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| 1 | Treatment strategies for colorectal carcinoma with synchronous liver metastases: Which way to go?显示文摘AIM: To offer an up-to-date review of all availabletreatment strategies for patients with synchronous colorectal liver metastases(CLM).METHODS: A comprehensive literature search was performed to identify articles related to the management of patients with synchronous CLM. A search of the electronic databases PubMed, MEDLINE, and Google Scholar was conducted in September 2014.The following search terms were used: synchronous colorectal liver metastases, surgery, stage Ⅳ colorectal cancer, liver-first approach, and up-front hepatectomy.These terms were employed in various combinations to maximize the search. Only articles written in English were included. Particular attention was devoted to studies and review articles that were published within the last six years(2009-2014). Additional searches of the cited references from primary articles were performed to further improve the review. The full texts of all relevant articles were accessed by two independent reviewers.RESULTS: Poor long-term outcomes of patients with synchronous CLM managed by a traditional treatment strategy have led to questions about the timing and sequence of possible therapeutic interventions. Thus,alternative paradigms called reverse strategies have been proposed. Presently, there are four treatment strategies available:(1) primary first approach(or traditional approach) comprises resection of the primary colorectal tumor followed by chemotherapy;subsequent liver resection is performed 3-6 mo after colorectal resection(provided that CLM are still resectable);(2) simultaneous resection of the primary colorectal tumor and CLM during a single operation presents intriguing options for a highly select group of patients, which can be associated with significant postoperative morbidity;(3) liver-first(or chemotherapy-first) approach comprises preoperative chemotherapy(3-6 cycles) followed by liver resection,adjuvant chemotherapy, and resection of the primary colorectal tumor(it is best suited for patients withasymptomatic primary tumors and initially unresectable or marginally resectable CLM); and(4) up-front hepatectomy(or 'true' liver-first approach) includes liver resection followed by adjuvant chemotherapy,colorectal resection, and adjuvant chemotherapy(strategy can be offered to patients with asymptomatic primary tumors and initially resectable CLM).CONCLUSION: None of the aforementioned strategies appears inferior. It is necessary to establish individual treatment plans in multidisciplinary team meetings through careful appraisal of all strategies. | Peter Ihnát Petr Vávra Pavel Zonca | 2015 | World Journal of Gastroenterology2015，21，22： | 10 |
| 2 | Electrical stress effect on poly-Si thin film transistors fabricated by metal induced lateral crystallization显示文摘 | IHN T H LEE B I JOO S K | 1997 | Jap J Appl Phys1997，36，： | 1 |
| 3 | Growth regulation in scleroderma fibroblasts: increased response to transforming growth factor-beta 1 显示文摘 | Kikuchi K Kadono T Ihn H | 1995 | J Invest Dermatol1995，105，1： | 1 |
| 4 | Poly(vinyl alcohol) nano- composites with different clays: pristine clays and organo- clays显示文摘 | Chang J H Jang T G Ihn K J | 2003 | J App Poly Sci2003，90，： | 1 |
| 5 | Effect of transition metal addition on liquid phase sintering of W-Cu显示文摘 | Ihn T H Lee S W Joo S K | 1994 | Powder Metallurgy1994，37，4： | 1 |
| 6 | Kondo effect in a manyelectron quantumring 显示文摘 | Fuhrer A Ihn T Ensslin K Wegscheider W Bichler M | 2004 | Phys Rev Lett2004，93，17： | 1 |
| 7 | Magnetic-field-depend-ent transmission phase of a double-dot system in aquantum ring 显示文摘 | Sigrist M Fuhrer A Ihn T Ensslin K Ulloa S E Wegscheider W Bichler M | 2004 | Phys Rev Lett2004，93，06： | 1 |
| 8 | Coherent Probing of Excited Quantum Dot States in an Interferometer显示文摘 | Sigrist M Ihn T Ensslin K | | 0，，03： | 1 |
| 9 | Growth regulation in scleroderma fibroblasts: increased response to transforming growth factor-beta 1 显示文摘 | Kikuchi K Kadono T Ihn H | 1995 | J Invest Dermatol1995，105，1： | 1 |
| 10 | Poly(vinyl alcohol) nanocomposites with different clays:prestine clays and organoclays显示文摘 | Chang J H Jang T G Ihn K J | 2003 | Journal of Applied Polymer Science2003，90，： | 1 |
| 11 | Effect of Transitionmetal addition on liquid phase sintering of W-Cu显示文摘 | IHN T H LEE S W JOO S K | 1994 | Powder Metal1994，，4： | 1 |
| 12 | Spin filter using a semiconductor quantum ring side-coupled to a quantum wire 显示文摘 | FUHRER A LUSCHER S IHN T | 2001 | Nature: London2001，413，： | 1 |
| 13 | Poly(vinyl alcohol) Nanocomposites with Different Clays:Pristine Clays and Organoclays显示文摘 | Chang J H Jang T Ihn K | 2003 | Journal of Applied Polymer Science2003，90，： | 1 |
| 14 | New elliptic function type UWB BPF based on capacitively coupled L/4 open T resonator 显示文摘 | DUON(3 T IHN S | 2009 | IEEE Transactions on Microwave Theory and Techniques2009，57，12： | 1 |
| 15 | Electrical stress effect on poly-Si thin film transistors fabricated by metal induced lateral crystallization 显示文摘 | Ihn T H Lee B I Joo S K | 1997 | Jp J Appl Phys1997，36，： | 1 |
| 16 | Energy spectra of quantum ring显示文摘 | Fuhrer A Luscher S Ihn T | 2001 | Nature2001，413，： | 1 |
| 17 | Characterization of SIS3, a no vel specific inhibitor of Smad3, and its effect on transforming growth factor betal-induced extracellular matrix expression显示文摘 | ]innin M Ihn H T amaki K | 2006 | MolPharmacol2006，60，： | 1 |
| 18 | Electrical stress effect on poly-Si thin film transistors fabricated by metal induced lateral crystallization显示文摘 | IHN T H LEE B I JOO S K | 1997 | JJAP1997，36，8： | 1 |
| 19 | Electron transport in a two-dimensional electron gas with magnetic barriers 显示文摘 | T Vancura T Ihn S Broderick | 2000 | Phys Rev B2000，62，： | 1 |
| 20 | Heat shock protein 105 is overexpressed in squamous cell carcinoma and extramammary Paget disease but not in basal cell carcinoma 显示文摘 | Muchemwa FC Nakatsura T Ihn H | 2006 | Br J Dermatol2006，155，： | 1 |
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