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| 1 | Diagnosis of gastrointestinal bleeding: A practical guide for clinicians显示文摘Gastrointestinal bleeding is a common problem encountered in the emergency department and in the primary care setting. Acute or overt gastrointestinal bleeding is visible in the form of hematemesis, melena or hematochezia. Chronic or occult gastrointestinal bleeding is notapparent to the patient and usually presents as positive fecal occult blood or iron deficiency anemia. Obscure gastrointestinal bleeding is recurrent bleeding when the source remains unidentified after upper endoscopy and colonoscopic evaluation and is usually from the small intestine. Accurate clinical diagnosis is crucial and guides definitive investigations and interventions. This review summarizes the overall diagnostic approach to gastrointestinal bleeding and provides a practical guide for clinicians. | Bong Sik Matthew Kim Bob T Li Alexander Engel Jaswinder S Samra Stephen Clarke Ian D Norton Angela E Li | 2014 | World Journal of Gastrointestinal Pathophysiology2014，5，4： | 13 |
| 2 | The cartilage specific microRNA-140 targets histone deacetylase 4 in mouse cells显示文摘 | Lee Tuddenham Guy Wheeler Sofia Ntounia-Fousara Jasmine Waters Mohammad K. Hajihosseini Ian Clark Tamas Dalmay | 2006 | FEBS Letters2006，，17： | 3 |
| 3 | 肺癌全基因组测序显示文摘肺癌是全球肿瘤发病率和病死率的主因,且预后很差。加强对肿瘤生物学的认识对肺癌研究至关重要。被誉为'下一代测序技术'的NGS技术(next-generation sequencing)是一种针对全基因组鉴定的有力工具,可以对致癌体细胞突变进行全面检测。大多数的NGS技术是基于平台特异性DNA文库进行多重聚合酶链反应(polymerase chain reaction,PCR),从而对目的基因扩增后测序。这种技术适用于高通量测序,可以检测出肿瘤中出现的全部基因组变异。缺点是这种技术需要在时间、实验设备、计算机数据分析、生物信息技术等各方面的大量投入。NGS技术已广泛应用于全基因组、外显子组、转录组和表观基因组的研究中,为肺癌研究和医疗模式带来改变。这项新技术的开展将转变当前对致癌信号通路的认识,可为癌症诊疗提供新的分子靶点。肺癌体细胞突变已有NGS技术的分析报道,但大规模基因组研究仍在进行中。个体化治疗策略将改善那些潜在获益患者的治疗方式,避免'无辜'患者受无效治疗带来的高额费用和不良反应。NGS的组织化、计算机化和生物信息化技术推动了科技的进步,同时,患者知情权和数据发布的相关伦理问题也浮现出来。信号通路中,驱动基因(driver gene)突变和传递基因(passenger gene)突变的区别,需要对测序结果进行细致解读。解读准确与否取决于DNA提取的样本类型、样本处理技术和样本含量。肿瘤异质性也会降低肿瘤基因突变的检测效能。NGS技术将推动对肿瘤基因突变的基础和临床研究,而且,也可应用于单细胞和游离的循环DNA,未来还将用于从体液和肿瘤亚群中获取的DNA样本。如果能进一步降低费用、提高检验速度和精度,NGS技术无疑将会成为肺癌研究的绝佳选择。 | Marissa Daniels Felicia Goh Casey M. Wright Krishna B. Sriram Vandana Relan Belinda E. Clarke Edwina E. Duhig Rayleen V. Bowman Ian A Yang Kwun M. Fong 孙岚 何建行 | 2013 | 国际病理科学与临床杂志2013，33，4： | 2 |
| 4 | Instructional design and technology grounded in Enactivism A para- digm shift? 显示文摘 | Qing Li Bruce Clark and Ian Winchester | 2010 | British Journal of Educational Tech nology2010，3，41： | 1 |
| 5 | Diagnostic molecular biomarkers for malignant pleural effusions显示文摘 | Krishna B Sriram Vandana Relan Belinda E Clarke Edwina E Duhig Ian A Yang Rayleen V Bowman YC Gary Lee Kwun M Fong | 2011 | Future Oncol2011，，6： | 1 |
| 6 | Improved post-thaw recovery of peripheral blood stem/progenitor cells using a novel intracellular-like cryopreservation solution显示文摘 | Dominic M. Clarke David J. Yadock Ian B. Nicoud Aby J. Mathew Shelly Heimfeld | 2009 | Cytotherapy2009，，4： | 1 |
| 7 | Plant community dynamics in a calcareous grassland under climate change manipulations显示文摘 | Marcelo Sternberg Valerie K. Brown Gregory J. Masters Ian P. Clarke | 1999 | Plant Ecology1999，，1： | 1 |
| 8 | Formative Assessment: Assessment Is for Serf-regulated Learning显示文摘 | Ian Clark | 2012 | Educ Psychol Rev2012，，24： | 1 |
| 9 | The roles of TNF in brain dysfunction and disease显示文摘 | Ian A. Clark Lisa M. Alleva Bryce Vissel | 2010 | Pharmacology and Therapeutics2010，，3： | 1 |
| 10 | A Context‐sensitive Approach to Analysing Talk in Strategy Meetings显示文摘 | Ian Clarke Winston Kwon Ruth Wodak | 2011 | Brit J Manage2011，，4： | 1 |
| 11 | Culture-independent molecular techniques for soil microbial ecology显示文摘 | Penny R. Hirsch Tim H. Mauchline Ian M. Clark | 2010 | Soil Biology and Biochemistry2010，，6： | 1 |
| 12 | The effect of vitamin E on blood pressure in individuals with type 2 diabetes: a randomized, double-blind, placebo-controlled trial显示文摘 | Natalie C Ward Jason HY Wu Michael W Clarke Ian B Puddey Valerie Burke Kevin D Croft Jonathan M Hodgson | 2007 | Journal of Hypertension2007，，1： | 1 |
| 13 | Towards a contemporary perspective of retail location显示文摘 | Ian Clarke David Bennison John Pal | 1997 | International Journal of Retail& Distribution Management1997，25，2： | 1 |
| 14 | Google Generation II :web behavior experiments with the B BC 显示文摘 | DAVID Nicholas IAN Rowlands DAVID Clark | 2011 | Aslib Proceedings2011，63，1： | 1 |
| 15 | Belief Formation in Ethical Consumer Groups:An Exploratory Study 显示文摘 | Deirdre Shaw Ian Clarke | 1999 | Marketing Intelligence & Planning1999，17，2： | 1 |
| 16 | A comparison of GPS, VLBI and model estimates of ocean tide loading displacements显示文摘 | Ian D. Thomas Matt A. King Peter J. Clarke | 2007 | Journal of Geodesy2007，，5： | 1 |
| 17 | Legitimacy in a Global Order显示文摘 | Ian Clark | 2003 | Review of International Studies2003，，： | 1 |
| 18 | Expression and function of matrix metalloproteinase (MMP)-28显示文摘 | Ursula R. Rodgers Lara Kevorkian Alison K. Surridge Jasmine G. Waters Tracey E. Swingler Kirsty Culley Sara Illman Jouko Lohi Andrew E. Parker Ian M. Clark | 2009 | Matrix Biology2009，，5： | 1 |
| 19 | Raman spectroscopic library of natural and synthetic pig- ments(pre--1850AD)显示文摘 | Ian M Bell Robin J H Clark Peter J Gibbs | 1997 | Spectrochimica Acta Part A1997，53，： | 1 |
| 20 | Retail power, competition and local consumer choice in the UK grocery sector 显示文摘 | Ian Clarke | 2000 | European Journal of Marketing2000，8，34： | 1 |
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