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| 1 | Chronic intestinal failure and short bowel syndrome in Crohn’s disease显示文摘Chronic intestinal failure(CIF)is a rare but feared complication of Crohn’s disease.Depending on the remaining length of the small intestine,the affected intestinal segment,and the residual bowel function,CIF can result in a wide spectrum of symptoms,from single micronutrient malabsorption to complete intestinal failure.Management of CIF has improved significantly in recent years.Advances in home-based parenteral nutrition,in particular,have translated into increased survival and improved quality of life.Nevertheless,60%of patients are permanently reliant on parenteral nutrition.Encouraging results with new drugs such as teduglutide have added a new dimension to CIF therapy.The outcomes of patients with CIF could be greatly improved by more effective prevention,understanding,and treatment.In complex cases,the care of patients with CIF requires a multidisciplinary approach involving not only physicians but also dietitians and nurses to provide optimal intestinal rehabilitation,nutritional support,and an improved quality of life.Here,we summarize current literature on CIF and short bowel syndrome,encompassing epidemiology,pathophysiology,and advances in surgical and medical management,and elucidate advances in the understanding and therapy of CIF-related complications such as catheter-related bloodstream infections and intestinal failure-associated liver disease. | Aysegül Aksan Karima Farrag Irina Blumenstein Oliver Schröder Axel U Dignass Jürgen Stein | 2021 | World Journal of Gastroenterology2021，27，24： | 4 |
| 2 | Panax ginseng natural populations: their past, current state and perspectives显示文摘瞄准:人参属人参,遗传和它 Primorye (俄国) 的自然人口的个体发生的结构的交配系统被调查。方法:基因差异用紧密相联的酶和荧光灯地基于的自动化放大碎片长度多型性(AFLP ) 和简单顺序被估计重复(SSR ) 标记。结果:在种类水平的全部的基因差异与紧密相联的酶是低的试金(0.023 ) ,和有 AFLP (0.255 ) 和 SSR (0.259 ) 的高度方法。它根据紧密相联的酶(>99%) 在人口以内被观察, AFLP (>85%) ,和 SSR (>73%) 试金。基因可变性分发的索引指出开拓殖民地在早 Holocene 在温暖的时期期间从南部的避难处由人参的 Sikhote-Alin 种。到异花受粉和自花传粉的人参植物的能力被显示出,人参属人参是容许的单性生殖的植物的假设被证实。人参的繁殖系统拥有授精进程的高粘性和稳定性帮助种类处于压力条件幸存。外部或内部的因素引起的骚乱能由于人参小卵或单性生殖的胚胎开发的形态基因的潜力被减少。因为一些生活阶段是不在的或很少发生,人参人口的生活阶段结构的分析证明所有他们不是完整成分的。结论:在所有 3 张人口,处女和年轻生产个人是占优势的。人口学习了的这个工具是可行的,自然人参人口的再介绍还是可能的。 | Yuri N ZHURAVLEV Olga G KOREN Galina D REUNOVA Tamara I MUZAROK Tatiyana Yu GORPENCHENKO Irina L KATS Yuliya A KHROLENKO | 2008 | Acta Pharmacologica Sinica2008，29，9： | 3 |
| 3 | Linagliptin alleviates fatty liver disease in diabetic db/db mice显示文摘AIM To study the effects of linagliptin on the structural signs of non-alcoholic fatty liver disease(NAFLD) in db/db mice. METHODS Male diabetic db /db mice(BKS.Cg-Dock7m+/+Leprdb/J) aged 10 wk received the dipeptidyl peptidase 4(DPP4) inhibitor linagliptin(10 mg/kg) or saline as a placebo once per day by gavage for 8 wk. Intact db/db mice served as controls. Structural changes in the liver were analyzed from light and electron microscopic images of sections from intact, placebo-treated and linagliptin-treated animals. We estimated the changes in hepatocytes, sinusoidal cells, liver microvasculature and lymphatic roots. Hepatic staining for lymphatic vessel endothelial hyaluronan receptor-1(LYVE-1) was assessed by immunohistochemistry. RESULTS In 18-wk-old diabetic mice, liver steatosis(predominantly microvesicular and mediovesicular steatosis) was accompanied by dilation of the roots of the lymphatic system, interlobular blood vessels and bile canaliculi. Compared to saline-treated mice, linagliptin-treated mice exhibited a reduction in the mean numeral densities of hepatocytes with lipid droplets(92.4% ± 1.7% vs 64.9% ± 5.8% per field of view, P = 0.0002) and a lower proportion of hepatocytes with a high density of lipid droplets(20.7% ± 3.6% vs 50.4% ± 3.1%, P = 0.0007). We observed heterogeneous hepatocytes and relatively preserved cell structures in the linagliptin group. Dilation of blood and lymphatic vessels, as well as ultrastructural changes in the hepatocyte endoplasmic reticulum and mitochondria, were alleviated by linagliptin treatment. In intact and placebo-treated mice, immunohistochemical staining for LYVE-1 was observed in the endothelial cells of interlobular lymphatic vessels and on the membranes of some endothelial sinusoidal cells. We observed an enlarged LYVE-1 reaction area in linagliptin-treated mice compared to intact and placebo-treated mice. The improvement in the structural parameters of the liver in linagliptin-treated mice was independent to changes in the plasma glucose levels. CONCLUSION The DPP4 inhibitor linagliptin alleviates liver steatosis and structural changes in the hepatic microvasculature and lymphatic roots in a model of NAFLD in diabetic db/db mice. | Svetlana V Michurina Irina Ju Ishenko Vadim V Klimontov Sergey A Archipov Natalia E Myakina Marina A Cherepanova Eugenii L Zavjalov Galina V Koncevaya Vladimir I Konenkov | 2016 | World Journal of Diabetes2016，7，19： | 2 |
| 4 | Evaluation of biodegradable electric conductive tube-guides and mesenchymal stem cells显示文摘AIM: To study the therapeutic effect of three tubeguides with electrical conductivity associated to mesenchymal stem cells(MSCs) on neuro-muscular regeneration after neurotmesis.METHODS: Rats with 10-mm gap nerve injury were tested using polyvinyl alcohol(PVA), PVA-carbon nanotubes(CNTs) and MSCs, and PVA-polypyrrole(PPy). The regenerated nerves and tibialis anterior muscles were processed for stereological studies after 20 wk. The functional recovery was assessed serially for gait biomechanical analysis, by extensor postural thrust, sciatic functional index and static sciatic functionalindex(SSI), and by withdrawal reflex latency(WRL). In vitro studies included cytocompatibility, flow cytometry, reverse transcriptase polymerase chain reaction and karyotype analysis of the MSCs. Histopathology of lung, liver, kidneys, and regional lymph nodes ensured the biomaterials biocompatibility. RESULTS: SSI remained negative throughout and independently from treatment. Differences between treted groups in the severity of changes in WRL existed, showing a faster regeneration for PVA-CNTs-MSCs(P < 0.05). At toe-off, less acute ankle joint angles were seen for PVA-CNTs-MSCs group(P = 0.051) suggesting improved ankle muscles function during the push off phase of the gait cycle. In PVA-PPy and PVA-CNTs groups, there was a 25% and 42% increase of average fiber area and a 13% and 21% increase of the 'minimal Feret's diameter' respectively. Stereological analysis disclosed a significantly(P < 0.05) increased myelin thickness(M), ratio myelin thickness/axon diameter(M/d) and ratio axon diameter/fiber diameter(d/D; g-ratio) in PVA-CNT-MSCs group(P < 0.05). CONCLUSION: Results revealed that treatment with MSCs and PVA-CNTs tube-guides induced better nerve fiber regeneration. Functional and kinematics analysis revealed positive synergistic effects brought by MSCs and PVA-CNTs. The PVA-CNTs and PVA-PPy are promising scaffolds with electric conductive properties, bio- and cytocompatible that might prevent the secondary neurogenic muscular atrophy by improving the reestablishment of the neuro-muscular junction. | Jorge Ribeiro Tiago Pereira Ana Rita Caseiro Paulo Armada-da-Silva Isabel Pires Justina Prada Irina Amorim Sandra Amado Miguel Franca Carolina Goncalves Maria Ascensao Lopes Jose Domingos Santos Dina Morais Silva Stefano Geuna Ana Lúcia Luís Ana Colette Maurício | 2015 | World Journal of Stem Cells2015，7，6： | 2 |
| 5 | The destruxins: Synthesis, biosynthesis, biotransformation, and biologi- cal activity 显示文摘 | Pedras M S Irina Z L Ward D E | 2002 | Phytochemistry2002，59，6： | 1 |
| 6 | Comparative evaluation of gene-set analysis methods显示文摘 | Qi L Irina Dinu Adeniyi JA Yutaka Y | 2007 | BMC Bioinformatics2007，8，： | 1 |
| 7 | Attentional Changes During Im- plicit Learning: Signal Validity Protects a Target Stimulus From the At- tentional Blink显示文摘 | EVAN J L IRINA M H JUSTIN A H | 2009 | Journal of Experimental Psychology2009，35，2： | 1 |
| 8 | Frequency and clinical determinants of post-storke depression显示文摘 | Anter L Irina S | 1998 | Stroke1998，29，11： | 1 |
| 9 | Electrothermal atomic absorption spectrometric determination of arsenic in essential lavender and rose oils显示文摘 | IRINA B KARADJOVA LEONARDO LAMPUGNANI DIMITER L TSALEV | 2005 | Talanta2005，，65： | 1 |
| 10 | Frequency and clinical determinants of post stroke depression 显示文摘 | TARJA A L IRINA S RISTO V | 1998 | Stroke1998，29，26： | 1 |
| 11 | Somatic cell nuclear transfer in horses: effect of oocyte morphology, embryo reconstruction method and donor cell type 显示文摘 | IRINA L GIOVANNA L ROBERTO D | 2005 | Reproduction2005，130，： | 1 |
| 12 | Production of Herpes of B virus Recombinant Glycoproreins and Evaluation of their Diagnostic Potential 显示文摘 | L Perelygina Ludmilaperelygina Irina Patru sheua | 2005 | Journal of Clinical Microbiology2005，，2： | 1 |
| 13 | Interdomain information transer during substrate activation of yeast pyruvate decarboxylase:the interaction between Cysteine 221 and Histidine 92显示文摘 | Haijuan L Brian B | 1998 | Biochemistry1998，37，： | 1 |
| 14 | Removal of heavy metal ions from aqueous solutions by alkaline-earth metal phosphates 显示文摘 | Irina L Shashkova Anatolii I Rat' ko | 1999 | Clloids and Surfaces A1999，160，： | 1 |
| 15 | Frequency and clinical determinants of post - stroke depression显示文摘 | Jcrja P Antero L Irina S | 1998 | Stroke1998，29，11： | 1 |
| 16 | 45:Inflammation-induced preterm birth (Ⅱ-PTB):prenatal ILl β blockade prevents neonatal brain injury in a region specific manner but not preterm birth显示文摘 | Irina B Kirstin L Michael M | | 0，，1： | 1 |
| 17 | Investigation of contact phenomena at cubic boron nitride-filler metal interface during electron beam brazing显示文摘 | IGOR L Pobol ALEXEY A Shipko IRINA G Nesteruk | 1997 | Diamond and Related Materials1997，，6： | 1 |
| 18 | Antibacterial potential of novel synthetic derivatives of 1,4-Naphthoquinone and their com- plexes with biosurfactants显示文摘 | Anna S Tatyana A Irina L | 2014 | RJPBCS2014，5，4： | 1 |
| 19 | Frequency and clinical determinants of post-storke depression显示文摘 | Tcrja P Antero L Irina S | 1998 | Stroke1998，29，11： | 1 |
| 20 | Investigation of contact phenomena at cubic boron nitride-filler metal interface during electron beam brazing显示文摘 | Igor L P Alexey A S Irina G N | 1997 | Diamond and Related Materials1997，6，8： | 1 |
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