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| 1 | Dysregulation of innate immunity in ulcerative colitis patients who fail anti-tumor necrosis factor therapy显示文摘AIM To study the innate immune function in ulcerative colitis(UC) patients who fail to respond to anti-tumor necrosis factor(TNF) therapy.METHODS Effects of anti-TNF therapy, inflammation and medications on innate immune function were assessed by measuring peripheral blood mononuclear cell(PBMC) cytokine expression from 18 inflammatory bowel disease patients pre- and 3 mo post-anti-TNF therapy. Toll-like receptor(TLR) expression and cytokine production post TLR stimulation was assessed in UC 'responders'(n = 12) and 'non-responders'(n = 12) and compared to healthy controls(n = 12). Erythrocyte sedimentation rate(ESR) and C-reactive protein(CRP) levels were measured in blood to assess disease severity/activity and inflammation. Pro-inflammatory(TNF, IL-1β, IL-6), immuno-regulatory(IL-10), Th1(IL-12, IFNγ) and Th2(IL-9, IL-13, IL-17A) cytokine expression was measured with enzyme-linked immunosorbent assay while TLR cellular composition and intracellular signalling was assessed with FACS.RESULTS Prior to anti-TNF therapy, responders and nonresponders had similar level of disease severity and activity. PBMC's ability to respond to TLR stimulation was not affected by TNF therapy, patient's severity of the disease and inflammation or their medication use. At baseline, non-responders had elevated innate but not adaptive immune responses compared to responders(P < 0.05). Following TLR stimulation, nonresponders had consistently reduced innate cytokine responses to all TLRs compared to healthy controls(P < 0.01) and diminished TNF(P < 0.001) and IL-1β(P < 0.01) production compared to responders. This innate immune dysfunction was associated with reduced number of circulating plasmacytoid dendritic cells(p DCs)(P < 0.01) but increased number of CD4+ regulatory T cells(Tregs)(P = 0.03) as well as intracellular accumulation of IRAK4 in non-responders following TLR-2,-4 and-7 activation(P < 0.001). CONCLUSION Reduced innate immunity in non-responders may explain reduced efficacy to anti-TNF therapy. These serological markers may prove useful in predicting the outcome of costly anti-TNF therapy. | Angela C Baird Dominic Mallon Graham Radford-Smith Julien Boyer Thierry Piche Susan L Prescott Ian C Lawrance Meri K Tulic | 2016 | World Journal of Gastroenterology2016，22，41： | 10 |
| 2 | The Roper-Suffridge extension operator and classes of biholomorphic mappings Dedicated to Professor Sheng GONG on the occasion of his 75th birthday显示文摘In this paper we give a survey about the Roper-Suffridge extension operator and the developments in the theory of univalent mappings in several variables to which it has led. We begin with the basic geometric properties (most of which now have a number of different proofs)and discuss relations with the theory of Loewner chains and generalizations and modifications of the operator, some of which are very recent. | GRAHAM Ian KOHR Gabriela | 2006 | Science China Mathematics2006，49，11： | 5 |
| 3 | Developing Wheat for Improved Yield and Adaptation Under a Changing Climate: Optimization of a Few Key Genes显示文摘世界上雨养无灌溉条件下种植的小麦常常受到干旱的影响。针对未来气候的模拟预测显示,除非采用适当的品种,否则温度上升和降雨模式的联合作用将加剧这种干旱情况,并可能造成小麦大幅度减产。由于物候基因的多样性,小麦具有广泛的适应性。小麦物候学提供了一个根据目标环境中可用水改变作物的发育阶段从而提高抗旱性。本文综述了春化(Vrn)、光周期(Ppd)和矮秆(Rht)基因等小麦物候学研究的最新进展。在不同气候条件下Vrn和Ppd基因的等位基因、单倍型和拷贝数有不同的反应,因而不仅可以改变发育阶段,而且可以改良产量。与模式植物拟南芥(Arabidopsis thaliana)相比,还有更多尚未发现的小麦物候基因,在目标环境中量化其效应将有助于通过育种提高小麦的耐旱性。因此,通过配置适当的物候基因、Rht基因和其他耐旱性相关的重要生理性状的组合,可以在水资源有限的环境中使产量最大化。 | M.A.N. Nazim Ud Dowl Ian Edwards Graham O'Hara Shahidul Islam Wujun Ma | 2018 | Engineering2018，4，4： | 3 |
| 4 | ESC/EAS Guidelines for the management of dyslipidaemias显示文摘 | Alberico L. Catapano ?eljko Reiner Guy De Backer Ian Graham Marja-Riitta Taskinen Olov Wiklund Stefan Agewall Eduardo Alegria M. John Chapman Paul Durrington Serap Erdine Julian Halcox Richard Hobbs John Kjekshus Pasquale Perrone Filardi Gabriele Riccardi | 2011 | Atherosclerosis2011，，： | 3 |
| 5 | Serious infections in patients with inflammatory bowel disease receiving anti‐tumor‐necrosis‐factor‐alpha therapy: An Australian and New Zealand experience显示文摘 | Ian CLawrance Graham LRadford‐Smith Peter ABampton Jane MAndrews Pok‐KernTan AnthonyCroft Richard BGearry Timothy H JFlorin | 2010 | Journal of Gastroenterology and Hepatology2010，，11： | 2 |
| 6 | Plasma Total Cysteine as a Risk Factor for Vascular Disease: The European Concerted Action Project显示文摘 | Lina El-Khairy Per M. Ueland Helga Refsum Ian M. Graham Stein E. Vollset | 2001 | Circulation: Journal of the American Heart Association2001，，21： | 2 |
| 7 | Vedolizumab for ulcerative colitis: Real world outcomes from a multicenter observational cohort of Australia and Oxford显示文摘BACKGROUND Vedolizumab(VDZ),a humanised monoclonal antibody that selectively inhibits alpha4-beta7 integrins is approved for use in adult moderate to severe ulcerative colitis(UC)patients.AIM To assess the efficacy and safety of VDZ in the real-world management of UC in a large multicenter cohort involving two countries and to identify predictors of achieving remission.METHODS A retrospective review of Australian and Oxford,United Kingdom data for UC patients.Clinical response at 3 mo,endoscopic remission at 6 mo and clinical remission at 3,6 and 12 mo were assessed.Cox regression models and Kaplan Meier curves were performed to assess the time to remission,time to failure and the covariates influencing them.Safety outcomes were recorded.RESULTS Three hundred and three UC patients from 14 centres in Australia and United Kingdom,[60%n=182,anti-TNF naïve]were included.The clinical response was 79%at 3 mo with more Australian patients achieving clinical response compared to Oxford(83%vs 70%P=0.01).Clinical remission for all patients was 56%,62%and 60%at 3,6 and 12 mo respectively.Anti-TNF naive patients were more likely to achieve remission than exposed patients at all the time points(3 mo 66%vs 40%P<0.001,6 mo 73%vs 46%P<0.001,12 mo 66%vs 51%P=0.03).More Australian patients achieved endoscopic remission at 6 mo compared to Oxford(69%vs 43%P=0.01).On multi-variate analysis,anti-TNF naïve patients were 1.8(95%CI:1.3-2.3)times more likely to achieve remission than anti-TNF exposed(P<0.001).32 patients(11%)had colectomy by 12 mo.CONCLUSION VDZ was safe and effective with 60%of UC patients achieving clinical remission at 12 mo and prior anti-TNF exposure influenced this outcome. | Samba Siva Reddy Pulusu Ashish Srinivasan Krupa Krishnaprasad Daniel Cheng Jakob Begun CharlotteKeung Daniel Van Langenberg Lena Thin Tamara Mogilevski Peter De Cruz Graham Radford-Smith Emma Flanagan Sally Bell Soleiman Kashkooli Miles Sparrow Simon Ghaly Peter Bampton Elise Sawyer Susan Connor Quart-ul-ain Rizvi Jane M Andrews Gillian Mahy Paola Chivers Simon Travis Ian Craig Lawrance | 2020 | World Journal of Gastroenterology2020，26，30： | 2 |
| 8 | ESC/EAS Guidelines for the management of dyslipidaemias显示文摘 | Alberico L. Catapano ?eljko Reiner Guy De Backer Ian Graham Marja-Riitta Taskinen Olov Wiklund Stefan Agewall Eduardo Alegria M. John Chapman Paul Durrington Serap Erdine Julian Halcox Richard Hobbs John Kjekshus Pasquale Perrone Filardi Gabriele Riccardi | 2011 | Atherosclerosis2011，，1： | 2 |
| 9 | Inter-observer agreement for Crohn’s disease sub-phenotypes using the Montreal Classification: How good are we? A multi-centre Australasian study显示文摘 | Krupa Krishnaprasad Jane M. Andrews Ian C. Lawrance Timothy Florin Richard B. Gearry Rupert W.L. Leong Gillian Mahy Peter Bampton Ruth Prosser Peta Leach Laurie Chitti Charles Cock Rachel Grafton Anthony R. Croft Sharon Cooke James D. Doecke Graham L. Rad | 2011 | Journal of Crohn’s and Colitis2011，，3： | 2 |
| 10 | Noninvasive ventilator triggering in chronic obstructive pulmonary disease显示文摘 | Ian M Stell Graham P | 2001 | Am J Respir Crit Care Med2001，164，： | 1 |
| 11 | Asymptotically spirallike mappings in several complex variables显示文摘 | Ian Graham Hidetaka Hamada Gabriela Kohr Mirela Kohr | 2008 | Journal d’Analyse Mathématique2008，，1： | 1 |
| 12 | Meta-igneous granulite xenoliths from Mount Ruapehu, New Zealand: Fragments of altered oceanic crust?显示文摘 | Ian J. Graham Peter Blattner Malcolm T. McCulloch | 1990 | Contributions to Mineralogy and Petrology1990，，6： | 1 |
| 13 | On the direct effect of clouds and atmospheric particles on the productivity and structure of vegetation显示文摘 | Michael L. Roderick Graham D. Farquhar Sandra L. Berry Ian R. Noble | 2001 | Oecologia2001，，1： | 1 |
| 14 | Cold and Light Control Seed Germination through the bHLH Transcription Factor SPATULA显示文摘 | Steven Penfield Eve-Marie Josse Rubini Kannangara Alison D. Gilday Karen J. Halliday Ian A. Graham | 2005 | Current Biology2005，，22： | 1 |
| 15 | Modeling and Managing state in Distributed Systems: The Role of OGSI and WSRF 显示文摘 | Ian Foster K Czajkowski D Ferguson J Frey S Graham D Snelling S Tuecke | 2005 | Proceedings of the IEEE: (S0018-9219)2005，93，3： | 1 |
| 16 | Screening for Antitumor Activity of 11 Species of Indonesian Zingiberaceae Using Human MCF-7 and HT-29 Cancer Cells显示文摘 | Chandra Kirana Ian R. Record Graeme H. McIntosh Graham P. Jones | 2003 | Pharmaceutical Biology2003，，： | 1 |
| 17 | Pathways of straight and branched chain fatty acid catabolism in higher plants显示文摘 | Ian A Graham Peter J Eastmond | 2002 | Progress in Lipid Research2002，，2： | 1 |
| 18 | Guided versus blind liver biopsy for chronic hepatitis C: clinical benefits and costs显示文摘 | Richard J Farrell Pauline F Smiddy Ruth M Pilkington Anne A Tobin Eoghan E Mooney Ian J Temperley George S McDonald Heather A Bowmer Graham F Wilson Dermot Kelleher | 1999 | Journal of Hepatology1999，，4： | 1 |
| 19 | Acupuncture for Neck Disorders显示文摘 | Kien Trinh Nadine Graham Anita Gross Charlie Goldsmith Ellen Wang Ian Cameron Theresa Kay | 2007 | Spine2007，，2： | 1 |
| 20 | On the direct effect of clouds and atmospheric particles on the productivity and structure of vegetation显示文摘 | Michael L. Roderick Graham D. Farquhar Sandra L. Berry Ian R. Noble | 2001 | Oecologia2001，，1： | 1 |
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