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| 1 | Anticancer effect of linalool via cancer-specific hydroxyl radical generation in human colon cancer显示文摘AIM To investigate the anticancer mechanisms of the monoterpenoid alcohol linalool in human colon cancer cells.METHODS The cytotoxic effect of linalool on the human colon cancer cell lines and a human fibroblast cell line was examined using the WST-8 assay. The apoptosisinducing effect of linalool was measured using the terminal deoxynucleotidyl transferase d UTP nickend labeling assay and flow cytometry with Annexin V. Oxidative stress was investigated by staining for diphenyl-1-pyrenylphosphine, which is a cellular lipid peroxidation marker, and electron spin resonance spectroscopy. Sixteen SCID mice xenografted with human cancer cells were randomized into 3 groups for in vivo analysis: control and low-dose and high-dose linalool groups. The control group was administered tap water orally every 3 d. The linalool treatment groups were administered 100 or 200 μg/kg linalool solution orally for the same period. All mice were sacrificed under anesthesia 21 d after tumor inoculation, and tumors and organs were collected for immunohistochemistry using an anti-4-hydroxynonenal antibody. Tumor weights were measured and compared between groups. RESULTS Linalool induced apoptosis of cancer cells in vitro, following the cancer-specific induction of oxidative stress, which was measured based on spontaneous hydroxyl radical production and delayed lipid peroxidation. Mice in the high-dose linalool group exhibited a 55% reduction in mean xenograft tumor weight compared with mice in the control group(P < 0.05). In addition, tumor-specific lipid peroxidation was observed in the in vivo model.CONCLUSION Linalool exhibited an anticancer effect via cancerspecific oxidative stress, and this agent has potential for application in colon cancer therapy. | Kenichi Iwasaki Yun-Wen Zheng Soichiro Murata Hiromu Ito Ken Nakayama Tomohiro Kurokawa Naoki Sano Takeshi Nowatari Myra O Villareal Yumiko N Nagano Hiroko Isoda Hirofumi Matsui Nobuhiro Ohkohchi | 2016 | World Journal of Gastroenterology2016，22，44： | 5 |
| 2 | 卒中介入治疗培训指南:国际多学会共识文件显示文摘1背景
缺血性卒中是全球人口死亡和残疾的首要原因。很多急性大血管闭塞(emergent large vesselocclusion,ELVO)患者都会遗留长期残疾。事实上,这些颅内大动脉闭塞经常会导致大面积脑损伤,进而造成患者死亡或严重致残。 | Lavine SD Cockroft K Hoh B Bambakidis N Khalessi AA Woo H Riina H Siddiqui A Hirsch JA Chong W Rice H Wenderoth J Mitchell P Coulthard A Signh TJ Phatorous C Khangure M Klurfan P ter Brugge K Iancu D Gunnarsson T Pongpech S Rodesch G Soderman M Taylor A Krings T Orbach D Picard L Suh DC Zheng HQ Jansen O Muto M Szikora I Pierot L Brouwer P Gralla J Renowden S Andersson T Fiehler J Turjman F White P Januel AC Spelle L Kulcsar Z Chapot R Biondi A Dima S Taschner C Szajner M Krajina A Sakai N Matsumaru Y Yoshknura S Ezura M Fujinaka T Iihara K Ishii A Higashi T Hirohata M Hyodo A Ito Y Kawanishi M Kiyosue H Kobayashi E Kobayashi S Kuwayama N Matsumoto Y Miyachi S Murayama Y Nagata I Nakahara I Nemoto S Niimi Y Oishi H Satomi J Satow T Sugiu K Tanaka M Terada T Yamagami H Diaz O Lylyk P Jayaraman MV Patsalides A Gandhi CD Lee SK Abruzzo T Albani B Ansari SA Arthur AS Baxter BW Bulsara KR Chen M Almandoz JE Fraser JF Heck DV Hetts SW Hussain MS Klucznik RP Leslie-Mawzi TM Mack WJ McTaggart RA Meyers PM Mocco J Prestigiacomo CA Pride GL Rasmussen PA Starke RM Sunenshine PJ Tarr RW Frei DF Pabo M Nogueira RG Zaidat OO Jovin T Linfante I Yavagal D Liebeskind D Novakovic R Pongpech S 许岩 孙瑞 郭芮兵 | 2017 | 国际脑血管病杂志2017，25，5： | 2 |
| 3 | Maxillary bone transportation inalveolar cleft-transport distraction osteogenesis for treatment ofalveolar cleft repair显示文摘 | Mitsugi M Ito O Alcalde RE | 2005 | Br J Plast Surg2005，58，5： | 1 |
| 4 | Permethrin may disrupt testosterone biosynthesis via mitochondrial membrane damage of leydig cells in adult male mouse显示文摘 | Zhang SY Ito Y Yamanoshita O | 2007 | Endocrinology2007，148，： | 1 |
| 5 | Importance of active oxygen-scavenging system in the recovery of rice seedlings after submergence 显示文摘 | Ella E S Kawano N Ito O | 2003 | Plant Science2003，165，1： | 1 |
| 6 | Interleukin-10 Expression Mediated by an Adeno-Associated Virus Vector Prevents Monocrotaline-Induced Pulmonary Arterial Hypertension in Rats 显示文摘 | Takayuki Ito Takashi O Miyashita H | 2007 | Circ Res2007，101，7： | 1 |
| 7 | Evolutionary analysis of the influenza A virus M gene with comparison of the M1 and M2 protein 显示文摘 | Ito T Gorman O T Kawaoka Y | 1991 | J Virol1991，65，10： | 1 |
| 8 | OX40 ligand shuts down IL-10-preducing regulatory T cells显示文摘 | Ito T Wang YH Duramad O | 2006 | Proc Natl Acad Sci USA2006，103，13： | 1 |
| 9 | p38 MAP kinase is required for vasopressin-stimulated HSP27 induction in aortic smooth muscle cells显示文摘 | Ito T Kozawa O Tanabe K | 2002 | Hypertension2002，35，2： | 1 |
| 10 | Immunochemica differences between two types catalase from cows milk cream显示文摘 | Ito O Akuzawa Kamata S | 1984 | Japanese Journal of Zootechnical Science1984，55，72： | 1 |
| 11 | Diffuse reflectance spectra of coals in the UV-visible and near-IR regions显示文摘 | ITO O | 1992 | Energy Fuels1992，6，5： | 1 |
| 12 | The molecular weight ratio of monomethoxypolyethylene glycol (mPEG) to protein determines the immunotolerogenicity of mPEG proteins显示文摘 | SO T ITO H O TSUJIHATA Y | 1999 | Protein Eng1999，12，： | 1 |
| 13 | TSLP-activated dendritic cells induce an inflammatory T helper type 2 cell response through OX40 ligand显示文摘 | Ito T Wang Y H Duramad O | 2005 | J Exp Med2005，202，： | 1 |
| 14 | Development of bioreactors for denitrification with immobilized Cells显示文摘 | MATSUMURA M TSUBOTA H ITO O | | 0，，2： | 1 |
| 15 | In situ measurement of temperature distribution across a proton exchange membrane fuel cell显示文摘 | Lee S K Ito K Toshihiro O | 2009 | Electrochemical and Solid-State Letters2009，12，9： | 1 |
| 16 | Clinicopathologic study on an ALS family with a heterozygous E478G optlneurin mutation 显示文摘 | Ito H Nakamura M Komure O | 2011 | Acta Neuropathol2011，122，2： | 1 |
| 17 | Effects of additives and oxygen on extraction yield with CS2-NMP mixed solvent for Argonne premium coal samples显示文摘 | Ishizuka T Takanohashi T Ito O | 1993 | Fuel1993，72，： | 1 |
| 18 | Sodium-A functional plant nutrient显示文摘 | Sobbarao G V Ito O Berry W L | | 0，，： | 1 |
| 19 | TSLP-activated dendritic cells induce an infl ammatory T helper type 2 cell response through OX40 ligand显示文摘 | Ito T Wang Y H Duramad O | 2005 | J Exp Med2005，202，： | 1 |
| 20 | Three-dimensional computed to- mography angiography for the preoperative evaluation of coronary artery disease in lung cancer patients显示文摘 | Watanabe F Hataji O Ito K | 2013 | World J Surg Oncol2013，11，1： | 1 |
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