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| 1 | CD4+ CD25+ Foxp3 PD1 - reg- ulatory T ceils in acute and stable relapsing-remitting multiple scle- rosis and their modulation by therapy 显示文摘 | Marina S Ivana M Renato L | 2008 | FASEB J2008，22，10： | 1 |
| 2 | Sustainable tourism management in Crikvenica, Croatia: An assessment of policy instruments 显示文摘 | Ivana L | 2010 | Tourism Management2010，31，1： | 1 |
| 3 | pH Optical sensors based on sol-gels: Chemical doping versus covalent immobilization显示文摘 | Aleksandra L Ines O Ivana M | 1998 | Analytica1998，367，13： | 1 |
| 4 | Investigation of Tungsten Carbide Supported Pd or Pt as AnodeCatalysts for PEM Fuel Cells 显示文摘 | Nikolic Vladimir M Zugic Dragana L Perovic Ivana M | 2013 | International Journal of Hydro-gen Energy2013，38，11： | 1 |
| 5 | Phase transformations due to isochronal annealing of Mg-rare earth-Sc-Mn squeeze cast alloys显示文摘 | BOHUMIL S IVANA S JITKA P FRANK V B BARRY L B | 2003 | Z Metallkd2003，94，： | 1 |
| 6 | Purification and properties of extracellular lipase from Streptomyces rimosus, Enzyme显示文摘 | Marija A Ivana L Tamara K | 1999 | Microbiol Technol1999，25，： | 1 |
| 7 | Survival and prognostic factors for AIDS and non-AIDS patients with Non-Hodgkin' s lymphoma in Bahia, Brazih A retrospective cohort study显示文摘 | Estela L Marinho M Ivana L | 2013 | ISRN Hematology2013，7，： | 1 |
| 8 | pH optical sensors based on sol-gels: ehe~cal doping remus covalent immobilization显示文摘 | Aleksandra L Ines O Ivana M | 1998 | Analytica1998，367，： | 1 |
| 9 | The Impact of Peak Oil on Tourism in Spain: An Input-Output Analysis of Price, Demand and Economy-Wide Effects 显示文摘 | IVANA L BERGH V D JEROEN C J M | 2013 | Energy2013，54，2： | 1 |
| 10 | Regional geographic vari- ations in kidney cancer incidence rates in european countries显示文摘 | Peng L Ariana Z Ivana H | 2015 | Eur Urol2015，67，6： | 1 |
| 11 | An alkyl polyglucoside- mixed emulsifier as stabilizer of emulsion systems : the influence of colloidal structure on emulsions skin hydration potential显示文摘 | Snezana S Milica L Ivana J | 2011 | J Colloid InteoCSci2011，358，1： | 1 |
| 12 | An alkyl polyglucoside-mixed emulsifier as stabilizer of emulsion systems:The influence of colloidal structure on emulsions skin hydration potential显示文摘 | Savica S Milica L Ivana J | 2011 | J Colloid Interface Sci2011，358，1： | 1 |
| 13 | Supramolecular complex of fluoxetine with β-cyclodextrin: An experimental and theoretical study显示文摘 | Frederico B S Ivana S L Juliana F L | 2008 | International Journal of Pharmaceutics2008，353，： | 1 |
| 14 | Anthocyanins Accumulation and Related Gene Expression in Red Orange Fruit Induced by Low Temperature Storage 显示文摘 | Angela Roberta L P Ivana P Paolo R | 2005 | Journal of Agricultural & Food Chemistry2005，53，23： | 1 |
| 15 | A memetic algorithm for minimum-cost vertex-biconnectivity augmentation of graphs显示文摘 | Ivana L Gunther R R | 2003 | Journalof Heuristics2003，9，： | 1 |
| 16 | Human IgG1 antibodies suppress angiogenesis in a target-independent manner显示文摘Aberrant angiogenesis is implicated in diseases affecting nearly 10%of the world’s population.The most widely used antiangiogenic drug is bevacizumab,a humanized IgG1 monoclonal antibody that targets human VEGFA.Although bevacizumab does not recognize mouse Vegfa,it inhibits angiogenesis in mice.Here we show bevacizumab suppressed angiogenesis in three mouse models not via Vegfa blockade but rather Fc-mediated signaling through FcγRI(CD64)and c-Cbl,impairing macrophage migration.Other approved humanized or human IgG1 antibodies without mouse targets(adalimumab,alemtuzumab,ofatumumab,omalizumab,palivizumab and tocilizumab),mouse IgG2a,and overexpression of human IgG1-Fc or mouse IgG2a-Fc,also inhibited angiogenesis in wild-type and FcγR humanized mice.This anti-angiogenic effect was abolished by Fcgr1 ablation or knockdown,Fc cleavage,IgG-Fc inhibition,disruption of Fc-FcγR interaction,or elimination of FcRγ-initated signaling.Furthermore,bevacizumab’s Fc region potentiated its anti-angiogenic activity in humanized VEGFA mice.Finally,mice deficient in FcγRI exhibited increased developmental and pathological angiogenesis.These findings reveal an unexpected anti-angiogenic function for FcγRI and a potentially concerning off-target effect of hIgG1 therapies. | Sasha Bogdanovich Younghee Kim Takeshi Mizutani Reo Yasuma Laura Tudisco Valeria Cicatiello Ana Bastos-Carvalho Nagaraj Kerur Yoshio Hirano Judit Z Baffi Valeria Tarallo Shengjian Li Tetsuhiro Yasuma Parthasarathy Arpitha Benjamin J Fowler Charles B Wright Ivana Apicella Adelaide Greco Arturo Brunetti Menotti Ruvo Annamaria Sandomenico Miho Nozaki Ryo Ijima Hiroki Kaneko Yuichiro Ogura Hiroko Terasaki Balamurali K Ambati Jeanette HW Leusen Wallace Y Langdon Michael R Clark Kathryn L Armour Pierre Bruhns J Sjef Verbeek Bradley D Gelfand Sandro De Falco Jayakrishna Ambati | 2016 | Signal Transduction and Targeted Therapy2016，1，1： | 0 |
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