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| 1 | Retrograde-viewing device improves adenoma detection rate in colonoscopies for surveillance and diagnostic workup显示文摘AIM:To determine which patients might benefit most from retrograde viewing during colonoscopy through subset analysis of randomized,controlled trial data.METHODS:The Third Eye Retroscope Randomized Clinical Evaluation(TERRACE) was a randomized,controlled,multicenter trial designed to evaluate the efficacy of a retrograde-viewing auxiliary imaging device that is used during colonoscopy to provide a second video image which allows viewing of areas on the proximal aspect of haustral folds and flexures that are difficult to see with the colonoscope's forward view.We performed a post-hoc analysis of the TERRACE data to determine whether certain subsets of the patient population would gain more benefit than others from use of the device.Subjects were patients scheduled for colonoscopy for screening,surveillance or diagnostic workup,and each underwent same-day tandem examinations with standard colonoscopy(SC) and Third Eye colonoscopy(TEC),randomized to SC followed by TEC or vice versa.RESULTS:Indication for colonoscopy was screening in 176/345 subjects(51.0%),surveillance after previous polypectomy in 87(25.2%) and diagnostic workup in 82(23.8%).In 4 subjects no indication was specified.Previously reported overall results had shown a net additional adenoma detection rate(ADR) with TEC of 23.2% compared to SC.Relative risk(RR) of missing adenomas with SC vs TEC as the initial procedure was 1.92(P = 0.029).Post-hoc subset analysis shows additional ADRs for TEC compared to SC were 4.4% for screening,35.7% for surveillance,55.4% for diagnostic and 40.7% for surveillance and diagnostic combined.The RR of missing adenomas with SC vs TEC was 1.11(P = 0.815) for screening,3.15(P = 0.014) for surveillance,8.64(P = 0.039) for diagnostic and 3.34(P = 0.003) for surveillance and diagnostic combined.Although a multivariate Poisson regression suggested gender as a possibly significant factor,subset analysis showed that the difference between genders was not statistically significant.Age,bowel prep quality and withdrawal time did not significantly affect the RR of missing adenomas with SC vs TEC.Mean sizes of adenomas detected with TEC and SC were similar at 0.59 cm and 0.56 cm,respectively(P = NS).CONCLUSION:TEC allows detection of significantly more adenomas compared to SC in patients undergoing surveillance or diagnostic workup,but not in screening patients(ClinicalTrials.gov Identifier:NCT01044732). | Peter D Siersema Amit Rastogi Anke M Leufkens Paul A Akerman Kassem Azzouzi Richard I Rothstein Frank P Vleggaar Alessandro Repici Giacomo Rando Patrick I Okolo Olivier Dewit Ana Ignjatovic Elizabeth Odstrcil James East Pierre H Deprez Brian P Saunders Anthony N Kalloo Bradley Creel Vikas Singh Anne Marie Lennon Daniel C DeMarco | 2012 | World Journal of Gastroenterology2012，18，26： | 6 |
| 2 | Synthesis and properties of hydroxyapatite/poly-L-lactide composite biomaterials显示文摘 | Ignjatovic N Tomic S Dakic M | | 0，，： | 2 |
| 3 | A recombinant fowl adenovirus expressing the SI gene of infectious bronchitis virus protects against challenge with infectious bronchitis virus 显示文摘 | Johnson M A Pooley C Ignjatovic J | 2003 | Vaccine2003，21，2122： | 1 |
| 4 | The designing of properties of hydroxyapatite/poly-l-lactide composite materials by hot pressing显示文摘 | Ignjatovic N Delijic K Vukcevic M | 2001 | Z Metallkd2001，92，： | 1 |
| 5 | Gastrointestinal stromal tumors显示文摘 | Ignjatovic M | 2002 | Vojnosanit Pregl2002，59，2： | 1 |
| 6 | A recombinant fowl adenovirus expressing the S1 gene of infectious bronchitis virus protects against challenge with infectious bronchitis virus显示文摘 | Johnson M A Pooley C Ignjatovic J | 2003 | Vaccine2003，21，2122： | 1 |
| 7 | Placental growth factor as short-term predicting biomarker in acute coronary syndrome patients with non-ST elevation myocardial infarction显示文摘 | Markovic M Ignjatovic S Dajak M | 2010 | South Med J2010，103，： | 1 |
| 8 | Secure Data Aggregation Tech- nique for Wireless Sensor Networks in the Presence of Collusion Attacks显示文摘 | Rezvani M Ignjatovic A Bertino E | 2013 | School Comput Sci and Eng Univ New South Wales Kensinton NSW Australia Tech Pep2013，34，6： | 1 |
| 9 | sythesis and properties of hydroxyapatite/polylactide composite biomaterials显示文摘 | Ignjatovic N Tomic S Dakic M | 1999 | Biomaterials1999，20，： | 1 |
| 10 | A recombinant fowi adenovirus expressing the S1 gene of infectious bronchitis virus protects against challenge with infectious bronchitis virus显示文摘 | Johnson M A Pooley C Ignjatovic J | 2003 | Vaccine2003，12，22： | 1 |
| 11 | Synthesis and proper- ties of hydroxyapatite/poly - L - lactide composite biomate- rials 显示文摘 | Ignjatovic'N Tomic' S Dakic' M | 1999 | Biomaterials1999，20，9： | 1 |
| 12 | Gastrointestinal stromal tumors显示文摘 | IGNJATOVIC M | 2002 | Vojnosanit Pregl2002，59，2： | 1 |
| 13 | The realization of Abel's inversion in the case of discharge with undetermined radius显示文摘 | IGNJATOVIC L M MIHAJLOV A A | 2002 | Journal of Quantitative Spectroscopy and Radiative Transfer2002，72，： | 1 |
| 14 | Nondeterministic automata: Equivalence, bisimulations, and uniform rela- tions 显示文摘 | Ciric M Ignjatovic J Basic M | 2014 | Information Sciences2014，261，： | 1 |
| 15 | Gastrointestinal st romal tumor 显示文摘 | Ignjatovic M | 2002 | Vojnosanit Pregl2002，59，2： | 1 |
| 16 | Ssr analysis for genetic structure and diversity determi-nation of maize local populations from former Yugoslavia territories显示文摘 | IGNJATOVIC'-MICIC'D DRINIC'S M NIKOLIC'A | | 0，，11： | 1 |
| 17 | Controlled Assembly of Poly(D,L-lactide-co-glycolide)/Hydroxyapatite Coreshell Nanospheres Under Ultrasonic Irradiation显示文摘 | Jevtic M Radulovic A Ignjatovic N | 2009 | Acta Biomater2009，5，1： | 1 |
| 18 | Total intravenous anesthesia us- ing remifentanil and propoofl with midazolam conduction in laporoscopic surgery of the gallbladder 显示文摘 | Romic P Ignjatovic D Rankovic M | 2001 | Acta C hir Iugosl2001，48，1： | 1 |
| 19 | Quality control in crowdsourcing systems 显示文摘 | ALLAHBAKHSH M BENATALLAH B IGNJATOVIC A | 2013 | IEEE Internet Compu- ting2013，17，2： | 1 |
| 20 | Morphologic characteristics of primary nonperforative intestinal blast injuries inrats their evolution to secondary perforations显示文摘 | Tatic′V Ignjatovic′D Jevtic′M | 1996 | J Trauma-Injury Inf Crit Care1996，40，： | 1 |
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