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| 1 | Transcatheter aortic valve implantation in very elderly patients: immediate results and medium term follow-up显示文摘ObjectiveTo 评估立即的 transcatheter 在有严重、征兆的大动脉的狭窄的很老的病人的大动脉的阀门培植(TAVI ) 结果和中期的后续(作为).MethodsThis multicenter,观察、未来的学习在三所医院里被执行。我们包括了连续很老(>85 年) 病人与作为严重由 TAVI 对待。主要端点是在包括的二 years.ResultsThe 研究从任何原因评估死亡率有一个平均数的 160 个连续病人 87 ± 变老;2.1 年(从 85 ~ 94 年的范围) 和 18.8%± 的吝啬的逻辑 EuroSCORE;11.2% 与 57 (35.6%) 病人得分 ≥20% 。程序的成功率是 97.5% ,与 25 (15.6%) 与主要流血经历尖锐复杂并发症的病人(最经常) 。全球死亡率在住院期间是 8.8%(n = 14 ) 并且 30 天的死亡率是 10%(n = 16 ) 。中部在时期上面列在后面是 252.24 ±232.17 天。在后续时期期间, 28 (17.5%) 病人们死了(他们中的 17 个由于心脏的原因) 。估计的二年全面、心脏的幸存率使用 Kaplan-Meier 方法分别地是 71% 和 86.4% 。比例的危险回归给看了的考克斯可变 EuroSCORE ≥20 是与全面 mortality.ConclusionsTAVI 联系的唯一的变量在很老的病人的一张选择人口安全、有效。我们的调查结果支持在病人的这个复杂的组的这个新过程的采纳。 | Isaac Pascual Antonio J Mu oz-García Diego López-Otero Pablo Avanzas Manuel F Jimenez-Navarro Belén Cid-Alvarez Raquel del Valle Juan H Alonso-Briales Raimundo Ocaranza-Sanchez José M Hemández Ramiro Trillo-Nouche César Morís | 2015 | Journal of Geriatric Cardiology2015，12，4： | 1 |
| 2 | Phase Ⅲ,randomized,double-blind,placebo-controlled multicenter trial of daily everolimus plus weekly trastuzumab and vinorelbine in trastuzumab-resistant,advanced breast cancer (BOLERO-3)显示文摘 | O' Regan R Ozguroglu M Andre F Toi M Jerusalem G Wilks S Isaacs C Xu B Masuda N Arena FP Yardley D Yap YS Mukhopadhyay P Douma S El-Hashimy M Taran T Sahmoud T Lebwohl D Gianni L | | 0，，15： | 1 |
| 3 | Association of ambient air pollution with respiratory hospitalization in a government designated 'area of concern': the case of Windsor, Ontario 显示文摘 | Isaac N L Karen Y F Kevin M G | 2005 | Environ Health Perspeet2005，113，3： | 1 |
| 4 | The stereochemistry of high pressure aldehyde addition to allylstannanes显示文摘 | ISAACS N S MARSHALL R L YOUNG D J | 1992 | Tetrahedron Lett1992，33，： | 1 |
| 5 | Serum tumor markers CEA,CYFRA21-1,and CA-125 are associated with worse prognosis in advanced nonsmall-cell lung cancer(NSCLC)显示文摘 | Susana C Isaac N Marina L | 2011 | Clin Lung Cancer2011，12，3： | 1 |
| 6 | Does arthroplasty type influence knee jointproprloception A longitudinal prospeetlve study comparing total and unicompartmental arthroplasty 显示文摘 | ISAAC S M BARKER K L DANIAL I N | 2007 | Knee2007，14，3： | 1 |
| 7 | Reactions of phosphite esters and trisdialkylaminophosphines with 5-substituted 1,3,4-thiadiazol derivatives 显示文摘 | Arsanious M H N Isaac Y A Boulos L S | 2001 | Heteroatom Chemistry2001，12，7： | 1 |
| 8 | Association of ambient air pollution with respiratory hospitalization in a government-designated 'area of concern':the case of Windsor,Ontario显示文摘 | Isaac N L Karen Y F Kevin M G | 2005 | Environmental Health Perspectives2005，113，3： | 1 |
| 9 | Association of ambient air pollution with respiratory hospitalization in a government-designated 'area of concern' : the case of Windsor, Ontario显示文摘 | ISAAC N L KAREN Y F KEVIN M G | 2005 | Environ Health Perspect2005，113，3： | 1 |
| 10 | Feeding rates and carbohydrate metabolism by Bemisia tabaci (Homoptera:Aleyrodidae) on different quality phloem saps显示文摘 | ISAACS R BYRNE D N HENDRIX D L | 1998 | Physiological Entomology1998，23，3： | 1 |
| 11 | Association of ambient air pollution with respiratory hospitaliza- tion in a government-designated 'area of concern': the case of Windsor, Ontario显示文摘 | Isaac N L Karen Y F Kevin M G | 2005 | Environ Health Perspect2005，113，2： | 1 |
| 12 | Does arthroplasty type influ- ence knee joint proprioception? A longitudinal prospective study comparing total and unicompartmcntal arthroplasty 显示文摘 | Isaac S M Barker K L Danial I N | 2007 | J Knee2007，14，4： | 1 |
| 13 | The geography of diabe- tes in London, Canada: The need for local level policy for prevention and management显示文摘 | Jordan W Isaac N Gillian L | 2010 | Int J Environ Res2010，7，5： | 1 |
| 14 | Does arthroplasty type influence knee joint proprioception?A longitudinal prospective study comparing total and unicompartmental arthroplasty显示文摘 | Isaac S M Barker K L Danial I N | 2007 | Knee2007，14，3： | 1 |
| 15 | Latin American consensus on hypertension in patients with diabetes type 2 and metabolic syndrome显示文摘 | Patricio López-Jaramillo Ramiro A. Sánchez Margarita Diaz Leonardo Cobos Alfonso Bryce Jose Z. Parra Carrillo Fernando Lizcano Fernando Lanas Isaac Sinay Iván D. Sierra Ernesto Pe?aherrera Mario Bendersky Helena Schmid Rodrigo Botero Manuel Urina Joffre L | 2013 | Journal of Hypertension2013，，2： | 1 |
| 16 | Association of ambient air pollution with respiratory hospitali- zation in government-designated 'area of concern':the case of Windsor,Ontario显示文摘 | Isaac N L Karen Y F Kevin M G | 2005 | Environ Health Per- spect2005，113，3： | 1 |
| 17 | Precise manipulation of chromosomes in vivo enables genome-wide codon replacement 显示文摘 | Isaacs F J Carr P A Wang H H Lajoie M J Sterling B Kraal L Tolonen A C Gianoulis T A Goodman D B Reppas N B | 2011 | Science2011，333，6040： | 1 |
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