufacturiiig2011，27，1： | 1 |
| 5 | Heavy metal distribution in sediment profiles of the Pearl River estuary, South China显示文摘 | Li X D Onyx W H Wai Y S Lia Bma3- J Colesb Michael H Ramseyb Iain Thornton | 2000 | Applied Geochemistry2000，15，5： | 1 |
| 6 | Evaluationof a Series of Bicyclic CXCR2 Antagonists显示文摘 | IAIN W CAROLINE A RUPERT A | 2008 | BioQrgMed Chem Lett2008，18，2： | 1 |
| 7 | A Biomechanical Comparison of Plate Configuration in Distal Humerus Fractures显示文摘 | Magnus W T Arnander Alexander Reeves Iain A R MacLeod Thomas M Pinto Arshad Khaleel | 2008 | Journal of Orthopaedic Trauma2008，，5： | 1 |
| 8 | Pax7 activates myogenic genes by recruitment of a histone methyltransfcrase complex 显示文摘 | Iain W M Ishibashi J Grand F L | 2008 | Nature Cell Biology2008，10，： | 1 |
| 9 | A new histological grading system to assess response of breast cancers to primary chemotherapy: prognostic significance and survival显示文摘 | Keith N Ogston Iain D Miller Simon Payne Andrew W Hutcheon Tarun K Sarkar Ian Smith A Schofield Steven D Heys | 2003 | The Breast2003，，5： | 1 |
| 10 | A Biomechanical Comparison of Plate Configuration in Distal Humerus Fractures显示文摘 | Magnus W T Arnander Alexander Reeves Iain A R MacLeod Thomas M Pinto Arshad Khaleel | 2008 | Journal of Orthopaedic Trauma2008，，5： | 1 |
| 11 | Evaluation of a series of bicyclie CXCR2 antagonists显示文摘 | Iain W Caroline A Rupert A | 2008 | Bioorg Med Chem Lett2008，18，： | 1 |
| 12 | A new histological grading system to assess response of breast cancers to primary chemotherapy: prognostic significance and survival显示文摘 | Keith N Ogston Iain D Miller Simon Payne Andrew W Hutcheon Tarun K Sarkar Ian Smith A Schofield Steven D Heys | 2003 | The Breast2003，，5： | 1 |
| 13 | Urban environmental geochemistry oftrace metals显示文摘 | Coby S C W Li X Iain T | 2006 | Environmental Pollution2006，142，1： | 1 |
| 14 | Does Pore Water Velocity Affect the Reaction Rates of Adsorptive Solute Transport in Soils? Demonstration with Pore-scale Modelling 显示文摘 | Zhang X John W C Iain M Y | 2008 | Advances in Water Resources2008，31，3： | 1 |
| 15 | Mattaj Meiosis: MeiRNA hits the spot 显示文摘 | Mutsuhito O Iain W | 1999 | Curr Biol1999，9，： | 1 |
| 16 | Temperature compensation for optical current sensors显示文摘 | W Iain Madden W Craig Michie Andrew Cruden | 1999 | Optical Engineering1999，38，10： | 1 |
| 17 | 将医疗保健干预措施从试验转化为实践显示文摘成千上万的试验结果从未被用于实践,因为其发表的报告未能详细地描述具体的干预措施。如何才能改进这些报告呢? | Paul Glasziou Iain Chalmers Douglas G Altman Hilda Bastian IsabeUe Boutron Anne Brice Gro Jamtvedt Andrew Farmer Davina Ghersi Trish Groves Carl Heneghan Sophie Hill Simon Lewin Susan Michie Rafael Perera Valerie Pomeroy Julie Tilson Sasha Shepperd John W Williams 周久顺(译) 张孔来(校) | 2010 | 英国医学杂志中文版2010，13，6： | 0 |
| 18 | 引证研究:系统性综述前提下的研究显示文摘牛顿也称自己是站在巨人肩膀之上。对于今天的医学研究者,任何新的研究计划也都应该建立在前人工作的基础之上。 | Hans Lund Klara Brunnhuber Carsten Juhl Karen Robinson Marlies Leenaars Bertil F Dorch Gro Jamtvedt Monica W Nortvedt Robin Christensen Iain Chalmers 傅晓红 黄莺子 | 2017 | 中国医院院长2017，13，14： | 0 |
| 19 | 引证研究:系统性综述前提下的研究显示文摘Hans Lund和同事们认为,为了避免研究的浪费,在开展任何新研究之前,都应该系统地回顾现有的证据。 | Hans Lund Klara Brunnhuber Carsten Juhl Karen Robinson Marlies Leenaars Bertil F Dorch Gro Jamtvedt Monica W Nortvedt Robin Christensen Iain Chalmers 傅晓红 黄莺子 唐金陵 | 2017 | 英国医学杂志中文版2017，20，6： | 0 |
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