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| 1 | A mix method of knowledge capitalization in maintenance显示文摘 | IVANA R BRIGITTE C M NOUREDDINE Z | 2008 | Journal of Intelligent Manufacturing2008，19，3： | 1 |
| 2 | Deficiency of Adenomatous Polyposis Coli protein in sporadic colorectal adenomas and its associations with clinical phenotype and histology显示文摘瞄准:评估腺瘤结肠息肉病(APC ) 蛋白质的损失的频率并且把 APC 地位与颜色的特征作比较表面的腺瘤。方法:APC 蛋白质的 Immunohistochemical 分析在 118 个腺瘤上被执行,结果与病人的恶意的潜力,腺瘤的地点,宏观的外观和年龄的参数相比。结果:APC 蛋白质的完全的损失在 28 被发现的 A (24%) 腺瘤,当(76%) 90 是 APC 时积极。腺瘤的吝啬的尺寸是 13.5 +/- 14.2 公里(95% CI 10.5-16.5 ) 在 APC 积极,并且 13.8 +/- 在 APC 否定的腺瘤的 15.5 公里(95% CI 7.8-19.8 )(P = 0.364 ) 。统计分析没至于组织学的类型揭示 APC 积极、否定的腺瘤之间的差别(P = 0.327 ) 并且发育异常的等级(P = 0.494 ) 。我们发现甚至先进的腺瘤没与非先进的肿瘤在他们的 APC 地位不同(P = 0.414 ) 。最后,当时,没有差别被发现地点(P = 0.157 ) ,宏观的外观(P = 0.571 ) 并且病人的年龄(P = 0.438 ) 在两个 APC 积极、否定的腺瘤之间被分析并且比较。结论:大多数腺瘤表示了全身的 APC 蛋白质,建议那蛋白质表情不是为对 APC 基因变化的评价的一个可靠标记。APC 蛋白质的完全的损失没影响腺瘤的形态学,地点,或外观,它也不受病人的年龄影响。 | Martin Bortlík Ivana Vítková Martina Pape(z|ˇ)ová Milada Kohoutová Ale(s|ˇ) Novotn(y|') Stanislav Adamec Petra Chalupná Milan Luká(s|ˇ) | 2006 | World Journal of Gastroenterology2006，12，24： | 1 |
| 3 | Phenol content, antioxidant activity and metal composition of croatian wines deriving from organically and conven- tionally grown grapes显示文摘 | IVANA V V MIRZA B IRENA Z | 2011 | Food Chemistry2011，124，： | 1 |
| 4 | A Mix Method of Knowledge Capitalization in Mainte nance显示文摘 | Ivana R Brigitte C M Noureddine Z | 2008 | Journal of Intelligent Manufacturing2008，19，3： | 1 |
| 5 | Pulmonary complications in diabetes mellitus:the role of glycemic control显示文摘 | Diego A Silvia V Ivana Z | 2004 | Curr Drug Targets Inflamm Allergy2004，3，4： | 1 |
| 6 | Angiogenesis in multiple myeloma显示文摘 | Christian JB Jan'S Ivana Z | 2006 | Eur J Cancer2006，42，11： | 1 |
| 7 | Regional geographic vari- ations in kidney cancer incidence rates in european countries显示文摘 | Peng L Ariana Z Ivana H | 2015 | Eur Urol2015，67，6： | 1 |
| 8 | A mix method of knowledge capitalization in maintenance显示文摘 | IVANA R BRIGITTE C M NOUREDDINE Z | 2008 | Journal of Intelligent Manufacturing2008，19，3： | 1 |
| 9 | Assessment of health-related quality of life in patients with myasthenia gravis in Belgrade (Serbia) 显示文摘 | Ivana Z Basta Tatjana D Pekmezovie Stojan Z perle | 2012 | Neurological Sciences2012，33，6： | 1 |
| 10 | Optimization of modern analytical SPME and SPDE methods for determination of trans-2-nonenal in barley, malt and beer显示文摘 | SVOBODA Z MIKULIKOVA R IVANA M Z | 2011 | Chromatographia2011，73，1： | 1 |
| 11 | Ab initio study of pristine and Si-doped capped carbon nanotubes interacting with nimesulide molecules显示文摘 | IVANA Z SOLANGE B FAGAN R | 2007 | Chem Phys Lett2007，439，46： | 1 |
| 12 | A Mix Method of Knowledge Capitalization in Maintenance显示文摘 | Ivana R Brigitte C M Noureddine Z | 2008 | Journal of Intelligent Manu-facturing2008，19，3： | 1 |
| 13 | Human IgG1 antibodies suppress angiogenesis in a target-independent manner显示文摘Aberrant angiogenesis is implicated in diseases affecting nearly 10%of the world’s population.The most widely used antiangiogenic drug is bevacizumab,a humanized IgG1 monoclonal antibody that targets human VEGFA.Although bevacizumab does not recognize mouse Vegfa,it inhibits angiogenesis in mice.Here we show bevacizumab suppressed angiogenesis in three mouse models not via Vegfa blockade but rather Fc-mediated signaling through FcγRI(CD64)and c-Cbl,impairing macrophage migration.Other approved humanized or human IgG1 antibodies without mouse targets(adalimumab,alemtuzumab,ofatumumab,omalizumab,palivizumab and tocilizumab),mouse IgG2a,and overexpression of human IgG1-Fc or mouse IgG2a-Fc,also inhibited angiogenesis in wild-type and FcγR humanized mice.This anti-angiogenic effect was abolished by Fcgr1 ablation or knockdown,Fc cleavage,IgG-Fc inhibition,disruption of Fc-FcγR interaction,or elimination of FcRγ-initated signaling.Furthermore,bevacizumab’s Fc region potentiated its anti-angiogenic activity in humanized VEGFA mice.Finally,mice deficient in FcγRI exhibited increased developmental and pathological angiogenesis.These findings reveal an unexpected anti-angiogenic function for FcγRI and a potentially concerning off-target effect of hIgG1 therapies. | Sasha Bogdanovich Younghee Kim Takeshi Mizutani Reo Yasuma Laura Tudisco Valeria Cicatiello Ana Bastos-Carvalho Nagaraj Kerur Yoshio Hirano Judit Z Baffi Valeria Tarallo Shengjian Li Tetsuhiro Yasuma Parthasarathy Arpitha Benjamin J Fowler Charles B Wright Ivana Apicella Adelaide Greco Arturo Brunetti Menotti Ruvo Annamaria Sandomenico Miho Nozaki Ryo Ijima Hiroki Kaneko Yuichiro Ogura Hiroko Terasaki Balamurali K Ambati Jeanette HW Leusen Wallace Y Langdon Michael R Clark Kathryn L Armour Pierre Bruhns J Sjef Verbeek Bradley D Gelfand Sandro De Falco Jayakrishna Ambati | 2016 | Signal Transduction and Targeted Therapy2016，1，1： | 0 |
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